NO20065037L - Fremgangsmate for rensing av albuminkonjugater - Google Patents
Fremgangsmate for rensing av albuminkonjugaterInfo
- Publication number
- NO20065037L NO20065037L NO20065037A NO20065037A NO20065037L NO 20065037 L NO20065037 L NO 20065037L NO 20065037 A NO20065037 A NO 20065037A NO 20065037 A NO20065037 A NO 20065037A NO 20065037 L NO20065037 L NO 20065037L
- Authority
- NO
- Norway
- Prior art keywords
- albumin
- albumin conjugates
- procedure
- conjugates
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/303—Extraction; Separation; Purification by precipitation by salting out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56522804P | 2004-04-23 | 2004-04-23 | |
PCT/CA2005/000614 WO2005103087A1 (en) | 2004-04-23 | 2005-04-22 | Method for the purification of albumin conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20065037L true NO20065037L (no) | 2007-01-11 |
Family
ID=35196920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20065037A NO20065037L (no) | 2004-04-23 | 2006-11-02 | Fremgangsmate for rensing av albuminkonjugater |
Country Status (25)
Country | Link |
---|---|
US (3) | US7307148B2 (zh) |
EP (3) | EP2230257A1 (zh) |
JP (1) | JP2007535507A (zh) |
CN (1) | CN1956998B (zh) |
AT (2) | ATE473244T1 (zh) |
AU (1) | AU2005235634B2 (zh) |
BR (1) | BRPI0510117A (zh) |
CA (1) | CA2564031A1 (zh) |
DE (2) | DE602005014969D1 (zh) |
DK (2) | DK1745078T3 (zh) |
EA (1) | EA011168B1 (zh) |
ES (2) | ES2347902T3 (zh) |
HK (2) | HK1096102A1 (zh) |
HR (1) | HRP20060362A2 (zh) |
IL (1) | IL178369A0 (zh) |
MA (1) | MA28587B1 (zh) |
MX (1) | MXPA06012260A (zh) |
NO (1) | NO20065037L (zh) |
PL (2) | PL2100904T3 (zh) |
PT (2) | PT2100904E (zh) |
RS (1) | RS20060578A (zh) |
SI (2) | SI1745078T1 (zh) |
TN (1) | TNSN06340A1 (zh) |
WO (1) | WO2005103087A1 (zh) |
ZA (1) | ZA200608475B (zh) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6924264B1 (en) * | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
ES2209885T3 (es) * | 1999-05-17 | 2004-07-01 | Conjuchem, Inc. | Peptidos insulinotropicos de larga duracion. |
US7582301B1 (en) * | 1999-05-17 | 2009-09-01 | Conjuchem Biotechnologies, Inc. | Long-lasting antiviral fusion inhibitor peptide conjugates comprising albumin and human immunodeficiency virus (HIV) peptides |
US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
CA2436399A1 (en) * | 2001-02-16 | 2002-08-29 | Conjuchem Inc. | Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders |
DE60229677D1 (de) | 2001-05-31 | 2008-12-11 | Conjuchem Biotechnologies Inc | Langwirkende Fusionspeptidinhibitoren gegen HIV-Infektion |
WO2005108418A1 (en) * | 2004-05-06 | 2005-11-17 | Conjuchem Biotechnologies Inc. | Compounds for specific viral target |
WO2007053946A1 (en) | 2005-11-09 | 2007-05-18 | Conjuchem Biotechnologies Inc. | Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin |
MX2008008076A (es) * | 2005-12-22 | 2008-11-28 | Conjuchem Biotechnologies Inc | Procesos para la produccion de conjugados preformados de albumina y un agente terapeutico. |
WO2008047241A2 (en) * | 2006-10-16 | 2008-04-24 | Conjuchem Biotechnologies Inc. | Modified corticotropin releasing factor peptides and uses thereof |
US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
US20090088378A1 (en) * | 2007-01-12 | 2009-04-02 | Omar Quraishi | Long lasting inhibitors of viral infection |
US20090088377A1 (en) * | 2007-05-16 | 2009-04-02 | Conjuchem Biotechnologies, Inc. | Cysteic acid derivatives of anti-viral peptides |
WO2008157824A2 (en) * | 2007-06-21 | 2008-12-24 | Conjuchem Biotechnologies Inc. | Thrombopoietin peptide conjugates |
WO2009075859A2 (en) * | 2007-12-11 | 2009-06-18 | Conjuchem Biotechnologies Inc. | Formulation of insulinotropic peptide conjugates |
US8871899B2 (en) * | 2007-12-31 | 2014-10-28 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
EP2262539B1 (en) | 2008-04-01 | 2015-07-15 | Novo Nordisk A/S | Insulin albumin conjugates |
CN101987868B (zh) * | 2009-07-30 | 2013-09-04 | 江苏豪森医药集团有限公司 | Glp-1类似物的衍生物或其可药用盐和用途 |
BR112012012945A2 (pt) | 2009-11-25 | 2020-12-29 | Arisgen Sa | Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo |
US9744155B2 (en) | 2012-03-28 | 2017-08-29 | Ixcela, Inc. | IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk |
PT3092010T (pt) * | 2014-01-10 | 2018-09-28 | Synthon Biopharmaceuticals Bv | Método para purificação de conjugados anticorpo-fármaco ligados por cys |
EP3099809A4 (en) * | 2014-01-31 | 2017-10-25 | Ixcela, Inc. | Covalently bound metabolites as biomarkers |
US9616109B2 (en) * | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
CN105111306A (zh) * | 2015-08-28 | 2015-12-02 | 北京工业大学 | 美洲短吻鳄白蛋白的分离方法 |
AU2017238246B2 (en) | 2016-03-24 | 2021-04-01 | The Administrators Of The Tulane Educational Fund | Conjugates of tacrolimus, their compositions, and their uses |
TWI794897B (zh) | 2017-09-28 | 2023-03-01 | 南韓商韓美藥品股份有限公司 | Glp-2衍生物之長效接合物 |
CN108840922A (zh) * | 2018-06-04 | 2018-11-20 | 河北常山生化药业股份有限公司 | 分离白蛋白非结合物、白蛋白结合物和小分子化合物的方法 |
CN108977423A (zh) * | 2018-08-17 | 2018-12-11 | 集美大学 | 一种从猪肺中分离提纯血管紧张素转化酶的方法 |
US11041847B1 (en) | 2019-01-25 | 2021-06-22 | Ixcela, Inc. | Detection and modification of gut microbial population |
CN109721653B (zh) * | 2019-03-05 | 2023-02-03 | 嘉兴学院 | 一种胰高血糖素样肽-1片段类似物及其应用 |
WO2021175275A1 (zh) * | 2020-03-06 | 2021-09-10 | 昆山新蕴达生物科技有限公司 | 疏水性修饰的白蛋白及其制备方法和用途 |
WO2021222759A1 (en) * | 2020-04-30 | 2021-11-04 | Board Of Regents, The University Of Texas System | Albumin drug conjugates and use thereof for the treatment of cancer |
US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4206199A (en) | 1977-07-22 | 1980-06-03 | Takeda Chemical Industries, Ltd. | Novel glucagon fragment and its derivatives |
US4251631A (en) | 1978-02-23 | 1981-02-17 | Research Products Rehovot Ltd. | Cross-linked enzyme membrane |
US4423034A (en) | 1980-10-16 | 1983-12-27 | Toyo Jozo Kabushiki Kaisha | Process for the preparation of antibodies |
US4678671A (en) * | 1981-12-15 | 1987-07-07 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
US4462941A (en) | 1982-06-10 | 1984-07-31 | The Regents Of The University Of California | Dynorphin amide analogs |
US4745100A (en) | 1985-05-14 | 1988-05-17 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
US4859604A (en) | 1987-08-27 | 1989-08-22 | Ampor, Inc. | Composition for stabilization of diagnostic reagents |
US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
US5843440A (en) * | 1990-10-03 | 1998-12-01 | Redcell Canada, Inc. | Cellular and serum protein anchors for modulating pharmacokinetics |
US5612034A (en) * | 1990-10-03 | 1997-03-18 | Redcell, Inc. | Super-globuling for in vivo extended lifetimes |
US5725804A (en) | 1991-01-15 | 1998-03-10 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
WO1992017492A1 (en) | 1991-04-05 | 1992-10-15 | Genentech, Inc. | PLATELET AGGREGATION INHIBITORS HAVING HIGH SPECIFICITY FOR GP IIbIII¿a? |
US5103233A (en) | 1991-04-16 | 1992-04-07 | General Electric Co. | Radar system with elevation-responsive PRF control, beam multiplex control, and pulse integration control responsive to azimuth angle |
CA2452130A1 (en) | 1992-03-05 | 1993-09-16 | Francis J. Burrows | Methods and compositions for targeting the vasculature of solid tumors |
JPH07102148B2 (ja) * | 1992-05-20 | 1995-11-08 | 株式会社ミドリ十字 | 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物 |
US5807827A (en) | 1992-06-12 | 1998-09-15 | Des-Tyr Dynorphin Partnership | Des-Tyr dynorphin analogues |
US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
US5614487A (en) | 1993-05-28 | 1997-03-25 | Genentech, Inc. | Sustained release pharmaceutical composition |
US20020018751A1 (en) * | 1993-10-15 | 2002-02-14 | BRIDON Dominique P. | Cellular and serum protein anchors for diagnostic imaging |
US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
