NO944700L - Nye tienotiazinderivater, fremgangsmåte for fremstilling derav samt farmasöytiske preparater inneholdende forbindelsene - Google Patents
Nye tienotiazinderivater, fremgangsmåte for fremstilling derav samt farmasöytiske preparater inneholdende forbindelseneInfo
- Publication number
- NO944700L NO944700L NO944700A NO944700A NO944700L NO 944700 L NO944700 L NO 944700L NO 944700 A NO944700 A NO 944700A NO 944700 A NO944700 A NO 944700A NO 944700 L NO944700 L NO 944700L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- aryl
- lower alkyl
- heteroaryl
- heteroatoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Det er beskrevet nye tlenotlazln-derlvater med generell formel: hvori: o o," s- N M-Q-R \\ f OR, (D A betyr laverealkyl, perfluorert laverealkyl, laverealkyl - oksy, halogen, nltro, cyano eller en mono- eller polycykllsk 5-12-leddet, eventuelt delvis hydrert aryl- eller heteroaryl- rest med 1-4 heteroatomer som O, S og N, som eventuelt kan være substituert med laverealkyl, per fluor laverealkyl , aryl, heteroaryl, substituert aryl, substituert hetero- aryl, halogen, laverealkoksy, aryloksy, substituert aryloksy, heteroaryloksy , substituert heteroaryloksy og nltro, hvori de aktuelle substltuentene l substituert aryl, substituert heteroaryl, substituert aryloksy og substituert heteroaryloksy betyr halogen, laverealkyl, perfluorlaverealkyl , laverealkoksy og lignende; w D betyr en 2-pyridylrest eller en rest X^TY , hvorved X og Y uavhengig av hverandre betyr CH, NR6, O eller S, hvor R6 betyr hydrogen eller laverealkyl, M betyr en enkeltbinding, en rettkjedet eller forgrenet hydrokarbonkjede med 1-12 karbonatomer i kjeden, hvorved denne kjeden kan inneholde en eller flere dobbelt- og/eller trippelbindinger og/eller et eller flere hetero- atomer som O, S og N, en 5-12-leddet mono- eller polycykllsk, eventuelt delvis hydrert aryl- eller heteroaryl- rest med 1-4 heteroatomer som O, S og N, som kan være substituert med halogen, laverealkyl eller laverealkoksy; O betyr en enkeltbinding eller et heteroatom som O, S og N; R betyr hydrogen, en 5-12-leddet mono- eller polycykllsk aryl- eller heteroaryl rest med 1-4 heteroatomer sera O, S og N, som eventuelt kan være delvis hydrert, eller også kan være substituert en eller flere ganger med halogen, laverealkyl eller laverealkoksy; R, O l ^^ og R! betyr hydrogen eller ¿ nvorl R2 betyr laverealkyl og #3 betyr laverealkyl, aryl eller -OR4, hvor R4 betyr laverealkyl, cykloalkyl med 4-8 karbonatomer eller aryl; samt deres farmasøytisk anvendbare salter. Det er videre beskrevet fremgangsmåter for fremstilling av forbin- delsene samt deres anvendelse ved fremstilling av legemidler.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT253193A AT400567B (de) | 1993-12-14 | 1993-12-14 | Neue arylsubstituierte thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung |
| AT253093A AT400437B (de) | 1993-12-14 | 1993-12-14 | Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung |
| AT102694A AT400568B (de) | 1994-05-18 | 1994-05-18 | Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO944700D0 NO944700D0 (no) | 1994-12-06 |
| NO944700L true NO944700L (no) | 1995-06-15 |
Family
ID=27146994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO944700A NO944700L (no) | 1993-12-14 | 1994-12-06 | Nye tienotiazinderivater, fremgangsmåte for fremstilling derav samt farmasöytiske preparater inneholdende forbindelsene |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5679678A (no) |
| EP (1) | EP0658559A1 (no) |
| JP (1) | JPH07267964A (no) |
| CN (1) | CN1109059A (no) |
| CA (1) | CA2137976A1 (no) |
| NO (1) | NO944700L (no) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
| EP1126838A4 (en) | 1998-10-30 | 2005-02-16 | Nitromed Inc | NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
| CZ20012160A3 (cs) * | 1998-12-25 | 2001-10-17 | Shionogi & Co., Ltd. | Heteroaromatické deriváty s inhibiční aktivitou proti HIV integráze |
| AU6016200A (en) * | 1999-07-16 | 2001-02-05 | Sankyo Company Limited | Coumarone analogues |
| WO2001083431A1 (fr) * | 2000-04-28 | 2001-11-08 | Shionogi & Co., Ltd. | Inhibiteurs de mmp-12 |
| US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
| JP4544857B2 (ja) | 2001-06-11 | 2010-09-15 | ヴァイロケム ファーマ インコーポレイテッド | Ｆｌａｖｉｖｉｒｕｓ感染の治療または予防のための化合物および方法 |
| CN1171892C (zh) | 2001-06-25 | 2004-10-20 | 李晶 | 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途 |
| US20050176791A1 (en) * | 2002-02-13 | 2005-08-11 | Oxford Alexander W. | 5-HT2B receptor antagonists |
| GB0203412D0 (en) * | 2002-02-13 | 2002-04-03 | Pharmagene Lab Ltd | 5-HT 2B receptor antagonists |
| JP2005526720A (ja) * | 2002-02-13 | 2005-09-08 | ファーマジーン ラボラトリーズ リミテッド | ５−ｈｔ２ｂ受容体アンタゴニスト |
| US7402608B2 (en) | 2002-12-10 | 2008-07-22 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| WO2005012263A1 (en) * | 2003-07-24 | 2005-02-10 | Pharmagene Laboratories Limited | 5-ht2b receptor antagonists |
| KR20090086081A (ko) | 2006-11-15 | 2009-08-10 | 바이로켐 파마 인코포레이티드 | 플라비바이러스 감염의 치료 또는 예방용 티오펜 유사체 |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| HUE035069T2 (en) * | 2011-12-28 | 2018-05-02 | Global Blood Therapeutics Inc | Substituted benzaldehyde compounds and their use to increase tissue oxygenation |
| WO2013146754A1 (ja) * | 2012-03-27 | 2013-10-03 | 塩野義製薬株式会社 | Ｔｒｐｖ４阻害活性を有する芳香族複素５員環誘導体 |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| KR20150132146A (ko) | 2013-03-15 | 2015-11-25 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
| US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CA2903022C (en) | 2013-03-15 | 2021-11-09 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| PE20161035A1 (es) | 2013-03-15 | 2016-11-13 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulacion de la hemoglobina |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| JP6809681B2 (ja) | 2014-02-07 | 2021-01-06 | グローバル ブラッド セラピューティクス インコーポレイテッド | ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形 |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| TW201731509A (zh) | 2015-12-04 | 2017-09-16 | 全球血液治療公司 | 針對２-羥基-６-（（２-（１-異丙基-１ｈ-吡唑-５-基）吡啶-３-基）甲氧基）-苯甲醛之劑量方案 |
| TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| CN106632403B (zh) * | 2017-01-23 | 2018-09-11 | 牡丹江医学院 | 一种手术用止痛消炎药及其制备方法 |
| EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
| EP4046988A1 (en) | 2018-11-19 | 2022-08-24 | Global Blood Therapeutics, Inc. | 2-formyl-3-hydroxyphenyloxymethyl compounds capable of modulating hemoglobin |
| CN111646987B (zh) * | 2020-06-05 | 2022-06-24 | 湖南师范大学 | 一种5-氨基噻唑类非甾体抗炎化合物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47877A (en) * | 1974-08-26 | 1978-10-31 | Sparamedica Ag | Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them |
| CH619236A5 (en) * | 1975-08-14 | 1980-09-15 | Hoffmann La Roche | Process for the preparation of thienothiazine derivatives |
| AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
| DE3371082D1 (de) * | 1982-09-09 | 1987-05-27 | Hoffmann La Roche | Thieno(2,3-e)-1,2-thiazine derivatives |
| NZ226477A (en) * | 1987-10-29 | 1990-07-26 | Cl Pharma | Substituted thieno (2,3-e)-1,2 thiazine derivatives and pharmaceutical compositions |
| AT399880B (de) * | 1992-07-03 | 1995-08-25 | Chem Pharm Forsch Gmbh | Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung |
-
1994
- 1994-12-05 EP EP94119114A patent/EP0658559A1/de not_active Withdrawn
- 1994-12-06 NO NO944700A patent/NO944700L/no unknown
- 1994-12-13 JP JP6309098A patent/JPH07267964A/ja not_active Withdrawn
- 1994-12-13 CA CA002137976A patent/CA2137976A1/en not_active Abandoned
- 1994-12-13 CN CN94119307A patent/CN1109059A/zh active Pending
- 1994-12-14 US US08/355,549 patent/US5679678A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1109059A (zh) | 1995-09-27 |
| JPH07267964A (ja) | 1995-10-17 |
| NO944700D0 (no) | 1994-12-06 |
| US5679678A (en) | 1997-10-21 |
| EP0658559A1 (de) | 1995-06-21 |
| CA2137976A1 (en) | 1995-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO944700L (no) | Nye tienotiazinderivater, fremgangsmåte for fremstilling derav samt farmasöytiske preparater inneholdende forbindelsene | |
| DK0687253T3 (da) | Hidtil ukendte 4-aminopyridiner, fremgangsmåde til deres fremstilling samt lægemidler indeholdende disse forbindelser | |
| US3488423A (en) | Process for producing anti-inflammatory effects and compositions | |
| DE68906552D1 (de) | Camptothecin-derivate und verfahren zu ihrer herstellung. | |
| HK1020194A1 (en) | Crystals of benzimidazole derivatives and their production | |
| ES2056214T3 (es) | Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso. | |
| AP9701039A0 (en) | Derivatives of 2- (2-oxo-ethlidene)-imidazolidin-4-one. | |
| ES2093753T3 (es) | Derivados de estireno. | |
| CA2161542A1 (en) | Novel 5-Pyrrolyl-2-Pyridylmethylsulfinyl Benzimidazole Derivatives | |
| NO970293L (no) | Substituerte camptothecinderivater og fremgangsmåte for deres fremstilling | |
| TW368501B (en) | 7-(2-aminoethyl)-benzothiazolones | |
| DK0649846T3 (da) | Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler | |
| SE7501365L (no) | ||
| UA8017A1 (uk) | Спосіб отримання похідних хінолінкарбонової кислоти | |
| AU2186288A (en) | Novel amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same | |
| ECSP941050A (es) | Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene | |
| NO944680L (no) | Nye tienotiazinerivater, en fremgangsmåte til fremstilling derav samt deres anvendelse | |
| ES2016017A6 (es) | Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico. | |
| NO932129L (no) | Fremgangsmaate for fremstilling og anvendelse av nye tienotiazinderivater | |
| ATE168371T1 (de) | 5-amino-5,6,7,8-tetrahydrochinoline und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| DK0432841T3 (da) | Spiro-indolin-oxazin-forbindelser med fotokromatiske og fotosensibiliserende egenskaber samt fremgangsmåde til deres fremstilling | |
| NO920619L (no) | Oxazinobenzazolforbindelser | |
| HU903511D0 (en) | Process for producing aminoketone derivatives and pharmaceutical preparatives containing these compounds | |
| GB898409A (en) | Process for the manufacture of 2-amino-ú=-triazolo[2,3-c]pyrimidines | |
| DE3679257D1 (de) | 4-cyanopiperidine-derivate, herstellung und anwendung. |