ATE169922T1 - Desoxyazaphospholipid-derivate mit inhibierender aktivität auf phospholipase - Google Patents

Desoxyazaphospholipid-derivate mit inhibierender aktivität auf phospholipase

Info

Publication number
ATE169922T1
ATE169922T1 AT94918338T AT94918338T ATE169922T1 AT E169922 T1 ATE169922 T1 AT E169922T1 AT 94918338 T AT94918338 T AT 94918338T AT 94918338 T AT94918338 T AT 94918338T AT E169922 T1 ATE169922 T1 AT E169922T1
Authority
AT
Austria
Prior art keywords
derivatives
inhibiting activity
desoxyazaphospholipide
phospholipase inhibiting
phospholipase
Prior art date
Application number
AT94918338T
Other languages
English (en)
Inventor
Germano Carganico
Casellas David Mauleon
Perez M Luisa Garcia
Original Assignee
Menarini Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Lab filed Critical Menarini Lab
Application granted granted Critical
Publication of ATE169922T1 publication Critical patent/ATE169922T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AT94918338T 1993-05-31 1994-05-18 Desoxyazaphospholipid-derivate mit inhibierender aktivität auf phospholipase ATE169922T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09301180A ES2065855B1 (es) 1993-05-31 1993-05-31 Procedimiento para la preparacion de nuevos derivados desoxiazafosfolipidicos con accion inhibidora de la fosfolipasa a2, nuevos derivados desoxiazafosfolipidicos obtenidos y utilizacion de los mismos.

Publications (1)

Publication Number Publication Date
ATE169922T1 true ATE169922T1 (de) 1998-09-15

Family

ID=8281999

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94918338T ATE169922T1 (de) 1993-05-31 1994-05-18 Desoxyazaphospholipid-derivate mit inhibierender aktivität auf phospholipase

Country Status (6)

Country Link
EP (1) EP0701561B1 (de)
AT (1) ATE169922T1 (de)
AU (1) AU6970394A (de)
DE (1) DE69412612D1 (de)
ES (1) ES2065855B1 (de)
WO (1) WO1994028004A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0906759A1 (de) * 1997-10-02 1999-04-07 Roche Diagnostics GmbH Neue Osteoblastenspezifische Mitogene: Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6911553B1 (en) 1997-10-02 2005-06-28 Roche Diagnostics Gmbh Osteoblast-specific mitogens and drugs containing such compounds
JP2004503604A (ja) 2000-07-24 2004-02-05 ザ・ユニバーシティ・オブ・クイーンズランド 化合物およびホスホリパーゼ阻害剤
AU2001272234B2 (en) * 2000-07-24 2006-06-01 The University Of Queensland Compounds and inhibitors of phospholipases
MXPA03008755A (es) 2001-03-26 2004-02-18 Novartis Ag Derivados de 2-amino-propanol.
JP5140824B2 (ja) * 2006-04-19 2013-02-13 国立大学法人 東京大学 リゾホスファチジルスレオニンおよびその誘導体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761404A (en) * 1985-07-01 1988-08-02 Merck & Co., Inc. Phospholipid analogs useful as PAF synthesis inhibitors
US5009956A (en) * 1987-02-24 1991-04-23 Univ Minnesota Phospholipase A2-resistant liposomes
EP0300397A2 (de) * 1987-07-23 1989-01-25 Hoechst-Roussel Pharmaceuticals Incorporated Hydroxy-, alkoxy- und benzyloxysubstituierte Phospholipide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente
US5145844A (en) * 1987-07-23 1992-09-08 Hoechst-Roussel Pharmaceuticals Incorporated Methods of using hydroxy-, alkoxy- and benzyloxy-substituted phospholipids to treat phospholipase A2 -mediated conditions and to alleviate pain
US5030733A (en) * 1987-07-23 1991-07-09 Hoechst-Roussel Pharmaceticals Incorporated Hydroxy-, alkoxy- and benzyloxy-substituted phospholipids
US5144045A (en) * 1990-11-13 1992-09-01 American Cyanamid Company Phosphocholine derivative inhibitors of phospholipase A2
US5208223A (en) * 1990-11-13 1993-05-04 American Cyanamid Company Phosphocholine derivative inhibitors of phospholipase A2
DE4234130A1 (de) * 1992-10-09 1994-04-14 Max Planck Gesellschaft Phospholipase A¶2¶ inhibierende Phosphatidylcholinverbindungen

Also Published As

Publication number Publication date
ES2065855A1 (es) 1995-02-16
WO1994028004A1 (en) 1994-12-08
ES2065855B1 (es) 1995-09-01
EP0701561B1 (de) 1998-08-19
DE69412612D1 (de) 1998-09-24
AU6970394A (en) 1994-12-20
EP0701561A1 (de) 1996-03-20

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties