NO20032758D0 - Krystallinske former av Atorvastatin - Google Patents

Krystallinske former av Atorvastatin

Info

Publication number
NO20032758D0
NO20032758D0 NO20032758A NO20032758A NO20032758D0 NO 20032758 D0 NO20032758 D0 NO 20032758D0 NO 20032758 A NO20032758 A NO 20032758A NO 20032758 A NO20032758 A NO 20032758A NO 20032758 D0 NO20032758 D0 NO 20032758D0
Authority
NO
Norway
Prior art keywords
crystalline forms
atorvastatin
directed
present
forms
Prior art date
Application number
NO20032758A
Other languages
English (en)
Norwegian (no)
Other versions
NO20032758L (no
Inventor
Paul Adriaan Van Der Schaaf
Fritz Blatter
Martin Szelagiewicz
Kai-Uwe Schoening
Original Assignee
Ciba Sc Holding Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Sc Holding Ag filed Critical Ciba Sc Holding Ag
Publication of NO20032758L publication Critical patent/NO20032758L/no
Publication of NO20032758D0 publication Critical patent/NO20032758D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20032758A 2000-12-27 2003-06-17 Krystallinske former av Atorvastatin NO20032758D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00811249 2000-12-27
PCT/EP2001/015012 WO2002051804A1 (fr) 2000-12-27 2001-12-19 Formes cristallines d'atorvastatine

Publications (2)

Publication Number Publication Date
NO20032758L NO20032758L (no) 2003-06-17
NO20032758D0 true NO20032758D0 (no) 2003-06-17

Family

ID=8175112

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032758A NO20032758D0 (no) 2000-12-27 2003-06-17 Krystallinske former av Atorvastatin

Country Status (23)

Country Link
US (4) US7538136B2 (fr)
EP (2) EP2000461A1 (fr)
JP (2) JP2004516311A (fr)
KR (1) KR100790766B1 (fr)
CN (1) CN1273449C (fr)
AT (1) ATE420070T1 (fr)
AU (1) AU2002224952B2 (fr)
CA (7) CA2626317A1 (fr)
CZ (1) CZ20032019A3 (fr)
DE (1) DE60137364D1 (fr)
ES (1) ES2319870T3 (fr)
HR (1) HRP20030607A2 (fr)
HU (1) HUP0302519A3 (fr)
IL (1) IL156280A0 (fr)
IS (1) IS6859A (fr)
MX (1) MXPA03005879A (fr)
NO (1) NO20032758D0 (fr)
NZ (1) NZ527048A (fr)
PL (1) PL365312A1 (fr)
PT (1) PT1345896E (fr)
SK (1) SK9532003A3 (fr)
WO (1) WO2002051804A1 (fr)
ZA (1) ZA200304297B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7411075B1 (en) * 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
CZ20031495A3 (cs) * 2000-11-03 2004-01-14 Teva Pharmaceutical Industries Ltd. Forma VII hemi-kalcium atorvastatinu
IL156055A0 (en) * 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
ES2319870T3 (es) * 2000-12-27 2009-05-14 Teva Pharmaceutical Industries Limited Formas cristalinas de atorvastatina.
BR0210666A (pt) 2001-06-29 2004-10-05 Warner Lambert Co Formas cristalinas do sal de cálcio do ácido [r-(r*,r*)]-2-(4-fluorofenil)-beta, delta-dihidróxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)c arbonil]-1h-pirrol-1-heptanóico (2:1) (atorvastatina)
US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
EP2292600A1 (fr) * 2001-07-30 2011-03-09 Dr. Reddy's Laboratories Ltd. Formes cristallines VI et VII d'atorvastatine calcium
PL370407A1 (en) * 2001-08-16 2005-05-30 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
US7563911B2 (en) * 2001-08-31 2009-07-21 Morepen Laboratories Ltd. Process for the preparation of amorphous atorvastin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
DE03713610T1 (de) * 2002-02-15 2005-10-20 Teva Pharma Neue kristallformen von atorvastatin-hemicalcium und verfahren zu deren herstellung, sowie neue verfahren zur herstellung der formen i, viii und ix von atorvastatin-hemicalcium
PL372241A1 (en) 2002-02-19 2005-07-11 Teva Pharmaceutical Industries Ltd. Processes for desolvating solvates of atorvastatin hemi-calcium and atorvastatin hemi-calcium essentially free of organic solvent
AU2002330735A1 (en) * 2002-09-03 2004-03-29 Morepen Laboratories Limited Atorvastatin calcium form vi or hydrates thereof
EP1424324A1 (fr) * 2002-11-28 2004-06-02 Teva Pharmaceutical Industries Limited Forme cristalline F de calcium d'atorvastatine
CA2508871C (fr) * 2002-11-28 2008-09-09 Teva Pharmaceutical Industries Ltd. Forme cristalline f de sel d'hemi-calcium d'astorvastatine
US20050271717A1 (en) 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
CA2666359A1 (fr) 2004-03-17 2005-10-06 Yatendra Kumar Procede de production d'atorvastatine calcique sous forme amorphe
EP1761489A1 (fr) * 2004-03-17 2007-03-14 Ranbaxy Laboratories Limited Forme cristalline d'hemi-calcium d'atorvastatine
JP2007536373A (ja) 2004-05-05 2007-12-13 ファイザー・プロダクツ・インク アトルバスタチンの塩形態
US8435530B2 (en) 2004-06-11 2013-05-07 Sbi Biotech Co., Ltd. Methods for suppressing activity of activated interferon-producing cells
EP1771455B1 (fr) * 2004-07-16 2016-05-11 LEK Pharmaceuticals d.d. Produits de degradation oxydante du calcium d'atorvastatine
BRPI0513422A (pt) 2004-07-20 2008-05-06 Warner Lambert Co formas de sais cálcio do ácido (r-(r*))-2-(4- fluorfenil)-(beta), (sigma)-diidróxi-5-(1-metiletil) -3-fenil-4-((fenilamino) carbonil)-1h-pirrol-1-heptanóico (2:1)
US7939675B2 (en) 2004-10-28 2011-05-10 Pfizer, Inc. Process for forming amorphous atorvastatin
WO2006048894A1 (fr) * 2004-11-05 2006-05-11 Morepen Laboratories Limited Nouvelles formes cristallines de calcium d'atorvastatine et procedes de fabrication
CA2499047A1 (fr) * 2005-03-01 2006-09-01 Apotex Pharmachem Inc. Methode de synthese d'un sel de semi-calcium d'atorvastatine
RU2409563C2 (ru) * 2005-04-08 2011-01-20 Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг Новая полиморфная форма кристаллической гемикальциевой соли аторвастатина
CA2547216A1 (fr) 2005-09-21 2007-03-21 Renuka D. Reddy Procede de recuit de l'atorvastatine amorphe
DE602006014193D1 (de) * 2005-11-21 2010-06-17 Warner Lambert Co Neue formen von är-(r*,r*)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure-magnesium
BRPI0610344A2 (pt) 2005-12-13 2016-11-29 Teva Pharma forma cristalizada do atorvastatin hemi-calcium, processo para sua preparação, produto famacêutico derivado e seu uso medicinal
EP1810667A1 (fr) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Composition pharmaceutique contenant de l'atorvastatin amorphé
MX2008002804A (es) * 2006-06-28 2008-04-02 Teva Pharma Formas cristalinas de atorvastatina.
WO2009007856A2 (fr) * 2007-07-11 2009-01-15 Actavis Group Ptc Ehf Nouveau polymorphe d'atorvastatine calcium et son utilisation pour la préparation d'atorvastatine calcium amorphe
KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN104983702A (zh) * 2015-07-23 2015-10-21 青岛蓝盛洋医药生物科技有限责任公司 一种治疗高胆固醇血症的药物阿托伐他汀钙组合物片剂
JP2019167295A (ja) * 2016-07-04 2019-10-03 ゼリア新薬工業株式会社 １，５−ベンゾジアゼピン化合物カルシウム塩の製造法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
CA2150372C (fr) * 1993-01-19 2002-08-20 Nancy L. Mills Composition orale stable de ci-981 et procede de preparation
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
IL128864A (en) * 1995-07-17 2007-10-31 Warner Lambert Co Atorostatin II form crystals and its hydrates, methods of preparation and pharmaceutical preparations containing it
HRP960313B1 (en) 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
US7411075B1 (en) * 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
ES2349364T3 (es) * 1999-11-17 2010-12-30 Teva Pharmaceutical Industries, Ltd. Procedimiento para la preparación de una forma polimórfica de atorvastatina cálcica.
JP2003517039A (ja) 1999-12-17 2003-05-20 ワーナー・ランバート・リサーチ・アンド・ディベロップメント・アイルランド・リミテッド 結晶質アトルバスタチンカルシウムの製造方法
CZ20031495A3 (cs) * 2000-11-03 2004-01-14 Teva Pharmaceutical Industries Ltd. Forma VII hemi-kalcium atorvastatinu
IL156055A0 (en) * 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
ES2319870T3 (es) * 2000-12-27 2009-05-14 Teva Pharmaceutical Industries Limited Formas cristalinas de atorvastatina.
WO2002057228A1 (fr) 2001-01-17 2002-07-25 Biocon India Limited Atorvastatine calcique
WO2002057229A1 (fr) 2001-01-19 2002-07-25 Biocon India Limited FORME V CRISTALLINE DE SEL HEMICALCIQUE D'ACIDE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIQUE (ATORVASTATINE)
SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
BR0210666A (pt) * 2001-06-29 2004-10-05 Warner Lambert Co Formas cristalinas do sal de cálcio do ácido [r-(r*,r*)]-2-(4-fluorofenil)-beta, delta-dihidróxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)c arbonil]-1h-pirrol-1-heptanóico (2:1) (atorvastatina)
EP2292600A1 (fr) * 2001-07-30 2011-03-09 Dr. Reddy's Laboratories Ltd. Formes cristallines VI et VII d'atorvastatine calcium

