NO970293L - Substituerte camptothecinderivater og fremgangsmåte for deres fremstilling - Google Patents
Substituerte camptothecinderivater og fremgangsmåte for deres fremstillingInfo
- Publication number
- NO970293L NO970293L NO970293A NO970293A NO970293L NO 970293 L NO970293 L NO 970293L NO 970293 A NO970293 A NO 970293A NO 970293 A NO970293 A NO 970293A NO 970293 L NO970293 L NO 970293L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- phenyl
- cycloalkyl
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 150000002431 hydrogen Chemical class 0.000 abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000006678 phenoxycarbonyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Substituerte camptothecinderivater av formel (I) hvor symbolet representerer en enkelt- eller dobbeltbinding; (I) substituert benzoyl, fenyl-Ci¿C^-alkanoyl, 'Ry, R2 OS ^3 ^i" som definert tinder (a) eller (b) nedenfor: (a) Ry og Rg er, hver uavhengig, hydrogen; C]^-C4-alkyl; C3-C7- cykloalkyl; fenyl-Cj^¿C(j-alkyl; en eventuelt substituert fenylrlng; -NR^Rfj hvor en av R5 og Rj, er hydrogen, Cy¿C(^- alkyl eller benzyl og den andre er hydrogen, Cj^-C^j-alkanoyl, en eventuelt substituert Cj-C^-alkoksykarbonyl, en eventuelt en eventuelt substituert C;i-C5-alkoksykarbonyl, en eventuelt substituert fenoksykarbonyl eller fenyl-Cj^-C^-alkoksykarbonyl, eller Rg og R^, 1 kombinasjon med det nltrogenatan til hvilket de er bundet, danner en 4-7-leddet, mettet, eventuelt substituert, heteromono- cyklisk rlngrest; COORs hvor Rg er hydrogen, C^-C^-alkyl, C3-C7-cykloalkyl eller fenyl-C^-C^j-alkyl; eller CORg, hvor Rg er Cj^-C^-alkyl, Cgr-Cy-cykloalkyl, fenyl-Cj-C^j-alkyl, en eventuelt substituert fenylrlng eller ^10^11 hvor RyQ og Ryy hver uavhengig er hydrogen eller Cj^-C(,-alkyl; og R3 er hydrogen, Cj¿C^-alkyl eller en eventuelt substituert fenylrlng; eller (b) R-y og R3, 1 kombinasjon, danner en 5-8-leddet, eventuelt substituert, karbonionoc.vkllsk ring; og R2 er hydrogen, C]^-C4-alkyl eller C3-C7-cykloalkyl; R4 er hydrogen, C]^-C(,-alkyl, C3-C7-cykloalkyl eller fenyl-Cj^-C(,-alkyl; X er hydrogen, C^-C(,-alkyl, C3-C7-cykloalkyl, C^-C^-alkoksy, C3-C7-cykloalkoksy, Cj-C^-alkanoyloksy, benzoyloksy, amino, hydroksy, nitro, halogen eller den er en metylendloksygruppe bundet til stillingene 10 og 11 1 molekylet, og de farmasoytisk akseptable saltene derav. Disse forbindelsene er nyttige 1 terapi som antltumormldler.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9510716.5A GB9510716D0 (en) | 1995-05-26 | 1995-05-26 | Substituted camptothecin derivatives and process for their preparation |
| PCT/EP1996/002008 WO1996037496A1 (en) | 1995-05-26 | 1996-05-10 | Substituted camptothecin derivatives and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO970293D0 NO970293D0 (no) | 1997-01-23 |
| NO970293L true NO970293L (no) | 1997-03-06 |
Family
ID=10775098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO970293A NO970293L (no) | 1995-05-26 | 1997-01-23 | Substituerte camptothecinderivater og fremgangsmåte for deres fremstilling |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5856333A (no) |
| EP (1) | EP0777670B1 (no) |
| JP (1) | JPH10503220A (no) |
| CN (1) | CN1159192A (no) |
| AR (1) | AR003126A1 (no) |
| AT (1) | ATE262532T1 (no) |
| AU (1) | AU5817996A (no) |
| BR (1) | BR9606396A (no) |
| CA (1) | CA2194700A1 (no) |
| DE (1) | DE69631943D1 (no) |
| GB (1) | GB9510716D0 (no) |
| HU (1) | HUP9702400A3 (no) |
| IL (1) | IL118410A0 (no) |
| NO (1) | NO970293L (no) |
| NZ (1) | NZ308514A (no) |
| PL (1) | PL318279A1 (no) |
| WO (1) | WO1996037496A1 (no) |
| ZA (1) | ZA964138B (no) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| GB9702807D0 (en) | 1997-02-12 | 1997-04-02 | Pharmacia & Upjohn Spa | Alkynyl-substituted camptothecins and process for their preparation |
| ATE329903T1 (de) * | 1997-02-14 | 2006-07-15 | Bionumerik Pharmaceuticals Inc | Hochgradig lipophile camptothecin-derivate |
| US6214841B1 (en) | 1997-05-15 | 2001-04-10 | Eli Lilly And Company | Antithrombotic compound |
| HUP9701554D0 (en) * | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| BR0108728A (pt) | 2000-02-28 | 2003-12-30 | Aventis Pharma Sa | Combinação farmacêutica terapêutica, e, método para tratar um c ncer. |
| US6548488B2 (en) | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
| US6545010B2 (en) | 2000-03-17 | 2003-04-08 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer |
| US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
| HUP0302629A3 (en) | 2000-10-27 | 2005-05-30 | Aventis Pharma Sa | Pharmaceutical compositions comprising a combination camptothecin and a stilbene derivative for the treatment of cancer |
| KR20050033546A (ko) | 2002-04-08 | 2005-04-12 | 글락소 그룹 리미티드 | (2-((2-알콕시)-페닐)-시클로펜트-1-에닐) 방향족 카르보및 헤테로시클릭산 및 유도체 |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| CN100406460C (zh) * | 2003-11-10 | 2008-07-30 | 中国科学院上海药物研究所 | 喜树碱的新衍生物、制备方法和用途 |
| WO2012050591A1 (en) | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
| US20090104254A1 (en) | 2004-12-22 | 2009-04-23 | Rutgers, The State University Of New Jersey | Controlled Release Hydrogels |
| KR101394768B1 (ko) | 2006-03-30 | 2014-05-21 | 드라이스 파마슈티컬스 아이엔씨 | 캄토테신-세포 투과 펩티드 결합체 및 이를 포함하는 약학 조성물 |
| CN101880285B (zh) * | 2010-06-24 | 2012-07-04 | 华东师范大学 | 一种烯丙基取代喜树碱化合物的合成方法 |
| CN104774209B (zh) * | 2014-01-15 | 2018-06-19 | 上海海和药物研究开发有限公司 | 一种9-烯丙基喜树碱衍生物的合成方法 |
| TW202547842A (zh) | 2021-04-29 | 2025-12-16 | 愛爾蘭商艾伯維製造管理無限公司 | 抗c-Met抗體藥物結合物 |
| CA3241734A1 (en) * | 2022-01-12 | 2023-07-20 | Amy Han | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US5340817A (en) * | 1987-04-14 | 1994-08-23 | Research Triangle Institute | Method of treating tumors with anti-tumor effective camptothecin compounds |
| US5122606A (en) * | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| WO1991004260A2 (en) * | 1989-09-15 | 1991-04-04 | Research Triangle Institute | 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs |
| GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
| GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
-
1995
- 1995-05-26 GB GBGB9510716.5A patent/GB9510716D0/en active Pending
-
1996
- 1996-05-10 PL PL96318279A patent/PL318279A1/xx unknown
- 1996-05-10 CA CA002194700A patent/CA2194700A1/en not_active Abandoned
- 1996-05-10 HU HU9702400A patent/HUP9702400A3/hu unknown
- 1996-05-10 CN CN96190541A patent/CN1159192A/zh active Pending
- 1996-05-10 US US08/776,192 patent/US5856333A/en not_active Expired - Fee Related
- 1996-05-10 EP EP96919763A patent/EP0777670B1/en not_active Expired - Lifetime
- 1996-05-10 WO PCT/EP1996/002008 patent/WO1996037496A1/en not_active Ceased
- 1996-05-10 DE DE69631943T patent/DE69631943D1/de not_active Expired - Lifetime
- 1996-05-10 BR BR9606396A patent/BR9606396A/pt not_active Application Discontinuation
- 1996-05-10 NZ NZ308514A patent/NZ308514A/en unknown
- 1996-05-10 AU AU58179/96A patent/AU5817996A/en not_active Abandoned
- 1996-05-10 AT AT96919763T patent/ATE262532T1/de not_active IP Right Cessation
- 1996-05-10 JP JP8535320A patent/JPH10503220A/ja not_active Withdrawn
- 1996-05-23 IL IL11841096A patent/IL118410A0/xx unknown
- 1996-05-23 ZA ZA964138A patent/ZA964138B/xx unknown
- 1996-05-24 AR ARP960102705A patent/AR003126A1/es unknown
-
1997
- 1997-01-23 NO NO970293A patent/NO970293L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10503220A (ja) | 1998-03-24 |
| BR9606396A (pt) | 1997-10-14 |
| GB9510716D0 (en) | 1995-07-19 |
| HUP9702400A2 (hu) | 1998-06-29 |
| HUP9702400A3 (en) | 1998-07-28 |
| WO1996037496A1 (en) | 1996-11-28 |
| AU5817996A (en) | 1996-12-11 |
| NZ308514A (en) | 1998-06-26 |
| AR003126A1 (es) | 1998-07-08 |
| EP0777670A1 (en) | 1997-06-11 |
| CN1159192A (zh) | 1997-09-10 |
| PL318279A1 (en) | 1997-06-09 |
| ZA964138B (en) | 1996-11-27 |
| ATE262532T1 (de) | 2004-04-15 |
| EP0777670B1 (en) | 2004-03-24 |
| IL118410A0 (en) | 1996-09-12 |
| US5856333A (en) | 1999-01-05 |
| NO970293D0 (no) | 1997-01-23 |
| CA2194700A1 (en) | 1996-11-28 |
| DE69631943D1 (de) | 2004-04-29 |
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