NO20033632L - Fremgangsmåter for bestemmelse av protein- og peptid- terminalsekvenser - Google Patents

Fremgangsmåter for bestemmelse av protein- og peptid- terminalsekvenser

Info

Publication number
NO20033632L
NO20033632L NO20033632A NO20033632A NO20033632L NO 20033632 L NO20033632 L NO 20033632L NO 20033632 A NO20033632 A NO 20033632A NO 20033632 A NO20033632 A NO 20033632A NO 20033632 L NO20033632 L NO 20033632L
Authority
NO
Norway
Prior art keywords
methods
molecules
mass
useful
terminal sequences
Prior art date
Application number
NO20033632A
Other languages
English (en)
Norwegian (no)
Other versions
NO20033632D0 (no
Inventor
Luke V Schneider
Robert Petesch
Michael P Hall
Original Assignee
Target Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Target Discovery Inc filed Critical Target Discovery Inc
Publication of NO20033632L publication Critical patent/NO20033632L/no
Publication of NO20033632D0 publication Critical patent/NO20033632D0/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Peptides Or Proteins (AREA)
NO20033632A 2000-10-19 2003-08-15 Fremgangsmåter for bestemmelse av protein- og peptid- terminalsekvenser NO20033632D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24216500P 2000-10-19 2000-10-19
US24239800P 2000-10-19 2000-10-19
PCT/US2001/049491 WO2002061661A2 (fr) 2000-10-19 2001-10-19 Procedes servant a determiner des sequences terminales de proteines et de peptides

Publications (2)

Publication Number Publication Date
NO20033632L true NO20033632L (no) 2003-08-15
NO20033632D0 NO20033632D0 (no) 2003-08-15

Family

ID=26934884

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20033632A NO20033632D0 (no) 2000-10-19 2003-08-15 Fremgangsmåter for bestemmelse av protein- og peptid- terminalsekvenser

Country Status (13)

Country Link
US (4) US6962818B2 (fr)
EP (3) EP1430436A2 (fr)
JP (3) JP4259869B2 (fr)
AT (1) ATE552348T1 (fr)
AU (2) AU2002246744B2 (fr)
CA (2) CA2425798A1 (fr)
DK (1) DK1358458T3 (fr)
ES (1) ES2385335T3 (fr)
IL (5) IL155518A0 (fr)
IS (1) IS6781A (fr)
NO (1) NO20033632D0 (fr)
PT (1) PT1358458E (fr)
WO (2) WO2002061661A2 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6716636B1 (en) 1999-04-20 2004-04-06 Target Discovery, Inc. Methods for sequencing proteins
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
CA2370539C (fr) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology Systeme et procede de notation de polymeres
US6824981B2 (en) * 2000-08-11 2004-11-30 Agilix Corporation Ultra-sensitive detection systems using alterable peptide tags
ES2385335T3 (es) * 2000-10-19 2012-07-23 Target Discovery, Inc. Marcaje de defecto de masa para la determinación de secuencias de oligómeros
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
EP1451588A4 (fr) * 2001-11-06 2005-03-09 Agilix Corp Systemes de detection codes sensibles
ITMI20020396A1 (it) * 2002-02-27 2003-08-27 Gian Luigi Gianfranceschi Procedimento per la determinazione automatica della composizione e/o della sequenza di un polimero
EP1590648A4 (fr) * 2002-05-20 2007-04-18 Massachusetts Inst Technology Nouvelle technique de determination de sequence par irm
US20040172200A1 (en) * 2002-11-22 2004-09-02 Kearney Paul Edward Constellation mapping and uses thereof
JP3817523B2 (ja) * 2003-02-14 2006-09-06 株式会社日立製作所 質量分析データ解析システム
JP4532874B2 (ja) * 2003-10-07 2010-08-25 キヤノン株式会社 質量分析可能な原子群を構成単位とする鎖状構造を有する分子に対して付加情報を付与して、情報記録コードとして利用する方法
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
GB0329554D0 (en) * 2003-12-22 2004-01-28 Micromass Ltd Mass spectrometer
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP4393270B2 (ja) * 2004-05-21 2010-01-06 株式会社日立ハイテクノロジーズ 質量分析装置および異性体分析方法
WO2006050130A2 (fr) * 2004-10-29 2006-05-11 Target Discovery, Inc. Analyse de glycanes utilisant le glucose deutere
CA2596117A1 (fr) * 2005-02-03 2006-08-10 Perkinelmer Las, Inc. Systemes de detection ultrasensible utilisant des signaux multidimensionnels
EP1894224A4 (fr) * 2005-05-27 2011-08-03 Ionwerks Inc Spectrometre de masse a temps de vol a mobilite ionique multifaisceau presentant des extraction ionique bipolaire et detection de zwitterions
JP5111399B2 (ja) * 2006-02-07 2013-01-09 アプライド バイオシステムズ （カナダ） リミテッド 質量分析のための化学ノイズの低減
JP5777269B2 (ja) * 2006-02-13 2015-09-09 フリューダイム カナダ インコーポレイテッド 元素分析によって実施される遺伝子発現アッセイ
WO2007095378A2 (fr) * 2006-02-15 2007-08-23 University Of Virginia Patent Foundation Marquage de masse pour l'analyse quantitative de biomolécules au moyen de phénylisocyanate étiqueté 13c
US7838303B2 (en) * 2006-07-27 2010-11-23 Agilent Technologies, Inc. Peptide derivatization method to increase fragmentation information from MS/MS spectra
DE102006035577A1 (de) * 2006-07-27 2008-01-31 Eberhard-Karls-Universität Tübingen Universitätsklinikum Röntgendichtes Konjugat
US7800057B2 (en) * 2007-06-01 2010-09-21 Perkinelmer Health Sciences, Inc. Atmospheric pressure ion source performance enhancement
US8536520B2 (en) 2007-08-06 2013-09-17 Iroa Technologies Llc Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US7820963B2 (en) 2007-08-06 2010-10-26 Metabolic Alayses, Inc. Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US8969251B2 (en) 2007-10-02 2015-03-03 Methabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
US20090095899A1 (en) * 2007-10-16 2009-04-16 Whitehouse Craig M Atmospheric pressure ion source performance enhancement
CN102203292B (zh) * 2008-10-29 2014-06-25 南克森制药公司 通过质谱分析法测序核酸分子
WO2011010964A1 (fr) 2009-07-22 2011-01-27 Agency For Science, Technology And Research Différentiation d’aminoacides isobariques et autres espèces
US8153961B2 (en) * 2009-08-31 2012-04-10 Thermo Finnigan Llc Methods for acquisition and deductive analysis of mixed fragment peptide mass spectra
PL390797A1 (pl) 2010-03-22 2011-09-26 Instytut Chemii Bioorganicznej Polskiej Akademii Nauk Biblioteka kombinatoryczna, sposób otrzymywania biblioteki kombinatorycznej, sposób identyfikacji sekwencji, sposób sekwencjonowania elementów kombinatorycznych bibliotek oligonukleotydów i/lub analogów oligonukleotydów, zastosowanie łącznika do tworzenia bibliotek kombinatorycznych oraz zestaw do identyfikacji sekwencji
NZ604013A (en) * 2010-06-16 2014-10-31 Abbott Lab Comparison of protein samples
US9046525B2 (en) * 2010-07-30 2015-06-02 California Institute Of Technology Method of determining the oligomeric state of a protein complex
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
EP2689250A1 (fr) 2011-03-23 2014-01-29 AbbVie Inc. Procédés et systèmes pour l'analyse d'échantillons protéiques
WO2012137804A1 (fr) * 2011-04-04 2012-10-11 株式会社Ｊｃｌバイオアッセイ Procédé pour la détermination de séquence oligonucléotidique
WO2013098609A1 (fr) * 2011-12-30 2013-07-04 Dh Technologies Development Pte. Ltd. Systèmes et procédés pour séquençage de peptides par spectrométrie de masse
EP3050074B1 (fr) * 2013-09-23 2020-08-26 Micromass UK Limited Évaluation de pointe pour les spectromètres de masse
JP2015121500A (ja) * 2013-12-25 2015-07-02 株式会社島津製作所 質量分析方法及び質量分析装置
EP3170006A1 (fr) 2014-07-18 2017-05-24 Thermo Finnigan LLC Procédés de spectrométrie de masse de mélanges de protéines de polypeptides au moyen de réaction de transfert de protons
EP3193352A1 (fr) 2016-01-14 2017-07-19 Thermo Finnigan LLC Procédés de caractérisation basée sur la spectrométrie de masse de molécules biologiques
EP3193174B1 (fr) 2016-01-14 2018-11-07 Thermo Finnigan LLC Procédés d'analyse spectrale descendante de masse multiplexé de mélanges de protéines ou de polypeptides
CN111164422B (zh) * 2017-08-07 2023-05-02 新加坡科技研究局 从液相色谱-质谱(lc-ms)数据中快速分析和鉴定脂质
US20190172553A1 (en) * 2017-11-08 2019-06-06 Koninklijke Philips N.V. Using k-mers for rapid quality control of sequencing data without alignment
WO2019232520A1 (fr) * 2018-06-01 2019-12-05 Cerno Bioscience Llc Analyse par spectre de masse de grosses molécules
JP2021534408A (ja) 2018-08-17 2021-12-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｄｅ ｎｏｖｏタンパク質シークエンシングのための方法
KR102648650B1 (ko) * 2018-10-25 2024-03-15 주식회사 엘지화학 고분자 말단기 분석 방법
CN113552204B (zh) * 2020-04-02 2024-06-21 株式会社岛津制作所 质谱分析方法和质谱系统
JP7249980B2 (ja) 2020-10-26 2023-03-31 日本電子株式会社 マススペクトル処理装置及び方法
CN112505328B (zh) * 2020-11-02 2024-02-13 武汉金开瑞生物工程有限公司 一种同位素标记试剂盒和标记方法

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4830010A (en) * 1986-04-04 1989-05-16 Marshall Barry J Methods for the diagnosis of gastrointestinal disorders
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4994155A (en) * 1988-12-09 1991-02-19 Learonal, Inc. High speed tin, lead or tin/lead alloy electroplating
US5174962A (en) * 1988-06-20 1992-12-29 Genomyx, Inc. Apparatus for determining DNA sequences by mass spectrometry
US4994165A (en) 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
CA1340966C (fr) * 1989-05-19 2000-04-18 Thomas R. Covey Procede d'analyse des proteines
US5100778A (en) 1989-10-03 1992-03-31 Monsanto Company Oligosaccharide sequencing
EP0639227A1 (fr) * 1991-05-07 1995-02-22 Oxford Glycosciences (Uk) Limited Sequen age d'oligosaccharides
WO1992021138A1 (fr) * 1991-05-21 1992-11-26 Analytica Of Brandford, Inc. Procede et appareil permettant d'ameliorer l'ionisation par electrovaporisation d'especes de solutes
CA2132012C (fr) 1992-03-25 2003-04-22 John W. Shell Comprime ou capsule pour administration par voie orale et liberation lente, a base de derive de substitution alkylique de cellulose
EP0846950A3 (fr) * 1992-07-24 1999-08-25 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Peptides utiles comme standards internes pour le microséquençage et procédé pour les utiliser
US5470753A (en) * 1992-09-03 1995-11-28 Selectide Corporation Peptide sequencing using mass spectrometry
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6194144B1 (en) * 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
WO1994016101A2 (fr) 1993-01-07 1994-07-21 Koester Hubert Sequençage d'adn par spectrometrie de masse
GB9310467D0 (en) 1993-05-20 1993-07-07 Oxford Glycosystems Ltd Glycoconjugates
US5386832A (en) * 1993-06-11 1995-02-07 New England Deaconess Hospital Liver function breath test using aromatic amino acids
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
DE4415480C2 (de) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI)
JP3415682B2 (ja) * 1994-08-10 2003-06-09 株式会社日立製作所 キャピラリー電気泳動・質量分析計
US5856082A (en) * 1994-08-31 1999-01-05 University Of British Columbia Devices and methods for characterizing proteins and peptides
US5766891A (en) * 1994-12-19 1998-06-16 Sloan-Kettering Institute For Cancer Research Method for molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US5625184A (en) * 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5827659A (en) * 1995-05-19 1998-10-27 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers using mass spectrometry
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US6004770A (en) * 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US5722642A (en) * 1996-02-16 1998-03-03 Bradshaw; Terry L. Standing privacy fence with a deployable bench
US5800784A (en) 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
CN100434531C (zh) 1997-01-15 2008-11-19 X齐里昂有限两合公司 与质量标记连接的杂交探针
US5953653A (en) 1997-01-28 1999-09-14 Mediaone Group, Inc. Method and system for preventing mobile roaming fraud
GB9710582D0 (en) 1997-05-22 1997-07-16 Oxford Glycosciences Uk Ltd A method for de novo peptide sequence determination
WO1999014375A2 (fr) 1997-09-19 1999-03-25 Genetrace Systems, Inc. Recherche de type de genes par spectrometrie de masse avec marqueurs de sequences repetees d'adn polymorphes
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
US5995989A (en) * 1998-04-24 1999-11-30 Eg&G Instruments, Inc. Method and apparatus for compression and filtering of data associated with spectrometry
US6359111B1 (en) * 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
ATE536422T1 (de) 1998-08-25 2011-12-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US6277644B1 (en) * 1999-03-22 2001-08-21 Beckman Coulter, Inc. Method for compositional tag sequencing
US6677114B1 (en) 1999-04-20 2004-01-13 Target Discovery, Inc. Polypeptide fingerprinting methods and bioinformatics database system
EP2293056A3 (fr) 1999-04-20 2011-06-29 Target Discovery, Inc. Procédé d'analyse d'une voie métabolique
US6391649B1 (en) * 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
US6699846B2 (en) 2000-03-17 2004-03-02 Corixa Corporation Mono- and disaccharides for the treatment of nitric oxide related disorders
ES2385335T3 (es) 2000-10-19 2012-07-23 Target Discovery, Inc. Marcaje de defecto de masa para la determinación de secuencias de oligómeros
JP2004521616A (ja) 2000-10-30 2004-07-22 カロバイオス， インコーポレイテッド 競合的選択による親和性成熟
US6875668B2 (en) 2000-11-03 2005-04-05 Advanced Micro Devices, Inc. Notched gate structure fabrication
US6727361B2 (en) * 2000-11-07 2004-04-27 Symyx Technologies, Inc. Phosphino substituted pyridine amine ligands
CA2429633A1 (fr) 2000-11-16 2002-05-30 Ciphergen Biosystems, Inc. Procede d'analyse de spectres de masse
EP1353617A2 (fr) 2001-01-18 2003-10-22 The Regents Of The University Of California Instrument chirurgical et methode de traitement du glaucome peu invasifs
WO2002062436A2 (fr) 2001-02-06 2002-08-15 Electronic Arts Inc. Integration de donnees en temps reel dans une application de jeu
US7265378B2 (en) 2002-07-10 2007-09-04 E. I. Du Pont De Nemours And Company Electronic devices made with electron transport and/or anti-quenching layers
JP2005533102A (ja) 2002-07-12 2005-11-04 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 微小器官によって生物学的プロセスを誘発する方法と装置
JP4116351B2 (ja) 2002-07-16 2008-07-09 ジヤトコ株式会社 車両の制御装置
GB0216571D0 (en) 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
JP2005241161A (ja) 2004-02-27 2005-09-08 Fujita Corp 変流量変更時の消費エネルギー算出方法および省エネルギー診断方法

Also Published As

Publication number Publication date
JP4259869B2 (ja) 2009-04-30
PT1358458E (pt) 2012-05-24
NO20033632D0 (no) 2003-08-15
ES2385335T3 (es) 2012-07-23
EP1430436A2 (fr) 2004-06-23
AU2002246744B2 (en) 2008-04-10
WO2002066952A2 (fr) 2002-08-29
DK1358458T3 (da) 2012-06-18
US20060073485A1 (en) 2006-04-06
US20040209251A1 (en) 2004-10-21
IL155281A (en) 2012-05-31
AU2002253825B8 (en) 2007-03-22
EP2479578A1 (fr) 2012-07-25
EP1358458B1 (fr) 2012-04-04
EP1358458A4 (fr) 2009-11-04
EP1358458A2 (fr) 2003-11-05
JP4467589B2 (ja) 2010-05-26
US8352193B2 (en) 2013-01-08
US20070154900A1 (en) 2007-07-05
US20020172961A1 (en) 2002-11-21
CA2426580C (fr) 2011-09-13
JP2004519665A (ja) 2004-07-02
IS6781A (is) 2003-04-11
WO2002061661A2 (fr) 2002-08-08
US6962818B2 (en) 2005-11-08
AU2002253825B2 (en) 2007-03-15
CA2426580A1 (fr) 2002-08-29
US7316931B2 (en) 2008-01-08
IL155518A (en) 2007-03-08
IL180304A (en) 2009-12-24
CA2425798A1 (fr) 2002-08-08
IL180304A0 (en) 2007-06-03
JP2007178443A (ja) 2007-07-12
WO2002061661A3 (fr) 2004-04-08
JP4020310B2 (ja) 2007-12-12
JP2004523751A (ja) 2004-08-05
IL155281A0 (en) 2003-11-23
WO2002066952A3 (fr) 2003-09-04
ATE552348T1 (de) 2012-04-15
IL155518A0 (en) 2003-11-23

Similar Documents

Publication Publication Date Title
NO20033632D0 (no) Fremgangsmåter for bestemmelse av protein- og peptid- terminalsekvenser
US6917037B2 (en) Mass spectrum analyzing system
Fenselau Peer reviewed: MALDI MS and strategies for protein analysis
Bradshaw et al. Direct detection of blood in fingermarks by MALDI MS profiling and imaging
Zhang et al. Tree analysis of mass spectral urine profiles discriminates transitional cell carcinoma of the bladder from noncancer patient
WO2003042774A3 (fr) Systeme de profilage de l'intensite de masse et utilisations correspondantes
Siegel Early discovery drug screening using mass spectrometry
Soderblom et al. Tandem mass spectrometry acquisition approaches to enhance identification of protein‐protein interactions using low‐energy collision‐induced dissociative chemical crosslinking reagents
JP2005503557A5 (fr)
CA2466861A1 (fr) Systemes de detection codes sensibles
DK1639130T3 (da) Prober, biblioteker og kits til analyse af blandinger af nukleinsyrer og metoder til opbygning af disse
JP2007256126A (ja) 質量分析システム
GB0119959D0 (en) Improvements in and relating to analysis
Longuespée et al. Spectroimmunohistochemistry: a novel form of MALDI mass spectrometry imaging coupled to immunohistochemistry for tracking antibodies
EP1211325A3 (fr) Appareil et cartouche de détection des biopolymeres
WO2003102992A3 (fr) Procede et appareil de detection d'interactions non covalentes par des mesures de la diffusion fondees sur la spectrometrie de masse
Koh et al. Affinity selection from synthetic peptide libraries enabled by de novo MS/MS sequencing
Chandra et al. Mass spectral analysis of acetylated peptides: Implications in proteomics
Kuyama et al. A new approach for detecting C‐terminal amidation of proteins and peptides by mass spectrometry in conjunction with chemical derivatization
Hjernø et al. Interpretation of tandem mass spectrometry (MSMS) spectra for peptide analysis
Nakamura et al. Characterization of a digested protein complex with quantitative aspects: An approach based on accurate mass chromatographic analysis with Fourier transform‐ion cyclotron resonance mass spectrometry
WO2002057743A3 (fr) Methodes d'analyse et de triage d'un ou de plusieurs analytes
WO2002059578A3 (fr) Procede et appareil de quantification rapide d'un phenol dihydrique
US20020106700A1 (en) Method for analyzing proteins
WO2004113563A3 (fr) Sondes, bibliotheques et trousses d'analyse pour melanges d'acides nucleiques et methodes de realisation

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application