NO20065441L - Fremgangsmate for fremstilling av atazanavir-bisulfat og nye varianter - Google Patents
Fremgangsmate for fremstilling av atazanavir-bisulfat og nye varianterInfo
- Publication number
- NO20065441L NO20065441L NO20065441A NO20065441A NO20065441L NO 20065441 L NO20065441 L NO 20065441L NO 20065441 A NO20065441 A NO 20065441A NO 20065441 A NO20065441 A NO 20065441A NO 20065441 L NO20065441 L NO 20065441L
- Authority
- NO
- Norway
- Prior art keywords
- bisulfate
- atazanavir
- preparation
- crystals
- atazanavir bisulfate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/127—Preparation from compounds containing pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Det tilveiebringes en fremgangsmåte for fremstilling av HlV-protease-hemmeren atazanavir-bisulfat, hvor en løsning av atazanavir som fri base blir omsatt med konsentrert svovelsyre i en mengde for å reagere med mindre enn ca. 15 vekt% av den frie basen, kimkrystaller av form A-krystaller av atazanavir-bisulfat blir satt til reaksjonsblandingen, og som krystaller av bisulfat-formen blir ytterligere konsentrert svovelsyre tilsatt i mange trinn i økende rater i henhold til en tredjegradsligning, for å bevirke dannelse av form A-krystaller av atazanavir-bisulfat. Det tilveiebringes også en fremgangsmåte for fremstilling av atazanavir-bisulfat som mønster C-materiale. Det tilveiebringes også en ny form av atazanavir-bisulfat som er form E3, som er et meget krystallinsk trietanolatsolvat av bisulfat-saltet fra etanol.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56804304P | 2004-05-04 | 2004-05-04 | |
US60753304P | 2004-09-07 | 2004-09-07 | |
US11/119,558 US7829720B2 (en) | 2004-05-04 | 2005-05-02 | Process for preparing atazanavir bisulfate and novel forms |
PCT/US2005/015333 WO2005108349A2 (en) | 2004-05-04 | 2005-05-03 | Process for preparing atazanavir bisulfate and novel forms |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20065441L true NO20065441L (no) | 2006-11-27 |
NO341013B1 NO341013B1 (no) | 2017-08-07 |
Family
ID=35310244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20065441A NO341013B1 (no) | 2004-05-04 | 2006-11-27 | Fremgangsmåte for fremstilling av atazanavirbisulfat,og former derav |
Country Status (20)
Country | Link |
---|---|
US (3) | US7829720B2 (no) |
EP (3) | EP2669273A1 (no) |
JP (1) | JP5086069B2 (no) |
KR (1) | KR101153606B1 (no) |
AU (2) | AU2005240622B2 (no) |
BR (1) | BRPI0509595B8 (no) |
CA (2) | CA2565629C (no) |
CY (1) | CY1116919T1 (no) |
DK (1) | DK1755596T5 (no) |
ES (1) | ES2552219T3 (no) |
HR (1) | HRP20150962T2 (no) |
HU (1) | HUE026242T2 (no) |
IL (1) | IL178965A (no) |
MX (1) | MXPA06012612A (no) |
NO (1) | NO341013B1 (no) |
PL (1) | PL1755596T3 (no) |
PT (1) | PT1755596E (no) |
RS (1) | RS54284B1 (no) |
SI (1) | SI1755596T1 (no) |
WO (1) | WO2005108349A2 (no) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200534879A (en) * | 2004-03-25 | 2005-11-01 | Bristol Myers Squibb Co | Coated tablet formulation and method |
US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
US7829720B2 (en) | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
