NO179044C - Fremgangsmåte for fremstilling av et glykosaminoglykanmodifisert protein - Google Patents
Fremgangsmåte for fremstilling av et glykosaminoglykanmodifisert proteinInfo
- Publication number
- NO179044C NO179044C NO904378A NO904378A NO179044C NO 179044 C NO179044 C NO 179044C NO 904378 A NO904378 A NO 904378A NO 904378 A NO904378 A NO 904378A NO 179044 C NO179044 C NO 179044C
- Authority
- NO
- Norway
- Prior art keywords
- glycosaminoglycan
- modified protein
- preparation
- protein
- glycosaminoglycan modified
- Prior art date
Links
- 229920002683 Glycosaminoglycan Polymers 0.000 title abstract 2
- 102000035118 modified proteins Human genes 0.000 title 1
- 108091005573 modified proteins Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Materials Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2081163A JP2975632B2 (ja) | 1990-03-30 | 1990-03-30 | グリコサミノグリカン修飾プロテイン |
Publications (4)
Publication Number | Publication Date |
---|---|
NO904378D0 NO904378D0 (no) | 1990-10-10 |
NO904378L NO904378L (no) | 1991-10-01 |
NO179044B NO179044B (no) | 1996-04-15 |
NO179044C true NO179044C (no) | 1996-07-24 |
Family
ID=13738789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO904378A NO179044C (no) | 1990-03-30 | 1990-10-10 | Fremgangsmåte for fremstilling av et glykosaminoglykanmodifisert protein |
Country Status (12)
Country | Link |
---|---|
US (1) | US5310881A (ko) |
EP (1) | EP0454898B1 (ko) |
JP (1) | JP2975632B2 (ko) |
KR (1) | KR100188382B1 (ko) |
AT (1) | ATE135375T1 (ko) |
AU (1) | AU649416B2 (ko) |
CA (1) | CA2027447A1 (ko) |
DE (1) | DE69025920T2 (ko) |
DK (1) | DK0454898T3 (ko) |
ES (1) | ES2083989T3 (ko) |
FI (1) | FI102836B1 (ko) |
NO (1) | NO179044C (ko) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE116546T1 (de) * | 1991-03-07 | 1995-01-15 | Kanto Ishi Pharma Co Ltd | Colominsäure und produkte einer teilweisen hydrolyse von colominsäure zur herstellung von arzneimitteln zur behandlung von hepatitis, nephritis und arthritis. |
GB9112212D0 (en) * | 1991-06-06 | 1991-07-24 | Gregoriadis Gregory | Pharmaceutical compositions |
US5846951A (en) * | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
GB2266239B (en) * | 1992-03-25 | 1996-03-06 | Jevco Ltd | Wound healing compositions containing chondroitin sulphate oligosaccharides |
CA2091544A1 (en) * | 1992-03-26 | 1993-09-27 | Shing F. Kwan | Stabilization of functional proteins |
HU217872B (hu) * | 1994-02-23 | 2000-04-28 | Kyowa Hakko Kogyo Co., Ltd. | Polipeptid alkalmazása vérlemezke termelődést elősegítő gyógyszer előállítására |
WO1995030432A1 (en) * | 1994-05-09 | 1995-11-16 | Boehringer Mannheim Gmbh | Use of chondroitin sulphate proteoglycans for protection of neurons |
US6228998B1 (en) | 1994-07-22 | 2001-05-08 | Seikagaku Kogyo Kabushiki Kaisha | Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide |
US5912000A (en) * | 1994-09-23 | 1999-06-15 | Zonagen, Inc. | Chitosan induced immunopotentiation |
PT789590E (pt) * | 1994-09-23 | 2002-12-31 | Zonagen Inc | Imunopotenciacao induzida por quitosano |
US5677276A (en) * | 1994-12-23 | 1997-10-14 | La Jolla Cancer Research Foundation | Immobilization of peptides to hyaluronate |
CA2232527C (en) * | 1995-09-19 | 2008-09-02 | Seikagaku Corporation | Anti-inflammatory agent |
US6491965B1 (en) * | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US6562781B1 (en) * | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
EP0972073A1 (en) * | 1996-09-25 | 2000-01-19 | Universal Healthwatch, Inc. | Diagnostic test devices with improved fluid movement and resistance to interferences |
AU6357900A (en) * | 1999-07-20 | 2001-02-05 | Amgen, Inc. | Hyaluronic acid-protein conjugates, pharmaceutical compositions and related methods |
ES2516041T3 (es) * | 2001-10-10 | 2014-10-30 | Ratiopharm Gmbh | Remodelación y glicoconjugación de la hormona del crecimiento humano (hGH) |
EP2305311A3 (en) * | 2001-10-10 | 2011-07-20 | BioGeneriX AG | Glycoconjugation of peptides |
DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
AU2003253399B2 (en) | 2002-09-11 | 2010-10-14 | Fresenius Kabi Deutschland Gmbh | Hasylated polypeptides, especially hasylated erythropoietin |
US8673333B2 (en) * | 2002-09-25 | 2014-03-18 | The Johns Hopkins University | Cross-linked polymer matrices, and methods of making and using same |
US7862831B2 (en) * | 2002-10-09 | 2011-01-04 | Synthasome, Inc. | Method and material for enhanced tissue-biomaterial integration |
