NO20050980L - Mikrobiologisk fremgangsmate for fremstilling av 7a-substituerte 11a-hydroksysteroider - Google Patents

Mikrobiologisk fremgangsmate for fremstilling av 7a-substituerte 11a-hydroksysteroider

Info

Publication number
NO20050980L
NO20050980L NO20050980A NO20050980A NO20050980L NO 20050980 L NO20050980 L NO 20050980L NO 20050980 A NO20050980 A NO 20050980A NO 20050980 A NO20050980 A NO 20050980A NO 20050980 L NO20050980 L NO 20050980L
Authority
NO
Norway
Prior art keywords
preparation
hydroxysteroids
substituted
microbiological process
compounds
Prior art date
Application number
NO20050980A
Other languages
English (en)
Norwegian (no)
Inventor
Ludwig Zorn
Hans-Peter Muhn
Rolf Bohlmann
Norbert Gallus
Hermann Kuenzer
Reinhard Nubbermeyer
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10233723A external-priority patent/DE10233723A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20050980L publication Critical patent/NO20050980L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO20050980A 2002-07-24 2005-02-23 Mikrobiologisk fremgangsmate for fremstilling av 7a-substituerte 11a-hydroksysteroider NO20050980L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10233723A DE10233723A1 (de) 2002-07-24 2002-07-24 Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene
US40295302P 2002-08-14 2002-08-14
PCT/EP2003/008111 WO2004011663A2 (de) 2002-07-24 2003-07-24 Mikrobiologische verfahren zur herstellung von 7alpha-substituierten 11alpha-hydroxysteroiden

Publications (1)

Publication Number Publication Date
NO20050980L true NO20050980L (no) 2005-02-23

Family

ID=31189296

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050980A NO20050980L (no) 2002-07-24 2005-02-23 Mikrobiologisk fremgangsmate for fremstilling av 7a-substituerte 11a-hydroksysteroider

Country Status (20)

Country Link
EP (1) EP1523568A2 (pt)
JP (1) JP4417838B2 (pt)
KR (1) KR101041328B1 (pt)
CN (1) CN100339486C (pt)
BR (1) BR0313210A (pt)
CA (1) CA2492079C (pt)
CO (1) CO5690563A2 (pt)
CR (1) CR7672A (pt)
EA (2) EA010572B1 (pt)
EC (1) ECSP055630A (pt)
HK (1) HK1081999A1 (pt)
HR (1) HRP20050172A2 (pt)
IL (1) IL166358A0 (pt)
MX (1) MXPA05001024A (pt)
NO (1) NO20050980L (pt)
NZ (2) NZ549529A (pt)
PH (1) PH12005500143B1 (pt)
PL (1) PL373808A1 (pt)
RS (1) RS51855B (pt)
WO (1) WO2004011663A2 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103834712A (zh) * 2012-11-26 2014-06-04 复旦大学 去氧孕烯中间体纳米脂质体生物转化的优化方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200804405A (en) * 2005-10-27 2008-01-16 Taiho Pharmaceutical Co Ltd Process for production of steroid compound
CN103214543B (zh) * 2012-12-25 2015-09-02 中国人民解放军海军医学研究所 新山楂酸衍生物、其制备方法及其在抗肿瘤药物中的应用
CN104862323B (zh) * 2015-06-02 2018-01-16 中国农业科学院生物技术研究所 修饰苯二酚类化合物的羟化酶基因

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL75841C (pt) 1949-06-11
US2658023A (en) * 1953-04-21 1953-11-03 Pfizer & Co C Oxygenation of steroids
US2985563A (en) * 1958-11-13 1961-05-23 Schering Corp 11alpha-hydroxylation of steroids by glomerella
US3004047A (en) * 1959-03-13 1961-10-10 Olin Mathieson 6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof
US3341557A (en) 1961-06-05 1967-09-12 Upjohn Co 7-methyltestosterones
US3203869A (en) * 1962-10-11 1965-08-31 Syntex Corp 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section
US5342834A (en) 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
EP1167380A3 (en) * 1995-12-11 2004-12-08 G.D. Searle & Co. 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
ES2175175T3 (es) * 1995-12-12 2002-11-16 Akzo Nobel Nv Un metodo microbiano para la 11alfa-hidroxilacion de esteroides.
GB9525194D0 (en) 1995-12-12 1996-02-07 Zeneca Ltd Pharmaceutical composition
US20020012694A1 (en) * 1997-09-17 2002-01-31 Alfred J. Moo-Young Transdermal administration of ment
US6767902B2 (en) 1997-09-17 2004-07-27 The Population Council, Inc. Androgen as a male contraceptive and non-contraceptive androgen replacement
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
PL357185A1 (en) 2000-02-15 2004-07-26 Schering Aktiengesellschaft Male contraceptive formulation comprising norethisterone
DE10104327A1 (de) * 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
MXPA05001017A (es) * 2002-07-25 2005-06-08 Schering Ag Composicion conteniendo un 11¦-halogeno esteroide androgenico y un gestageno asi como un anticonceptivo masculino basado en esta composicion.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103834712A (zh) * 2012-11-26 2014-06-04 复旦大学 去氧孕烯中间体纳米脂质体生物转化的优化方法

Also Published As

Publication number Publication date
NZ549529A (en) 2008-04-30
PL373808A1 (en) 2005-09-19
CO5690563A2 (es) 2006-10-31
CN100339486C (zh) 2007-09-26
EA010572B1 (ru) 2008-10-30
RS51855B (sr) 2012-02-29
MXPA05001024A (es) 2005-05-16
EA200601030A1 (ru) 2006-10-27
CR7672A (es) 2006-05-29
JP4417838B2 (ja) 2010-02-17
CN1671858A (zh) 2005-09-21
CA2492079A1 (en) 2004-02-05
AU2003281677A1 (en) 2004-02-16
PH12005500143B1 (en) 2011-03-25
EP1523568A2 (de) 2005-04-20
KR101041328B1 (ko) 2011-06-14
WO2004011663A3 (de) 2004-07-15
MX260952B (pt) 2008-10-01
KR20050026507A (ko) 2005-03-15
IL166358A0 (en) 2006-01-16
JP2006503813A (ja) 2006-02-02
BR0313210A (pt) 2005-06-28
HK1081999A1 (en) 2006-05-26
WO2004011663A2 (de) 2004-02-05
WO2004011663A9 (de) 2004-05-06
CA2492079C (en) 2012-01-10
HRP20050172A2 (en) 2005-04-30
ECSP055630A (es) 2005-04-18
NZ537871A (en) 2006-10-27
EA200500224A1 (ru) 2005-08-25
RS20050045A (en) 2007-06-04
EA008147B1 (ru) 2007-04-27

Similar Documents

Publication Publication Date Title
HK1089444A1 (en) Dihydropteridinones, method for the production and use thereof in the form of drugs
HUP0303283A2 (hu) Új piridinilcsoporttal szubsztituált pirazolopiridin-származékok, előállításuk és alkalmazásuk szív- és keringési betegségek kezelésére alkalmas gyógyszerkészítmény előállítására
PL376793A1 (pl) Spirocykliczne pochodne cykloheksanu
NZ526470A (en) Pyrazole compounds useful as protein kinase inhibitors
TW200510325A (en) 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
HRP20050359B1 (hr) Novi postupak za industrijsku sintezu stroncij renalata i njegovih hidrata
NO20006645L (no) Ny form av irbesartan, fremgangsmåte for å oppnå den nevnte form og farmasöytiske preparater inneholdende den samme
NO20062599L (no) Fremgangsmate for syntese av perindopril og farmasoytisk akseptable salter derav
HUP0303034A2 (hu) Új 7-azaindol-származékok, foszfodiészteráz-4 inhibitorjakénti alkalmazásuk és eljárás az előállításukra
NO20050980L (no) Mikrobiologisk fremgangsmate for fremstilling av 7a-substituerte 11a-hydroksysteroider
MX9800412A (es) Preparacion de 3-hidroxipirazoles n-substituidos.
NO20063012L (no) Fremgangsmaten for syntesen av perindopril og farmasoytisk akseptable salter derav
NO20010559D0 (no) Fremgangsmåte for syntese av (1H)-benzo[c]kinolizin-3-ones derivater
NO20064352L (no) Fremgangsmate for fremstilling av pyrrolidinoksimer
HUP0302408A2 (hu) Új aminotriazolon-vegyületek, eljárás ezek előállítására és ezeket tartalmazó gyógyászati készítmények
ATE177424T1 (de) N-substituierte naphthalimide, ihre herstellung und verwendung
RS20110079A (en) MICROBIOLOGICAL PROCEDURE FOR THE PREPARATION OF 7ALFA-SUBSTITUTED 11ALFA-HYDROXYSTEROIDS
MXPA05013649A (es) Fluorbutenos nematicidas que contienen tiazolina.
NO990285L (no) Tienylcykloheksan-derivater for tienylcykloheksyl-syntese
DE60306361D1 (de) Verfahren zur herstellung von benazeprilhydrochloride
ES2009949A6 (es) Procedimiento de preparacion de nuevos derivados de aril-heteroarilcetonas.
RS20060049A (en) Novel n-substituted indolyl-3-glycoxylic acid amides, use thereof as a medicament and method for the production thereof
NO993650L (no) Nye forbindelser med hemoregulerende effekt
SG145571A1 (en) Intermediates useful in the synthesis of hiv-protease inhibitors and methods for preparing the same

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application