NO162518C - Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater. - Google Patents

Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater.

Info

Publication number
NO162518C
NO162518C NO842203A NO842203A NO162518C NO 162518 C NO162518 C NO 162518C NO 842203 A NO842203 A NO 842203A NO 842203 A NO842203 A NO 842203A NO 162518 C NO162518 C NO 162518C
Authority
NO
Norway
Prior art keywords
chloro
preparation
new
benzothiazepine derivatives
therapeutic effective
Prior art date
Application number
NO842203A
Other languages
English (en)
Norwegian (no)
Other versions
NO842203L (no
NO162518B (no
Inventor
Mikio Takeda
Tokuro Ohishi
Hiromichi Nakajima
Taku Nagao
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838315364A external-priority patent/GB8315364D0/en
Priority claimed from GB848400983A external-priority patent/GB8400983D0/en
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of NO842203L publication Critical patent/NO842203L/no
Priority to NO863823A priority Critical patent/NO163566C/no
Publication of NO162518B publication Critical patent/NO162518B/no
Publication of NO162518C publication Critical patent/NO162518C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J123/00—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers
    • C09J123/02—Adhesives based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
    • C09J123/04—Homopolymers or copolymers of ethene
    • C09J123/08—Copolymers of ethene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO842203A 1983-06-03 1984-06-01 Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater. NO162518C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO863823A NO163566C (no) 1983-06-03 1986-09-25 1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838315364A GB8315364D0 (en) 1983-06-03 1983-06-03 8-chloro-1 5-benzothiazepine derivatives
GB848400983A GB8400983D0 (en) 1984-01-14 1984-01-14 8-chloro-1,5-benzothiazepine derivatives

Publications (3)

Publication Number Publication Date
NO842203L NO842203L (no) 1984-12-04
NO162518B NO162518B (no) 1989-10-02
NO162518C true NO162518C (no) 1990-01-10

Family

ID=26286299

Family Applications (2)

Application Number Title Priority Date Filing Date
NO842203A NO162518C (no) 1983-06-03 1984-06-01 Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater.
NO863823A NO163566C (no) 1983-06-03 1986-09-25 1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO863823A NO163566C (no) 1983-06-03 1986-09-25 1,5-benzothiazepinderivater som er anvendelige som utgangsmaterialer ved fremstilling av nye, terapeutisk aktive 8-klor-1,5-benzothiazepinderivater.

Country Status (18)

Country Link
US (1) US4567175A (de)
EP (1) EP0127882B1 (de)
KR (1) KR900005697B1 (de)
AT (1) ATE22889T1 (de)
AU (1) AU563093B2 (de)
BG (2) BG40964A3 (de)
CA (2) CA1237719A (de)
DD (1) DD218619A5 (de)
DE (1) DE3460972D1 (de)
DK (2) DK167185B1 (de)
ES (2) ES8506677A1 (de)
HK (1) HK81888A (de)
HU (2) HU191933B (de)
MY (1) MY101748A (de)
NO (2) NO162518C (de)
PH (1) PH21627A (de)
PT (1) PT78682B (de)
SU (2) SU1299508A3 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585768A (en) * 1984-04-10 1986-04-29 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and processes for preparing the same
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
USRE33072E (en) * 1985-06-20 1989-09-26 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
JPS62161776A (ja) * 1986-01-07 1987-07-17 Tanabe Seiyaku Co Ltd １，５−ベンゾチアゼピン誘導体の製法
US4652561A (en) * 1986-02-26 1987-03-24 Hoffmann-La Roche Inc. Naphtho[1,2-b]-1,4-thiazepinones
IL81954A0 (en) * 1986-03-24 1987-10-20 Hoffmann La Roche Naphthothiazocinones,their manufacture and pharmaceutical compositions containing them
US4778791A (en) * 1986-05-16 1988-10-18 Tanabe Seiyaku Co., Ltd. Pharmaceutical composition for improving constitution of lipids in blood
JPS63107925A (ja) * 1986-05-23 1988-05-12 Tanabe Seiyaku Co Ltd 動脈硬化症予防・治療剤
ES2038668T3 (es) * 1986-08-20 1993-08-01 Mcneilab, Inc. Vasodilatadores de benzotiazepina dotados de sustitucion aralquilica.
IL85257A (en) * 1987-02-10 1993-02-21 Tanabe Seiyaku Co Pharmaceutical compositions containing 2-(4-methoxyphenyl) 3-acetoxy-5-- (2-(dimethylamino) ethyl) -8-chloro-2,3- dihydro-1,5-benzothiazepin -4 (5h)-one having renal function-improving effect and diuretic effect
JPS6445376A (en) * 1987-08-12 1989-02-17 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
JPS6450872A (en) * 1987-08-21 1989-02-27 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
AT389446B (de) * 1987-10-08 1989-12-11 Tanabe Seiyaku Co Verwendung eines 8-chlorobenzothiazepins zur herstellung eines arzneimittels
US4808580A (en) * 1987-12-17 1989-02-28 Hoffmann-La Roche Inc. Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering
US4908469A (en) * 1988-05-18 1990-03-13 Marion Laboratories, Inc. 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines
US4879289A (en) * 1988-05-24 1989-11-07 Marion Laboratories, Inc. Method of ameliorating epileptic seizures
US4963545A (en) * 1988-05-24 1990-10-16 Marion Laboratories, Inc. Benzothiazepine anti-seizure method
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5002942A (en) * 1988-07-25 1991-03-26 Sankyo Company, Limited 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders
IT1226301B (it) * 1988-07-26 1990-12-27 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem.
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus
US4952692A (en) * 1989-04-04 1990-08-28 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
US5128469A (en) * 1989-04-28 1992-07-07 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
ATE116643T1 (de) * 1989-04-28 1995-01-15 Tanabe Seiyaku Co Verfahren zur herstellung von 1,5- benzothiazepinderivaten.
ZA906810B (en) * 1989-08-31 1991-10-30 Marion Merrell Dow Inc Heterogeneous synthesis of azepinones from esters
US5250680A (en) * 1989-08-31 1993-10-05 Merrell Dow Pharmaceuticals Inc. Heterogeneous synthesis of azepinones from esters
US5244803A (en) * 1989-09-13 1993-09-14 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-phenylglycidic acid esters
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines
CA2030160A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Benzothiazepine metastasis treatment
CA2030159A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Anti-cancer drug potentiators
US5112969A (en) * 1990-04-02 1992-05-12 Merrell Dow Pharmaceuticals Inc. Cyano esters and azepinones
US5055575A (en) * 1990-04-12 1991-10-08 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
IT1240651B (it) * 1990-05-17 1993-12-17 Zambon Spa Processo per la risoluzione di derivati glicidici
CA2049655C (en) * 1990-09-17 1996-11-12 Akio Odawara Pharmaceutical composition for inhibiting platelet aggregation
ES2073301T3 (es) * 1991-05-20 1995-08-01 Marion Laboratories Inc Composicion multi-capa de liberacion controlada.
US5378698A (en) * 1991-10-21 1995-01-03 Shionogi & Co., Ltd. Benzothiazepine derivatives
CA2087743C (en) * 1992-02-06 1999-04-27 Akio Odawara Pharmaceutical composition for inhibiting platelet aggregation
KR950003279A (ko) * 1993-07-29 1995-02-16 고사이 아끼오 플루오로알칸 카르복사미드 유도체의 제조방법
US5705638A (en) * 1995-12-05 1998-01-06 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-hydroxy-1,5-benzothiazepine derivative and intermediate therefor
DE778272T1 (de) * 1995-12-05 1997-11-20 Tanabe Seiyaku Co Optisch aktive Benzothiazepinderivate und Verfahren zu ihrer Herstellung
CA2197816A1 (en) * 1996-02-23 1997-08-24 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivative
IT1302261B1 (it) 1998-09-24 2000-09-05 Zambon Spa Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
AP2005003232A0 (en) 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
AU2005269465A1 (en) * 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
CA2590533C (en) * 2004-11-23 2010-09-07 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (de) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie
ATE551059T1 (de) * 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
BR6915295D0 (pt) * 1969-01-25 1973-04-12 Tanabe Seiyaku Co Indicador cronologico de evento em transmissao televisada

