NO148813C - Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater - Google Patents

Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater

Info

Publication number
NO148813C
NO148813C NO782022A NO782022A NO148813C NO 148813 C NO148813 C NO 148813C NO 782022 A NO782022 A NO 782022A NO 782022 A NO782022 A NO 782022A NO 148813 C NO148813 C NO 148813C
Authority
NO
Norway
Prior art keywords
carbostyric
derivatives
preparation
pharmacologically active
analogy procedure
Prior art date
Application number
NO782022A
Other languages
English (en)
Norwegian (no)
Other versions
NO148813B (no
NO782022L (no
Inventor
Takao Nishi
Hiraki Ueda
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NO782022L publication Critical patent/NO782022L/no
Publication of NO148813B publication Critical patent/NO148813B/no
Publication of NO148813C publication Critical patent/NO148813C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
NO782022A 1977-06-10 1978-06-09 Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater NO148813C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (3)

Publication Number Publication Date
NO782022L NO782022L (no) 1978-12-12
NO148813B NO148813B (no) 1983-09-12
NO148813C true NO148813C (no) 1983-12-21

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
NO782022A NO148813C (no) 1977-06-10 1978-06-09 Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater

Country Status (21)

Country Link
US (1) US4298739A (esLanguage)
AR (2) AR224345A1 (esLanguage)
AT (1) AT367038B (esLanguage)
AU (1) AU510138B2 (esLanguage)
CA (1) CA1098907A (esLanguage)
CH (1) CH636087A5 (esLanguage)
DE (1) DE2825048A1 (esLanguage)
DK (1) DK149449C (esLanguage)
ES (2) ES470690A1 (esLanguage)
FI (1) FI69300C (esLanguage)
FR (1) FR2393795B1 (esLanguage)
GB (1) GB2002745B (esLanguage)
IE (1) IE46852B1 (esLanguage)
IT (1) IT1108326B (esLanguage)
MX (1) MX5527E (esLanguage)
NL (1) NL178074C (esLanguage)
NO (1) NO148813C (esLanguage)
NZ (1) NZ187452A (esLanguage)
PH (1) PH14670A (esLanguage)
PT (1) PT68157A (esLanguage)
SE (1) SE444562B (esLanguage)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
ZA851131B (en) * 1984-02-15 1986-09-24 Syntex Inc (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)oxyalkylamides
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
TW201305B (esLanguage) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
EP0569592A4 (en) * 1991-08-23 1994-12-07 Otsuka Pharma Co Ltd CARBOSTYRILE DERIVATIVE AND PLATELET ANTIAGGREGATOR.
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
BRPI0618643A2 (pt) 2005-11-09 2011-09-06 Combinatorx Inc composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
RU2553676C2 (ru) 2009-08-21 2015-06-20 Оцука Фармасьютикал Ко., Лтд. СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНОГО БЕНЗО[b][1,4]ДИАЗЕПИН-2,4-ДИОНА
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (en) 2011-03-01 2024-03-05 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (esLanguage) * 1972-12-14 1977-10-03
JPS5234629B2 (esLanguage) * 1973-02-03 1977-09-05
SE431451B (sv) * 1973-10-24 1984-02-06 Otsuka Pharma Co Ltd Forfarande for framstellning av 2,3-dihydroxipropoxikinoliner eller -isokinoliner
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
DK254878A (da) 1979-02-09
FI69300B (fi) 1985-09-30
GB2002745A (en) 1979-02-28
CH636087A5 (de) 1983-05-13
DK149449B (da) 1986-06-16
PT68157A (en) 1978-07-01
SE7806710L (sv) 1978-12-11
NO148813B (no) 1983-09-12
DE2825048A1 (de) 1978-12-14
AU3686678A (en) 1979-12-13
SE444562B (sv) 1986-04-21
CA1098907A (en) 1981-04-07
US4298739A (en) 1981-11-03
ES479138A1 (es) 1979-07-01
AR224345A1 (es) 1981-11-30
AU510138B2 (en) 1980-06-12
FR2393795A1 (fr) 1979-01-05
MX5527E (es) 1983-09-23
ATA421378A (de) 1981-10-15
DK149449C (da) 1986-11-24
GB2002745B (en) 1982-02-17
IE781104L (en) 1978-12-10
FI781811A7 (fi) 1978-12-11
IE46852B1 (en) 1983-10-05
NZ187452A (en) 1980-05-27
NO782022L (no) 1978-12-12
DE2825048C2 (esLanguage) 1991-05-08
AT367038B (de) 1982-05-25
ES470690A1 (es) 1979-10-16
AR225755A1 (es) 1982-04-30
NL7806245A (nl) 1978-12-12
FI69300C (fi) 1986-01-10
FR2393795B1 (fr) 1986-07-25
IT1108326B (it) 1985-12-09
NL178074C (nl) 1986-01-16
IT7868355A0 (it) 1978-06-09
PH14670A (en) 1981-10-30

Similar Documents

Publication Publication Date Title
NO148813C (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive karbostyrilderivater
NO800626L (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive polyolderivater
NO792829L (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive tetrazolylalkoksy-karbostyrilderivater
NO149923C (no) Analogifremgangsmaate for fremstlling av fysiologisk aktive prolinderivater
NO147243C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive ftalanderivater
NO149962C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive imidazolderivater
NO782127L (no) Fremgangsmaate for fremstilling av fysiologisk aktive isoksazolo-pyridin-derivater
NO148148C (no) Fremgangsmaate til fremstilling av terapeutisk aktive 4-hydroksy-2-pyrrolidinonderivater
NO141411C (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive erytromycin-derivater
NO151411C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-aryloksy-2-hydroksy-3-alkylenaminopropan-derivater
NO780883L (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive 4-acylamino-fenyl-etanolaminer
NO145792C (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive pyrimidon-derivater
NO148777C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive antrakinon-derivater
NO145842C (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive indolizinderivater
NO149065C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzodiazepinderivater
NO154013C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive sesquiterpenderivater.
NO149313C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridobenzodiazepiner
NO149037C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridobenzodiazepiner
NO145951C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolinderivater
NO148673C (no) Analogifremgangsmaate ved fremstilling av farmakologisk virksomme tiofenderivater
NO148454C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolidin-dionderivater
SE7803035L (sv) Forfarande for framstellning av tienopyridinderivat
NO151285C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive di-o-n-alkyl-glycerolderivater
NO149388C (no) Analogi-fremgangsmaate for fremstilling av farmakologisk aktive karbostyril-derivater
NO148291C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive basisk substituerte teofyllinderivater