ATE476501T1 - Verfahren zur reinigung von factor vii - Google Patents
Verfahren zur reinigung von factor viiInfo
- Publication number
- ATE476501T1 ATE476501T1 AT06700982T AT06700982T ATE476501T1 AT E476501 T1 ATE476501 T1 AT E476501T1 AT 06700982 T AT06700982 T AT 06700982T AT 06700982 T AT06700982 T AT 06700982T AT E476501 T1 ATE476501 T1 AT E476501T1
- Authority
- AT
- Austria
- Prior art keywords
- factor vii
- procedure
- purifying factor
- purifying
- rfvii
- Prior art date
Links
- 229940012413 factor vii Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 2
- 102100023804 Coagulation factor VII Human genes 0.000 abstract 1
- 108010023321 Factor VII Proteins 0.000 abstract 1
- 108010054265 Factor VIIa Proteins 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Processing Of Solid Wastes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64412605P | 2005-01-14 | 2005-01-14 | |
| PCT/DK2006/000024 WO2006074664A1 (en) | 2005-01-14 | 2006-01-13 | Method for purification of factor vii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476501T1 true ATE476501T1 (de) | 2010-08-15 |
Family
ID=36010990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06700982T ATE476501T1 (de) | 2005-01-14 | 2006-01-13 | Verfahren zur reinigung von factor vii |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090047723A1 (de) |
| EP (1) | EP1841863B1 (de) |
| AT (1) | ATE476501T1 (de) |
| CY (1) | CY1110867T1 (de) |
| DE (1) | DE602006015907D1 (de) |
| DK (1) | DK1841863T3 (de) |
| ES (1) | ES2349112T3 (de) |
| PL (1) | PL1841863T3 (de) |
| PT (1) | PT1841863E (de) |
| WO (1) | WO2006074664A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1877037A2 (de) * | 2005-04-28 | 2008-01-16 | Novo Nordisk Health Care AG | Verschlossener behälter mit einem aktivierten faktor-vii-polypeptid, herstellungsverfahren dafür sowie kit und verfahren zur verwendung des kits |
| FR2901796A1 (fr) * | 2006-05-31 | 2007-12-07 | Lab Francais Du Fractionnement | Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait |
| SMT201800554T1 (it) | 2009-06-16 | 2018-11-09 | Genzyme Corp | Metodi migliorati per la purificazione di vettori di aav ricombinanti |
| JP5773454B2 (ja) | 2010-01-15 | 2015-09-02 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | アパタイトの表面中和方法 |
| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| TWI621625B (zh) | 2010-09-17 | 2018-04-21 | 巴克斯歐塔公司 | 在弱酸性至中性ｐｈ中經由具有組胺酸的水性調配物穩定免疫球蛋白 |
| US9488625B2 (en) | 2010-12-15 | 2016-11-08 | Baxalta GmbH | Purification of factor VIII using a conductivity gradient |
| EP2670704B1 (de) | 2011-02-02 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Apatitoberflächenneutralisierung mit alkalischen lösungen |
| WO2013180933A1 (en) | 2012-05-30 | 2013-12-05 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| JP6297029B2 (ja) * | 2012-05-31 | 2018-03-20 | エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ | 多様な官能基を有する粒子による免疫グロブリンｇ調製物のクロマトグラフィー精製 |
| US9175279B1 (en) | 2013-03-15 | 2015-11-03 | Csl Limited | Method of purifying factor VII and/or factor VIIa |
| WO2015200282A1 (en) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
| EP3157863B1 (de) | 2014-06-23 | 2023-06-21 | Bio-Rad Laboratories, Inc. | In-situ-restaurierung von apatit |
| WO2018052827A1 (en) | 2016-09-13 | 2018-03-22 | Bayer Healthcare Llc | Factor viia glycoforms |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4473553A (en) * | 1983-12-02 | 1984-09-25 | Miles Laboratories, Inc. | Process for producing a lipoprotein-poor concentrate of coagulation factors VII and VIIa |
| US4470969A (en) * | 1983-12-02 | 1984-09-11 | Miles Laboratories, Inc. | Process for producing a concentrate of coagulation factors VII and VIIa |
| US4637932A (en) * | 1984-10-15 | 1987-01-20 | Miles Laboratories, Inc. | Process for producing a concentrate enriched in coagulation factors VII and VIIa |
| US4981952A (en) * | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
| DK38293D0 (da) * | 1993-03-31 | 1993-03-31 | Novo Nordisk As | Fremstilling af proteiner |
| DE4406515C1 (de) * | 1994-02-28 | 1995-10-19 | Immuno Ag | Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine |
| AT408613B (de) * | 1998-06-17 | 2002-01-25 | Immuno Ag | Pharmazeutisches faktor vii-präparat |
| US6451987B1 (en) * | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
| DE19937218A1 (de) * | 1999-08-06 | 2001-02-08 | Aventis Behring Gmbh | Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| US20070037966A1 (en) * | 2004-05-04 | 2007-02-15 | Novo Nordisk A/S | Hydrophobic interaction chromatography purification of factor VII polypeptides |
-
2006
- 2006-01-13 EP EP06700982A patent/EP1841863B1/de not_active Not-in-force
- 2006-01-13 US US11/813,263 patent/US20090047723A1/en not_active Abandoned
- 2006-01-13 DE DE602006015907T patent/DE602006015907D1/de active Active
- 2006-01-13 WO PCT/DK2006/000024 patent/WO2006074664A1/en not_active Ceased
- 2006-01-13 PT PT06700982T patent/PT1841863E/pt unknown
- 2006-01-13 PL PL06700982T patent/PL1841863T3/pl unknown
- 2006-01-13 DK DK06700982.9T patent/DK1841863T3/da active
- 2006-01-13 AT AT06700982T patent/ATE476501T1/de active
- 2006-01-13 ES ES06700982T patent/ES2349112T3/es active Active
-
2010
- 2010-10-27 CY CY20101100968T patent/CY1110867T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1841863E (pt) | 2010-10-25 |
| DK1841863T3 (da) | 2010-11-29 |
| CY1110867T1 (el) | 2015-06-10 |
| EP1841863A1 (de) | 2007-10-10 |
| WO2006074664A1 (en) | 2006-07-20 |
| DE602006015907D1 (de) | 2010-09-16 |
| US20090047723A1 (en) | 2009-02-19 |
| ES2349112T3 (es) | 2010-12-28 |
| PL1841863T3 (pl) | 2011-05-31 |
| EP1841863B1 (de) | 2010-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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