ATE169922T1 - Desoxyazaphospholipid-derivate mit inhibierender aktivität auf phospholipase - Google Patents
Desoxyazaphospholipid-derivate mit inhibierender aktivität auf phospholipaseInfo
- Publication number
- ATE169922T1 ATE169922T1 AT94918338T AT94918338T ATE169922T1 AT E169922 T1 ATE169922 T1 AT E169922T1 AT 94918338 T AT94918338 T AT 94918338T AT 94918338 T AT94918338 T AT 94918338T AT E169922 T1 ATE169922 T1 AT E169922T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- inhibiting activity
- desoxyazaphospholipide
- phospholipase inhibiting
- phospholipase
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 title 1
- 102000015439 Phospholipases Human genes 0.000 title 1
- 108010064785 Phospholipases Proteins 0.000 title 1
- 102100037611 Lysophospholipase Human genes 0.000 abstract 1
- 108010058864 Phospholipases A2 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09301180A ES2065855B1 (es) | 1993-05-31 | 1993-05-31 | Procedimiento para la preparacion de nuevos derivados desoxiazafosfolipidicos con accion inhibidora de la fosfolipasa a2, nuevos derivados desoxiazafosfolipidicos obtenidos y utilizacion de los mismos. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE169922T1 true ATE169922T1 (de) | 1998-09-15 |
Family
ID=8281999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94918338T ATE169922T1 (de) | 1993-05-31 | 1994-05-18 | Desoxyazaphospholipid-derivate mit inhibierender aktivität auf phospholipase |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0701561B1 (de) |
| AT (1) | ATE169922T1 (de) |
| AU (1) | AU6970394A (de) |
| DE (1) | DE69412612D1 (de) |
| ES (1) | ES2065855B1 (de) |
| WO (1) | WO1994028004A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0906759A1 (de) * | 1997-10-02 | 1999-04-07 | Roche Diagnostics GmbH | Neue Osteoblastenspezifische Mitogene: Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6911553B1 (en) | 1997-10-02 | 2005-06-28 | Roche Diagnostics Gmbh | Osteoblast-specific mitogens and drugs containing such compounds |
| AU2001272234B2 (en) * | 2000-07-24 | 2006-06-01 | The University Of Queensland | Compounds and inhibitors of phospholipases |
| CA2417127A1 (en) | 2000-07-24 | 2002-01-31 | The University Of Queensland | Compounds and inhibitors of phospholipases |
| DK1377593T3 (da) | 2001-03-26 | 2006-04-10 | Novartis Ag | 2-Amino-propanolderivater |
| JP5140824B2 (ja) * | 2006-04-19 | 2013-02-13 | 国立大学法人 東京大学 | リゾホスファチジルスレオニンおよびその誘導体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4761404A (en) * | 1985-07-01 | 1988-08-02 | Merck & Co., Inc. | Phospholipid analogs useful as PAF synthesis inhibitors |
| US5009956A (en) * | 1987-02-24 | 1991-04-23 | Univ Minnesota | Phospholipase A2-resistant liposomes |
| US5030733A (en) * | 1987-07-23 | 1991-07-09 | Hoechst-Roussel Pharmaceticals Incorporated | Hydroxy-, alkoxy- and benzyloxy-substituted phospholipids |
| EP0300397A2 (de) * | 1987-07-23 | 1989-01-25 | Hoechst-Roussel Pharmaceuticals Incorporated | Hydroxy-, alkoxy- und benzyloxysubstituierte Phospholipide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente |
| US5145844A (en) * | 1987-07-23 | 1992-09-08 | Hoechst-Roussel Pharmaceuticals Incorporated | Methods of using hydroxy-, alkoxy- and benzyloxy-substituted phospholipids to treat phospholipase A2 -mediated conditions and to alleviate pain |
| US5208223A (en) * | 1990-11-13 | 1993-05-04 | American Cyanamid Company | Phosphocholine derivative inhibitors of phospholipase A2 |
| US5144045A (en) * | 1990-11-13 | 1992-09-01 | American Cyanamid Company | Phosphocholine derivative inhibitors of phospholipase A2 |
| DE4234130A1 (de) * | 1992-10-09 | 1994-04-14 | Max Planck Gesellschaft | Phospholipase A¶2¶ inhibierende Phosphatidylcholinverbindungen |
-
1993
- 1993-05-31 ES ES09301180A patent/ES2065855B1/es not_active Expired - Fee Related
-
1994
- 1994-05-18 EP EP94918338A patent/EP0701561B1/de not_active Expired - Lifetime
- 1994-05-18 AU AU69703/94A patent/AU6970394A/en not_active Abandoned
- 1994-05-18 AT AT94918338T patent/ATE169922T1/de not_active IP Right Cessation
- 1994-05-18 WO PCT/EP1994/001608 patent/WO1994028004A1/en active IP Right Grant
- 1994-05-18 DE DE69412612T patent/DE69412612D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69412612D1 (de) | 1998-09-24 |
| EP0701561B1 (de) | 1998-08-19 |
| ES2065855A1 (es) | 1995-02-16 |
| ES2065855B1 (es) | 1995-09-01 |
| WO1994028004A1 (en) | 1994-12-08 |
| EP0701561A1 (de) | 1996-03-20 |
| AU6970394A (en) | 1994-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |