NO20032758L - Krystallinske former av Atorvastatin - Google Patents

Krystallinske former av Atorvastatin

Info

Publication number
NO20032758L
NO20032758L NO20032758A NO20032758A NO20032758L NO 20032758 L NO20032758 L NO 20032758L NO 20032758 A NO20032758 A NO 20032758A NO 20032758 A NO20032758 A NO 20032758A NO 20032758 L NO20032758 L NO 20032758L
Authority
NO
Norway
Prior art keywords
crystalline forms
atorvastatin
directed
present
forms
Prior art date
Application number
NO20032758A
Other languages
English (en)
Other versions
NO20032758D0 (no
Inventor
Paul Adriaan Van Der Schaaf
Fritz Blatter
Martin Szelagiewicz
Kai-Uwe Schoening
Original Assignee
Ciba Sc Holding Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Sc Holding Ag filed Critical Ciba Sc Holding Ag
Publication of NO20032758L publication Critical patent/NO20032758L/no
Publication of NO20032758D0 publication Critical patent/NO20032758D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20032758A 2000-12-27 2003-06-17 Krystallinske former av Atorvastatin NO20032758D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00811249 2000-12-27
PCT/EP2001/015012 WO2002051804A1 (en) 2000-12-27 2001-12-19 Crystalline forms of atorvastatin

Publications (2)

Publication Number Publication Date
NO20032758L true NO20032758L (no) 2003-06-17
NO20032758D0 NO20032758D0 (no) 2003-06-17

Family

ID=8175112

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032758A NO20032758D0 (no) 2000-12-27 2003-06-17 Krystallinske former av Atorvastatin

Country Status (23)

Country Link
US (4) US7538136B2 (no)
EP (2) EP2000461A1 (no)
JP (2) JP2004516311A (no)
KR (1) KR100790766B1 (no)
CN (1) CN1273449C (no)
AT (1) ATE420070T1 (no)
AU (1) AU2002224952B2 (no)
CA (7) CA2623600A1 (no)
CZ (1) CZ20032019A3 (no)
DE (1) DE60137364D1 (no)
ES (1) ES2319870T3 (no)
HR (1) HRP20030607A2 (no)
HU (1) HUP0302519A3 (no)
IL (1) IL156280A0 (no)
IS (1) IS6859A (no)
MX (1) MXPA03005879A (no)
NO (1) NO20032758D0 (no)
NZ (1) NZ527048A (no)
PL (1) PL365312A1 (no)
PT (1) PT1345896E (no)
SK (1) SK9532003A3 (no)
WO (1) WO2002051804A1 (no)
ZA (1) ZA200304297B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
US6605636B2 (en) * 2000-11-03 2003-08-12 Teva Pharmaceutical Industries Ltd. Atorvastatin hemi-calcium form VII
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
CN1273449C (zh) * 2000-12-27 2006-09-06 特瓦制药工业有限公司 阿伐他汀的晶型
NZ529557A (en) 2001-06-29 2005-05-27 Warner Lambert Co Crystalline forms of `R-(R*,R*)!-2-(4-fluorophenyl)- beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- 'phenylamino)carbonyl!-1H-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
BR0211488A (pt) * 2001-07-30 2004-08-17 Reddys Lab Ltd Dr Formas cristalinas vi e vii de atorvastina cálcica
IL160077A0 (en) * 2001-08-16 2004-06-20 Teva Pharma Processes for preparing calcium salt forms of statins
WO2003018547A2 (en) * 2001-08-31 2003-03-06 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
ES2241507T1 (es) * 2002-02-15 2005-11-01 Teva Pharmaceutical Industries Ltd. Nuevas formas de cristal de atorvastatina semicalcica y procedimientos para su preparacion, asi como nuevos procedimientos para la preparacion de las formas i, viii y ix de atorvastatina semicalcica.
PL372241A1 (en) 2002-02-19 2005-07-11 Teva Pharmaceutical Industries Ltd. Processes for desolvating solvates of atorvastatin hemi-calcium and atorvastatin hemi-calcium essentially free of organic solvent
US20060122403A1 (en) * 2002-09-03 2006-06-08 Sanjay Suri Atorvastatin calcium form vi or hydrates thereof
EP1572643A2 (en) * 2002-11-28 2005-09-14 Teva Pharmaceutical Industries Ltd. Crystalline form f of atorvastatin hemi-calcium salt
EP1424324A1 (en) * 2002-11-28 2004-06-02 Teva Pharmaceutical Industries Limited Crystalline form F of Atorvastatin hemi-calcium salt
US20050271717A1 (en) 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
EP1761489A1 (en) * 2004-03-17 2007-03-14 Ranbaxy Laboratories Limited Crystalline form of atorvastatin hemi calcium
ATE545629T1 (de) 2004-03-17 2012-03-15 Ranbaxy Lab Ltd Verfahren zur herstellung von atorvastatin- calcium in amorpher form
EP1745020A2 (en) 2004-05-05 2007-01-24 Pfizer Products Incorporated Salt forms of atorvastatin
US8435530B2 (en) 2004-06-11 2013-05-07 Sbi Biotech Co., Ltd. Methods for suppressing activity of activated interferon-producing cells
CA2573969C (en) * 2004-07-16 2014-02-04 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
EP1771412A2 (en) 2004-07-20 2007-04-11 Warner-Lambert Company LLC Crystalline forms of [r-(r*)]-2-(4-fluorophenyl)-bet a,gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-hept anoic acid calcium salt (2:1)
RU2007115543A (ru) 2004-10-28 2008-12-10 Уорнер-Ламберт Компани Эл-Эл-Си (US) Способ получения аморфного аторвастатина
WO2006048894A1 (en) * 2004-11-05 2006-05-11 Morepen Laboratories Limited Novel crystalline forms of atorvastatin calcium and processes for preparing them.
CA2499047A1 (en) * 2005-03-01 2006-09-01 Apotex Pharmachem Inc. Process for producing atorvastatin hemicalcium
EP1868993B1 (en) * 2005-04-08 2014-04-30 EGIS Gyógyszergyár Nyilvánosan Müködõ Részvénytársaság Process for the preparation of a new crystalline atorvastatin hemicalcium salt polymorph form
CA2547216A1 (en) * 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
PT1957452E (pt) 2005-11-21 2010-05-25 Warner Lambert Co Novas formas de ácido [r-(r*,r*)]-2-(4-fluorofenil)-b,b--di-hidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1h-pirrole-1-heptanóico magnésico
BRPI0610344A2 (pt) * 2005-12-13 2016-11-29 Teva Pharma forma cristalizada do atorvastatin hemi-calcium, processo para sua preparação, produto famacêutico derivado e seu uso medicinal
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
MX2008002804A (es) * 2006-06-28 2008-04-02 Teva Pharma Formas cristalinas de atorvastatina.
US20100260851A1 (en) * 2007-07-11 2010-10-14 Actavis Group Ptc Ehf Novel Polymorph of Atorvastatin Calcium and Use Thereof for the Preparation of Amorphous Atorvastatin Calcium
KR20120011249A (ko) * 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN104983702A (zh) * 2015-07-23 2015-10-21 青岛蓝盛洋医药生物科技有限责任公司 一种治疗高胆固醇血症的药物阿托伐他汀钙组合物片剂
JP2019167295A (ja) * 2016-07-04 2019-10-03 ゼリア新薬工業株式会社 １，５−ベンゾジアゼピン化合物カルシウム塩の製造法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
ES2133158T3 (es) * 1993-01-19 1999-09-01 Warner Lambert Co Formulacion ci-981 oral, estable y proceso de preparacion del mismo.
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
SK284202B6 (sk) * 1995-07-17 2004-10-05 Warner-Lambert Company Kryštalické formy I, II a IV atorvastatínu, to je semivápenatej soli kyseliny [R-(R*,R*)]-2-(4-fluórfenyl)-beta,delta-dihydroxy- 5-(1-metyletyl)-3-fenyl-4-(fenylamino)karbonyl]-1H-pyrol-1- heptánovej, alebo jeho hydrátu, farmaceutické kompozície obsahujúce uvedené kryštalické formy a kryštalické formy na použitie ako liečivo
HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
HRP960313B1 (en) * 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
PL355805A1 (en) * 1999-11-17 2004-05-17 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
US7411075B1 (en) * 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
AU780247B2 (en) 1999-12-17 2005-03-10 Pfizer Science And Technology Ireland Limited A process for producing crystalline atorvastatin calcium
US6605636B2 (en) 2000-11-03 2003-08-12 Teva Pharmaceutical Industries Ltd. Atorvastatin hemi-calcium form VII
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
CN1273449C (zh) * 2000-12-27 2006-09-06 特瓦制药工业有限公司 阿伐他汀的晶型
WO2002057228A1 (en) 2001-01-17 2002-07-25 Biocon India Limited Atorvastatin calcium
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
NZ529557A (en) * 2001-06-29 2005-05-27 Warner Lambert Co Crystalline forms of `R-(R*,R*)!-2-(4-fluorophenyl)- beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- 'phenylamino)carbonyl!-1H-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
BR0211488A (pt) * 2001-07-30 2004-08-17 Reddys Lab Ltd Dr Formas cristalinas vi e vii de atorvastina cálcica

