ATE307111T1 - Serinprotease-inhibitoren - Google Patents
Serinprotease-inhibitorenInfo
- Publication number
- ATE307111T1 ATE307111T1 AT00911572T AT00911572T ATE307111T1 AT E307111 T1 ATE307111 T1 AT E307111T1 AT 00911572 T AT00911572 T AT 00911572T AT 00911572 T AT00911572 T AT 00911572T AT E307111 T1 ATE307111 T1 AT E307111T1
- Authority
- AT
- Austria
- Prior art keywords
- serine protease
- protease inhibitors
- compounds
- factor
- kallikrein
- Prior art date
Links
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 108010054265 Factor VIIa Proteins 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 108060005987 Kallikrein Proteins 0.000 abstract 1
- 102000001399 Kallikrein Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 229940012414 factor viia Drugs 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11577299P | 1999-01-13 | 1999-01-13 | |
| US15202999P | 1999-09-01 | 1999-09-01 | |
| PCT/US2000/000673 WO2000041531A2 (en) | 1999-01-13 | 2000-01-11 | Serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE307111T1 true ATE307111T1 (de) | 2005-11-15 |
Family
ID=26813550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00911572T ATE307111T1 (de) | 1999-01-13 | 2000-01-11 | Serinprotease-inhibitoren |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US6472393B1 (de) |
| EP (1) | EP1144373B1 (de) |
| JP (1) | JP2002534449A (de) |
| KR (1) | KR100838418B1 (de) |
| CN (1) | CN100488947C (de) |
| AT (1) | ATE307111T1 (de) |
| AU (1) | AU771776B2 (de) |
| BR (1) | BR0008755A (de) |
| CA (1) | CA2356934A1 (de) |
| CZ (1) | CZ20012508A3 (de) |
| DE (1) | DE60023266T2 (de) |
| ES (1) | ES2251363T3 (de) |
| HU (1) | HUP0105077A3 (de) |
| IL (2) | IL144032A0 (de) |
| MX (1) | MXPA01007038A (de) |
| NO (1) | NO20013462L (de) |
| NZ (1) | NZ512736A (de) |
| PL (1) | PL350042A1 (de) |
| WO (1) | WO2000041531A2 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100488947C (zh) * | 1999-01-13 | 2009-05-20 | 杰南技术公司 | 丝氨酸蛋白酶抑制剂 |
| WO2001023349A1 (fr) * | 1999-09-30 | 2001-04-05 | Mitsubishi Chemical Corporation | Derives d'acylsulfonamide |
| WO2002034711A1 (en) | 2000-10-20 | 2002-05-02 | Biocryst Pharmaceuticals, Inc. | Biaryl compounds as serine protease inhibitors |
| EP1364960A4 (de) * | 2001-02-02 | 2005-05-18 | Chugai Pharmaceutical Co Ltd | Peptidderivate |
| DE10130374A1 (de) * | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Substituierte N-Acyl-anilinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| US7838560B2 (en) * | 2002-03-11 | 2010-11-23 | The Medicines Company (Leipzig) Gmbh | Urokinase inhibitors, production and use thereof |
| GB0207637D0 (en) * | 2002-04-02 | 2002-05-15 | Karobio Ab | Novel compound |
| WO2003101941A2 (en) * | 2002-05-31 | 2003-12-11 | Genzyme Corporation | Alpha acyloxyacetamides for kallikrein and urokinase inhibition |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| EP1594845A4 (de) * | 2003-02-11 | 2008-05-21 | Bristol Myers Squibb Co | Als serinproteaseinhibitoren geeignete benzolacetamidverbindungen |
| EP1594505A4 (de) * | 2003-02-11 | 2008-08-13 | Bristol Myers Squibb Co | Phenylglycin-derivate als serin-protease-hemmer |
| WO2004113316A1 (en) * | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Benzofuran inhibitors of factor viia |
| US7250447B2 (en) | 2003-05-20 | 2007-07-31 | Genentech, Inc. | Acylsulfamide inhibitors of factor VIIa |
| DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| ATE479676T1 (de) * | 2005-01-10 | 2010-09-15 | Bristol Myers Squibb Co | Als antikoagulanzien verwendbare phenylglycinamid-derivate |
| EP2537520A1 (de) | 2005-03-29 | 2012-12-26 | Biocryst Pharmaceuticals, Inc. | Hepatits-C-Therapien |
| AU2006202083A1 (en) * | 2005-06-03 | 2006-12-21 | Reto Brun | Linear dicationic terphenyls and their aza analogues as antiparasitic agents |
| US7964619B2 (en) * | 2005-06-03 | 2011-06-21 | The University Of North Carolina At Chapel Hill | Teraryl components as antiparasitic agents |
| US7456195B2 (en) * | 2005-06-24 | 2008-11-25 | Bristol-Myers Squibb Company | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants |
| CA2647423C (en) | 2006-03-24 | 2015-02-17 | Eisai R&D Management Co., Ltd. | Triazolone derivative |
| US7776832B2 (en) | 2006-04-21 | 2010-08-17 | Gem Pharmaceuticals, Llc | Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines |
| DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| TW200831080A (en) * | 2006-12-15 | 2008-08-01 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
| SI2114980T1 (sl) | 2007-01-12 | 2012-11-30 | Biocryst Pharm Inc | Protivirusni nukleozidni analogi |
| KR101519028B1 (ko) | 2007-04-13 | 2015-05-11 | 써던 리서취 인스티튜트 | 항혈관형성제 및 사용방법 |
| EP2178849A1 (de) * | 2007-07-31 | 2010-04-28 | Mallinckrodt Inc. | Integrierte photoaktive wirkstoffe und ihre verwendung |
| WO2009038157A1 (ja) | 2007-09-21 | 2009-03-26 | Eisai R & D Management Co., Ltd. | ２，３－ジヒドロ－イミノイソインドール誘導体 |
| TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| WO2010036407A2 (en) | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
| KR20120093754A (ko) | 2009-03-10 | 2012-08-23 | 메드 디스커버리 에스에이 | 세린 프로테아제 저해제의 호중구감소증 치료에서의 용도 |
| TW201206905A (en) | 2010-05-20 | 2012-02-16 | Eisai R & Amp D Man Co Ltd | Prodrug of triazolone compound |
| WO2012004678A2 (en) | 2010-07-07 | 2012-01-12 | The Medicines Company (Leipzig) Gmbh | Serine protease inhibitors |
| US9187484B2 (en) | 2012-05-02 | 2015-11-17 | Southern Research Institute | Triazolopyridazine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof |
| CA2939219C (en) | 2014-02-11 | 2023-02-28 | Mitokinin Llc | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| CN108934162A (zh) | 2015-12-16 | 2018-12-04 | 南方研究所 | 吡咯并嘧啶化合物、作为激酶lrrk2抑制剂的用途及其制备方法 |
| CN110177553A (zh) | 2016-11-17 | 2019-08-27 | 北卡罗来纳大学教堂山分校 | 烷基吡咯并嘧啶类似物及其制备和使用方法 |
| US10450263B2 (en) | 2017-02-10 | 2019-10-22 | Southern Research Institute | Benzo annulenes as antiviral agents |
| US11160826B1 (en) | 2017-03-03 | 2021-11-02 | United States Government As Represented By The Department Of Veterans Affairs | Cholesterol lowering drugs for the treatment of hepatic encephalopathy |
| KR20200019228A (ko) | 2017-06-21 | 2020-02-21 | 미토키닌, 인크. | 신경퇴행성 및 미토콘드리아 질환의 치료를 위한 조성물 및 이를 사용하는 방법 |
| WO2019084455A1 (en) | 2017-10-26 | 2019-05-02 | Southern Research Institute | DIPEPTIDE ANALOGS AS TGF-BETA INHIBITORS |
| DK3551188T3 (da) | 2017-10-31 | 2024-01-08 | Southern Res Inst | Substituerede quinazolinsulfonamider som hæmmere af thioredoxin-interagerende protein (txnip) |
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| AU2019256465B2 (en) | 2018-04-19 | 2024-10-03 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| AU2019351731A1 (en) | 2018-10-02 | 2021-05-20 | The United States Government As Represented By The Department Of Veterans Affairs | Spak kinase inhibitors as neuroprotective agents |
| US20220251134A1 (en) | 2019-06-14 | 2022-08-11 | Southern Research Institute | 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof |
| CN114641295A (zh) | 2019-09-17 | 2022-06-17 | 犹他大学研究基金会 | 苯并咪唑及其使用方法 |
| UY38912A (es) | 2019-10-09 | 2021-05-31 | Biocryst Pharm Inc | Inhibidores del factor d del complemento para administración oral |
| AU2020396100A1 (en) | 2019-12-04 | 2022-06-16 | Southern Research Institute | Modulators of Programmed Death-Ligand-1 and/or Programmed Death-Ligand-2 |
| EP4125845A4 (de) | 2020-04-02 | 2024-05-15 | Southern Research Institute | Neue 2-pyrimidonanaloga als wirksame antivirale mittel gegen alphaviren |
| AR121715A1 (es) | 2020-04-03 | 2022-06-29 | Biocryst Pharm Inc | Pirrolopirimidinaminas como inhibidores del sistema del complemento |
| WO2021222637A1 (en) | 2020-04-30 | 2021-11-04 | United States Government As Represented By The Department Of Veterans Affairs | Krüppel-like factor 15 (klf15) small molecule agonists in kidney disease |
| CA3194653A1 (en) | 2020-10-02 | 2022-04-07 | Mitokinin, Inc. | Compositions and methods of treating kidney disease and fibrosis |
| WO2022109066A1 (en) | 2020-11-18 | 2022-05-27 | Southern Research Institute | Compounds for the treatment of acute and chronic kidney disease |
| US11623918B2 (en) | 2020-11-18 | 2023-04-11 | Southern Research Institute | Compounds for the treatment of acute and chronic kidney disease |
| WO2023076392A1 (en) | 2021-10-26 | 2023-05-04 | Southern Research Institute | Development of novel clofarabine analogs for cancer therapy |
| WO2023122212A2 (en) | 2021-12-21 | 2023-06-29 | Southern Research Institute | Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of sars virus |
| WO2023147352A1 (en) | 2022-01-27 | 2023-08-03 | Trilink Biotechnologies, Llc | Trinucleotide cap analogs and methods of use thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| DE4342154A1 (de) | 1993-12-10 | 1995-06-14 | Behringwerke Ag | Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien |
| NZ296210A (en) | 1994-12-02 | 1998-05-27 | Yamanouchi Pharma Co Ltd | Amidinonaphthyl derivatives to inhibit activated blood coagulation factor x |
| DE69630214T2 (de) * | 1995-03-10 | 2004-07-15 | Berlex Laboratories, Inc., Richmond | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien |
| WO1997049404A1 (en) * | 1996-06-25 | 1997-12-31 | Eli Lilly And Company | Anticoagulant agents |
| US6020357A (en) * | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| TW542822B (en) * | 1997-01-17 | 2003-07-21 | Ajinomoto Kk | Benzamidine derivatives |
| NZ500353A (en) * | 1997-04-14 | 2002-02-01 | Cor Therapeutics Inc | Cyclic diaza compounds that are selective inhibitors of factor Xa |
| AU741099B2 (en) * | 1997-04-14 | 2001-11-22 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
| AU6896398A (en) * | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| AU747531B2 (en) | 1997-04-14 | 2002-05-16 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
| DE19718181A1 (de) * | 1997-04-30 | 1998-11-05 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US5998424A (en) * | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
| EP0987274A1 (de) * | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Faktor VIIa Inhibitore |
| CN100488947C (zh) * | 1999-01-13 | 2009-05-20 | 杰南技术公司 | 丝氨酸蛋白酶抑制剂 |
-
2000
- 2000-01-11 CN CNB008044228A patent/CN100488947C/zh not_active Expired - Fee Related
- 2000-01-11 DE DE60023266T patent/DE60023266T2/de not_active Expired - Lifetime
- 2000-01-11 US US09/509,104 patent/US6472393B1/en not_active Expired - Fee Related
- 2000-01-11 BR BRPI0008755-6A patent/BR0008755A/pt not_active Application Discontinuation
- 2000-01-11 MX MXPA01007038A patent/MXPA01007038A/es active IP Right Grant
- 2000-01-11 WO PCT/US2000/000673 patent/WO2000041531A2/en not_active Ceased
- 2000-01-11 HU HU0105077A patent/HUP0105077A3/hu not_active Application Discontinuation
- 2000-01-11 KR KR1020017008804A patent/KR100838418B1/ko not_active Expired - Fee Related
- 2000-01-11 ES ES00911572T patent/ES2251363T3/es not_active Expired - Lifetime
- 2000-01-11 AT AT00911572T patent/ATE307111T1/de not_active IP Right Cessation
- 2000-01-11 EP EP00911572A patent/EP1144373B1/de not_active Expired - Lifetime
- 2000-01-11 NZ NZ512736A patent/NZ512736A/en not_active IP Right Cessation
- 2000-01-11 IL IL14403200A patent/IL144032A0/xx active IP Right Grant
- 2000-01-11 CZ CZ20012508A patent/CZ20012508A3/cs unknown
- 2000-01-11 PL PL00350042A patent/PL350042A1/xx not_active Application Discontinuation
- 2000-01-11 JP JP2000593153A patent/JP2002534449A/ja active Pending
- 2000-01-11 CA CA002356934A patent/CA2356934A1/en not_active Abandoned
- 2000-01-11 AU AU33451/00A patent/AU771776B2/en not_active Ceased
-
2001
- 2001-06-27 IL IL144032A patent/IL144032A/en not_active IP Right Cessation
- 2001-07-12 NO NO20013462A patent/NO20013462L/no not_active Application Discontinuation
-
2002
- 2002-08-19 US US10/224,114 patent/US6919369B2/en not_active Expired - Fee Related
-
2005
- 2005-03-24 US US11/088,511 patent/US20050186198A1/en not_active Abandoned
-
2006
- 2006-09-29 US US11/537,482 patent/US20070037813A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6472393B1 (en) | 2002-10-29 |
| HUP0105077A2 (hu) | 2002-05-29 |
| CN100488947C (zh) | 2009-05-20 |
| IL144032A0 (en) | 2002-04-21 |
| AU3345100A (en) | 2000-08-01 |
| KR100838418B1 (ko) | 2008-06-13 |
| WO2000041531A3 (en) | 2001-08-16 |
| US6919369B2 (en) | 2005-07-19 |
| AU771776B2 (en) | 2004-04-01 |
| NO20013462L (no) | 2001-09-12 |
| US20050186198A1 (en) | 2005-08-25 |
| BR0008755A (pt) | 2007-05-29 |
| CA2356934A1 (en) | 2000-07-20 |
| CZ20012508A3 (cs) | 2002-02-13 |
| IL144032A (en) | 2006-06-11 |
| MXPA01007038A (es) | 2002-07-30 |
| KR20010101852A (ko) | 2001-11-15 |
| EP1144373B1 (de) | 2005-10-19 |
| US20030212071A1 (en) | 2003-11-13 |
| DE60023266D1 (de) | 2005-11-24 |
| JP2002534449A (ja) | 2002-10-15 |
| CN1342139A (zh) | 2002-03-27 |
| NO20013462D0 (no) | 2001-07-12 |
| NZ512736A (en) | 2003-11-28 |
| PL350042A1 (en) | 2002-10-21 |
| HUP0105077A3 (en) | 2005-04-28 |
| EP1144373A2 (de) | 2001-10-17 |
| US20070037813A1 (en) | 2007-02-15 |
| WO2000041531A2 (en) | 2000-07-20 |
| ES2251363T3 (es) | 2006-05-01 |
| DE60023266T2 (de) | 2006-07-13 |
| EP1144373A3 (de) | 2002-01-02 |
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