NO20042843L - Mikrofluidinnretning og overflate dekorasjonsprosess for fast fase affinitets-bindings-analyser - Google Patents

Mikrofluidinnretning og overflate dekorasjonsprosess for fast fase affinitets-bindings-analyser

Info

Publication number
NO20042843L
NO20042843L NO20042843A NO20042843A NO20042843L NO 20042843 L NO20042843 L NO 20042843L NO 20042843 A NO20042843 A NO 20042843A NO 20042843 A NO20042843 A NO 20042843A NO 20042843 L NO20042843 L NO 20042843L
Authority
NO
Norway
Prior art keywords
solid phase
microfluidic device
binding assays
affinity binding
surface decoration
Prior art date
Application number
NO20042843A
Other languages
English (en)
Norwegian (no)
Inventor
Paul Yager
Elena Garcia
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of NO20042843L publication Critical patent/NO20042843L/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/058—Flat flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
NO20042843A 2001-12-05 2004-07-05 Mikrofluidinnretning og overflate dekorasjonsprosess for fast fase affinitets-bindings-analyser NO20042843L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33760601P 2001-12-05 2001-12-05
PCT/US2002/038953 WO2003048736A2 (en) 2001-12-05 2002-12-05 Microfluidic device and surface decoration process for solid phase affinity binding assays

Publications (1)

Publication Number Publication Date
NO20042843L true NO20042843L (no) 2004-08-24

Family

ID=23321226

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042843A NO20042843L (no) 2001-12-05 2004-07-05 Mikrofluidinnretning og overflate dekorasjonsprosess for fast fase affinitets-bindings-analyser

Country Status (7)

Country Link
US (1) US7258837B2 (ja)
EP (1) EP1461606A4 (ja)
JP (3) JP4191608B2 (ja)
AU (1) AU2002360499A1 (ja)
CA (1) CA2468674A1 (ja)
NO (1) NO20042843L (ja)
WO (1) WO2003048736A2 (ja)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
JP4191608B2 (ja) * 2001-12-05 2008-12-03 ユニヴァーシティ オブ ワシントン 固相アフィニティー結合アッセイのための、微小流体デバイスおよび表面修飾プロセス
US20070178477A1 (en) * 2002-01-16 2007-08-02 Nanomix, Inc. Nanotube sensor devices for DNA detection
US20070227907A1 (en) * 2006-04-04 2007-10-04 Rajiv Shah Methods and materials for controlling the electrochemistry of analyte sensors
AT500427B1 (de) * 2002-05-29 2009-02-15 Anagnostics Bioanalysis Gmbh Vorrichtung zur analyse von bestandteilen einer probe
JP4109022B2 (ja) * 2002-06-13 2008-06-25 富士フイルム株式会社 測定装置および該測定装置の使用方法
JP3883934B2 (ja) * 2002-08-29 2007-02-21 富士フイルムホールディングス株式会社 生化学解析用ユニットを利用した化学発光法
GB2395006A (en) * 2002-10-29 2004-05-12 Micro Chemical Systems Ltd Apparatus and method for performing an assay
SE0300823D0 (sv) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
EP1648286B1 (en) * 2003-07-12 2017-12-20 Accelerate Diagnostics, Inc. Sensitive and rapid biodetection
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US7357898B2 (en) * 2003-07-31 2008-04-15 Agency For Science, Technology And Research Microfluidics packages and methods of using same
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
EP1776181B1 (en) 2004-01-26 2013-09-11 The President and Fellows of Harvard College Fluid delivery system and method
US7351538B2 (en) * 2004-08-23 2008-04-01 U.S. Genomics Systems and methods for detecting and analyzing polymers
WO2006024023A2 (en) * 2004-08-24 2006-03-02 Nanomix, Inc. Nanotube sensor devices for dna detection
JP2008514966A (ja) * 2004-09-30 2008-05-08 クイデル コーポレイション 第１及び第２流路を有する分析装置
US20060078471A1 (en) * 2004-10-12 2006-04-13 Witty Thomas R Apparatus and method for a precision flow assay
WO2006042734A1 (de) * 2004-10-15 2006-04-27 Siemens Aktiengesellschaft Verfahren zur durchführung einer elektrochemischen messung an einer flüssigen messprobe in einer über leitungen zugänglichen messkammer und zugehörige anordnung
US7405054B1 (en) * 2004-12-13 2008-07-29 University Of Washington Uw Tech Transfer - Invention Licensing Signal amplification method for surface plasmon resonance-based chemical detection
JP4520873B2 (ja) * 2005-02-02 2010-08-11 セイコーインスツル株式会社 解離定数測定装置、解離定数測定方法、及び解離定数測定プログラム
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9206384B2 (en) 2011-12-03 2015-12-08 Emd Millipore Corporation Micro-incubation systems for microfluidic cell culture and methods
ES2865180T3 (es) 2005-07-07 2021-10-15 Univ California Aparato para formación de cultivo celular
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
AT502549B1 (de) * 2005-10-07 2007-06-15 Anagnostics Bioanalysis Gmbh Vorrichtung zur analyse von flüssigen proben
US20070099022A1 (en) * 2005-11-01 2007-05-03 The U.S. Of America As Represented By The Secretary Of The Navy Non-chromium post-treatment for aluminum coated steel
EP1996330A2 (en) * 2006-03-15 2008-12-03 Koninklijke Philips Electronics N.V. Microelectronic device with controllable reference substance supply
US20090087925A1 (en) * 2007-10-01 2009-04-02 Zyomyx, Inc. Devices and methods for analysis of samples with depletion of analyte content
WO2008043041A1 (en) * 2006-10-04 2008-04-10 University Of Washington Method and device for rapid parallel microfluidic molecular affinity assays
US20080160623A1 (en) * 2006-12-27 2008-07-03 Xing Su Method and device for bioanalyte quantification by on/off kinetics of binding complexes
US8999636B2 (en) * 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
US8345253B2 (en) * 2007-02-21 2013-01-01 The Royal Institution for the Advancement of Learning/McGill University and Her Majesty the Queen in Right of Canada System and method for surface plasmon resonance based detection of molecules
DE102007012866A1 (de) * 2007-03-09 2008-09-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Flusskanalsystem und Verfahren zum Anbinden von Analyten an Liganden
JP5305361B2 (ja) 2007-05-04 2013-10-02 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニー 流体コネクタおよびマイクロ流体システム
US20090075361A1 (en) * 2007-06-14 2009-03-19 University Of Rochester Microfluidic Device and Method of Manufacturing the Microfluidic Device
US9457497B2 (en) 2007-06-14 2016-10-04 University Of Rochester Microfluidic device and method of manufacturing the microfluidic device
US9346197B2 (en) 2007-06-14 2016-05-24 University Of Rochester Microfluidic device and method of manufacturing the microfluidic device
WO2009009127A2 (en) * 2007-07-12 2009-01-15 U.S. Genomics, Inc. Method and system for transferring and/or concentrating a sample
AU2008276027B2 (en) 2007-07-16 2014-09-04 California Institute Of Technology Arrays, substrates, devices, methods and systems for detecting target molecules
EP2017618A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Methods and systems for detecting
US20100227767A1 (en) * 2007-07-26 2010-09-09 Boedicker James Q Stochastic confinement to detect, manipulate, and utilize molecules and organisms
EP2185940A4 (en) * 2007-08-20 2016-06-01 Nomadics Inc GRADIENT INJECTION FOR BIOSENSING
US20090087924A1 (en) * 2007-09-29 2009-04-02 Magdalena Bynum Microfluidic reverse affinity-blot device
US20090130746A1 (en) * 2007-10-25 2009-05-21 Canon U.S. Life Sciences, Inc. Microchannel surface coating
US20090136948A1 (en) * 2007-10-31 2009-05-28 Jongyoon Han Nanoconfinement- based devices and methods of use thereof
WO2009089189A2 (en) 2008-01-03 2009-07-16 Cellasic Cell culture array system for automated assays and methods of operation and manufacture thereof
US20100285612A1 (en) * 2008-01-16 2010-11-11 Yuzuru Iwasaki Flow rate measurement apparatus, antigen concentration measurement apparatus, flow cell, flow rate measurement method, and antigen concentration measuring method
JP4861353B2 (ja) * 2008-02-01 2012-01-25 日本電信電話株式会社 フローセル
CN102149812A (zh) * 2008-02-21 2011-08-10 埃凡特拉生物科技公司 基于液体流经阵列的分析
DE502008001323D1 (de) * 2008-06-05 2010-10-28 Roche Diagnostics Gmbh Verfahren zum Bestimmen eines Analyten in einer Flüssigkeitsprobe und Analysevorrichtung
US20100025238A1 (en) * 2008-07-31 2010-02-04 Medtronic Minimed, Inc. Analyte sensor apparatuses having improved electrode configurations and methods for making and using them
US8700114B2 (en) * 2008-07-31 2014-04-15 Medtronic Minmed, Inc. Analyte sensor apparatuses comprising multiple implantable sensor elements and methods for making and using them
EP2349566B1 (en) 2008-10-03 2016-01-06 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
US8361716B2 (en) * 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
CN102301002A (zh) 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
