ATE188702T1 - Thienodiazepinverbindungen und ihre verwendung - Google Patents
Thienodiazepinverbindungen und ihre verwendungInfo
- Publication number
- ATE188702T1 ATE188702T1 AT91916944T AT91916944T ATE188702T1 AT E188702 T1 ATE188702 T1 AT E188702T1 AT 91916944 T AT91916944 T AT 91916944T AT 91916944 T AT91916944 T AT 91916944T AT E188702 T1 ATE188702 T1 AT E188702T1
- Authority
- AT
- Austria
- Prior art keywords
- antidemential
- cholecystokinin
- useful
- inhibitory action
- medicine
- Prior art date
Links
- CCDMBTCSHSROMD-UHFFFAOYSA-N 7h-thieno[3,2-c]diazepine Chemical class C1=CN=NC2=CCSC2=C1 CCDMBTCSHSROMD-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 102100025841 Cholecystokinin Human genes 0.000 abstract 2
- 101800001982 Cholecystokinin Proteins 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 229940107137 cholecystokinin Drugs 0.000 abstract 2
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102100021022 Gastrin Human genes 0.000 abstract 1
- 108010052343 Gastrins Proteins 0.000 abstract 1
- 206010061459 Gastrointestinal ulcer Diseases 0.000 abstract 1
- 208000016222 Pancreatic disease Diseases 0.000 abstract 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000024691 pancreas disease Diseases 0.000 abstract 1
- 210000000578 peripheral nerve Anatomy 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- -1 thienodiazepine compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1991/001315 WO1993007152A1 (en) | 1991-09-30 | 1991-09-30 | Thienodiazepine compound and its use |
| CA002097285A CA2097285C (en) | 1991-09-30 | 1991-09-30 | Thienodiazepine compounds and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE188702T1 true ATE188702T1 (de) | 2000-01-15 |
Family
ID=25676237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91916944T ATE188702T1 (de) | 1991-09-30 | 1991-09-30 | Thienodiazepinverbindungen und ihre verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5439905A (de) |
| EP (1) | EP0559891B1 (de) |
| KR (1) | KR970002640B1 (de) |
| AT (1) | ATE188702T1 (de) |
| CA (1) | CA2097285C (de) |
| DE (1) | DE69131907T2 (de) |
| ES (1) | ES2140396T3 (de) |
| WO (1) | WO1993007152A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2159344A1 (en) * | 1993-03-30 | 1994-10-13 | Minoru Moriwaki | Cell adhesion inhibitor and thienotriazolodiazepine compound |
| US5426185A (en) * | 1993-11-22 | 1995-06-20 | Merck & Co., Inc. | Antiarrhythmic benzodiazepines |
| WO1995032963A1 (en) * | 1994-06-01 | 1995-12-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienylazole compound and thienotriazolodiazepine compound |
| SK282019B6 (sk) * | 1994-08-18 | 2001-10-08 | Merck & Co., Inc. | 2,3-dihydro-1-(2,2,2-trifluóretyl)-2-oxo-5-fenyl-1h-1,4- benzodiazepínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| US5691331A (en) * | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
| WO1996040656A1 (en) * | 1995-06-07 | 1996-12-19 | Merck & Co., Inc. | Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3yl)-3-amides |
| US5726171A (en) * | 1995-06-07 | 1998-03-10 | Merck & Co Inc | N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides |
| US5631251A (en) * | 1995-06-07 | 1997-05-20 | Merck & Co., Inc. | 5-cyclopropyl-1,4 benzodiazepine-2-ones |
| US5700797A (en) * | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
| EP0907644A4 (de) * | 1996-06-28 | 2003-02-05 | Merck & Co Inc | Pharmazeutische zubereitung |
| US5776930A (en) * | 1996-06-28 | 1998-07-07 | Merck & Company, Inc. | Pharmaceutical preparation |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (de) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomainhemmer und ihre verwendungen |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| EP2864336B1 (de) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazolazepinbromdomänenhemmer und verwendungen davon |
| CA2952830C (en) | 2014-06-20 | 2022-11-01 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| KR101675984B1 (ko) | 2015-02-23 | 2016-11-14 | 한양대학교 에리카산학협력단 | 티에노디아제핀 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989005812A1 (fr) * | 1987-12-22 | 1989-06-29 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de thienodiazepine et leur utilisation en medecine |
| JP2953045B2 (ja) * | 1989-12-01 | 1999-09-27 | 吉富製薬株式会社 | チエノジアゼピン化合物 |
| IL96613A0 (en) * | 1989-12-18 | 1991-09-16 | Merck & Co Inc | Pharmaceutical compositions containing benzodiazepine analogs |
-
1991
- 1991-09-30 CA CA002097285A patent/CA2097285C/en not_active Expired - Fee Related
- 1991-09-30 ES ES91916944T patent/ES2140396T3/es not_active Expired - Lifetime
- 1991-09-30 KR KR1019930701592A patent/KR970002640B1/ko not_active Expired - Fee Related
- 1991-09-30 DE DE69131907T patent/DE69131907T2/de not_active Expired - Fee Related
- 1991-09-30 WO PCT/JP1991/001315 patent/WO1993007152A1/ja not_active Ceased
- 1991-09-30 EP EP91916944A patent/EP0559891B1/de not_active Expired - Lifetime
- 1991-09-30 AT AT91916944T patent/ATE188702T1/de not_active IP Right Cessation
-
1993
- 1993-05-27 US US08/066,130 patent/US5439905A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5439905A (en) | 1995-08-08 |
| WO1993007152A1 (en) | 1993-04-15 |
| DE69131907D1 (de) | 2000-02-17 |
| ES2140396T3 (es) | 2000-03-01 |
| EP0559891A1 (de) | 1993-09-15 |
| EP0559891B1 (de) | 2000-01-12 |
| KR970002640B1 (ko) | 1997-03-07 |
| EP0559891A4 (de) | 1994-03-16 |
| CA2097285A1 (en) | 1993-03-31 |
| DE69131907T2 (de) | 2000-06-15 |
| CA2097285C (en) | 2000-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |