NO146637C - Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt inklusjonskompleks av cyclodextrin og 1-(p-klorbenzoyl)-5-methoxy-2-methyl-indol-3-yl-eddiksyre - Google Patents

Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt inklusjonskompleks av cyclodextrin og 1-(p-klorbenzoyl)-5-methoxy-2-methyl-indol-3-yl-eddiksyre

Info

Publication number
NO146637C
NO146637C NO790261A NO790261A NO146637C NO 146637 C NO146637 C NO 146637C NO 790261 A NO790261 A NO 790261A NO 790261 A NO790261 A NO 790261A NO 146637 C NO146637 C NO 146637C
Authority
NO
Norway
Prior art keywords
chlorobenzoyl
indol
cyclodextrin
methoxy
methyl
Prior art date
Application number
NO790261A
Other languages
English (en)
Norwegian (no)
Other versions
NO790261L (no
NO146637B (no
Inventor
Jozsef Szejtli
Lajos Szente
Agoston David
Sandor Virag
Gyula Sebestyen
Attila Mandi
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of NO790261L publication Critical patent/NO790261L/no
Publication of NO146637B publication Critical patent/NO146637B/no
Publication of NO146637C publication Critical patent/NO146637C/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
NO790261A 1978-01-27 1979-01-26 Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt inklusjonskompleks av cyclodextrin og 1-(p-klorbenzoyl)-5-methoxy-2-methyl-indol-3-yl-eddiksyre NO146637C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78CI1803A HU176215B (en) 1978-01-27 1978-01-27 Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1

Publications (3)

Publication Number Publication Date
NO790261L NO790261L (no) 1979-07-30
NO146637B NO146637B (no) 1982-08-02
NO146637C true NO146637C (no) 1982-11-10

Family

ID=10994689

Family Applications (1)

Application Number Title Priority Date Filing Date
NO790261A NO146637C (no) 1978-01-27 1979-01-26 Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt inklusjonskompleks av cyclodextrin og 1-(p-klorbenzoyl)-5-methoxy-2-methyl-indol-3-yl-eddiksyre

Country Status (23)

Country Link
US (1) US4228160A (xx)
JP (1) JPS54117018A (xx)
AT (1) AT360554B (xx)
AU (1) AU518750B2 (xx)
BE (1) BE873725A (xx)
CA (1) CA1119115A (xx)
CH (1) CH638819A5 (xx)
CS (1) CS207742B2 (xx)
DD (1) DD141312A1 (xx)
DE (1) DE2902297A1 (xx)
DK (1) DK154977C (xx)
ES (1) ES477181A1 (xx)
FI (1) FI65441C (xx)
FR (1) FR2415631A1 (xx)
GB (1) GB2016499B (xx)
HU (1) HU176215B (xx)
IL (1) IL56309A (xx)
IT (1) IT1118282B (xx)
NL (1) NL7808792A (xx)
NO (1) NO146637C (xx)
PL (1) PL117208B1 (xx)
SE (1) SE445353B (xx)
SU (1) SU915807A3 (xx)

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JPS5830032B2 (ja) * 1981-02-18 1983-06-27 呉羽化学工業株式会社 ビフイダス菌の増殖剤
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JPS58177949A (ja) * 1982-04-12 1983-10-18 Takeda Chem Ind Ltd ランカシジン群抗生物質包接化合物
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US5321014A (en) * 1991-06-28 1994-06-14 The United States Of America As Represented By The Department Of Health And Human Services Molecular encapsulation and delivery of alkenes alkynes and long chain alkanes, to living mammalian cells
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CN107184989B (zh) * 2017-05-18 2020-09-08 宁夏蓝博思化学技术有限公司 甘草素-环糊精或环糊精衍生物包合物及组合物及制备方法及用途

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Also Published As

Publication number Publication date
FR2415631A1 (fr) 1979-08-24
CS207742B2 (en) 1981-08-31
FR2415631B1 (xx) 1981-12-24
JPS54117018A (en) 1979-09-11
ATA59179A (de) 1980-06-15
DE2902297C2 (xx) 1989-02-09
AU4367179A (en) 1979-08-02
CA1119115A (en) 1982-03-02
NL7808792A (nl) 1979-07-31
NO790261L (no) 1979-07-30
SE445353B (sv) 1986-06-16
FI790198A (fi) 1979-07-28
IL56309A (en) 1981-09-13
AT360554B (de) 1981-01-26
PL213015A1 (pl) 1979-12-17
PL117208B1 (en) 1981-07-31
DE2902297A1 (de) 1979-08-02
NO146637B (no) 1982-08-02
AU518750B2 (en) 1981-10-15
DK154977C (da) 1989-06-12
BE873725A (fr) 1979-05-16
SU915807A3 (en) 1982-03-23
ES477181A1 (es) 1979-10-16
SE7900479L (sv) 1979-07-28
DD141312A1 (de) 1980-04-23
IT1118282B (it) 1986-02-24
IT7967050A0 (it) 1979-01-11
DK35079A (da) 1979-07-28
DK154977B (da) 1989-01-16
FI65441C (fi) 1984-05-10
US4228160A (en) 1980-10-14
GB2016499B (en) 1982-07-28
HU176215B (en) 1981-01-28
FI65441B (fi) 1984-01-31
GB2016499A (en) 1979-09-26
CH638819A5 (de) 1983-10-14

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