TWI354569B (en) * | 2004-05-28 | 2011-12-21 | Bristol Myers Squibb Co | Coated tablet formulation and method |
US7642049B2 (en) | 2006-06-30 | 2010-01-05 | Bristol-Myers Squibb Company | Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms |
PL2003120T3 (pl) | 2007-06-12 | 2010-04-30 | Concert Pharmaceuticals Inc | Pochodne azapeptydu jako inhibitory proteazy HIV |
DE602008005896D1 (de) * | 2007-06-22 | 2011-05-12 | Bristol Myers Squibb Co | Tablettierte atazanavirhaltige zusammensetzungen |
KR20100033378A (ko) * | 2007-06-22 | 2010-03-29 | 브리스톨-마이어스 스큅 컴퍼니 | 아타자나비르를 함유하는 정제 조성물 |
DE602008005462D1 (de) * | 2007-06-22 | 2011-04-21 | Bristol Myers Squibb Co | Tablettierte atazanavirhaltige zusammensetzungen |
DK2170292T3 (da) * | 2007-06-22 | 2014-04-07 | Bristol Myers Squibb Holdings Ireland | Atazanavirholdige sammensætninger i tabletform |
WO2010079497A2 (en) * | 2009-01-12 | 2010-07-15 | Hetero Research Foundation | Novel polymorph of atazanavir sulfate |
WO2011027324A1 (en) | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Polymorphic forms of atazanavir sulfate |
AU2010313571B2 (en) | 2009-10-26 | 2014-07-31 | Merck Sharp & Dohme Llc | Solid pharmaceutical compositions containing an integrase inhibitor |
WO2011127244A2 (en) | 2010-04-09 | 2011-10-13 | Bristol-Myers Squibb Company | ATAZANAVIR SULFATE FORMULATIONS WITH IMPROVED pH EFFECT |
WO2012041488A1 (en) | 2010-09-28 | 2012-04-05 | Ratiopharm Gmbh | Dry processing of atazanavir |
WO2013014633A1 (en) | 2011-07-27 | 2013-01-31 | Ranbaxy Laboratories Limited | Process for preparation of atazanavir or its bisulfate salt |
US8461347B2 (en) | 2011-08-05 | 2013-06-11 | Scinopharm Taiwan, Ltd. | Process for preparing form A of atazanavir sulfate |
US9382207B2 (en) | 2012-08-24 | 2016-07-05 | Laurus Labs Private Limited | Process for the preparation of atazanavir bisulfate |
WO2014036690A1 (zh) * | 2012-09-04 | 2014-03-13 | 上海迪赛诺化学制药有限公司 | 制备阿扎那韦硫酸氢盐a型结晶的方法 |
CA2900705A1 (en) | 2013-02-12 | 2014-08-21 | Cipla Limited | Process for preparing atazanavir sulphate |
CN115215792A (zh) * | 2022-06-27 | 2022-10-21 | 江西富祥药业股份有限公司 | 一种制备阿扎那韦或其硫酸盐的方法 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US658435A (en) * | 1900-03-22 | 1900-09-25 | William T Ginn | Coal-digger. |
US4026897A (en) | 1974-01-31 | 1977-05-31 | Otsuka Pharmaceutical Company | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives |
US3980637A (en) | 1975-03-17 | 1976-09-14 | Bristol-Myers Company | Production of amoxicillin |
DE3403329A1 (de) * | 1984-02-01 | 1985-08-01 | Horst Dr. 4019 Monheim Zerbe | Pharmazeutisches produkt in form von pellets mit kontinuierlicher, verzoegerter wirkstoffabgabe |
JPS6186211A (ja) | 1984-10-04 | 1986-05-01 | 日本碍子株式会社 | セラミックス複合構造体及びその製造法 |
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
US5158777A (en) * | 1990-02-16 | 1992-10-27 | E. R. Squibb & Sons, Inc. | Captopril formulation providing increased duration of activity |
CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
US5428048A (en) * | 1993-11-08 | 1995-06-27 | American Home Products Corporation | Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents |
GB9407386D0 (en) * | 1994-04-14 | 1994-06-08 | Smithkline Beecham Plc | Pharmaceutical formulation |
TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
KR100486051B1 (ko) * | 1996-04-22 | 2005-09-09 | 노파르티스 아게 | 항바이러스활성헤테로시클릭아자헥산유도체 |
US5849911A (en) * | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
GB9715896D0 (en) | 1997-07-28 | 1997-10-01 | Sca Packaging Ltd | Containers |
US6087383A (en) * | 1998-01-20 | 2000-07-11 | Bristol-Myers Squibb Company | Bisulfate salt of HIV protease inhibitor |
FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
WO2000056719A1 (en) * | 1999-03-22 | 2000-09-28 | Bristol-Myers Squibb Company | FUSED PYRIDOPYRIDAZINE INHIBITORS OF cGMP PHOSPHODIESTERASE |
US6414002B1 (en) * | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
CA2390557A1 (en) | 1999-11-11 | 2001-05-17 | Kyorin Pharmaceutical Co., Ltd. | Solid preparations for oral use |
DE60124861T2 (de) | 2000-01-21 | 2007-05-10 | Novartis Ag | Zusammensetzungen bestehend aus dipeptidylpeptidase-iv inhibitoren und antidiabetica |
US6254888B1 (en) * | 2000-01-28 | 2001-07-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for coating pharmaceutical dosage forms |
US6395767B2 (en) * | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
YU34501A (sh) | 2000-05-26 | 2003-10-31 | Pfizer Products Inc. | Postupak reaktivne kristalizacije radi povećanja veličine čestica |
IL145106A0 (en) * | 2000-08-30 | 2002-06-30 | Pfizer Prod Inc | Intermittent administration of a geowth hormone secretagogue |
US6670344B2 (en) * | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US6946146B2 (en) | 2001-04-18 | 2005-09-20 | Nostrum Pharmaceuticals Inc. | Coating for a sustained release pharmaceutical composition |
BR0306928A (pt) | 2002-01-15 | 2004-11-09 | Ranbaxy Lab Ltd | Composições farmacêuticas estáveis compreendendo inibidores de enzimas conversoras de angiotensina (ace) |
KR100456833B1 (ko) | 2002-08-01 | 2004-11-10 | 주식회사 대웅 | 아목시실린 및 클라불라네이트를 함유하는 유핵정 |
TW200534879A (en) * | 2004-03-25 | 2005-11-01 | Bristol Myers Squibb Co | Coated tablet formulation and method |
US7829720B2 (en) | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
US20050288343A1 (en) * | 2004-05-19 | 2005-12-29 | Andrew Rusowicz | Process of preparing substituted carbamates and intermediates thereof |
TWI354569B (en) * | 2004-05-28 | 2011-12-21 | Bristol Myers Squibb Co | Coated tablet formulation and method |
-
2005
- 2005-05-02 US US11/119,558 patent/US7829720B2/en active Active
- 2005-05-03 AU AU2005240622A patent/AU2005240622B2/en active Active
- 2005-05-03 HU HUE05744537A patent/HUE026242T2/en unknown
- 2005-05-03 RS RS20150653A patent/RS54284B1/en unknown
- 2005-05-03 ES ES05744537.1T patent/ES2552219T3/es active Active
- 2005-05-03 SI SI200532001T patent/SI1755596T1/sl unknown
- 2005-05-03 PT PT57445371T patent/PT1755596E/pt unknown
- 2005-05-03 PL PL05744537T patent/PL1755596T3/pl unknown
- 2005-05-03 BR BRPI0509595A patent/BRPI0509595B8/pt active IP Right Grant
- 2005-05-03 MX MXPA06012612A patent/MXPA06012612A/es active IP Right Grant
- 2005-05-03 CA CA2565629A patent/CA2565629C/en active Active
- 2005-05-03 CA CA2777216A patent/CA2777216A1/en not_active Abandoned
