NO20013462L - Serinproteaseinhibitorer - Google Patents

Serinproteaseinhibitorer

Info

Publication number
NO20013462L
NO20013462L NO20013462A NO20013462A NO20013462L NO 20013462 L NO20013462 L NO 20013462L NO 20013462 A NO20013462 A NO 20013462A NO 20013462 A NO20013462 A NO 20013462A NO 20013462 L NO20013462 L NO 20013462L
Authority
NO
Norway
Prior art keywords
serine protease
protease inhibitors
compounds
factor
kallikrein
Prior art date
Application number
NO20013462A
Other languages
English (en)
Norwegian (no)
Other versions
NO20013462D0 (no
Inventor
Ignacio Aliagas-Martin
Dean R Artis
Michael S Dina
John A Flygare
Richard A Goldsmith
Regina A Munroe
Alan G Olivero
Richard Pastor
Thomas E Rawson
Kirk D Robarge
Daniel P Sutherlin
Kenneth J Weese
Aihe Zhou
Yan Zhu
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO20013462D0 publication Critical patent/NO20013462D0/no
Publication of NO20013462L publication Critical patent/NO20013462L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51Y being a hydrogen or a carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20013462A 1999-01-13 2001-07-12 Serinproteaseinhibitorer NO20013462L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11577299P 1999-01-13 1999-01-13
US15202999P 1999-09-01 1999-09-01
PCT/US2000/000673 WO2000041531A2 (en) 1999-01-13 2000-01-11 Serine protease inhibitors

Publications (2)

Publication Number Publication Date
NO20013462D0 NO20013462D0 (no) 2001-07-12
NO20013462L true NO20013462L (no) 2001-09-12

Family

ID=26813550

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013462A NO20013462L (no) 1999-01-13 2001-07-12 Serinproteaseinhibitorer

Country Status (19)

