NO20024201L - Substituerte 3-fenyl-5-alkoksy-1,3,4-oksdiazol-2-on og anvendelse derav for hemning av hormonsensitiv lipase - Google Patents
Substituerte 3-fenyl-5-alkoksy-1,3,4-oksdiazol-2-on og anvendelse derav for hemning av hormonsensitiv lipaseInfo
- Publication number
- NO20024201L NO20024201L NO20024201A NO20024201A NO20024201L NO 20024201 L NO20024201 L NO 20024201L NO 20024201 A NO20024201 A NO 20024201A NO 20024201 A NO20024201 A NO 20024201A NO 20024201 L NO20024201 L NO 20024201L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- alkyl
- cycloalkyl
- aryl
- oxdiazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Det er beskrevet substituerte 3-fenyl-5-alkoksy-l,3,4-oksdiazol-2-oner med formel (1). hvori Rbetyr CC-alkyl og C-Cy-sykloalkyl; R, R, Rog R5 betyr hydrogen, halogen, nitro, C-Q-alkyl, C|-C-alkyloksy, substituert C-C-aryl-CI-C4-alkyloksy, C-C-aryloksy, C-C-aryl, C-Cx-sykloalkyl eller O-CC-sykloalkyl eller 2-oksopyrrolidin-l-yl, 2,5-dimetylpyrrol-l-yl eller NRA-R, under den forutsetning at R, R, Rog Rikke samtidig betyr hydrogen og minst én av restene R2, R3, R4 eller Rstår for resten 2-oksopyrrolidin-l-yl, 2,5-dimetylpyrrol-l-yl eller NR(-A-R, med R6 = hydrogen, C-G-alkyl eller substituert C-C,-aryl-C,-C-aIkyl, A = enkeltbinding, COn, SOn eller CONH; n = 1 eller 2; R= hydrogen, substituert C,-C|-alkyl, C:-C,- alkenyl, Cf,-C„-aryl-CC-alkyl, C-Cx-sykloalkyl-C-C-alkyl, C-Cx-sykloalkyl, C-aryl-C-Ch-alkenyl, Cf,-C-aryl, difenyl, difenyl-C|-C-alkyl, indanyl, eller gruppen Het-(CH)-, med r = 0, 1,2 eller 3 og Het = mettet eller umettet 5-7-leddet heterosyklus, som kan være benzokondensert og substituert, samt en fremgangsmåte for fremstilling av forbindelsene. Forbindelsene viser en hemmende virkning på den hormonsensitive lipasen, HSL.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2000110968 DE10010968A1 (de) | 2000-03-07 | 2000-03-07 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
DE2001102265 DE10102265C1 (de) | 2001-01-18 | 2001-01-18 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
PCT/EP2001/001898 WO2001066531A1 (de) | 2000-03-07 | 2001-02-20 | Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one (und) ihre verwendung zur hemmung der hormonsensitiven lipase |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20024201D0 NO20024201D0 (no) | 2002-09-03 |
NO20024201L true NO20024201L (no) | 2002-09-03 |
NO323483B1 NO323483B1 (no) | 2007-05-21 |
Family
ID=26004720
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20024201A NO323483B1 (no) | 2000-03-07 | 2002-09-03 | Substituerte 3-fenyl-5-alkoksy-1,3,4-oksdiazol-2-on og anvendelse derav for hemning av hormonsensitiv lipase samt fremgangsmate for fremstilling av forbindelsene. |
Country Status (28)
Country | Link |
---|---|
US (1) | US6369088B2 (no) |
EP (1) | EP1263745B1 (no) |
JP (1) | JP2003525931A (no) |
KR (1) | KR100790763B1 (no) |
CN (1) | CN1261419C (no) |
AR (1) | AR027611A1 (no) |
AT (1) | ATE267184T1 (no) |
AU (1) | AU784827B2 (no) |
BR (1) | BR0108974A (no) |
CA (1) | CA2401953A1 (no) |
DE (1) | DE50102325D1 (no) |
DK (1) | DK1263745T3 (no) |