- 2005-05-03 EP EP20130175944 patent/EP2669273A1/en not_active Withdrawn
- 2005-05-03 WO PCT/US2005/015333 patent/WO2005108349A2/en active Application Filing
- 2005-05-03 DK DK05744537.1T patent/DK1755596T5/en active
- 2005-05-03 EP EP05744537.1A patent/EP1755596B9/en active Active
- 2005-05-03 JP JP2007511502A patent/JP5086069B2/ja active Active
- 2005-05-03 EP EP15180557.9A patent/EP2980074A1/en not_active Ceased
- 2005-05-03 KR KR1020067025370A patent/KR101153606B1/ko active IP Right Grant
-
2006
- 2006-10-31 IL IL178965A patent/IL178965A/en active IP Right Grant
- 2006-11-27 NO NO20065441A patent/NO341013B1/no unknown
-
2009
- 2009-01-27 US US12/360,468 patent/US7838678B2/en active Active
-
2010
- 2010-04-16 AU AU2010201538A patent/AU2010201538B2/en active Active
- 2010-10-08 US US12/900,588 patent/US8513428B2/en active Active
-
2015
- 2015-09-11 HR HRP20150962TT patent/HRP20150962T2/hr unknown
- 2015-11-10 CY CY20151101005T patent/CY1116919T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20065441L (no) | Fremgangsmate for fremstilling av atazanavir-bisulfat og nye varianter | |
TW200600498A (en) | Process for preparing atazanavir bisulfate and novel forms | |
NO20074055L (no) | Prosesser for a fremstille 4-(fenoksy-5-metylpyrimidin-4-yloksy)piperidin-1-karboksylsyrederivater og relaterte forbindelser | |
CN101497601B (zh) | 伊马替尼的合成方法 | |
Kuang et al. | Utilization of the 1, 2, 5-thiadiazolidin-3-one 1, 1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates | |
MX2008002093A (es) | Catalisis para la sintesis de cf3i y cf3cf2i. | |
Xie et al. | Synthesis and evaluation of substituted 3-(pyridin-2-yl) benzenesulfonamide derivatives as potent herbicidal agents | |
DK1697326T3 (da) | Krystalform af en quinolinforbindelse og fremgangsmåde til fremstilling deraf | |
Pan et al. | Design, synthesis and biological activities of Nilotinib derivates as antitumor agents | |
MD4391C1 (ro) | Formă cristalină nouă VII a agomelatinei, procedeu de preparare şi utilizarea acesteia, şi compoziţie farmaceutică care o conţine | |
US20170283380A1 (en) | Intermediate for Synthesizing Paroxetine, Method for Preparing the same, and Uses Thereof | |
NO20082005L (no) | Syntese av renininhibitorer omfattende en cyklotilfoyelsesreaksjon | |
WO2007105021A3 (en) | Duloxetine salts | |
WO2020134137A1 (zh) | 一种r-3-氯丝氨酸甲酯盐酸盐的制备方法 | |
TW201245114A (en) | Process for the preparation of pyrazole carboxylic acid amides | |
TW310262B (no) | ||
DK1725526T3 (da) | Fremgangsmåde til fremstilling af pyrrolidinoximer | |
CN105001163B (zh) | 一种四取代咪唑的合成方法 | |
CN106883189A (zh) | 用二硒醚、炔酸和叠氮合成含硒的三氮唑类化合物的方法 | |
JP5740042B2 (ja) | 化合物、化合物の製造方法、及び化合物の精製方法 | |
Gein et al. | Synthesis and Structure (Z)-N-Aryl-2-hydroxy-4-oxo-4-phenylbut-2-enamides | |
CN106458928A (zh) | 含醚性氧原子的全氟烷基取代嘧啶环化合物及其制造方法 | |
CN104003887A (zh) | 一种盐酸溴己新的制备方法 | |
JP2017517531A (ja) | ピペリジン−4−カルボチオアミドの製造 | |
CN103772308B (zh) | 5-氨基-3-(1-乙基-1-甲基丙基)异噁唑中间体的制备方法和异噁草胺的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH |
|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH |
|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMI, CH |