Also Published As

Publication number Publication date
EP1345896A1 (en) 2003-09-24
CZ20032019A3 (cs) 2003-10-15
PT1345896E (pt) 2009-02-19
CA2623600A1 (en) 2002-07-04
US20040220255A1 (en) 2004-11-04
CA2623599A1 (en) 2002-07-04
HUP0302519A2 (hu) 2003-12-29
ZA200304297B (en) 2004-08-16
WO2002051804A1 (en) 2002-07-04
US20030114686A1 (en) 2003-06-19
IL156280A0 (en) 2004-01-04
JP2004516311A (ja) 2004-06-03
CA2622727A1 (en) 2002-07-04
CA2626317A1 (en) 2002-07-04
SK9532003A3 (en) 2004-04-06
US7538136B2 (en) 2009-05-26
CA2431068C (en) 2008-06-10
IS6859A (is) 2003-06-24
PL365312A1 (en) 2004-12-27
KR100790766B1 (ko) 2008-01-03
HRP20030607A2 (en) 2005-06-30
CA2622477A1 (en) 2002-07-04
EP2000461A1 (en) 2008-12-10
NZ527048A (en) 2004-12-24
DE60137364D1 (de) 2009-02-26
JP2009221216A (ja) 2009-10-01
HUP0302519A3 (en) 2008-10-28
CN1273449C (zh) 2006-09-06
EP1345896B1 (en) 2009-01-07
US20090281162A1 (en) 2009-11-12
KR20030064880A (ko) 2003-08-02
NO20032758D0 (no) 2003-06-17
MXPA03005879A (es) 2003-09-10
CA2622697A1 (en) 2002-07-04
ES2319870T3 (es) 2009-05-14
CN1483022A (zh) 2004-03-17
US20060205805A1 (en) 2006-09-14
ATE420070T1 (de) 2009-01-15
CA2431068A1 (en) 2002-07-04
AU2002224952B2 (en) 2007-04-05

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