CY1110867T1 - Μεθοδος για τον καθαρισμο του παραγοντα vii - Google Patents

Μεθοδος για τον καθαρισμο του παραγοντα vii

Info

Publication number
CY1110867T1
CY1110867T1 CY20101100968T CY101100968T CY1110867T1 CY 1110867 T1 CY1110867 T1 CY 1110867T1 CY 20101100968 T CY20101100968 T CY 20101100968T CY 101100968 T CY101100968 T CY 101100968T CY 1110867 T1 CY1110867 T1 CY 1110867T1
Authority
CY
Cyprus
Prior art keywords
factor vii
cleaning
rfvii
rfviia
recombinant
Prior art date
Application number
CY20101100968T
Other languages
English (en)
Inventor
Rikkle Bolding Jensen
Frank Bech Nygaard
Original Assignee
Bayer Healthcare, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare, Llc filed Critical Bayer Healthcare, Llc
Publication of CY1110867T1 publication Critical patent/CY1110867T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

Μία μέθοδος για τον καθαρισμό του ανασυνδυασμένου Παράγοντα VII (rFVII) ή ανασυνδυασμένου ενεργοποιημένου Παράγοντα VII (rFVIIa), που περιλαμβάνει την υποβολή του rFVII ή του rFVIIa σε υγρή χρωματογραφία σε μία στήλη υδροξυαπατίτη (ΗΑΡ).
CY20101100968T 2005-01-14 2010-10-27 Μεθοδος για τον καθαρισμο του παραγοντα vii CY1110867T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64412605P 2005-01-14 2005-01-14
EP06700982A EP1841863B1 (en) 2005-01-14 2006-01-13 Method for purification of factor vii

Publications (1)

Publication Number Publication Date
CY1110867T1 true CY1110867T1 (el) 2015-06-10

Family

ID=36010990

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100968T CY1110867T1 (el) 2005-01-14 2010-10-27 Μεθοδος για τον καθαρισμο του παραγοντα vii

Country Status (10)

Country Link
US (1) US20090047723A1 (el)
EP (1) EP1841863B1 (el)
AT (1) ATE476501T1 (el)
CY (1) CY1110867T1 (el)
DE (1) DE602006015907D1 (el)
DK (1) DK1841863T3 (el)
ES (1) ES2349112T3 (el)
PL (1) PL1841863T3 (el)
PT (1) PT1841863E (el)
WO (1) WO2006074664A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007013156A (es) * 2005-04-28 2008-01-18 Novo Nordisk Healthcare Ag Envase cerrado que comprende un polipeptido del factor vii activado, procesos para la preparacion del mismo y kit y metodo para el uso del kit.
FR2901796A1 (fr) * 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
CA3077531C (en) 2009-06-16 2022-09-20 Genzyme Corporation Improved methods for purification of recombinant aav vectors
CA2787009C (en) 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
US8895707B2 (en) * 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
AR083035A1 (es) 2010-09-17 2013-01-30 Baxter Int ESTABILIZACION DE INMUNOGLOBULINAS MEDIANTE UNA FORMULACION ACUOSA CON HISTIDINA A pH ACIDO DEBIL A NEUTRO, COMPOSICION ACUOSA DE INMUNOGLOBULINA
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
US9592540B2 (en) 2011-02-02 2017-03-14 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
CN104507952B (zh) * 2012-05-30 2018-08-10 生物辐射实验室股份有限公司 基于磷灰石的色谱树脂的原位恢复
EP2855504B1 (en) * 2012-05-31 2018-10-24 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
US9175279B1 (en) 2013-03-15 2015-11-03 Csl Limited Method of purifying factor VII and/or factor VIIa
EP3157689B1 (en) 2014-06-23 2021-04-28 Bio-Rad Laboratories, Inc. Apatite pretreatment
EP3157551B1 (en) 2014-06-23 2023-02-15 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
SG11201901989VA (en) 2016-09-13 2019-04-29 Bayer Healthcare Llc Factor viia glycoforms

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4470969A (en) * 1983-12-02 1984-09-11 Miles Laboratories, Inc. Process for producing a concentrate of coagulation factors VII and VIIa
US4473553A (en) * 1983-12-02 1984-09-25 Miles Laboratories, Inc. Process for producing a lipoprotein-poor concentrate of coagulation factors VII and VIIa
US4637932A (en) * 1984-10-15 1987-01-20 Miles Laboratories, Inc. Process for producing a concentrate enriched in coagulation factors VII and VIIa
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
DK38293D0 (da) * 1993-03-31 1993-03-31 Novo Nordisk As Fremstilling af proteiner
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
AT408613B (de) * 1998-06-17 2002-01-25 Immuno Ag Pharmazeutisches faktor vii-präparat
US6451987B1 (en) * 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
DE19937218A1 (de) * 1999-08-06 2001-02-08 Aventis Behring Gmbh Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie
US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
US20070037966A1 (en) * 2004-05-04 2007-02-15 Novo Nordisk A/S Hydrophobic interaction chromatography purification of factor VII polypeptides

Also Published As

Publication number Publication date
US20090047723A1 (en) 2009-02-19
PL1841863T3 (pl) 2011-05-31
WO2006074664A1 (en) 2006-07-20
DE602006015907D1 (de) 2010-09-16
ES2349112T3 (es) 2010-12-28
EP1841863B1 (en) 2010-08-04
DK1841863T3 (da) 2010-11-29
ATE476501T1 (de) 2010-08-15
PT1841863E (pt) 2010-10-25
EP1841863A1 (en) 2007-10-10

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