DK2376226T3 (en) 2008-12-18 2018-10-15 Opko Diagnostics Llc IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES
DE202010018623U1 (de) 2009-02-02 2018-12-07 Opko Diagnostics, Llc Strukturen zur Steuerung der Lichtwechselwirkung mit mikrofluidischen Vorrichtungen
US20120045827A1 (en) * 2009-03-09 2012-02-23 Biofactura, Inc. Separation of antigen-specific memory b cells with a conjugated biopolymer surface
WO2011017436A2 (en) * 2009-08-04 2011-02-10 The Johns Hopkins University A high precision quantitative assay composition and methods of use therefor
US8859268B2 (en) * 2009-10-08 2014-10-14 Los Alamos National Security, Llc Quantitative multiplex detection of pathogen biomarkers
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
WO2013134741A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2011066361A1 (en) 2009-11-24 2011-06-03 Claros Diagnostics, Inc. Fluid mixing and delivery in microfluidic systems
US9733242B2 (en) 2012-10-07 2017-08-15 Sevident, Inc. Devices for capturing analyte
US9910040B2 (en) 2012-07-09 2018-03-06 Sevident, Inc. Molecular nets comprising capture agents and linking agents
KR100968334B1 (ko) 2009-11-27 2010-07-08 강릉원주대학교산학협력단 바이오센서에 사용되는 여러 분석물질의 검출 방법
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
TWI461689B (zh) * 2010-04-01 2014-11-21 Univ Nat Cheng Kung 含有乾粉狀試劑的血液凝固測試用生醫晶片
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
EP2560005B1 (en) * 2010-04-14 2016-12-07 Nitto Boseki Co., Ltd Test instrument for measuring analyte in sample, and method for measuring analyte using same
WO2011130625A1 (en) 2010-04-16 2011-10-20 Claros Diagnostics, Inc. Feedback control in microfluidic systems
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
CN103140755B (zh) 2010-07-22 2016-03-16 哈希公司 用于碱度分析的芯片上实验室
US10114020B2 (en) * 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
JP5978287B2 (ja) 2011-03-22 2016-08-24 サイヴェク・インコーポレイテッド マイクロ流体装置並びに製造及び使用の方法
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
JP5177915B2 (ja) * 2011-04-25 2013-04-10 日本電信電話株式会社 フローセル
US20130087020A1 (en) * 2011-10-07 2013-04-11 University Of Southern California Continuous flow synthesis of nanomaterials using ionic liquids in microfluidic reactors
US9518291B2 (en) * 2011-12-23 2016-12-13 California Institute Of Technology Devices and methods for biological sample-to-answer and analysis
US8883088B2 (en) 2011-12-23 2014-11-11 California Institute Of Technology Sample preparation devices and systems
CN103217519B (zh) 2012-01-20 2017-06-20 奥索临床诊断有限公司 具有多个试剂池的测定装置
BR102013001394A2 (pt) * 2012-01-20 2014-12-02 Ortho Clinical Diagnostics Inc Dispositivo de ensaio de baixo volume que tem uma sensibilidade aumentada
TWI638277B (zh) 2012-03-05 2018-10-11 Ｏｐｋｏ診斷法有限責任公司 用於確定前列腺癌相關事件之機率之分析系統及方法
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
JP6128764B2 (ja) * 2012-06-27 2017-05-17 京セラ株式会社 バイオセンサ、検出方法、検出システム及び検出装置
JP2014011974A (ja) * 2012-07-04 2014-01-23 Sony Corp 化学反応用マイクロチップ及びその製造方法
US9651549B2 (en) * 2012-07-13 2017-05-16 Genisphere, Llc Lateral flow assays using DNA dendrimers
WO2014031997A1 (en) 2012-08-24 2014-02-27 Yale University System, device and method for high-throughput multi-plexed detection
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP4170031A1 (en) 2012-10-23 2023-04-26 Caris Science, Inc. Aptamers and uses thereof
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
EP2912432B1 (en) 2012-10-24 2018-07-04 Genmark Diagnostics Inc. Integrated multiplex target analysis
EP2911791A4 (en) 2012-10-29 2016-11-02 Mbio Diagnostics Inc SYSTEM FOR IDENTIFYING BIOLOGICAL PARTICLES, CARTRIDGE AND ASSOCIATED METHODS
WO2014071256A1 (en) 2012-11-05 2014-05-08 California Institute Of Technology Instruments for biological sample preparation devices
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
WO2014100434A1 (en) 2012-12-19 2014-06-26 Caris Science, Inc. Compositions and methods for aptamer screening
HUE038527T2 (hu) * 2012-12-28 2018-10-29 Cellestis Ltd Sejtek által közvetített immunválasz
CA2841692C (en) * 2013-02-12 2023-08-22 Zhong Ding Reagent zone deposition pattern
US9588027B2 (en) 2013-03-13 2017-03-07 UPKO Diagnostics, LLC Mixing of fluids in fluidic systems
CN105339791B (zh) * 2013-03-14 2019-02-15 赛维德恩特有限公司 固相上的分子网
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US9453613B2 (en) 2013-03-15 2016-09-27 Genmark Diagnostics, Inc. Apparatus, devices, and methods for manipulating deformable fluid vessels
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP2016533752A (ja) 2013-08-28 2016-11-04 カリス ライフ サイエンシズ スウィッツァーランド ホー オリゴヌクレオチドプローブおよびその使用
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
MY192513A (en) 2014-03-28 2022-08-24 Opko Diagnostics Llc Compositions and methods related to diagnosis of prostate cancer
EP3204752B1 (en) * 2014-10-06 2019-07-24 Biosurfit, S.A. Binding assay analysis
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
CN107407638B (zh) 2014-12-03 2021-01-12 伊索普莱西斯公司 细胞分泌特征的分析和筛选
WO2016094766A1 (en) 2014-12-12 2016-06-16 Opko Diagnostics, Llc Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
US11353448B2 (en) 2015-02-13 2022-06-07 California Institute Of Technology Methods and compositions for quantifying metabolites and proteins from single cells
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
ES2867798T3 (es) 2015-03-27 2021-10-20 Opko Diagnostics Llc Estándares del antígeno prostático y usos de estos
WO2016161022A2 (en) 2015-03-30 2016-10-06 Accerlate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
CA2993652A1 (en) 2015-07-28 2017-02-02 Caris Science, Inc. Targeted oligonucleotides
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
US10731166B2 (en) 2016-03-18 2020-08-04 Caris Science, Inc. Oligonucleotide probes and uses thereof
CA3025486A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
US10359391B2 (en) 2016-07-07 2019-07-23 e-SENS, Inc. Sensor with a membrane having full circumferential adhesion
JP7348066B2 (ja) 2016-11-11 2023-09-20 アイソプレキシス コーポレイション 単一細胞のゲノム、トランスクリプトームおよびプロテオームの同時解析のための組成物および方法
US11525783B2 (en) 2016-11-22 2022-12-13 IsoPlexis Corporation Systems, devices and methods for cell capture and methods of manufacture thereof
US10464063B2 (en) 2017-04-07 2019-11-05 e-SENS, Inc. Microfluidics chip with sensor die clamping structures
US10710068B2 (en) 2017-09-20 2020-07-14 e-SENSE, Inc. Microfluidic chip with chemical sensor having back-side contacts
WO2020113237A1 (en) 2018-11-30 2020-06-04 Caris Mpi, Inc. Next-generation molecular profiling
CN211905402U (zh) * 2019-11-22 2020-11-10 京东方科技集团股份有限公司 检测芯片及检测系统
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
US20240069050A1 (en) * 2020-12-11 2024-02-29 Horiba, Ltd. Testing device, and method and program for information processing

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932100A (en) * 1995-06-16 1999-08-03 University Of Washington Microfabricated differential extraction device and method
DE69619400T2 (de) * 1995-06-16 2002-09-26 Univ Washington Seattle Flacher mikrogefertigter querstromfilter für flüssigkeiten
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
AU7526496A (en) * 1995-10-25 1997-05-15 University Of Washington Surface plasmon resonance electrode as chemical sensor
US5991048A (en) * 1995-10-25 1999-11-23 University Of Washington Surface plasmon resonance light pipe sensor
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6541213B1 (en) * 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US20020090644A1 (en) * 1999-05-21 2002-07-11 Weigl Bernhard H. Microscale diffusion immunoassay
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
WO1997047390A1 (en) * 1996-06-14 1997-12-18 University Of Washington Absorption-enhanced differential extraction device
US6039897A (en) * 1996-08-28 2000-03-21 University Of Washington Multiple patterned structures on a single substrate fabricated by elastomeric micro-molding techniques
US5748827A (en) * 1996-10-23 1998-05-05 University Of Washington Two-stage kinematic mount
US6159739A (en) * 1997-03-26 2000-12-12 University Of Washington Device and method for 3-dimensional alignment of particles in microfabricated flow channels
JP2002503336A (ja) * 1997-05-16 2002-01-29 アルバータ リサーチ カウンシル 微量流通システムおよびその使用方法
US5974867A (en) * 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
US6136272A (en) * 1997-09-26 2000-10-24 University Of Washington Device for rapidly joining and splitting fluid layers
US6007775A (en) * 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
JP2001518624A (ja) * 1997-09-26 2001-10-16 ユニバーシティ・オブ・ワシントン 同時の粒子分離および化学反応
DE19814811C1 (de) * 1998-04-02 1999-08-05 Inst Physikalische Hochtech Ev Anordnung für die Oberflächenplasmonen-Resonanz-Spektroskopie
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6482306B1 (en) * 1998-09-22 2002-11-19 University Of Washington Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer
US6067157A (en) * 1998-10-09 2000-05-23 University Of Washington Dual large angle light scattering detection
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6480282B1 (en) * 1999-05-06 2002-11-12 University Of Washington Capillary surface plasmon resonance sensors and multisensors
US6649358B1 (en) * 1999-06-01 2003-11-18 Caliper Technologies Corp. Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
EP1190241A4 (en) 1999-06-03 2004-03-31 Univ Washington Microfluidic devices for border electrophoresis and isoelectric focusing
DE19948087B4 (de) * 1999-10-06 2008-04-17 Evotec Ag Verfahren zur Herstellung eines Reaktionssubstrats
US6875619B2 (en) * 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6408884B1 (en) * 1999-12-15 2002-06-25 University Of Washington Magnetically actuated fluid handling devices for microfluidic applications
US20020142618A1 (en) * 2000-08-04 2002-10-03 Caliper Technologies Corp. Control of operation conditions within fluidic systems
JP2004509335A (ja) * 2000-09-18 2004-03-25 ユニバーシティ　オブ　ワシントン 複数のフローストリーム間の流体界面の回転操作のための微小流体デバイス
JP4191608B2 (ja) * 2001-12-05 2008-12-03 ユニヴァーシティ オブ ワシントン 固相アフィニティー結合アッセイのための、微小流体デバイスおよび表面修飾プロセス