Also Published As

Publication number Publication date
PT78682B (en) 1986-07-11
NO842203L (no) 1984-12-04
AU2887384A (en) 1984-12-06
DK272884A (da) 1984-12-04
AU563093B2 (en) 1987-06-25
KR850000033A (ko) 1985-02-25
NO163566C (no) 1990-06-27
ES533009A0 (es) 1985-08-01
NO863823L (no) 1984-12-04
ATE22889T1 (de) 1986-11-15
HK81888A (en) 1988-10-14
EP0127882A1 (de) 1984-12-12
EP0127882B1 (de) 1986-10-15
NO863823D0 (no) 1986-09-25
BG41130A3 (en) 1987-04-15
CA1237719A (en) 1988-06-07
DK167185B1 (da) 1993-09-13
KR900005697B1 (ko) 1990-08-06
HU191933B (en) 1987-04-28
SU1299508A3 (ru) 1987-03-23
ES8602720A1 (es) 1985-12-01
ES541557A0 (es) 1985-12-01
DE3460972D1 (en) 1986-11-20
DK272884D0 (da) 1984-06-01
BG40964A3 (en) 1987-03-14
MY101748A (en) 1992-01-17
NO162518B (no) 1989-10-02
NO163566B (no) 1990-03-12
DD218619A5 (de) 1985-02-13
PH21627A (en) 1987-12-11
SU1362401A3 (ru) 1987-12-23
ES8506677A1 (es) 1985-08-01
HU193865B (en) 1987-12-28
DK104792A (da) 1992-08-24
US4567175A (en) 1986-01-28
DK104792D0 (da) 1992-08-24
CA1231097A (en) 1988-01-05
HUT37929A (en) 1986-03-28
PT78682A (pt) 1985-01-01
DK167186B1 (da) 1993-09-13

Similar Documents

Publication Publication Date Title
NO162518C (no) Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater.
ES2000185A6 (es) Procedimiento para preparar derivados de acidos piridoncaboxilicos
NO163568C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
NO854565L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 6- eller 9-klor-1,5-benzothiazepinderivater.
DE3561513D1 (en) 3n-substituted 3,4-dihydropyrimidine derivatives, processes for preparing them and pharmaceutical compositions
NO170580C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive piperidinderivater
ES2059451T3 (es) Derivados de naftotiazepina y su procedimiento de preparacion.
YU42057B (en) Process for preparing 1-furyl-3,4-dihyndro isoquinolines