Also Published As

Publication number Publication date
CA2623599A1 (fr) 2002-07-04
CA2623600A1 (fr) 2002-07-04
JP2009221216A (ja) 2009-10-01
NO20032758L (no) 2003-06-17
AU2002224952B2 (en) 2007-04-05
HUP0302519A3 (en) 2008-10-28
CZ20032019A3 (cs) 2003-10-15
US7538136B2 (en) 2009-05-26
PL365312A1 (en) 2004-12-27
HRP20030607A2 (en) 2005-06-30
US20090281162A1 (en) 2009-11-12
ZA200304297B (en) 2004-08-16
EP1345896B1 (fr) 2009-01-07
EP1345896A1 (fr) 2003-09-24
KR20030064880A (ko) 2003-08-02
US20040220255A1 (en) 2004-11-04
CA2626317A1 (fr) 2002-07-04
IL156280A0 (en) 2004-01-04
PT1345896E (pt) 2009-02-19
ATE420070T1 (de) 2009-01-15
CN1483022A (zh) 2004-03-17
ES2319870T3 (es) 2009-05-14
CN1273449C (zh) 2006-09-06
HUP0302519A2 (hu) 2003-12-29
NZ527048A (en) 2004-12-24
JP2004516311A (ja) 2004-06-03
CA2622477A1 (fr) 2002-07-04
CA2431068C (fr) 2008-06-10
CA2622727A1 (fr) 2002-07-04
DE60137364D1 (de) 2009-02-26
CA2431068A1 (fr) 2002-07-04
US20060205805A1 (en) 2006-09-14
MXPA03005879A (es) 2003-09-10
WO2002051804A1 (fr) 2002-07-04
CA2622697A1 (fr) 2002-07-04
SK9532003A3 (en) 2004-04-06
EP2000461A1 (fr) 2008-12-10
IS6859A (is) 2003-06-24
US20030114686A1 (en) 2003-06-19
KR100790766B1 (ko) 2008-01-03

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