DK145493D0 (da) | 1993-12-23 | 1993-12-23 | Dako As | Antistof |
US5580853A (en) | 1994-03-22 | 1996-12-03 | New England Deaconess Hospital | Modified polypeptides with increased biological activity |
EP0759768A4 (en) | 1994-04-07 | 2000-08-09 | Proteinix Company | VASOACTIVE COLON PEPTIDE |
US5574008A (en) | 1994-08-30 | 1996-11-12 | Eli Lilly And Company | Biologically active fragments of glucagon-like insulinotropic peptide |
DE69532492T2 (de) * | 1994-08-31 | 2004-12-02 | Mitsubishi Pharma Corp. | Verfahren zur Reinigung von rekombinantem menschlichem Serumalbumin |
US5939390A (en) | 1995-03-09 | 1999-08-17 | Novo Nordisk A/S | Pharmaceutical composition |
US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
US5654276A (en) | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
US6277583B1 (en) * | 1996-02-07 | 2001-08-21 | Conjuchem, Inc. | Affinity labeling libraries and applications thereof |
ES2256888T3 (es) | 1996-06-05 | 2006-07-16 | Roche Diagnostics Gmbh | Analogos de exendina, proceso para su preparacion y medicamentos que los contienen. |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
PT966297E (pt) | 1996-08-08 | 2009-03-18 | Amylin Pharmaceuticals Inc | Regulação da motilidade gastrintestinal |
US6006753A (en) | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
AU4351897A (en) * | 1996-09-16 | 1998-04-02 | Conjuchem, Inc. | Affinity labeling libraries with tagged leaving groups |
UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
ATE289517T1 (de) | 1996-11-12 | 2005-03-15 | Novo Nordisk As | Verwendung von glp-1 peptiden |
HU222666B1 (hu) * | 1996-11-15 | 2003-09-29 | Genentech, Inc. | Eljárás neuorotrofinok tisztítására |
DK1629849T4 (en) | 1997-01-07 | 2017-12-04 | Amylin Pharmaceuticals Llc | Pharmaceutical compositions comprising exedins and agonists thereof |
US6723530B1 (en) | 1997-02-05 | 2004-04-20 | Amylin Pharmaceuticals, Inc. | Polynucleotides encoding proexendin, and methods and uses thereof |
CA2283834A1 (en) | 1997-03-31 | 1998-10-08 | James Arthur Hoffmann | Glucagon-like peptide-1 analogs |
DE69806066T2 (de) * | 1997-11-07 | 2003-02-06 | Conjuchem, Inc. | Affinitätsmarkierer für menschliches serum albumin |
US6437092B1 (en) * | 1998-11-06 | 2002-08-20 | Conjuchem, Inc. | Conjugates of opioids and endogenous carriers |
EP1007561B1 (en) * | 1997-11-07 | 2002-04-17 | Conjuchem, Inc. | Novel conjugates of opioids and endogenous carriers |
US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
JP2003522099A (ja) | 1998-02-27 | 2003-07-22 | ノボ ノルディスク アクティーゼルスカブ | 遅延作用プロファイルを有するglp−1のglp−1誘導体及びエキセンジン |
US6107489A (en) * | 1998-03-17 | 2000-08-22 | Conjuchem, Inc. | Extended lifetimes in vivo renin inhibitors |
US6998387B1 (en) | 1998-03-19 | 2006-02-14 | Amylin Pharmaceuticals, Inc. | Human appetite control by glucagon-like peptide receptor binding compounds |
US20030170250A1 (en) * | 1998-03-23 | 2003-09-11 | Ezrin Alan M. | Local delivery of long lasting therapeutic agents |
US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
US6440417B1 (en) * | 1998-11-06 | 2002-08-27 | Conjuchem, Inc. | Antibodies to argatroban derivatives and their use in therapeutic and diagnostic treatments |
US7399489B2 (en) * | 1999-01-14 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Exendin analog formulations |
ES2343072T3 (es) | 1999-01-14 | 2010-07-22 | Amylin Pharmaceuticals, Inc. | Exendina para la supresion del glucagon. |
DE60021166T3 (de) | 1999-01-14 | 2019-08-22 | Amylin Pharmaceuticals, Llc | Neue exendin agonist formulierungen und deren verabreichung |
US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
ES2209885T3 (es) * | 1999-05-17 | 2004-07-01 | Conjuchem, Inc. | Peptidos insulinotropicos de larga duracion. |
US7144854B1 (en) | 1999-09-10 | 2006-12-05 | Conjuchem, Inc. | Long lasting anti-angiogenic peptides |
US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
US7582301B1 (en) * | 1999-05-17 | 2009-09-01 | Conjuchem Biotechnologies, Inc. | Long-lasting antiviral fusion inhibitor peptide conjugates comprising albumin and human immunodeficiency virus (HIV) peptides |
US6887470B1 (en) * | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US7601691B2 (en) * | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
US6849714B1 (en) * | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
DE19926154A1 (de) * | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
AU5325200A (en) | 1999-06-21 | 2001-01-09 | Eli Lilly And Company | Synergistic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof to treat metabolic instability associated with non-insulin dependent diabetes |
US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
DE19932782A1 (de) * | 1999-07-14 | 2001-01-18 | Biotest Pharma Gmbh | Verfahren zur chromatographischen Fraktionierung von Plasma oder Serum, so erhaltene Präparate und deren Verwendung |
DE19936780A1 (de) | 1999-08-09 | 2001-02-15 | Basf Ag | Neue Antagonisten von Integrinrezeptoren |
US6706892B1 (en) * | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
US7090851B1 (en) | 1999-09-10 | 2006-08-15 | Conjuchem Inc. | Long lasting fusion peptide inhibitors of viral infection |
US20020003999A1 (en) * | 2000-03-09 | 2002-01-10 | Claus Bonde | Discharge and stacker device |
US6926898B2 (en) * | 2000-04-12 | 2005-08-09 | Human Genome Sciences, Inc. | Albumin fusion proteins |
AU2001263230B2 (en) | 2000-05-19 | 2005-03-10 | Amylin Pharmaceuticals, Llc | Treatment of acute coronary syndrome with glp-1 |
MXPA02006118A (es) | 2000-10-20 | 2004-08-23 | Amylin Pharmaceuticals Inc | Tratamiento de la invernacion del miocardio y cardiopatia diabetica con un peptido glp-1. |
WO2002047716A2 (en) | 2000-12-13 | 2002-06-20 | Eli Lilly And Company | Chronic treatment regimen using glucagon-like insulinotropic peptides |
EP1355941A2 (en) * | 2001-02-02 | 2003-10-29 | ConjuChem, Inc. | Long lasting growth hormone releasing factor derivatives |
CA2436399A1 (en) * | 2001-02-16 | 2002-08-29 | Conjuchem Inc. | Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders |
DE60229677D1 (de) * | 2001-05-31 | 2008-12-11 | Conjuchem Biotechnologies Inc | Langwirkende Fusionspeptidinhibitoren gegen HIV-Infektion |
SE526227C2 (sv) * | 2002-05-15 | 2005-08-02 | North China Pharmaceutical Group | Metod för rening av rekombinant humant serumalbumin |
US6861236B2 (en) | 2002-05-24 | 2005-03-01 | Applied Nanosystems B.V. | Export and modification of (poly)peptides in the lantibiotic way |
US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
KR20060109940A (ko) * | 2003-12-18 | 2006-10-23 | 노보 노르디스크 에이/에스 | 알부민-유사제에 연결된 신규 glp-1 유사체 |
-
2005
- 2005-04-22 DE DE602005014969T patent/DE602005014969D1/de active Active
- 2005-04-22 RS RSP-2006/0578A patent/RS20060578A/sr unknown
- 2005-04-22 EP EP10164991A patent/EP2230257A1/en not_active Withdrawn
- 2005-04-22 CA CA002564031A patent/CA2564031A1/en not_active Abandoned
- 2005-04-22 ES ES09162758T patent/ES2347902T3/es active Active
- 2005-04-22 US US11/112,277 patent/US7307148B2/en not_active Expired - Fee Related
- 2005-04-22 BR BRPI0510117-4A patent/BRPI0510117A/pt not_active IP Right Cessation
- 2005-04-22 PT PT09162758T patent/PT2100904E/pt unknown
- 2005-04-22 DK DK05735795T patent/DK1745078T3/da active
- 2005-04-22 EP EP09162758A patent/EP2100904B1/en not_active Not-in-force
- 2005-04-22 JP JP2007508697A patent/JP2007535507A/ja active Pending
- 2005-04-22 SI SI200530766T patent/SI1745078T1/sl unknown
- 2005-04-22 PL PL09162758T patent/PL2100904T3/pl unknown
- 2005-04-22 PL PL05735795T patent/PL1745078T3/pl unknown
- 2005-04-22 AT AT09162758T patent/ATE473244T1/de active
- 2005-04-22 PT PT05735795T patent/PT1745078E/pt unknown
- 2005-04-22 ES ES05735795T patent/ES2328591T3/es active Active
- 2005-04-22 DE DE602005022239T patent/DE602005022239D1/de active Active
- 2005-04-22 DK DK09162758.8T patent/DK2100904T3/da active
- 2005-04-22 MX MXPA06012260A patent/MXPA06012260A/es active IP Right Grant
- 2005-04-22 AT AT05735795T patent/ATE433999T1/de active
- 2005-04-22 EP EP05735795A patent/EP1745078B1/en not_active Revoked
- 2005-04-22 SI SI200531088T patent/SI2100904T1/sl unknown
- 2005-04-22 EA EA200601959A patent/EA011168B1/ru not_active IP Right Cessation
- 2005-04-22 WO PCT/CA2005/000614 patent/WO2005103087A1/en active Application Filing
- 2005-04-22 CN CN2005800127938A patent/CN1956998B/zh active Active
- 2005-04-22 AU AU2005235634A patent/AU2005235634B2/en not_active Ceased
-
2006
- 2006-09-28 IL IL178369A patent/IL178369A0/en unknown
- 2006-10-11 ZA ZA200608475A patent/ZA200608475B/en unknown
- 2006-10-20 TN TNP2006000340A patent/TNSN06340A1/en unknown
- 2006-10-23 HR HR20060362A patent/HRP20060362A2/xx not_active Application Discontinuation
- 2006-11-02 NO NO20065037A patent/NO20065037L/no not_active Application Discontinuation
- 2006-11-20 MA MA29463A patent/MA28587B1/fr unknown
-
2007
- 2007-02-01 HK HK07101258.8A patent/HK1096102A1/xx not_active IP Right Cessation
- 2007-10-30 US US11/981,474 patent/US20080146783A1/en not_active Abandoned
-
2010
- 2010-03-15 HK HK10102645.3A patent/HK1136305A1/xx not_active IP Right Cessation
- 2010-09-17 US US12/885,036 patent/US20120022234A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20065037L (no) | Fremgangsmate for rensing av albuminkonjugater | |
JP2005206602A5 (zh) | ||
NO20075091L (no) | Fremgangsmate for rensing av antistoffer | |
DK1156835T3 (da) | Fremgangsmåde til radiomærkning af proteiner med Yttrium-90 | |
DK0489423T3 (da) | Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelsen af disse forbindelser som lægemidler | |
NZ587511A (en) | Purified lymphotoxin-beta-receptor immunoglobulin fusion proteins and methods of their purification | |
BRPI0611600B8 (pt) | método para purificação de uma proteína tendo uma região fc a partir de um líquido fonte compreendendo a proteína e uma ou mais impurezas, e kit | |
WO2010048192A3 (en) | Viral inactivation during purification of antibodies | |
EP1568710A3 (en) | Antibody purification method | |
ATE476501T1 (de) | Verfahren zur reinigung von factor vii | |
ATE361930T1 (de) | Proteinreinigung mittels chromatographie und darauffolgende filtration auf beladener schicht | |
DK1596192T3 (da) | Fremgangsmåde til at separering af proteiner ved kapillær elektroforese og buffersammensætning til kapillær elektroforese | |
WO2010048313A3 (en) | Recombinant fcrn and variants thereof for purification of fc-containing fusion proteins | |
ATE532071T1 (de) | Verfahren zur verminderung von eiweiss in proben | |
DE602008004747D1 (de) | Verfahren zur aufreinigung hydrophober proteine | |
WO2007001834A3 (en) | Methods and apparatus for improving the sensitivity of capillary zone electrophoresis | |
DE602005020049D1 (de) | Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie | |
Yardimci et al. | Method development and validation for the simultaneous determination of rosiglitazone and metformin in pharmaceutical preparations by capillary zone electrophoresis | |
Fuentes et al. | Solid phase proteomics: Dramatic reinforcement of very weak protein–protein interactions | |
DE50212790D1 (de) | Verfahren zum nachweis von blutzell-antigenen und gegen diese gerichtete antikörper | |
DE602004018674D1 (de) | Grosstechnisches verfahren zur abtrennung und aufreinigung von fentanyl durch präparative umkehrphasenchromatographie | |
RU2004127706A (ru) | Способ определения антипирина в слюне | |
ITBO20040200A1 (it) | Prodotto per la mummificazione dei cadaveri dei topi | |
RU2006126645A (ru) | Сорбент для удаления иммуноглобулинов | |
RU2003136353A (ru) | Способ фракционирования эритроцитов в градиенте плотности раствора агарозы |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |