NO165070C - Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydrobenztiazoler. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydrobenztiazoler.

Info

Publication number
NO165070C
NO165070C NO855195A NO855195A NO165070C NO 165070 C NO165070 C NO 165070C NO 855195 A NO855195 A NO 855195A NO 855195 A NO855195 A NO 855195A NO 165070 C NO165070 C NO 165070C
Authority
NO
Norway
Prior art keywords
group
phenyl
alkyl
hydrogen atom
alkenyl
Prior art date
Application number
NO855195A
Other languages
English (en)
Norwegian (no)
Other versions
NO165070B (no
NO855195L (no
Inventor
Gerhart Griss
Claus Schneider
Rudolf Hurnaus
Rudolf Bauer
Joachim Mierau
Dieter Hinzen
Guenter Schingnitz
Walter Kobinger
Ludwig Pichler
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25827684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO165070(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19843447075 external-priority patent/DE3447075A1/de
Priority claimed from DE19853508947 external-priority patent/DE3508947A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO855195L publication Critical patent/NO855195L/no
Publication of NO165070B publication Critical patent/NO165070B/no
Publication of NO165070C publication Critical patent/NO165070C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cereal-Derived Products (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO855195A 1984-12-22 1985-12-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydrobenztiazoler. NO165070C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843447075 DE3447075A1 (de) 1984-12-22 1984-12-22 Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
DE19853508947 DE3508947A1 (de) 1985-03-13 1985-03-13 Mittel zur behandlung des parkinsonismus bzw. der parkinsonschen-erkrankung

Publications (3)

Publication Number Publication Date
NO855195L NO855195L (no) 1986-06-23
NO165070B NO165070B (no) 1990-09-10
NO165070C true NO165070C (no) 1990-12-19

Family

ID=25827684

Family Applications (1)

Application Number Title Priority Date Filing Date
NO855195A NO165070C (no) 1984-12-22 1985-12-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydrobenztiazoler.

Country Status (25)