Also Published As

Publication number Publication date
JP4191608B2 (ja) 2008-12-03
US7258837B2 (en) 2007-08-21
AU2002360499A1 (en) 2003-06-17
WO2003048736A2 (en) 2003-06-12
JP2005512045A (ja) 2005-04-28
JP2008304476A (ja) 2008-12-18
JP2008304475A (ja) 2008-12-18
EP1461606A2 (en) 2004-09-29
CA2468674A1 (en) 2003-06-12
US20030124623A1 (en) 2003-07-03
EP1461606A4 (en) 2005-06-29
WO2003048736A3 (en) 2003-09-12

Similar Documents

Publication Publication Date Title
NO20042843L (no) Mikrofluidinnretning og overflate dekorasjonsprosess for fast fase affinitets-bindings-analyser
AU2002353107A8 (en) Microfluidic devices and methods for two-dimensional separations
GB2397256B (en) Apparatus and methods for microfluidic applications
EP1497318A4 (en) BINDING MOLECULES FOR FC ZONE POLYPEPTIDES
DE60224651D1 (de) Aufbringen von löslichen materialien
GB2395196B (en) Microfluidic device and methods for construction and application
AU2002351291A8 (en) Adhesiveless microfluidic device fabrication
DK1390389T3 (da) Cripto-blokerende antistoffer og anvendelser deraf
EP1481234A4 (en) METHOD AND APPARATUS FOR INCREASING THE DYNAMIC RANGE AND PRECISION OF LINKED TITRAGES
DE60210160D1 (de) Snowboardbindung
AU2003270004A8 (en) Microfluidic affinity system using polydimethylsiloxane and a surface modification process
NO20034921D0 (no) Skibinding
HUP0400030A3 (en) Antibodies specific for cd44v6
IL174689A0 (en) Native immunoglobulin binding reagents and methods for making and using same
DE60212776D1 (de) Spezifisches Bindungsanalyseverfahren
DE60222217D1 (de) Tintenzusammensetzung zum Phasenaustausch
DK1164375T3 (da) Assay til antitransglutaminaseantistoffer
DE60231239D1 (de) Bindungsassay-vorrichtung mit nicht-absorbierendem trägermaterial
GB0111218D0 (en) Assays methods and means
GB0311961D0 (en) Mass-based toxin assay and substrates therefor
AU2002360822A1 (en) Microfluidic analytical apparatus
GB0421143D0 (en) Microfluidic device
FI20010959A0 (fi) Seurattava pipetti
DE60135294D1 (de) System zum Binden von Dokumenten
ATA8342001A (de) Einrichtung zum pyrometallurgischen aufarbeiten von abfallstoffen

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application