NO178374C - Analogifremgangsmåte for fremstilling av nye terapeutisk aktive acetylcholinesteraseinhibitorer - Google Patents

Analogifremgangsmåte for fremstilling av nye terapeutisk aktive acetylcholinesteraseinhibitorer

Info

Publication number
NO178374C
NO178374C NO902776A NO902776A NO178374C NO 178374 C NO178374 C NO 178374C NO 902776 A NO902776 A NO 902776A NO 902776 A NO902776 A NO 902776A NO 178374 C NO178374 C NO 178374C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
acetylcholinesterase inhibitors
analogous process
new therapeutically
Prior art date
Application number
NO902776A
Other languages
English (en)
Norwegian (no)
Other versions
NO902776L (no
NO902776D0 (no
NO178374B (no
Inventor
Daniel Schirlin
Jean-Noel Collard
Jean-Marie Hornsperger
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO902776D0 publication Critical patent/NO902776D0/no
Publication of NO902776L publication Critical patent/NO902776L/no
Publication of NO178374B publication Critical patent/NO178374B/no
Publication of NO178374C publication Critical patent/NO178374C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
NO902776A 1989-06-22 1990-06-21 Analogifremgangsmåte for fremstilling av nye terapeutisk aktive acetylcholinesteraseinhibitorer NO178374C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89401775A EP0403713A1 (fr) 1989-06-22 1989-06-22 Inhibiteurs d'acétylcholinestérase

Publications (4)

Publication Number Publication Date
NO902776D0 NO902776D0 (no) 1990-06-21
NO902776L NO902776L (no) 1990-12-27
NO178374B NO178374B (no) 1995-12-04
NO178374C true NO178374C (no) 1996-03-13

Family

ID=8202963

Family Applications (1)

Application Number Title Priority Date Filing Date
NO902776A NO178374C (no) 1989-06-22 1990-06-21 Analogifremgangsmåte for fremstilling av nye terapeutisk aktive acetylcholinesteraseinhibitorer

Country Status (19)

Country Link
EP (2) EP0403713A1 (fr)
JP (1) JP2879951B2 (fr)
KR (1) KR0139529B1 (fr)
CN (1) CN1027759C (fr)
AR (1) AR247214A1 (fr)
AT (1) ATE119535T1 (fr)
AU (1) AU626428B2 (fr)
CA (1) CA2019231C (fr)
DE (1) DE69017543T2 (fr)
DK (1) DK0409676T3 (fr)
ES (1) ES2072406T3 (fr)
FI (1) FI97619C (fr)
HU (1) HU210569B (fr)
IE (1) IE66155B1 (fr)
IL (1) IL94779A (fr)
NO (1) NO178374C (fr)
NZ (1) NZ234136A (fr)
PT (1) PT94449B (fr)
ZA (1) ZA904715B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0611769A1 (fr) * 1993-02-16 1994-08-24 Merrell Dow Pharmaceuticals Inc. Inhibiteurs d'acétylcholinerase silylés
US5523442A (en) * 1993-02-16 1996-06-04 Merrell Pharmaceuticals Inc. Silylated acetylcholinesterase inhibitors
EP0627400A1 (fr) * 1993-06-04 1994-12-07 Merrell Dow Pharmaceuticals Inc. Inhibiteurs aromatiques d'acétylcholinesterase
US5554780A (en) * 1994-05-05 1996-09-10 Merrell Pharmaceuticals Inc. Process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives
US5486638A (en) * 1994-11-08 1996-01-23 Marion Merrell Dow Inc. Process for the preparation of 1-halo-3-trialkysilanyl-benzene derivatives
EP0749972A1 (fr) 1995-06-21 1996-12-27 Merrell Pharmaceuticals Inc. Procédé de préparation de dérivées de 1-(3-trialkylsilylphényl)-2,2,2-trifluorométhyléthanone
US6673784B1 (en) 1996-03-19 2004-01-06 G. D. Searle & Co. Electrophilic ketones for the treatment of herpesvirus infections
CN1059702C (zh) * 1997-12-30 2000-12-20 中国科学院上海细胞生物学研究所 从哺乳类细胞中获得脑型乙酰胆碱酯酶的方法
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US6084117A (en) * 1999-11-22 2000-07-04 Albemarle Corporation Production of silated haloarenes by selective silylation of polyhaloarenes
EP2533645B1 (fr) 2010-02-09 2016-07-27 The Johns Hopkins University Procédés et compositions pour améliorer la fonction cognitive
EP2919788A4 (fr) 2012-11-14 2016-05-25 Univ Johns Hopkins Méthodes et compositions pour le traitement de la schizophrénie
MX362886B (es) 2012-12-13 2019-02-22 H Lundbeck As Composición sinérgica que comprende vortioxetina y donepezilo para incrementar los niveles de acetilcolina en el cerebro, y el uso de la misma en el tratamiento de una disfunción cognitiva.
DK2968220T3 (da) 2013-03-15 2021-06-14 Agenebio Inc Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
EP2968237A4 (fr) 2013-03-15 2016-08-31 Univ Johns Hopkins Procédés et compositions pour améliorer la fonction cognitive
BR112017025031B1 (pt) 2015-05-22 2023-03-21 Agenebio, Inc Composições farmacêuticas de liberação prolongada de levetiracetam

