NO20055694L - Fremgangsmate for fremstilling av (4-hydroksy-6-oksotetrahydropyran-2-yl)acetonitril og derivater derav - Google Patents
Fremgangsmate for fremstilling av (4-hydroksy-6-oksotetrahydropyran-2-yl)acetonitril og derivater deravInfo
- Publication number
- NO20055694L NO20055694L NO20055694A NO20055694A NO20055694L NO 20055694 L NO20055694 L NO 20055694L NO 20055694 A NO20055694 A NO 20055694A NO 20055694 A NO20055694 A NO 20055694A NO 20055694 L NO20055694 L NO 20055694L
- Authority
- NO
- Norway
- Prior art keywords
- hydroxy
- acetonitrile
- preparation
- pyran
- tetrahydro
- Prior art date
Links
- NUTZEIABCUGDLR-UHFFFAOYSA-N 2-(4-hydroxy-6-oxooxan-2-yl)acetonitrile Chemical compound OC1CC(CC#N)OC(=O)C1 NUTZEIABCUGDLR-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 229960005370 atorvastatin Drugs 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03101227 | 2003-05-02 | ||
| PCT/NL2004/000284 WO2004096788A1 (en) | 2003-05-02 | 2004-04-28 | Process fot the preparation of (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitrile and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20055694D0 NO20055694D0 (no) | 2005-12-01 |
| NO20055694L true NO20055694L (no) | 2006-02-02 |
Family
ID=33395971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20055694A NO20055694L (no) | 2003-05-02 | 2005-12-01 | Fremgangsmate for fremstilling av (4-hydroksy-6-oksotetrahydropyran-2-yl)acetonitril og derivater derav |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7423162B2 (uk) |
| EP (1) | EP1620423B1 (uk) |
| JP (1) | JP2006525323A (uk) |
| KR (1) | KR20060011984A (uk) |
| CN (2) | CN1780826B (uk) |
| AT (1) | ATE386734T1 (uk) |
| AU (1) | AU2004234308A1 (uk) |
| BR (1) | BRPI0409866A (uk) |
| CA (1) | CA2524457A1 (uk) |
| CO (1) | CO5700715A2 (uk) |
| CY (1) | CY1113498T1 (uk) |
| DE (1) | DE602004011921T2 (uk) |
| DK (1) | DK1620423T3 (uk) |
| EA (1) | EA010100B1 (uk) |
| ES (1) | ES2300769T3 (uk) |
| IL (1) | IL171539A (uk) |
| IS (1) | IS8159A (uk) |
| NO (1) | NO20055694L (uk) |
| NZ (1) | NZ543294A (uk) |
| PL (1) | PL1620423T3 (uk) |
| SI (1) | SI1620423T1 (uk) |
| UA (1) | UA83662C2 (uk) |
| WO (1) | WO2004096788A1 (uk) |
| ZA (1) | ZA200508862B (uk) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101113163B1 (ko) | 2003-07-25 | 2012-02-17 | 브래드포드 파마 리미티드 | 스타틴, 특히 아토르바스타틴의 제조에 유용한 중간체화합물 및 그 제조방법 |
| US7701550B2 (en) | 2004-08-19 | 2010-04-20 | Asml Netherlands B.V. | Lithographic apparatus and device manufacturing method |
| DE102005022284A1 (de) * | 2005-05-13 | 2006-11-23 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen |
| US8047545B2 (en) * | 2007-11-07 | 2011-11-01 | Douglas Press, Inc. | Lottery-type game with rollover feature |
| EP2247739B1 (en) * | 2008-01-23 | 2018-05-16 | LEK Pharmaceuticals d.d. | ((2s,4r)-4,6-dihydroxytetrahydro-2h-pyran-2-yl)methyl carboxylate and process for its production employing a 2-deoxyribose-5-phosphate aldolase (dera) |
| MX2013002674A (es) * | 2010-09-09 | 2013-06-13 | Dsm Sinochem Pharm Bv | Sales de esteres de acido 7-amino-3,5-dihidroxiheptanoico. |
| EP2616454B1 (en) * | 2010-09-16 | 2015-04-15 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Esters of hexanoic acids as intermediates for the preparation of atorvastatin |
| CN105669637A (zh) * | 2014-11-21 | 2016-06-15 | 南京博优康远生物医药科技有限公司 | 一种3,5,6-取代己酸酯衍生物的制备方法 |
