NO163956C - Analogifremgangsmaate til fremstilling av terapeutisk aktive (4-piperidinylmetyl- og -hetero)puriner. - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk aktive (4-piperidinylmetyl- og -hetero)puriner.

Info

Publication number
NO163956C
NO163956C NO862504A NO862504A NO163956C NO 163956 C NO163956 C NO 163956C NO 862504 A NO862504 A NO 862504A NO 862504 A NO862504 A NO 862504A NO 163956 C NO163956 C NO 163956C
Authority
NO
Norway
Prior art keywords
piperidinylmethyl
purines
hetero
preparation
compounds
Prior art date
Application number
NO862504A
Other languages
English (en)
Other versions
NO862504D0 (no
NO163956B (no
NO862504L (no
Inventor
Frans Eduard Janssens
Gaston Stanislas Marcell Diels
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO862504D0 publication Critical patent/NO862504D0/no
Publication of NO862504L publication Critical patent/NO862504L/no
Publication of NO163956B publication Critical patent/NO163956B/no
Publication of NO163956C publication Critical patent/NO163956C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO862504A 1985-06-24 1986-06-23 Analogifremgangsmaate til fremstilling av terapeutisk aktive (4-piperidinylmetyl- og -hetero)puriner. NO163956C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858515934A GB8515934D0 (en) 1985-06-24 1985-06-24 (4-piperidinomethyl and-hetero)purines

Publications (4)

Publication Number Publication Date
NO862504D0 NO862504D0 (no) 1986-06-23
NO862504L NO862504L (no) 1986-12-29
NO163956B NO163956B (no) 1990-05-07
NO163956C true NO163956C (no) 1990-08-15

Family

ID=10581240

Family Applications (1)

Application Number Title Priority Date Filing Date
NO862504A NO163956C (no) 1985-06-24 1986-06-23 Analogifremgangsmaate til fremstilling av terapeutisk aktive (4-piperidinylmetyl- og -hetero)puriner.

Country Status (21)

Country Link
US (1) US5041448A (no)
EP (1) EP0206415B1 (no)
JP (1) JPS62487A (no)
KR (1) KR930009356B1 (no)
AT (1) ATE85055T1 (no)
AU (1) AU588890B2 (no)
CA (1) CA1267889A (no)
DE (1) DE3687601T2 (no)
DK (1) DK169073B1 (no)
ES (1) ES8800682A1 (no)
FI (1) FI85704C (no)
GB (1) GB8515934D0 (no)
GR (1) GR861580B (no)
HU (1) HU199143B (no)
IE (1) IE59658B1 (no)
IL (1) IL79193A0 (no)
NO (1) NO163956C (no)
NZ (1) NZ216536A (no)
PT (1) PT82824B (no)
SU (1) SU1581221A3 (no)
ZA (1) ZA864677B (no)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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US4943580A (en) * 1987-03-09 1990-07-24 Janssen Pharmaceutica N.V. Anti-histaminic benzimidazole, imidazopyridine and purine derivatives
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
US5151424A (en) * 1987-07-01 1992-09-29 Janssen Pharmaceutica N.V. Pharmacologically active (Bicyclic heterocyclyl)methyl and -hetero) substituted hexahydro-1H-azepines and pyrrolidines
GB8716313D0 (en) * 1987-07-10 1987-08-19 Janssen Pharmaceutica Nv 2-(heterocyclylalkyl)imidazopyridines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
US5272150A (en) * 1989-04-07 1993-12-21 Janssen Pharmaceutica N.V. Hydroxyalkylfuranyl derivatives
US5360807A (en) * 1990-07-19 1994-11-01 Janssen Pharmaceutica N.V. Substituted thiazolyl and substituted pyridinyl derivatives
NZ238863A (en) * 1990-07-19 1993-03-26 Janssen Pharmaceutica Nv Substituted thiazolyl and pyridinyl derivatives
KR100190299B1 (ko) * 1990-07-19 1999-06-01 디르크 반테 신규한 옥사졸릴 유도체
US5217980A (en) * 1990-07-19 1993-06-08 Janssen Pharmaceutica N.V. Oxazolyl and piperidinyl substituted benimidazolyl compounds
WO1992006086A1 (en) * 1990-10-01 1992-04-16 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
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BR9712792A (pt) * 1996-08-28 1999-12-14 Procter & Gamble Inibidores de metaloprotease bidentada.
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WO1999045011A1 (en) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Glycine transport inhibitors
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US7482337B2 (en) * 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
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RU2328498C9 (ru) * 2002-12-04 2008-12-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Соединения с конденсированным 1,3-дигидроимидазольным циклом
US7566707B2 (en) 2003-06-18 2009-07-28 Boehringer Ingelheim International Gmbh Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
EP2145888A1 (en) 2003-09-18 2010-01-20 Conforma Therapeutics Corporation Deazapurine derivatives as HSP90-Inhibitors
DE10355304A1 (de) * 2003-11-27 2005-06-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US7501426B2 (en) * 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004009039A1 (de) * 2004-02-23 2005-09-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel
US7393847B2 (en) * 2004-03-13 2008-07-01 Boehringer Ingleheim International Gmbh Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions
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US7439370B2 (en) * 2004-05-10 2008-10-21 Boehringer Ingelheim International Gmbh Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides
DE102004030502A1 (de) 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
DE102004043944A1 (de) * 2004-09-11 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
DE102004044221A1 (de) * 2004-09-14 2006-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 3-Methyl-7-butinyl-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
BRPI0609509A2 (pt) 2005-03-30 2010-04-13 Conforma Therapeutics Corp composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
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EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
US8071583B2 (en) * 2006-08-08 2011-12-06 Boehringer Ingelheim International Gmbh Pyrrolo[3,2-D] pyrimidines as DPP-IV inhibitors for the treatment of diabetes mellitus
WO2009024542A2 (en) * 2007-08-17 2009-02-26 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
CN102123704B (zh) * 2008-08-15 2014-02-12 勃林格殷格翰国际有限公司 用于治疗fab-相关疾病的嘌呤衍生物
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JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
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JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
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Also Published As

Publication number Publication date
US5041448A (en) 1991-08-20
AU588890B2 (en) 1989-09-28
GB8515934D0 (en) 1985-07-24
FI862655A7 (fi) 1986-12-25
CA1267889A (en) 1990-04-17
ES8800682A1 (es) 1987-11-16
FI85704B (fi) 1992-02-14
FI85704C (fi) 1992-05-25
GR861580B (en) 1986-10-21
KR930009356B1 (ko) 1993-09-28
NO862504D0 (no) 1986-06-23
AU5919186A (en) 1987-01-08
IE861674L (en) 1986-12-24
HU199143B (en) 1990-01-29
PT82824B (pt) 1988-07-29
DE3687601D1 (de) 1993-03-11
NO163956B (no) 1990-05-07
HUT42095A (en) 1987-06-29
SU1581221A3 (ru) 1990-07-23
JPS62487A (ja) 1987-01-06
DK295286D0 (da) 1986-06-23
ATE85055T1 (de) 1993-02-15
EP0206415A3 (en) 1988-03-16
NZ216536A (en) 1988-10-28
IL79193A0 (en) 1986-09-30
KR870000335A (ko) 1987-02-17
IE59658B1 (en) 1994-03-09
EP0206415B1 (en) 1993-01-27
ES556381A0 (es) 1987-11-16
DK295286A (da) 1986-12-25
NO862504L (no) 1986-12-29
ZA864677B (en) 1988-02-24
DE3687601T2 (de) 1993-06-03
DK169073B1 (da) 1994-08-08
FI862655A0 (fi) 1986-06-23
EP0206415A2 (en) 1986-12-30
PT82824A (en) 1986-07-01

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