Country Link
US (3) US4731374A (fi)
EP (1) EP0186087B1 (fi)
KR (1) KR930009791B1 (fi)
AT (1) ATE45735T1 (fi)
AU (1) AU583874B2 (fi)
BG (1) BG62023B2 (fi)
CA (1) CA1263653A (fi)
CS (1) CS409991A3 (fi)
DE (1) DE3572485D1 (fi)
DK (1) DK168862B1 (fi)
ES (5) ES8702787A1 (fi)
FI (1) FI81787C (fi)
GR (1) GR853126B (fi)
HK (1) HK78692A (fi)
HU (1) HU193618B (fi)
IE (1) IE58863B1 (fi)
IL (1) IL77415A (fi)
LU (1) LU90208I2 (fi)
MX (1) MX9202792A (fi)
NL (1) NL980002I2 (fi)
NO (1) NO165070C (fi)
NZ (1) NZ214661A (fi)
PH (1) PH24533A (fi)
PT (1) PT81735B (fi)
SG (1) SG82492G (fi)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3620813A1 (de) * 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung
US4826860A (en) * 1987-03-16 1989-05-02 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
US4988699A (en) * 1989-03-14 1991-01-29 Warner-Lambert Company Substituted tetrahydrobenzothiazoles as dopaminergic agents
DE3923689A1 (de) * 1989-07-18 1991-01-24 Boehringer Ingelheim Kg Neue verwendung von tetrahydrobenzthiazolderivaten als arzneistoffe
DE3930282A1 (de) * 1989-09-11 1991-03-21 Boehringer Ingelheim Kg Verwendung von dopamin-autorezeptor-agonisten bei der behandlung von drogenabhaengigkeit
DE3937271A1 (de) * 1989-11-09 1991-05-16 Boehringer Ingelheim Kg Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol
FR2674853B1 (fr) * 1991-04-03 1995-01-20 Synthelabo Derives de piperidinylguanidine, leur preparation et leur application en therapeutique.
DE4241013A1 (de) 1992-12-05 1994-06-09 Boehringer Ingelheim Kg Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung
US5650420A (en) * 1994-12-15 1997-07-22 Pharmacia & Upjohn Company Pramipexole as a neuroprotective agent
US6156777A (en) * 1994-12-15 2000-12-05 Pharmacia & Upjohn Company Use of pramipexole as a neuroprotective agent
DE19507752A1 (de) * 1995-03-06 1996-09-12 Bayer Ag Verfahren zur Herstellung von substituierten Cyclohexanonen
DE19536916A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Kg Inhalative Applikation von 2-Amino-6n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol, insbesondere seines (-)-Enantiomeren, sowie deren pharmakologisch verträgliche Säureadditionssalze
DK0923542T3 (da) * 1996-05-31 2003-11-17 Upjohn Co Arylsubstituerede cycliske aminer som selektive dopamin-D3-ligander
DE19701619B4 (de) * 1997-01-17 2007-10-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Pramipexol zur Behandlung des restless legs syndroms
US6001861A (en) 1998-01-16 1999-12-14 Pharmacia & Upjohn Company Use of pramipexole in the treatment of restless legs syndrome
AU760439B2 (en) * 1998-05-15 2003-05-15 Pharmacia & Upjohn Company Cabergoline and pramipexole: new uses and combinations
SE9802360D0 (sv) 1998-07-01 1998-07-01 Wikstroem Hakan Vilhelm New 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins ((basic)-N-substituted and (basic)-N,N-disubstituted derivatives of 2,6-diamino-thiazolo(4,5-f)indan and 2,7-di-amino-thiazolo(4,5-g)tetralin
DE19830201A1 (de) * 1998-07-07 2000-01-13 Boehringer Ingelheim Pharma Mittel mit antidepressiver Wirkung
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
PE20011074A1 (es) 2000-02-23 2001-10-04 Upjohn Co Uso de pramipexol en el tratamiento de trastornos de adiccion
EP1303502A2 (en) * 2000-07-06 2003-04-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Tetrahydrobenzothiazole analogues as neuroprotective agents
US6277875B1 (en) 2000-07-17 2001-08-21 Andrew J. Holman Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
ES2187249B1 (es) 2000-09-18 2004-09-16 Synthon Bv Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
WO2002069974A1 (en) * 2001-03-05 2002-09-12 Andrew Holman Administration of sleep restorative agents
DE10137453A1 (de) * 2001-08-02 2003-02-20 Boehringer Ingelheim Pharma Pramlpexol als Antikonvulsivum
DE10138275A1 (de) * 2001-08-10 2003-02-27 Boehringer Ingelheim Pharma Verbindungen zur Beseitigung der Anhedonie
US20060281797A1 (en) * 2001-12-11 2006-12-14 University Of Virginia Patent Foundation Neurorestoration with R(+) Pramipexole
AU2002360600B2 (en) * 2001-12-11 2007-11-29 University Of Virginia Patent Foundation Use of pramipexole to treat amyotrophic lateral sclerosis
US20030166696A1 (en) * 2002-01-24 2003-09-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pramipexole for the treatment of HIV dementia
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US20050226926A1 (en) * 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
MY136318A (en) * 2002-07-25 2008-09-30 Pharmacia Corp Sustained-release tablet composition
PE20040134A1 (es) * 2002-07-25 2004-03-06 Pharmacia Corp Forma de dosificacion de una vez al dia de pramipexol
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
DE102004006808A1 (de) * 2004-02-11 2005-09-01 Grünenthal GmbH Substituierte 4,5,6,7-Tetrahydro-benzothiazol-2-ylamin-Verbindungen
WO2005092871A2 (en) 2004-03-19 2005-10-06 Dipharma S.P.A. Intermediates for the preparation of pramipexole
ES2245604B1 (es) 2004-06-25 2006-12-01 Ragactives, S. L. Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles.
WO2006012276A1 (en) * 2004-06-30 2006-02-02 Amr Technology, Inc. Process for preparing chirally pure 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoles by liquid chromatographic resolution
CA2553311A1 (en) * 2004-07-01 2006-01-12 Alembic Limited Improved process for the preparation of biologically active tetrahydrobenzthiazole derivative
US20080096939A1 (en) * 2004-07-03 2008-04-24 Andreas Keil Process For Preparation Of Pramipexole By Chiral Chromatography
UA93608C2 (ru) * 2004-08-13 2011-02-25 Берингер Ингельхайм Интернациональ Гмбх композициЯ таблетки пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, СПОСОБ EE ИЗГОТОВЛЕНИЯ И EE ПРИМЕНЕНИЕ
WO2006015943A2 (en) * 2004-08-13 2006-02-16 Boehringer Ingelheim International Gmbh Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
JP5122287B2 (ja) * 2004-10-07 2013-01-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Pi3キナーゼ
US20060148866A1 (en) * 2004-12-30 2006-07-06 Chemagis Ltd. Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
WO2006117614A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
EP1731514A1 (en) 2005-06-02 2006-12-13 Sandoz AG Process for the preparation of Pramipexole
DE602006009670D1 (de) * 2005-08-15 2009-11-19 Univ Virginia Neurorestauration mit r(+) pramipexol
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
JP2009511618A (ja) * 2005-10-18 2009-03-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中度から重度のむずむず脚症候群(rls)を治療するためのプラミペキソールの使用
WO2007072497A2 (en) * 2005-12-02 2007-06-28 Alembic Limited Stabilized pharmaceutical composition of pramipexole and method of preparation thereof
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US20090041844A1 (en) * 2006-02-10 2009-02-12 Boehringer Ingelheim International Gmbh Modified Release Formulation
US20090098202A1 (en) * 2006-02-10 2009-04-16 Boehringer Ingelheim International Gmbh Extended Release Formulation
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
CA2652251A1 (en) 2006-05-16 2007-11-29 Knopp Neurosciences, Inc. Compositions of r(+) and s(-) pramipexole and methods for using the same
EP2465500A1 (en) 2006-05-16 2012-06-20 Knopp Neurosciences, Inc. Therapeutically effective amounts of R(+) and S(-) pramipexole for use in the treatment of parkinson's disease
WO2007131804A1 (en) 2006-05-17 2007-11-22 Synthon B.V. Tablet composition with a prolonged release of tamsulosin
WO2008001200A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal composition having enhanced color stability
US20080254118A1 (en) * 2007-04-11 2008-10-16 Hans-Werner Wernersbach Process for preparing pramipexole dihydrochloride tablets
WO2008041240A1 (en) * 2006-10-03 2008-04-10 Cadila Healthcare Limited Process for preparing (s)-pramipexole and its intermediates
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
WO2008086353A1 (en) * 2007-01-08 2008-07-17 Zurawski Vincent R Jr Propargyl-containing derivatives of tetrahydro-benzthiazoles and methods of making and using the same
SI22446A (sl) * 2007-02-07 2008-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za sintezo pramipeksola in njegovih farmacevtsko sprejemljivih soli
AU2008224844B2 (en) * 2007-03-14 2012-08-09 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
US20080254117A1 (en) * 2007-04-10 2008-10-16 Noel Cotton Process for preparing pramipexole dihydrochloride tablets
EP2543389A3 (en) 2007-08-02 2013-04-24 Gilead Biologics, Inc. Methods and compositions inhibiting a lysyl oxidase (-like) protein for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis
GB0721333D0 (en) * 2007-10-31 2007-12-12 Motac Neuroscience Ltd Medicaments
US20090247537A1 (en) * 2008-03-25 2009-10-01 William Dale Overfield Methods for preventing or treating bruxism using dopaminergic agents
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
CN102802418A (zh) * 2009-06-19 2012-11-28 诺普神经科学股份有限公司 用于治疗肌萎缩性侧索硬化的组合物和方法
WO2011022670A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vivo screening assays
CA2771774A1 (en) * 2009-08-21 2011-02-24 Gilead Biologics, Inc. In vitro screening assays
KR20120063488A (ko) 2009-08-21 2012-06-15 길리아드 바이오로직스, 인크. 리실 옥시다제 및 loxl2로부터의 촉매 도메인
RU2012110587A (ru) * 2009-08-21 2013-09-27 Джилид Байолоджикс, Инк. Терапевтические способы и композиции
RU2015124151A (ru) * 2009-08-21 2015-12-27 Джилид Байолоджикс, Инк. Способы и композиции для лечения фиброзных заболеваний легких
TR200906997A1 (tr) 2009-09-11 2011-03-21 Sanovel �La� San. Ve T�C. A. �. Pramipeksol farmasötik bileşimleri.
TR200907554A1 (tr) 2009-10-06 2011-04-21 Sanovel İlaç San.Ve Ti̇c.A.Ş. Oral yolla dağılan pramıpexole bileşimleri.
WO2011086182A2 (en) 2010-01-18 2011-07-21 Synthon Bv Pramipexole extended release tablets
AU2011212830B2 (en) 2010-02-04 2014-05-22 Gilead Biologics, Inc. Antibodies that bind to lysyl oxidase-like 2 (LOXL2) and methods of use therefor
WO2011109596A1 (en) 2010-03-03 2011-09-09 Knopp Neurosciences Synthesis of chirally purified substituted benzothiazole diamines
TR201001862A1 (tr) 2010-03-11 2011-10-21 Sanovel �La� San.Ve T�C.A.�. Kontrollü salım gerçekleştiren pramipeksol formülasyonları.
EP2575780A1 (en) 2010-05-24 2013-04-10 Lupin Limited Extended release formulation of pramipexole
EP2462925A1 (en) 2010-11-12 2012-06-13 Neuraxpharm Arzneimittel GmbH Pramipexole Dihydrochloride Granulate
TWI537274B (zh) 2011-03-14 2016-06-11 橘生藥品工業股份有限公司 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途
WO2012140604A1 (en) 2011-04-15 2012-10-18 Sandoz Ag Stable formulations of pramipexole hydrochloride
ITMI20110666A1 (it) * 2011-04-19 2012-10-20 Dipharma Francis Srl Procedimento per la preparazione di (r) ed (s) pramipexolo e suoi intermedi
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
EP2732812A1 (de) 2012-11-15 2014-05-21 Aristo Pharma GmbH Pramipexol-Retardtablettenformulierung
US9585885B2 (en) 2012-12-10 2017-03-07 Kissei Pharmaceutical Co., Ltd. Substituted pyrido[2,3-g]quinazolines as dopamine D2 receptor agonists
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
DK3019167T3 (da) 2013-07-12 2021-03-15 Knopp Biosciences Llc Behandling af forhøjede niveauer af eosinophiler og/eller basophiler
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
WO2015023790A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
EP2870961B1 (en) 2013-11-06 2018-07-18 Sanovel Ilac Sanayi ve Ticaret A.S. Effervescent formulations of pramipexole
EP2870965A1 (en) 2013-11-06 2015-05-13 Sanovel Ilac Sanayi ve Ticaret A.S. Oral liquid pharmaceutical formulations of pramipexole
CN103626718A (zh) * 2013-12-13 2014-03-12 山东新华制药股份有限公司 盐酸普拉克索的工业化制备方法
CN103664820B (zh) * 2013-12-30 2016-01-27 四川科伦药业股份有限公司 普拉克索类似物及其制备方法
AU2017281789B2 (en) 2016-06-23 2023-04-13 Corium, LLC. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
KR20230098349A (ko) 2016-07-27 2023-07-03 코리움, 엘엘씨 염 약물의 염 약물에서 중성 약물으로의 제자리 전환에 의한 저용해도 또는 불안정한 이온화되지 않은 중성 약물의 경피성 제제 및 전달 방법
CN109789113A (zh) 2016-07-27 2019-05-21 考里安国际公司 美金刚透皮递送系统
CA3031944A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
MX2019012088A (es) 2017-04-10 2020-02-07 Chase Therapeutics Corp Combinacion de antagonista nk1 y metodo para tratar sinucleinopatias.
EP3645120A4 (en) 2017-06-30 2021-03-24 Chase Pharmaceuticals Corporation NK-1 ANTAGONIST COMPOSITIONS AND METHODS OF USE IN THE TREATMENT OF DEPRESSION
US11173132B2 (en) 2017-12-20 2021-11-16 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
CN110734413A (zh) * 2019-12-02 2020-01-31 山东铂源药业有限公司 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN111333593B (zh) * 2020-04-22 2022-04-29 湖北可赛化工有限公司 一种合成4-甲基-2肼基苯并噻唑的方法
WO2022105644A1 (zh) * 2020-11-19 2022-05-27 四川科伦药物研究院有限公司 苯并噻唑类化合物的盐及其晶体形式和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB812512A (en) * 1956-04-12 1959-04-29 Bayer Ag Compositions for combating nematodes
DE2136233A1 (de) * 1971-07-20 1973-02-01 Riedel De Haen Ag Tetrahydrobenzthiazolderivate enthaltende pharmazeutische praeparate
FR2406635A1 (fr) * 1977-10-24 1979-05-18 Logeais Labor Jacques Nouveaux derives du benzo(d)thiazole, leur procede de preparation et leurs applications en therapeutique
FR2459239A1 (fr) * 1979-06-20 1981-01-09 Logeais Labor Jacques Nouveaux derives amines du benzothiazole, leur procede de preparation et leur application en therapeutique
DE3027528A1 (de) * 1980-07-19 1982-02-18 Basf Ag, 6700 Ludwigshafen Ueberbrueckte thiazolyloxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
ZA864626B (en) * 1985-06-24 1988-02-24 Lilly Co Eli Dialkylaminotetrahydrobenzothiazoles and oxazoles

Also Published As

Publication number Publication date
DE3572485D1 (en) 1989-09-28
FI81787B (fi) 1990-08-31
MX9202792A (es) 1992-06-30
PT81735B (pt) 1988-04-21
FI855102A0 (fi) 1985-12-20
PT81735A (de) 1986-01-01
ES8707514B9 (es) 2011-04-14
LU90208I2 (fr) 1998-04-06
ES556875A0 (es) 1987-08-01
ES8702787A1 (es) 1987-01-16
IL77415A (en) 1990-03-19
FI81787C (fi) 1990-12-10
HK78692A (en) 1992-10-23
NO165070B (no) 1990-09-10
PH24533A (en) 1990-08-03
ES556874A0 (es) 1987-08-01
ES556873A0 (es) 1987-08-01
ES8707513A1 (es) 1987-08-01
IE853270L (en) 1986-06-22
EP0186087B1 (de) 1989-08-23
HU193618B (en) 1987-11-30
US4731374A (en) 1988-03-15
KR860004862A (ko) 1986-07-14
KR930009791B1 (ko) 1993-10-11
AU5154485A (en) 1986-07-17
US4843086A (en) 1989-06-27
GR853126B (fi) 1986-04-22
ES550235A0 (es) 1987-01-16
CS409991A3 (en) 1992-09-16
ES8707514A1 (es) 1987-08-01
HUT39736A (en) 1986-10-29
IE58863B1 (en) 1993-11-17
FI855102A (fi) 1986-06-23
BG62023B2 (bg) 1998-12-30
ES8707515A1 (es) 1987-08-01
DK168862B1 (da) 1994-06-27
NZ214661A (en) 1990-04-26
EP0186087A1 (de) 1986-07-02
AU583874B2 (en) 1989-05-11
DK590285D0 (da) 1985-12-18
ATE45735T1 (de) 1989-09-15
NO855195L (no) 1986-06-23
NL980002I2 (nl) 1998-05-06
CA1263653A (en) 1989-12-05
SG82492G (en) 1992-12-04
US4886812A (en) 1989-12-12
NL980002I1 (nl) 1998-03-02
DK590285A (da) 1986-06-23

Similar Documents

Publication Publication Date Title
NO165070C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydrobenztiazoler.
IL66650A (en) Dibenzoxepines and dibenzooxazepines,their preparation and pharmaceutical compositions containing them
DE3777852D1 (de) Dekahydrochinolinderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
ES546555A0 (es) Procedimiento para la obtencion de benzodisultamas
FR2611713B1 (fr) Nouveaux derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
ATE53839T1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-onacetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES497949A0 (es) Procedimiento para la preparacion de nuevos 4-amino-2,6-dia-riltetrahidrotiopiranos sustituidos

Legal Events

Date Code Title Description
MK1K Patent expired