NO177712C - Analogifremgangsmåte for fremstilling av nye terapeutisk virksomme alkylfosfonoseriner - Google Patents

Analogifremgangsmåte for fremstilling av nye terapeutisk virksomme alkylfosfonoseriner

Info

Publication number
NO177712C
NO177712C NO904416A NO904416A NO177712C NO 177712 C NO177712 C NO 177712C NO 904416 A NO904416 A NO 904416A NO 904416 A NO904416 A NO 904416A NO 177712 C NO177712 C NO 177712C
Authority
NO
Norway
Prior art keywords
alkylphosphonoserines
preparation
therapeutically effective
analogous process
novel therapeutically
Prior art date
Application number
NO904416A
Other languages
English (en)
Other versions
NO177712B (no
NO904416L (no
NO904416D0 (no
Inventor
Hans Brachwitz
Reinhild Schonfeld
Peter Langen
Friedrich Paltauf
Albin Hermetter
Original Assignee
Asta Medica Ag
Hafslund Nycomed Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DD31486888A external-priority patent/DD299727A7/de
Priority claimed from DD31835988A external-priority patent/DD289892A7/de
Application filed by Asta Medica Ag, Hafslund Nycomed Pharma filed Critical Asta Medica Ag
Publication of NO904416L publication Critical patent/NO904416L/no
Publication of NO904416D0 publication Critical patent/NO904416D0/no
Publication of NO177712B publication Critical patent/NO177712B/no
Publication of NO177712C publication Critical patent/NO177712C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO904416A 1988-04-19 1990-10-12 Analogifremgangsmåte for fremstilling av nye terapeutisk virksomme alkylfosfonoseriner NO177712C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DD31486888A DD299727A7 (de) 1988-04-19 1988-04-19 Alkyl- und alkenylphospho-l-serine, verfahren zu ihrer herstellung und verwendung
DD31835988A DD289892A7 (de) 1988-07-27 1988-07-27 Verfahren zur herstellung von alkylphosphonserinen
PCT/EP1989/000393 WO1989010370A1 (en) 1988-04-19 1989-04-13 New alkylphosphono- and phosphoserines, method for preparing them, and pharmaceutical substances containing them

Publications (4)

Publication Number Publication Date
NO904416L NO904416L (no) 1990-10-12
NO904416D0 NO904416D0 (no) 1990-10-12
NO177712B NO177712B (no) 1995-07-31
NO177712C true NO177712C (no) 1995-11-08

Family

ID=25748200

Family Applications (1)

Application Number Title Priority Date Filing Date
NO904416A NO177712C (no) 1988-04-19 1990-10-12 Analogifremgangsmåte for fremstilling av nye terapeutisk virksomme alkylfosfonoseriner

Country Status (11)

Country Link
US (1) US5155099A (no)
EP (2) EP0338407B1 (no)
JP (1) JPH03504965A (no)
DE (1) DE58904595D1 (no)
DK (1) DK167810B1 (no)
ES (1) ES2056998T3 (no)
FI (1) FI91966C (no)
GR (1) GR3008598T3 (no)
HU (1) HU204278B (no)
NO (1) NO177712C (no)
WO (1) WO1989010370A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5117034A (en) * 1989-10-24 1992-05-26 Fuji Photo Film Co., Ltd. Phosphatidylserine derivatives
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
WO1992019627A2 (en) * 1991-04-25 1992-11-12 The University Of British Columbia Phosphonates and phosphinates as anti-cancer, -inflammatory, -allergy and -myocarditis agents
US5506217A (en) * 1991-04-25 1996-04-09 The University Of British Columbia Phosphonates as anti-cancer agents
DE4132344A1 (de) * 1991-09-27 1993-04-01 Max Planck Gesellschaft Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis
US6254879B1 (en) 1991-09-27 2001-07-03 Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. Methods of treating protozoal diseases
DE4229877C2 (de) * 1992-09-04 1994-09-15 Max Delbrueck Centrum Phospho- bzw. Phosphono-(N-acyl)-serine und ihre Herstellung
WO2003024423A1 (en) * 2001-09-18 2003-03-27 Vasogen Ireland Limited Apoptosis-mimicking synthetic entities and use thereof in medical treatment
US6878532B1 (en) 2003-04-28 2005-04-12 Sioux Biochemical, Inc. Method of producing phosphatidylserine
US20100029903A1 (en) * 2005-12-14 2010-02-04 Novo Nordisk A/S Polypeptide Protracting Tags

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD238979A1 (de) * 1985-07-03 1986-09-10 Akad Wissenschaften Ddr Verfahren zur herstellung von o-alkylglycerophosphoserin-analogen
DD239405A1 (de) * 1985-07-15 1986-09-24 Akad Wissenschaften Ddr Verfahren zur herstellung von trifluoralkyl-glycerophospho-l-serinen
US4916249A (en) * 1985-07-03 1990-04-10 Hans Brachwitz Glycero-3(2)-phospho-L-serine derivatives and salts thereof
DD238978A1 (de) * 1985-07-03 1986-09-10 Akad Wissenschaften Ddr Verfahren zur herstellung von 2-o-alkyl-i-des oxy-1-halogenglycero-3-phospho-l-serinen
US4751320A (en) * 1985-11-27 1988-06-14 Kao Corporation Phosphoric ester and process for producing same
JPH064651B2 (ja) * 1985-11-27 1994-01-19 花王株式会社 リン酸エステルおよびその製造方法
DE3606633A1 (de) * 1986-02-28 1987-09-03 Max Planck Gesellschaft Neue phosphoverbindungen und diese enthaltende arzneimittel
JPH0761276B2 (ja) * 1986-11-14 1995-07-05 名糖産業株式会社 酵素法リン脂質−ｄ−セリン誘導体の製造法

Also Published As

Publication number Publication date
EP0338407A1 (de) 1989-10-25
NO177712B (no) 1995-07-31
FI91966B (fi) 1994-05-31
US5155099A (en) 1992-10-13
DK250090D0 (da) 1990-10-17
WO1989010370A1 (en) 1989-11-02
ES2056998T3 (es) 1994-10-16
HUT51632A (en) 1990-05-28
FI91966C (fi) 1994-09-12
DK250090A (da) 1990-10-17
EP0413700A1 (de) 1991-02-27
DE58904595D1 (de) 1993-07-15
NO904416L (no) 1990-10-12
HU204278B (en) 1991-12-30
DK167810B1 (da) 1993-12-20
JPH03504965A (ja) 1991-10-31
NO904416D0 (no) 1990-10-12
FI905051A0 (fi) 1990-10-15
GR3008598T3 (no) 1993-10-29
EP0338407B1 (de) 1993-06-09

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