WO2004029137A2 (en) * | 2002-09-25 | 2004-04-08 | Johns Hopkins University School Of Medicine | Cross-linked polymer matrices, and methods of making and using same |
WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
WO2005016949A2 (en) | 2003-08-12 | 2005-02-24 | Lipoxen Technologies Limited | Sialic acid derivatives |
WO2006089119A2 (en) * | 2005-02-18 | 2006-08-24 | Cartilix, Inc. | Biological adhesive |
EP1853634B1 (en) | 2005-02-23 | 2016-08-10 | Lipoxen Technologies Limited | Activated sialic acid derivatives for protein derivatisation and conjugation |
EP1886696A1 (en) * | 2006-08-03 | 2008-02-13 | Endotis Pharma | Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins |
US8658593B2 (en) | 2011-06-06 | 2014-02-25 | The Cleveland Clinic Foundation | Treatment of extracellular matrix to reduce inflammation |
JP6478115B2 (ja) * | 2013-09-30 | 2019-03-06 | 生化学工業株式会社 | タンパク質の血中滞留性の増強方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2824092A (en) * | 1955-01-04 | 1958-02-18 | Robert E Thompson | Process of preparation of a gelatincarboxymethyl cellulose complex |
GB1479268A (en) * | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
US4301153A (en) * | 1977-03-21 | 1981-11-17 | Riker Laboratories, Inc. | Heparin preparation |
CA1171375A (en) * | 1980-09-15 | 1984-07-24 | Ulf P.F. Lindahl | Oligosaccharides having selective anticoagulation activity |
US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
NL188622C (nl) * | 1981-12-15 | 1992-08-17 | Cordis Europ | Werkwijze ter verbetering van de bloedcompatibiliteit van een materiaaloppervlak door bekleding daarvan met een heparine of heparine-analoga en een eiwit houdende film, alsmede voorwerp, omvattende een oppervlak met verbeterde bloedcompatibiliteit verkregen onder toepassing van een op het oppervlak aangebrachte heparine of heparine-analoga en een eiwit houdende film. |
US4526714A (en) * | 1982-12-13 | 1985-07-02 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
SE8200751L (sv) * | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
US4585754A (en) * | 1984-01-09 | 1986-04-29 | Valcor Scientific, Ltd. | Stabilization of proteins and peptides by chemical binding with chondroitin |
US4863907A (en) * | 1984-06-29 | 1989-09-05 | Seikagaku Kogyo Co., Ltd. | Crosslinked glycosaminoglycans and their use |
DE3680524D1 (de) * | 1986-04-22 | 1991-08-29 | Valcor Scient Ltd | Verfahren zur stabilisierung von proteinen. |
US4745180A (en) * | 1986-06-27 | 1988-05-17 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using heparin fragments |
DE3636590A1 (de) * | 1986-10-28 | 1988-05-26 | Braun Melsungen Ag | Blutersatzmittel |
FR2631970B1 (fr) * | 1988-05-24 | 1993-12-24 | Sanofi | N-polyosyl-polypeptides |
DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
WO1990001332A1 (en) * | 1988-08-10 | 1990-02-22 | Cetus Corporation | Plasminogen activator-heparin conjugates |
-
1990
- 1990-03-30 JP JP2081163A patent/JP2975632B2/ja not_active Expired - Lifetime
- 1990-10-10 AU AU64506/90A patent/AU649416B2/en not_active Ceased
- 1990-10-10 NO NO904378A patent/NO179044C/no unknown
- 1990-10-11 FI FI905003A patent/FI102836B1/fi not_active IP Right Cessation
- 1990-10-12 CA CA002027447A patent/CA2027447A1/en not_active Abandoned
- 1990-10-12 AT AT90119607T patent/ATE135375T1/de active
- 1990-10-12 DE DE69025920T patent/DE69025920T2/de not_active Expired - Fee Related
- 1990-10-12 EP EP90119607A patent/EP0454898B1/en not_active Expired - Lifetime
- 1990-10-12 ES ES90119607T patent/ES2083989T3/es not_active Expired - Lifetime
- 1990-10-12 KR KR1019900016160A patent/KR100188382B1/ko not_active IP Right Cessation
- 1990-10-12 DK DK90119607.1T patent/DK0454898T3/da active
-
1992
- 1992-07-02 US US07/908,910 patent/US5310881A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2975632B2 (ja) | 1999-11-10 |
FI905003A0 (fi) | 1990-10-11 |
JPH03284698A (ja) | 1991-12-16 |
AU649416B2 (en) | 1994-05-26 |
US5310881A (en) | 1994-05-10 |
AU6450690A (en) | 1991-10-31 |
ES2083989T3 (es) | 1996-05-01 |
ATE135375T1 (de) | 1996-03-15 |
FI102836B (fi) | 1999-02-26 |
FI905003A (fi) | 1991-10-01 |
NO904378D0 (no) | 1990-10-10 |
KR910016770A (ko) | 1991-11-05 |
CA2027447A1 (en) | 1991-10-01 |
DE69025920T2 (de) | 1996-08-14 |
FI102836B1 (fi) | 1999-02-26 |
DE69025920D1 (de) | 1996-04-18 |
EP0454898A1 (en) | 1991-11-06 |
DK0454898T3 (da) | 1996-04-15 |
NO179044B (no) | 1996-04-15 |
KR100188382B1 (ko) | 1999-06-01 |
EP0454898B1 (en) | 1996-03-13 |
NO904378L (no) | 1991-10-01 |
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