NO20014220D0 - <Kappa>-agonist-forbindelser og farmasöytiske preparater derav - Google Patents
<Kappa>-agonist-forbindelser og farmasöytiske preparater deravInfo
- Publication number
- NO20014220D0 NO20014220D0 NO20014220A NO20014220A NO20014220D0 NO 20014220 D0 NO20014220 D0 NO 20014220D0 NO 20014220 A NO20014220 A NO 20014220A NO 20014220 A NO20014220 A NO 20014220A NO 20014220 D0 NO20014220 D0 NO 20014220D0
- Authority
- NO
- Norway
- Prior art keywords
- kappa
- pharmaceutical preparations
- agonist compounds
- agonist
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/612,680 US5646151A (en) | 1996-03-08 | 1996-03-08 | Kappa agonist compounds and pharmaceutical formulations thereof |
US08/796,078 US5688955A (en) | 1996-03-08 | 1997-02-05 | Kappa agonist compounds and pharmaceutical formulations thereof |
PCT/US1997/003353 WO1997032857A1 (en) | 1996-03-08 | 1997-03-01 | Kappa agonist compounds and pharmaceutical formulations thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20014220L NO20014220L (no) | 1998-11-09 |
NO20014220D0 true NO20014220D0 (no) | 2001-08-31 |
NO313634B1 NO313634B1 (no) | 2002-11-04 |
Family
ID=24454205
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19984107A NO313194B1 (no) | 1996-03-08 | 1998-09-07 | Kappa-agonist-forbindelser, anvendelse derav, samt farmasöytiske preparater |
NO20014220A NO313634B1 (no) | 1996-03-08 | 2001-08-31 | Kappa-agonist-forbindelser, anvendelse derav og farmasöytiske preparater |
NO20014219A NO313633B1 (no) | 1996-03-08 | 2001-08-31 | Kappa-agonist-forbindelser, anvendelse derav og farmasöytiske preparater |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19984107A NO313194B1 (no) | 1996-03-08 | 1998-09-07 | Kappa-agonist-forbindelser, anvendelse derav, samt farmasöytiske preparater |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20014219A NO313633B1 (no) | 1996-03-08 | 2001-08-31 | Kappa-agonist-forbindelser, anvendelse derav og farmasöytiske preparater |
Country Status (8)
Country | Link |
---|---|
US (3) | US5646151A (no) |
EP (1) | EP0885199A4 (no) |
KR (2) | KR100378494B1 (no) |
AU (1) | AU717126B2 (no) |
BR (1) | BR9707958A (no) |
CA (1) | CA2240728C (no) |
NO (3) | NO313194B1 (no) |
WO (1) | WO1997032857A1 (no) |
Families Citing this family (64)
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US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
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US6750216B2 (en) * | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US5763445A (en) * | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
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GB8804104D0 (en) * | 1988-02-23 | 1988-03-23 | Glaxo Group Ltd | Chemical compounds |
JPH02138254A (ja) * | 1988-02-23 | 1990-05-28 | Glaxo Group Ltd | 複素環誘導体 |
DK247789A (da) * | 1988-05-23 | 1989-11-24 | Glaxo Group Ltd | Piperazinderivater |
US5021413B1 (en) * | 1988-08-24 | 1994-12-13 | Sankyo Co | Analgesic thiomorpholins, their preparation, and pharmaceutical compositions containing them |
GB8824400D0 (en) * | 1988-10-18 | 1988-11-23 | Glaxo Group Ltd | Chemical compounds |
AU626949B2 (en) * | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
DK626889A (da) * | 1988-12-16 | 1990-06-17 | Roussel Uclaf | Indanderivater, deres fremstilling samt laegemidler med indhold deraf |
DE4034785A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
US5232978A (en) * | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
PT94070A (pt) * | 1989-05-18 | 1991-01-08 | Glaxo Group Ltd | Processo para a preparacao de derivados de piperazina |
JPH06511231A (ja) * | 1991-05-21 | 1994-12-15 | スミスクライン・ビーチャム・ファーマシューティチ・ソシエタ・ペル・アチオニ | 2−(ピロリジニル−1−メチル)−ピペリジン誘導体およびκ受容体アゴニストとしてのその使用 |
DE4215213A1 (de) * | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Arylacetamide |
US5475019A (en) * | 1993-02-08 | 1995-12-12 | East Carolina University | Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compounds |
US5804595A (en) * | 1995-12-05 | 1998-09-08 | Regents Of The University Of Minnesota | Kappa opioid receptor agonists |
-
1996
- 1996-03-08 US US08/612,680 patent/US5646151A/en not_active Expired - Lifetime
-
1997
- 1997-03-01 KR KR10-2000-7010910A patent/KR100378494B1/ko not_active IP Right Cessation
- 1997-03-01 BR BR9707958-8A patent/BR9707958A/pt not_active Application Discontinuation
- 1997-03-01 WO PCT/US1997/003353 patent/WO1997032857A1/en not_active Application Discontinuation
- 1997-03-01 AU AU21954/97A patent/AU717126B2/en not_active Ceased
- 1997-03-01 CA CA002240728A patent/CA2240728C/en not_active Expired - Fee Related
- 1997-03-01 KR KR1019980705347A patent/KR19990081823A/ko not_active Application Discontinuation
- 1997-03-01 EP EP97914850A patent/EP0885199A4/en not_active Withdrawn
- 1997-07-23 US US08/899,086 patent/US5744458A/en not_active Expired - Fee Related
-
1998
- 1998-03-03 US US09/034,661 patent/US5945443A/en not_active Expired - Fee Related
- 1998-09-07 NO NO19984107A patent/NO313194B1/no unknown
-
2001
- 2001-08-31 NO NO20014220A patent/NO313634B1/no unknown
- 2001-08-31 NO NO20014219A patent/NO313633B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
CA2240728C (en) | 2005-10-18 |
KR100378494B1 (ko) | 2003-03-29 |
AU717126B2 (en) | 2000-03-16 |
NO984107L (no) | 1998-11-09 |
US5646151A (en) | 1997-07-08 |
CA2240728A1 (en) | 1997-09-12 |
NO20014220L (no) | 1998-11-09 |
US5945443A (en) | 1999-08-31 |
US5744458A (en) | 1998-04-28 |
NO313633B1 (no) | 2002-11-04 |
NO984107D0 (no) | 1998-09-07 |
WO1997032857A1 (en) | 1997-09-12 |
EP0885199A1 (en) | 1998-12-23 |
NO313194B1 (no) | 2002-08-26 |
BR9707958A (pt) | 2000-01-04 |
NO313634B1 (no) | 2002-11-04 |
KR19990081823A (ko) | 1999-11-15 |
NO20014219D0 (no) | 2001-08-31 |
NO20014219L (no) | 1998-11-09 |
AU2195497A (en) | 1997-09-22 |
EP0885199A4 (en) | 2000-11-29 |
JP3522767B2 (ja) | 2004-04-26 |
JP2002502362A (ja) | 2002-01-22 |
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