| CN112501223B (zh) * | 2020-11-23 | 2022-08-12 | 江苏阿尔法药业股份有限公司 | 制备2-((2r，4r)-4-羟基-6-氧代四氢-2h-吡喃-2-基)乙腈的方法 |
| CN116102482A (zh) * | 2022-08-17 | 2023-05-12 | 重庆普佑生物医药有限公司 | 一种阿托伐他汀钙的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5097045A (en) * | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| JP2006512086A (ja) * | 2002-09-20 | 2006-04-13 | ダイヴァーサ コーポレイション | スタチンおよびスタチン中間体の合成のための酵素化学的方法 |
-
2004
- 2004-04-28 BR BRPI0409866-8A patent/BRPI0409866A/pt not_active IP Right Cessation
- 2004-04-28 JP JP2006507876A patent/JP2006525323A/ja not_active Withdrawn
- 2004-04-28 NZ NZ543294A patent/NZ543294A/en unknown
- 2004-04-28 PL PL04730128T patent/PL1620423T3/pl unknown
- 2004-04-28 DE DE602004011921T patent/DE602004011921T2/de not_active Expired - Lifetime
- 2004-04-28 SI SI200430673T patent/SI1620423T1/sl unknown
- 2004-04-28 CN CN2004800117927A patent/CN1780826B/zh not_active Expired - Fee Related
- 2004-04-28 US US10/554,294 patent/US7423162B2/en not_active Expired - Fee Related
- 2004-04-28 UA UAA200511372A patent/UA83662C2/uk unknown
- 2004-04-28 AU AU2004234308A patent/AU2004234308A1/en not_active Abandoned
- 2004-04-28 DK DK04730128T patent/DK1620423T3/da active
- 2004-04-28 CN CN201010111364.9A patent/CN101775000B/zh not_active Expired - Fee Related
- 2004-04-28 ES ES04730128T patent/ES2300769T3/es not_active Expired - Lifetime
- 2004-04-28 AT AT04730128T patent/ATE386734T1/de active
- 2004-04-28 EA EA200501734A patent/EA010100B1/ru not_active IP Right Cessation
- 2004-04-28 WO PCT/NL2004/000284 patent/WO2004096788A1/en active IP Right Grant
- 2004-04-28 CA CA002524457A patent/CA2524457A1/en not_active Abandoned
- 2004-04-28 KR KR1020057020818A patent/KR20060011984A/ko not_active Application Discontinuation
- 2004-04-28 EP EP04730128A patent/EP1620423B1/en not_active Expired - Lifetime
-
2005
- 2005-10-23 IL IL171539A patent/IL171539A/en active IP Right Grant
- 2005-11-01 ZA ZA200508862A patent/ZA200508862B/xx unknown
- 2005-11-02 CO CO05111845A patent/CO5700715A2/es not_active Application Discontinuation
- 2005-11-30 IS IS8159A patent/IS8159A/is unknown
- 2005-12-01 NO NO20055694A patent/NO20055694L/no not_active Application Discontinuation
-
2008
- 2008-05-13 CY CY20081100505T patent/CY1113498T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20055694D0 (no) | 2005-12-01 |
| ZA200508862B (en) | 2007-02-28 |
| EP1620423A1 (en) | 2006-02-01 |
| EP1620423B1 (en) | 2008-02-20 |
| US20060258733A1 (en) | 2006-11-16 |
| CN101775000B (zh) | 2014-09-24 |
| US7423162B2 (en) | 2008-09-09 |
| DE602004011921D1 (de) | 2008-04-03 |
| KR20060011984A (ko) | 2006-02-06 |
| AU2004234308A1 (en) | 2004-11-11 |
| IL171539A (en) | 2011-03-31 |
| CN1780826A (zh) | 2006-05-31 |
| WO2004096788A1 (en) | 2004-11-11 |
| DK1620423T3 (da) | 2008-05-26 |
| EA200501734A1 (ru) | 2006-04-28 |
| CA2524457A1 (en) | 2004-11-11 |
| CN1780826B (zh) | 2010-05-26 |
| DE602004011921T2 (de) | 2009-02-19 |
| IS8159A (is) | 2005-11-30 |
| UA83662C2 (uk) | 2008-08-11 |
| NZ543294A (en) | 2008-05-30 |
| ES2300769T3 (es) | 2008-06-16 |
| CN101775000A (zh) | 2010-07-14 |
| EA010100B1 (ru) | 2008-06-30 |
| PL1620423T3 (pl) | 2008-07-31 |
| CY1113498T1 (el) | 2016-06-22 |
| SI1620423T1 (sl) | 2008-06-30 |
| CO5700715A2 (es) | 2006-11-30 |
| ATE386734T1 (de) | 2008-03-15 |
| JP2006525323A (ja) | 2006-11-09 |
| BRPI0409866A (pt) | 2006-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |