DE69631943D1 - Substituierte camptothecinderivate und verfahren zur ihrer herstellung - Google Patents

Substituierte camptothecinderivate und verfahren zur ihrer herstellung

Info

Publication number
DE69631943D1
DE69631943D1 DE69631943T DE69631943T DE69631943D1 DE 69631943 D1 DE69631943 D1 DE 69631943D1 DE 69631943 T DE69631943 T DE 69631943T DE 69631943 T DE69631943 T DE 69631943T DE 69631943 D1 DE69631943 D1 DE 69631943D1
Authority
DE
Germany
Prior art keywords
substituted
production
camptothecine
derivatives
camptothecine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69631943T
Other languages
English (en)
Inventor
Walter Cabri
Ilaria Candiani
Angelo Bedeschi
Franco Zarini
Sergio Penco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of DE69631943D1 publication Critical patent/DE69631943D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE69631943T 1995-05-26 1996-05-10 Substituierte camptothecinderivate und verfahren zur ihrer herstellung Expired - Lifetime DE69631943D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9510716.5A GB9510716D0 (en) 1995-05-26 1995-05-26 Substituted camptothecin derivatives and process for their preparation
PCT/EP1996/002008 WO1996037496A1 (en) 1995-05-26 1996-05-10 Substituted camptothecin derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
DE69631943D1 true DE69631943D1 (de) 2004-04-29

Family

ID=10775098

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631943T Expired - Lifetime DE69631943D1 (de) 1995-05-26 1996-05-10 Substituierte camptothecinderivate und verfahren zur ihrer herstellung

Country Status (18)

Country Link
US (1) US5856333A (de)
EP (1) EP0777670B1 (de)
JP (1) JPH10503220A (de)
CN (1) CN1159192A (de)
AR (1) AR003126A1 (de)
AT (1) ATE262532T1 (de)
AU (1) AU5817996A (de)
BR (1) BR9606396A (de)
CA (1) CA2194700A1 (de)
DE (1) DE69631943D1 (de)
GB (1) GB9510716D0 (de)
HU (1) HUP9702400A3 (de)
IL (1) IL118410A0 (de)
NO (1) NO970293L (de)
NZ (1) NZ308514A (de)
PL (1) PL318279A1 (de)
WO (1) WO1996037496A1 (de)
ZA (1) ZA964138B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
GB9702807D0 (en) 1997-02-12 1997-04-02 Pharmacia & Upjohn Spa Alkynyl-substituted camptothecins and process for their preparation
WO1998035940A1 (en) * 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
AU7292398A (en) 1997-05-15 1998-12-08 Eli Lilly And Company Antithrombotic compound
HUP9701554D0 (en) * 1997-09-18 1997-11-28 Human Oltoanyagtermeloe Gyogys Pharmaceutical composition containing plazma proteins
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
SK12242002A3 (sk) 2000-02-28 2003-02-04 Aventis Pharma S. A. Farmaceutické kombinácie obsahujúce camptotecin a pyrimidínový derivát na liečenie rakoviny
US6548488B2 (en) 2000-03-17 2003-04-15 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
US6545010B2 (en) 2000-03-17 2003-04-08 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
YU29803A (sh) 2000-10-27 2006-05-25 Aventis Pharma S.A. Kombinacija kamptotekina i derivata stilbena za lečenje raka
US7232821B2 (en) 2002-04-08 2007-06-19 Glaxo Group Limited (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
CN100406460C (zh) * 2003-11-10 2008-07-30 中国科学院上海药物研究所 喜树碱的新衍生物、制备方法和用途
WO2006069344A2 (en) 2004-12-22 2006-06-29 Rutgers, The State University Of New Jersey Controlled release hydrogels
WO2012050591A1 (en) 2010-10-15 2012-04-19 Rutgers, The State University Of New Jersey Hydrogel formulation for dermal and ocular delivery
CA2658015A1 (en) 2006-03-30 2007-10-11 Diatos S.A. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
CN101880285B (zh) * 2010-06-24 2012-07-04 华东师范大学 一种烯丙基取代喜树碱化合物的合成方法
CN104774209B (zh) * 2014-01-15 2018-06-19 上海海和药物研究开发有限公司 一种9-烯丙基喜树碱衍生物的合成方法
UY39743A (es) 2021-04-29 2022-11-30 Abbvie Inc Conjugados de anticuerpo anti-c-met y fármaco

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5122606A (en) * 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US5340817A (en) * 1987-04-14 1994-08-23 Research Triangle Institute Method of treating tumors with anti-tumor effective camptothecin compounds
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
WO1991004260A2 (en) * 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation

Also Published As

Publication number Publication date
NZ308514A (en) 1998-06-26
CN1159192A (zh) 1997-09-10
GB9510716D0 (en) 1995-07-19
CA2194700A1 (en) 1996-11-28
PL318279A1 (en) 1997-06-09
NO970293D0 (no) 1997-01-23
HUP9702400A2 (hu) 1998-06-29
EP0777670B1 (de) 2004-03-24
EP0777670A1 (de) 1997-06-11
NO970293L (no) 1997-03-06
BR9606396A (pt) 1997-10-14
US5856333A (en) 1999-01-05
JPH10503220A (ja) 1998-03-24
AU5817996A (en) 1996-12-11
HUP9702400A3 (en) 1998-07-28
ZA964138B (en) 1996-11-27
AR003126A1 (es) 1998-07-08
ATE262532T1 (de) 2004-04-15
WO1996037496A1 (en) 1996-11-28
IL118410A0 (en) 1996-09-12

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Legal Events

Date Code Title Description
8332 No legal effect for de