EE (1) | EE04877B1 (no) |
ES (1) | ES2218383T3 (no) |
HK (1) | HK1054036B (no) |
HR (1) | HRP20020732A2 (no) |
HU (1) | HUP0302772A3 (no) |
IL (1) | IL151518A (no) |
MX (1) | MXPA02008038A (no) |
NO (1) | NO323483B1 (no) |
NZ (1) | NZ521207A (no) |
PL (1) | PL359702A1 (no) |
PT (1) | PT1263745E (no) |
RU (1) | RU2281283C2 (no) |
SK (1) | SK12752002A3 (no) |
TR (1) | TR200401217T4 (no) |
WO (1) | WO2001066531A1 (no) |
YU (1) | YU57802A (no) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
US6900233B2 (en) | 2002-02-28 | 2005-05-31 | Aventis Pharma Deutschland Gmbh | Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof |
DE10208987A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
DE10208986A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Verwendung substituierter 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one zur Herstellung von Arzneimitteln mit hemmender Wirkung an der pankreatischen Lipase |
US20030236288A1 (en) * | 2002-02-28 | 2003-12-25 | Karl Schoenafinger | Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase |
SE0203753D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
US20090082435A1 (en) * | 2005-04-28 | 2009-03-26 | The Regents Of The University Of California | Methods, Compositions, And Compounds For Modulation Of Monoacylglycerol Lipase, Pain, And Stress-Related Disorders |
CN101225085B (zh) * | 2007-01-17 | 2011-09-21 | 天津天士力集团有限公司 | 苯基呋咱氮类一氧化氮供体型2-苯胺嘧啶衍生物、其制备方法、含有该化合物的组合物及其用途 |
TW201033163A (en) * | 2008-10-20 | 2010-09-16 | Sumitomo Chemical Co | Method for manufacturing oxadiazolinone compound and intermediate thereof |
TW201028406A (en) | 2008-12-23 | 2010-08-01 | Bial Portela & Ca Sa | 5-O-substituted 3-N-aryl-1,3,4-oxadiazolones for medical use |
WO2011108724A1 (ja) | 2010-03-04 | 2011-09-09 | 味の素株式会社 | 糖尿病又は肥満症の予防又は治療剤 |
US8501768B2 (en) * | 2011-05-17 | 2013-08-06 | Hoffmann-La Roche Inc. | Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds |
JP6007417B2 (ja) * | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規glp−1受容体安定剤および調節剤 |
AU2012352349B2 (en) | 2011-12-12 | 2017-08-17 | Receptos Llc | Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes |
KR102271179B1 (ko) | 2013-06-11 | 2021-07-01 | 셀진 인터내셔널 Ii 에스에이알엘 | 신규의 glp-1 수용체 조절제 |
UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
MX2017000972A (es) | 2014-07-25 | 2017-07-27 | Celgene Int Ii Sarl | Nuevos moduladores del receptor de peptido similar a glucagon 1 (glp-1). |
WO2016094729A1 (en) | 2014-12-10 | 2016-06-16 | Celgene International Ii Sarl | Glp-1 receptor modulators |
WO2016109501A1 (en) | 2014-12-30 | 2016-07-07 | Karos Pharmaceuticals, Inc. | Amide compounds as tryptophan hydroxylase inhibitors |
US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
CN108863774A (zh) * | 2018-06-09 | 2018-11-23 | 石家庄市绿丰化工有限公司 | 一种2,4-二氯苯乙酰氯合成的方法 |
CN113227093A (zh) | 2018-11-14 | 2021-08-06 | 阿尔塔万特科学公司 | 结晶螺环化合物、包含该化合物的剂型、用于疾病治疗的方法和再结晶方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2299328A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Derives de l'alcoyloxy-5 phenyl-3 oxyde azo |
US4076824A (en) | 1975-02-03 | 1978-02-28 | Rhone-Poulenc Industries | Anthelmintic oxadiazolinone derivatives |
FR2299028A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Nouvea |
DK156439C (da) | 1980-09-15 | 1990-01-22 | Shell Int Research | 7-substituerede 2,3-dihydrobenzofuranderivater samt pesticidpraeparater indeholdende disse og en fremgangsmaade til bekaempelse af skadelige organismer |
DE3267258D1 (en) | 1981-06-15 | 1985-12-12 | Shell Int Research | 7-substituted 2,3-dihydrobenzofurans, their preparation and their use as pesticides or as chemical intermediates |
US5236939A (en) | 1989-09-23 | 1993-08-17 | Bayer Aktiengesellschaft | Substituted 1,3,4-oxa(thia)diazolinones process for their preparation and their use of combating endoparasites |
DE3931843A1 (de) | 1989-09-23 | 1991-04-04 | Bayer Ag | Substituierte 1,3,4-oxa(thia)diazolinone verfahren zu ihrer herstellung und ihre verwendung der bekaempfung von endoparasiten |
US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
-
2001
- 2001-02-20 IL IL151518A patent/IL151518A/en not_active IP Right Cessation
- 2001-02-20 DE DE50102325T patent/DE50102325D1/de not_active Expired - Lifetime
- 2001-02-20 SK SK1275-2002A patent/SK12752002A3/sk unknown
- 2001-02-20 BR BR0108974-9A patent/BR0108974A/pt not_active IP Right Cessation
- 2001-02-20 ES ES01905805T patent/ES2218383T3/es not_active Expired - Lifetime
- 2001-02-20 WO PCT/EP2001/001898 patent/WO2001066531A1/de active IP Right Grant
- 2001-02-20 EE EEP200200498A patent/EE04877B1/xx not_active IP Right Cessation
- 2001-02-20 HU HU0302772A patent/HUP0302772A3/hu unknown
- 2001-02-20 AT AT01905805T patent/ATE267184T1/de not_active IP Right Cessation
- 2001-02-20 JP JP2001565347A patent/JP2003525931A/ja not_active Abandoned
- 2001-02-20 MX MXPA02008038A patent/MXPA02008038A/es active IP Right Grant
- 2001-02-20 PL PL35970201A patent/PL359702A1/xx not_active IP Right Cessation
- 2001-02-20 RU RU2002126556/04A patent/RU2281283C2/ru not_active IP Right Cessation
- 2001-02-20 NZ NZ521207A patent/NZ521207A/en unknown
- 2001-02-20 KR KR1020027011634A patent/KR100790763B1/ko not_active IP Right Cessation
- 2001-02-20 TR TR2004/01217T patent/TR200401217T4/xx unknown
- 2001-02-20 CA CA002401953A patent/CA2401953A1/en not_active Abandoned
- 2001-02-20 AU AU33787/01A patent/AU784827B2/en not_active Ceased
- 2001-02-20 DK DK01905805T patent/DK1263745T3/da active
- 2001-02-20 YU YU57802A patent/YU57802A/sh unknown
- 2001-02-20 EP EP01905805A patent/EP1263745B1/de not_active Expired - Lifetime
- 2001-02-20 CN CNB018062156A patent/CN1261419C/zh not_active Expired - Fee Related
- 2001-02-20 PT PT01905805T patent/PT1263745E/pt unknown
- 2001-03-05 AR ARP010101037A patent/AR027611A1/es not_active Application Discontinuation
- 2001-03-06 US US09/799,082 patent/US6369088B2/en not_active Expired - Lifetime
-
2002
- 2002-09-03 NO NO20024201A patent/NO323483B1/no unknown
- 2002-09-05 HR HRP20020732 patent/HRP20020732A2/hr not_active Application Discontinuation
-
2003
- 2003-09-09 HK HK03106394.6A patent/HK1054036B/zh not_active IP Right Cessation
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