NO20072286L - Hemming av HCV NS3-NS4A-protease - Google Patents
Hemming av HCV NS3-NS4A-proteaseInfo
- Publication number
- NO20072286L NO20072286L NO20072286A NO20072286A NO20072286L NO 20072286 L NO20072286 L NO 20072286L NO 20072286 A NO20072286 A NO 20072286A NO 20072286 A NO20072286 A NO 20072286A NO 20072286 L NO20072286 L NO 20072286L
- Authority
- NO
- Norway
- Prior art keywords
- hcv
- genotype
- relates
- activity
- inhibition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
S a m m e n d r a g Foreliggende oppfinnelse vedrører å hemme aktiviteten av ikke-genotype 1-hepatitt C-virus (HCV) NS3-NS4A-proteaseaktivitet. Nærmere bestemt vedrører oppfinnelsen å hemme aktiviteten av proteasen fra HCV genotype-2 eller HCV genotype-3. Metodene ifølge oppfinnelsen benytter inhibitorer som virker ved å inngripe i livssyklusen for HCV, og de er også nyttige som antivirale midler. Oppfinnelsen vedrører videre sammensetninger som omfatter slike forbindelser enten for anvendelse ex vivo eller for administrasjon til en pasient som lider av genotype-2 eller genotype-3 HCV-infeksjon. Oppfinnelsen vedrører også metoder for å behandle en HCV-infeksjon i en pasient ved å administrere en sammensetning som omfatter en forbindelse ifølge denne oppfinnelse. ?? ?? ?? ??
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61541204P | 2004-10-01 | 2004-10-01 | |
PCT/US2005/035191 WO2006039488A2 (en) | 2004-10-01 | 2005-09-30 | Hcv ns3-ns4a protease inhibition |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20072286L true NO20072286L (no) | 2007-05-02 |
Family
ID=36143080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20072286A NO20072286L (no) | 2004-10-01 | 2007-05-02 | Hemming av HCV NS3-NS4A-protease |
Country Status (17)
Country | Link |
---|---|
US (2) | US20080267915A1 (no) |
EP (2) | EP2374464A3 (no) |
JP (3) | JP2008514723A (no) |
KR (2) | KR20130083938A (no) |
CN (2) | CN102160891A (no) |
AU (1) | AU2005291918A1 (no) |
BR (1) | BRPI0516825A (no) |
CA (1) | CA2583472A1 (no) |
IL (1) | IL182339A0 (no) |
MX (1) | MX2007003812A (no) |
NO (1) | NO20072286L (no) |
NZ (1) | NZ554351A (no) |
RU (2) | RU2007116265A (no) |
SG (2) | SG191661A1 (no) |
TW (2) | TW201300108A (no) |
WO (1) | WO2006039488A2 (no) |
ZA (1) | ZA200703484B (no) |
Families Citing this family (45)
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IL129407A0 (en) * | 1996-10-18 | 2000-02-17 | Vertex Pharma | Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof |
MY148123A (en) * | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
EP2546246A3 (en) | 2005-05-13 | 2013-04-24 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
WO2006127289A1 (en) * | 2005-05-20 | 2006-11-30 | Valeant Research & Development | Treatment of hcv with subtherapeutic doses of ribavirin |
WO2007011777A2 (en) * | 2005-07-18 | 2007-01-25 | Novartis Ag | Small animal model for hcv replication |
US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
JP5646814B2 (ja) * | 2006-03-06 | 2014-12-24 | アッヴィ・インコーポレイテッド | Hcvを治療するためのリトナビルの組成物及び使用方法 |
CA2646229A1 (en) * | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
CA2643680A1 (en) | 2006-04-11 | 2007-11-22 | Novartis Ag | Hcv/hiv inhibitors and their uses |
CA2670260A1 (en) | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
TW200846343A (en) | 2007-02-27 | 2008-12-01 | Vertex Pharma | Co-crystals and pharmaceutical compositions comprising the same |
WO2008106058A2 (en) | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
ATE530546T1 (de) | 2007-08-30 | 2011-11-15 | Vertex Pharma | Kokristalle und pharmazeutische zusammensetzungen damit |
KR101218882B1 (ko) * | 2007-10-10 | 2013-01-07 | 노파르티스 아게 | 스피로피롤리딘, 및 hcv 및 hiv 감염에 대한 그의 용도 |
AU2009335904A1 (en) * | 2008-12-19 | 2011-08-04 | Gilead Sciences, Inc. | HCV NS3 protease inhibitors |
US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
WO2011068715A1 (en) | 2009-11-25 | 2011-06-09 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
KR20120130173A (ko) | 2009-12-24 | 2012-11-29 | 버텍스 파마슈티칼스 인코포레이티드 | 플라비바이러스 감염을 치료 또는 예방하기 위한 유사체들 |
MX2012009926A (es) * | 2010-02-25 | 2012-10-05 | Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg | Un proceso para la preparacion de peptidos prolil sustituidos y peptidomimeticos similares. |
TW201139438A (en) | 2010-03-24 | 2011-11-16 | Vertex Pharma | Analogues for the treatment or prevention of flavivirus infections |
WO2011119860A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
