DK0649846T3 - Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents

Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number
DK0649846T3
DK0649846T3 DK94115961T DK94115961T DK0649846T3 DK 0649846 T3 DK0649846 T3 DK 0649846T3 DK 94115961 T DK94115961 T DK 94115961T DK 94115961 T DK94115961 T DK 94115961T DK 0649846 T3 DK0649846 T3 DK 0649846T3
Authority
DK
Denmark
Prior art keywords
compounds
pharmaceuticals
preparation
galanthamine derivatives
galanthamine
Prior art date
Application number
DK94115961T
Other languages
English (en)
Inventor
W Jr Kosley Raymond
Larry Davis
Veronica Taberna
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK0649846T3 publication Critical patent/DK0649846T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DK94115961T 1993-10-15 1994-10-10 Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler DK0649846T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/137,444 US6316439B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (1)

Publication Number Publication Date
DK0649846T3 true DK0649846T3 (da) 2002-04-15

Family

ID=22477461

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94115961T DK0649846T3 (da) 1993-10-15 1994-10-10 Galanthaminderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Country Status (23)

Country Link
US (1) US6316439B1 (da)
EP (1) EP0649846B1 (da)
JP (1) JP2664343B2 (da)
KR (1) KR100227957B1 (da)
CN (1) CN1039910C (da)
AT (1) ATE211474T1 (da)
AU (1) AU696170B2 (da)
CA (1) CA2118172C (da)
CZ (1) CZ283731B6 (da)
DE (1) DE69429570T2 (da)
DK (1) DK0649846T3 (da)
EG (1) EG20726A (da)
ES (1) ES2170759T3 (da)
FI (1) FI108722B (da)
IL (1) IL111275A (da)
NO (1) NO307464B1 (da)
NZ (1) NZ264682A (da)
PL (1) PL177549B1 (da)
PT (1) PT649846E (da)
RO (1) RO114134B1 (da)
RU (1) RU2109743C1 (da)
TW (1) TW289754B (da)
ZA (1) ZA948061B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
EP2311463A1 (en) * 1999-12-10 2011-04-20 Bonnie M. Davis Analogs of galanthamine and lycoramine as modulators of nicotinic receptors
JP2005503345A (ja) * 2001-04-30 2005-02-03 バイエル・コーポレーシヨン 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040254146A1 (en) * 2002-05-21 2004-12-16 Nastech Pharmaceutical Company Inc. Carboxylate salts of galantamine and their pharmaceutical use
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
WO2005065662A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
CA2551946A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Immediate, controlled and sustained release formulations of galantamine
US20080045500A1 (en) * 2004-07-01 2008-02-21 Eisai R&D Management Co., Ltd. Nerve Regeneration Stimulator
EP2425845A1 (en) * 2004-12-23 2012-03-07 Voyager Pharmaceutical Corporation Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
PT1895994E (pt) * 2005-05-13 2010-12-03 Alza Corp Sistema de administração de medicamentos de camada múltipla com barreira contra o fluxo de material do reservatório
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1937226A2 (en) * 2005-09-23 2008-07-02 Alza Corporation Transdermal galantamine delivery system
ES2463715T3 (es) 2008-04-14 2014-05-29 Neurodyn Life Sciences Inc. Derivados de galantamina como profármacos para el tratamiento de enfermedades del cerebro humano
CA2768668A1 (en) * 2009-07-23 2011-01-27 Shire Llc Galantamine amino acid and peptide prodrugs and uses thereof
WO2015176069A2 (en) * 2014-05-16 2015-11-19 Synaptec Development Llc CLEARANCE OF AMYLOID ß
EP4029867A1 (en) 2021-01-13 2022-07-20 Alpha Cognition Inc. Solid forms of galantamine benzoate gluconate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
ATE411026T1 (de) * 1987-05-04 2008-10-15 Bonnie Davis Mittel zur behandlung der alzheimer-krankheit
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
DE69229781T2 (de) 1991-05-14 2000-01-05 Ernir Snorrason Behandlung des ermüdungssyndroms mit cholinesteraseinhibitoren
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
PT649846E (pt) 2002-06-28
FI944823A (fi) 1995-04-16
CA2118172C (en) 2000-01-04
ZA948061B (en) 1995-06-06
FI108722B (fi) 2002-03-15
IL111275A (en) 2003-01-12
NZ264682A (en) 1995-07-26
KR950011445A (ko) 1995-05-15
ATE211474T1 (de) 2002-01-15
CZ283731B6 (cs) 1998-06-17
RU2109743C1 (ru) 1998-04-27
US6316439B1 (en) 2001-11-13
AU7581394A (en) 1995-05-04
CA2118172A1 (en) 1995-04-16
IL111275A0 (en) 1994-12-29
EP0649846A1 (en) 1995-04-26
PL305457A1 (en) 1995-04-18
DE69429570D1 (de) 2002-02-07
JPH07188239A (ja) 1995-07-25
PL177549B1 (pl) 1999-12-31
EP0649846B1 (en) 2002-01-02
NO943895L (no) 1995-04-18
AU696170B2 (en) 1998-09-03
RU94036745A (ru) 1996-12-10
JP2664343B2 (ja) 1997-10-15
ES2170759T3 (es) 2002-08-16
KR100227957B1 (ko) 1999-11-01
EG20726A (en) 1999-12-29
NO943895D0 (no) 1994-10-14
CN1108657A (zh) 1995-09-20
FI944823A0 (fi) 1994-10-13
DE69429570T2 (de) 2002-08-29
CZ254594A3 (en) 1995-07-12
CN1039910C (zh) 1998-09-23
NO307464B1 (no) 2000-04-10
RO114134B1 (ro) 1999-01-29
TW289754B (da) 1996-11-01

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