NO20016099L - Optisk aktive pyrrolopyridazinforbindelser - Google Patents

Optisk aktive pyrrolopyridazinforbindelser

Info

Publication number
NO20016099L
NO20016099L NO20016099A NO20016099A NO20016099L NO 20016099 L NO20016099 L NO 20016099L NO 20016099 A NO20016099 A NO 20016099A NO 20016099 A NO20016099 A NO 20016099A NO 20016099 L NO20016099 L NO 20016099L
Authority
NO
Norway
Prior art keywords
optically active
compounds
activity against
active pyrrolopyridazine
alkyl
Prior art date
Application number
NO20016099A
Other languages
English (en)
Other versions
NO20016099D0 (no
Inventor
Masahiko Hagihara
Nobuhiko Shibakawa
Keiji Matsunobu
Hiroshi Fujiwara
Keiichi Ito
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of NO20016099D0 publication Critical patent/NO20016099D0/no
Publication of NO20016099L publication Critical patent/NO20016099L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Optisk aktive pyrrolopyridazin- forbindelser med generell formel (I) R (D eller farmakologisk akseptable salter derav: (hvori R1 er alkyl; R2 og R3 er hver uavhengig alkyl; R4 er eventuelt substituert aryl; og A er imino, oksygen eller svovel). Forbindelsene og saltene utviser en glimrende inhiberende akti- vitet overfor sekresjonen av magesalt- syre, en beskyttende aktivitet for mage- slimhinnen og en glimrende antimikrobi- ell aktivitet overfor Helicobacter pylori, og er anvendbare som legemidler, i særdeleshet preventive eller tera- peutiske midler for ulcerøse sykdommer.
NO20016099A 1999-06-15 2001-12-14 Optisk aktive pyrrolopyridazinforbindelser NO20016099L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16767999 1999-06-15
PCT/JP2000/003895 WO2000077003A1 (fr) 1999-06-15 2000-06-15 Composes de pyrrolopyridazine optiquement actifs

Publications (2)

Publication Number Publication Date
NO20016099D0 NO20016099D0 (no) 2001-12-14
NO20016099L true NO20016099L (no) 2002-02-07

Family

ID=15854223

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20016099A NO20016099L (no) 1999-06-15 2001-12-14 Optisk aktive pyrrolopyridazinforbindelser

Country Status (25)

Country Link
US (1) US6670360B2 (no)
EP (1) EP1186607B1 (no)
KR (1) KR100583663B1 (no)
CN (1) CN1170829C (no)
AT (1) ATE240957T1 (no)
AU (1) AU757611B2 (no)
BR (1) BR0011666A (no)
CA (1) CA2375848A1 (no)
CZ (1) CZ290935B6 (no)
DE (1) DE60002860T2 (no)
DK (1) DK1186607T3 (no)
ES (1) ES2198319T3 (no)
HK (1) HK1044341B (no)
HU (1) HUP0201434A3 (no)
IL (2) IL147088A0 (no)
MX (1) MXPA01013011A (no)
NO (1) NO20016099L (no)
NZ (1) NZ516194A (no)
PL (1) PL356479A1 (no)
PT (1) PT1186607E (no)
RU (1) RU2222541C2 (no)
TR (1) TR200103685T2 (no)
TW (1) TWI287014B (no)
WO (1) WO2000077003A1 (no)
ZA (1) ZA200110279B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2399380A1 (en) * 2000-02-10 2001-08-16 Sankyo Company, Limited Pyrrolopyridazine compound
TW200418479A (en) * 2002-09-25 2004-10-01 Sankyo Co Pharmaceutical compositions for the treatment or prevention of visceral pains
AU2003266622A1 (en) * 2002-09-25 2004-04-19 Sankyo Company, Limited Medicinal composition for inhibiting increase in blood gastrin concentration
CN101361738A (zh) 2003-11-03 2009-02-11 阿斯利康(瑞典)有限公司 治疗隐匿性胃食管反流的咪唑并[1,2-a]吡啶衍生物
WO2006038773A1 (en) * 2004-09-03 2006-04-13 Yuhan Corporation Pyrrolo[3,2-b]pyridine derivatives and processes for the preparation thereof
CN101003537A (zh) * 2006-01-17 2007-07-25 上海恒瑞医药有限公司 吡咯并哒嗪类衍生物及其制备方法和用途
WO2011004882A1 (ja) 2009-07-09 2011-01-13 ラクオリア創薬株式会社 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤
CN105367550A (zh) * 2014-08-11 2016-03-02 江苏柯菲平医药股份有限公司 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7754691A (en) 1990-04-27 1991-11-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel pyridazines
WO1992006979A1 (de) 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine
ATE179419T1 (de) 1991-10-25 1999-05-15 Byk Gulden Lomberg Chem Fab Pyrrolo-pyridazine mit magen- und darmschutzwirkungen
ATE229020T1 (de) * 1994-01-19 2002-12-15 Sankyo Co Pyrrolopyridazin-derivate

Also Published As

Publication number Publication date
ATE240957T1 (de) 2003-06-15
NO20016099D0 (no) 2001-12-14
US20020156079A1 (en) 2002-10-24
ES2198319T3 (es) 2004-02-01
PL356479A1 (en) 2004-06-28
BR0011666A (pt) 2002-03-19
CZ290935B6 (cs) 2002-11-13
HK1044341A1 (en) 2002-10-18
RU2222541C2 (ru) 2004-01-27
CN1170829C (zh) 2004-10-13
CA2375848A1 (en) 2000-12-21
EP1186607A1 (en) 2002-03-13
US6670360B2 (en) 2003-12-30
WO2000077003A1 (fr) 2000-12-21
EP1186607B1 (en) 2003-05-21
AU757611B2 (en) 2003-02-27
EP1186607A4 (en) 2002-07-03
CZ20014505A3 (cs) 2002-05-15
TWI287014B (en) 2007-09-21
HUP0201434A3 (en) 2003-09-29
PT1186607E (pt) 2003-08-29
KR100583663B1 (ko) 2006-05-26
DE60002860T2 (de) 2004-05-06
NZ516194A (en) 2003-03-28
CN1370172A (zh) 2002-09-18
IL147088A0 (en) 2002-08-14
DE60002860D1 (de) 2003-06-26
KR20020022703A (ko) 2002-03-27
ZA200110279B (en) 2003-05-28
HUP0201434A2 (en) 2002-08-28
DK1186607T3 (da) 2003-09-01
IL147088A (en) 2006-12-31
TR200103685T2 (tr) 2002-05-21
AU5426900A (en) 2001-01-02
MXPA01013011A (es) 2002-11-07
HK1044341B (zh) 2003-10-03

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application