CA2794145A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
AU2011232348A1 (en) | 2010-03-24 | 2012-10-11 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of Flavivirus infections |
WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
WO2011159826A2 (en) | 2010-06-15 | 2011-12-22 | Vertex Pharmaceuticals Incorporated | Hcv ns5b protease mutants |
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EP2585448A1 (en) | 2010-06-28 | 2013-05-01 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
WO2012006070A1 (en) | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
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CN104383541A (zh) | 2011-10-21 | 2015-03-04 | 艾伯维公司 | 用于治疗hcv的包含至少两种直接抗病毒剂和利巴韦林但无干扰素的方法 |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
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JP5924587B2 (ja) * | 2012-09-18 | 2016-05-25 | 国立大学法人 鹿児島大学 | 血中hcv検出方法及び抗hcv治療の効果判定方法 |
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CA3022119A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
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US20050187192A1 (en) | 2004-02-20 | 2005-08-25 | Kucera Pharmaceutical Company | Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses |
WO2006016930A2 (en) * | 2004-05-14 | 2006-02-16 | Intermune, Inc. | Methods for treating hcv infection |
-
2005
- 2005-09-30 EP EP11157671A patent/EP2374464A3/en not_active Withdrawn
- 2005-09-30 KR KR1020137017402A patent/KR20130083938A/ko not_active Application Discontinuation
- 2005-09-30 JP JP2007534798A patent/JP2008514723A/ja active Pending
- 2005-09-30 MX MX2007003812A patent/MX2007003812A/es not_active Application Discontinuation
- 2005-09-30 WO PCT/US2005/035191 patent/WO2006039488A2/en active Application Filing
- 2005-09-30 NZ NZ554351A patent/NZ554351A/en not_active IP Right Cessation
- 2005-09-30 EP EP05808364A patent/EP1804821A4/en not_active Withdrawn
- 2005-09-30 SG SG2013044839A patent/SG191661A1/en unknown
- 2005-09-30 SG SG200906375-1A patent/SG155967A1/en unknown
- 2005-09-30 CN CN2009102625660A patent/CN102160891A/zh active Pending
- 2005-09-30 CN CNA2005800412316A patent/CN101072575A/zh active Pending
- 2005-09-30 TW TW101116449A patent/TW201300108A/zh unknown
- 2005-09-30 TW TW094134425A patent/TW200621233A/zh unknown
- 2005-09-30 RU RU2007116265/14A patent/RU2007116265A/ru not_active Application Discontinuation
- 2005-09-30 AU AU2005291918A patent/AU2005291918A1/en not_active Abandoned
- 2005-09-30 BR BRPI0516825-2A patent/BRPI0516825A/pt not_active IP Right Cessation
- 2005-09-30 CA CA002583472A patent/CA2583472A1/en not_active Abandoned
- 2005-09-30 KR KR1020077009838A patent/KR20070061570A/ko active Application Filing
- 2005-09-30 US US11/576,017 patent/US20080267915A1/en not_active Abandoned
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2007
- 2007-03-29 IL IL182339A patent/IL182339A0/en unknown
- 2007-04-30 ZA ZA200703484A patent/ZA200703484B/xx unknown
- 2007-05-02 NO NO20072286A patent/NO20072286L/no not_active Application Discontinuation
-
2010
- 2010-08-24 RU RU2010135497/15A patent/RU2010135497A/ru not_active Application Discontinuation
- 2010-11-22 US US12/951,926 patent/US20110059886A1/en not_active Abandoned
-
2011
- 2011-11-10 JP JP2011246034A patent/JP2012102098A/ja not_active Ceased
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2014
- 2014-07-11 JP JP2014142885A patent/JP2014237664A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2006039488A3 (en) | 2007-02-22 |
ZA200703484B (en) | 2008-09-25 |
TW201300108A (zh) | 2013-01-01 |
JP2008514723A (ja) | 2008-05-08 |
JP2012102098A (ja) | 2012-05-31 |
BRPI0516825A (pt) | 2008-09-23 |
MX2007003812A (es) | 2007-05-24 |
EP2374464A2 (en) | 2011-10-12 |
KR20070061570A (ko) | 2007-06-13 |
CA2583472A1 (en) | 2006-04-13 |
CN101072575A (zh) | 2007-11-14 |
EP1804821A4 (en) | 2009-07-15 |
KR20130083938A (ko) | 2013-07-23 |
US20110059886A1 (en) | 2011-03-10 |
AU2005291918A1 (en) | 2006-04-13 |
JP2014237664A (ja) | 2014-12-18 |
CN102160891A (zh) | 2011-08-24 |
NZ554351A (en) | 2010-02-26 |
RU2007116265A (ru) | 2008-11-10 |
SG155967A1 (en) | 2009-10-29 |
WO2006039488A2 (en) | 2006-04-13 |
RU2010135497A (ru) | 2012-02-27 |
SG191661A1 (en) | 2013-07-31 |
IL182339A0 (en) | 2007-07-24 |
EP2374464A3 (en) | 2011-10-26 |
EP1804821A2 (en) | 2007-07-11 |
US20080267915A1 (en) | 2008-10-30 |
TW200621233A (en) | 2006-07-01 |
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