Country Link
US (4) US6472393B1 (es)
EP (1) EP1144373B1 (es)
JP (1) JP2002534449A (es)
KR (1) KR100838418B1 (es)
CN (1) CN100488947C (es)
AT (1) ATE307111T1 (es)
AU (1) AU771776B2 (es)
BR (1) BR0008755A (es)
CA (1) CA2356934A1 (es)
CZ (1) CZ20012508A3 (es)
DE (1) DE60023266T2 (es)
ES (1) ES2251363T3 (es)
HU (1) HUP0105077A3 (es)
IL (2) IL144032A0 (es)
MX (1) MXPA01007038A (es)
NO (1) NO20013462L (es)
NZ (1) NZ512736A (es)
PL (1) PL350042A1 (es)
WO (1) WO2000041531A2 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE307111T1 (de) * 1999-01-13 2005-11-15 Genentech Inc Serinprotease-inhibitoren
WO2001023349A1 (fr) * 1999-09-30 2001-04-05 Mitsubishi Chemical Corporation Derives d'acylsulfonamide
AU1339302A (en) 2000-10-20 2002-05-06 Biocryst Pharm Inc Biaryl compounds as serine protease inhibitors
US7001887B2 (en) 2001-02-02 2006-02-21 Chugai Seiyaku Kabushiki Kaisha Peptide derivatives
DE10130374A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel
ATE399175T1 (de) * 2002-03-11 2008-07-15 Curacyte Ag Hemmstoffe der urokinase, ihre herstellung und verwendung
GB0207637D0 (en) * 2002-04-02 2002-05-15 Karobio Ab Novel compound
AU2003231865A1 (en) * 2002-05-31 2003-12-19 Genzyme Corporation Alpha acyloxyacetamides for kallikrein and urokinase inhibition
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
WO2004072102A2 (en) * 2003-02-11 2004-08-26 Bristol-Myers Squibb Company Benzene acetamide compounds useful as serine protease inhibitors
US7122559B2 (en) * 2003-02-11 2006-10-17 Bristol-Myers Squibb Company Phenylglycine derivatives useful as serine protease inhibitors
EP1628954A2 (en) * 2003-05-20 2006-03-01 Genentech, Inc. Acylsulfamide inhibitors of factor viia
US7273886B2 (en) * 2003-05-20 2007-09-25 Genentech, Inc. Benzofuran inhibitors of factor VIIa
DE10342108A1 (de) * 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
US7622585B2 (en) * 2005-01-10 2009-11-24 Bristol-Myers Squibb Company Phenylglycinamide derivatives useful as anticoagulants
US7514410B2 (en) 2005-03-29 2009-04-07 Biocryst Pharmaceuticals, Inc. Hepatitis C therapies
US8101636B2 (en) * 2005-06-03 2012-01-24 The University Of North Carolina At Chapel Hill Linear dicationic terphenyls and their aza analogues as antiparasitic agents
US7964619B2 (en) * 2005-06-03 2011-06-21 The University Of North Carolina At Chapel Hill Teraryl components as antiparasitic agents
DE602006011752D1 (de) * 2005-06-24 2010-03-04 Bristol Myers Squibb Co Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate
PT2000465E (pt) * 2006-03-24 2011-02-10 Eisai R&D Man Co Ltd Derivado de triazolona
US7776832B2 (en) 2006-04-21 2010-08-17 Gem Pharmaceuticals, Llc Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
TW200831080A (en) * 2006-12-15 2008-08-01 Irm Llc Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
ES2390188T3 (es) 2007-01-12 2012-11-07 Biocryst Pharmaceuticals, Inc. Análogos de nucleósidos antivirales
CA2874595A1 (en) 2007-04-13 2009-02-19 Southern Research Institute Use of terfenadine for treating breast and ovarian tumors
EP2178849A1 (en) * 2007-07-31 2010-04-28 Mallinckrodt Inc. Integrated photoactive agents and uses thereof
WO2009038157A1 (ja) 2007-09-21 2009-03-26 Eisai R & D Management Co., Ltd. 2,3-ジヒドロ-イミノイソインドール誘導体
TW200942243A (en) 2008-03-05 2009-10-16 Biocryst Pharm Inc Antiviral therapeutic agents
WO2010036407A2 (en) 2008-05-15 2010-04-01 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
JP5667094B2 (ja) 2009-03-10 2015-02-12 エムイーディー ディスカバリー エスエー 好中球減少症の処置におけるセリンプロテアーゼ阻害剤の使用
TW201206905A (en) 2010-05-20 2012-02-16 Eisai R & Amp D Man Co Ltd Prodrug of triazolone compound
ES2483802T3 (es) 2010-07-07 2014-08-07 The Medicines Company (Leipzig) Gmbh Inhibidores de serina proteasa
EP2844660B1 (en) 2012-05-02 2017-11-01 Southern Research Institute Triazolopyridazine compounds, use as inhibitors of the kinase lrrk2, and methods for preparation thereof
CA2939219C (en) 2014-02-11 2023-02-28 Mitokinin Llc Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
US10023579B2 (en) 2015-12-16 2018-07-17 Southern Research Institute Pyrrolopyrimidine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof
WO2018094227A1 (en) 2016-11-17 2018-05-24 The University Of North Carolina At Chapel Hill Alkyl pyrrolopyrimidine analogs and methods of making and using same
US10450263B2 (en) 2017-02-10 2019-10-22 Southern Research Institute Benzo annulenes as antiviral agents
US11160826B1 (en) 2017-03-03 2021-11-02 United States Government As Represented By The Department Of Veterans Affairs Cholesterol lowering drugs for the treatment of hepatic encephalopathy
WO2018237145A1 (en) 2017-06-21 2018-12-27 Mitokinin, Inc. COMPOSITIONS AND METHODS USING THEM FOR THE TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE
CA3080193A1 (en) 2017-10-26 2019-05-02 Southern Research Institute Dipeptide analogs as tgf-beta inhibitors
WO2019089693A1 (en) 2017-10-31 2019-05-09 Southern Research Institute Substituted quinazoline sulfonamides as thioredoxin interacting protein (txnip) inhibitors
TW202010742A (zh) 2018-04-06 2020-03-16 美商百歐克斯製藥公司 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑
CA3097003A1 (en) 2018-04-19 2019-10-24 Southern Research Institute 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer
CN114502174A (zh) 2019-06-14 2022-05-13 南方研究院 2,4,7取代的-7-脱氮-2′-脱氧-2′-氟阿拉伯糖基核苷和核苷酸前药及其用途
JP2023520480A (ja) 2020-04-02 2023-05-17 サウザーン リサーチ インスチチュート アルファウイルスに対する強力な抗ウイルス剤としての新規2-ピリミドン類似体
US11753374B2 (en) 2020-11-18 2023-09-12 Southern Reserach Institute Compounds for the treatment of acute and chronic kidney disease
EP4247375A1 (en) 2020-11-18 2023-09-27 Southern Research Institute Compounds for the treatment of acute and chronic kidney disease
WO2023122212A2 (en) 2021-12-21 2023-06-29 Southern Research Institute Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of sars virus
WO2023147352A1 (en) 2022-01-27 2023-08-03 Trilink Biotechnologies, Llc Trinucleotide cap analogs and methods of use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
DE4342154A1 (de) 1993-12-10 1995-06-14 Behringwerke Ag Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
US5869501A (en) 1994-12-02 1999-02-09 Yamanouchi Pharmaceutical Co. Ltd Amidinonaphthyl derivative or salt thereof
ES2208737T3 (es) * 1995-03-10 2004-06-16 Berlex Laboratories, Inc. Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
WO1997049404A1 (en) * 1996-06-25 1997-12-31 Eli Lilly And Company Anticoagulant agents
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
TW542822B (en) * 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
WO1998046628A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
JP2002513412A (ja) * 1997-04-14 2002-05-08 シーオーアール セラピューティクス インコーポレイテッド 選択的Xa因子阻害剤
EP0977772A1 (en) * 1997-04-14 2000-02-09 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
AU6896398A (en) * 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
DE19718181A1 (de) 1997-04-30 1998-11-05 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
US5998424A (en) * 1997-06-19 1999-12-07 Dupont Pharmaceuticals Company Inhibitors of factor Xa with a neutral P1 specificity group
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
ATE307111T1 (de) * 1999-01-13 2005-11-15 Genentech Inc Serinprotease-inhibitoren

Also Published As

Publication number Publication date
ATE307111T1 (de) 2005-11-15
EP1144373A3 (en) 2002-01-02
NO20013462D0 (no) 2001-07-12
CA2356934A1 (en) 2000-07-20
BR0008755A (pt) 2007-05-29
CN1342139A (zh) 2002-03-27
ES2251363T3 (es) 2006-05-01
CZ20012508A3 (cs) 2002-02-13
EP1144373A2 (en) 2001-10-17
US20050186198A1 (en) 2005-08-25
AU771776B2 (en) 2004-04-01
IL144032A (en) 2006-06-11
PL350042A1 (en) 2002-10-21
US20030212071A1 (en) 2003-11-13
HUP0105077A2 (hu) 2002-05-29
HUP0105077A3 (en) 2005-04-28
MXPA01007038A (es) 2002-07-30
AU3345100A (en) 2000-08-01
CN100488947C (zh) 2009-05-20
JP2002534449A (ja) 2002-10-15
US20070037813A1 (en) 2007-02-15
NZ512736A (en) 2003-11-28
EP1144373B1 (en) 2005-10-19
US6919369B2 (en) 2005-07-19
DE60023266D1 (de) 2005-11-24
KR100838418B1 (ko) 2008-06-13
KR20010101852A (ko) 2001-11-15
IL144032A0 (en) 2002-04-21
WO2000041531A3 (en) 2001-08-16
DE60023266T2 (de) 2006-07-13
WO2000041531A2 (en) 2000-07-20
US6472393B1 (en) 2002-10-29

Similar Documents

Publication Publication Date Title
ATE307111T1 (de) Serinprotease-inhibitoren
PT1383731E (pt) Compostos de biarilo como inibidores de serina-protease
ATE268766T1 (de) Stickstoff enthaltende heterobicyclen als factor xa inhibitoren
DE60122750D1 (de) Amidine-inhibitoren der serine-proteasen
TR200103493T2 (tr) Metaloproteaz önleyicileri
NO20015462D0 (no) Anvendelse av fthalazinderivater
TW200637843A (en) Phenylglycinamide derivatives useful as anticoagulants
WO2004113278A3 (en) Acylsulfamide inhibitors of factor viia
TR200402535T4 (tr) Serin proteaz inhibitörleri.
TR199801569T2 (xx) Serin proteaz inhibit�rleri.
SE9602646D0 (sv) Pharmaceutically-useful compounds
ATE304532T1 (de) Inhibitoren von serin proteasen
NO20004698L (no) Quinoksalinoner som serin protease inhibitorer sÕ som faktor XA og trombin
GB0030303D0 (en) Compounds
EE200000322A (et) Uued ühendid
TR199801704T2 (xx) Serin proteaz inhibit�rleri.
DE60113252D1 (de) Inhibitoren von serin proteasen
EE200100315A (et) Amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena
SE0001803D0 (sv) New compounds i
BR0017074A (pt) Combinações de inibidor de ace-antagonista de vasopressina
IS7162A (is) Nýjar möndlusýruafleiður og notkun þeirra sem þrombínhemla
ATE290878T1 (de) Inhibierung von invasiver remodulierung
WO2003051831A3 (en) Protease inhibitors of the coagulation cascade isolated from dysidea sponges

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application