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL25820A (en) * 1966-05-22 1971-02-25 Yissum Res Dev Co Silicon containing beta-hydroxy alpha-phenyl carboxylic acids,their amide and ester derivatives and intermediates for their preparation
US4835099A (en) * 1986-11-20 1989-05-30 Becton, Dickinson And Company Signal enhancement in immunoassay by modulation of enzymatic catalysis

Also Published As

Publication number Publication date
HU210569B (en) 1995-05-29
DK0409676T3 (da) 1995-03-27
AU5758490A (en) 1991-01-03
FI903104A0 (fi) 1990-06-20
EP0409676A1 (fr) 1991-01-23
HUT54695A (en) 1991-03-28
KR910000757A (ko) 1991-01-30
AU626428B2 (en) 1992-07-30
CA2019231A1 (fr) 1990-12-22
CN1027759C (zh) 1995-03-01
NO902776L (no) 1990-12-27
IL94779A (en) 1996-09-12
JPH0338591A (ja) 1991-02-19
ZA904715B (en) 1991-04-24
ATE119535T1 (de) 1995-03-15
JP2879951B2 (ja) 1999-04-05
NZ234136A (en) 1994-04-27
CN1048389A (zh) 1991-01-09
DE69017543T2 (de) 1995-07-06
EP0403713A1 (fr) 1990-12-27
IE902252A1 (en) 1991-01-16
FI97619B (fi) 1996-10-15
NO902776D0 (no) 1990-06-21
HU903933D0 (en) 1990-11-28
CA2019231C (fr) 2000-07-11
EP0409676B1 (fr) 1995-03-08
IE66155B1 (en) 1995-12-13
IE902252L (en) 1990-12-22
PT94449A (pt) 1991-02-08
ES2072406T3 (es) 1995-07-16
FI97619C (fi) 1997-01-27
PT94449B (pt) 1997-02-28
KR0139529B1 (ko) 1998-07-01
DE69017543D1 (de) 1995-04-13
NO178374B (no) 1995-12-04
AR247214A1 (es) 1994-11-30

Similar Documents

Publication Publication Date Title
NO179584C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler
NO179639C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte piperidinforbindelser
NO170023C (no) Analogifremgangsmaate for fremstilling av nye terapeutisk aktive alfa-glucosidaseinhibitorer
NO177387C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive imidazo-kondenserte, 6-leddede, heterocykliske forbindelser
NO180586C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte imidazoler
NO175978C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-aza-bicykliske forbindelser
FI96861C (fi) Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
NO176759C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-substituerte-2-oksindol-derivater
NO178619C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive di-t-butylfenoler
NO179448C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive forbindelser
NO179283C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte azoler
NO178374C (no) Analogifremgangsmåte for fremstilling av nye terapeutisk aktive acetylcholinesteraseinhibitorer
NO175100C (no) Analogifremgangsmåte til fremstilling av terapeutisk aktive 4(3H)-pteridinoner
NO176273C (no) Analogifremgangsmåte for fremstilling av aktive substituerte benzamider
NO177096C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner
NO173334C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
FI93444B (fi) Menetelmä terapeuttisesti aktiivisten dihydropyridiinijohdannaisten valmistamiseksi
NO175976C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 4-(1,6-dihydro-6-okso-pyridazinyl-3-oksy)-3-kromanolderivater
NO174892C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte dihydropyrrolizinforbindelser
NO174391C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater
NO173607C (no) Analogifremgangsmaate for fremstilling av nye terapeutisk aktive tienotriazolo-diazepin-derivater
NO174203C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive
NO178698C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive glycerolderivater
NO177712C (no) Analogifremgangsmåte for fremstilling av nye terapeutisk virksomme alkylfosfonoseriner
NO174774C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive benzodiazepiner

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN DECEMBER 2000