US4313935A
(en)
*
|
1979-03-05 |
1982-02-02 |
Fujisawa Pharmaceutical Co., Ltd. |
Antibiotic FR-900129 substance, a process for the preparation thereof and pharmaceutical compositions containing the same
|
US4301248A
(en)
*
|
1979-12-21 |
1981-11-17 |
Bristol-Myers Company |
Fermentation process for making rachelmycin
|
US4423230A
(en)
*
|
1980-11-18 |
1983-12-27 |
The Upjohn Company |
Preparation of an intermediate for N-(methylsulfonyl)-1,2,8,8a-cyclopropa[c][1,2-b:-4,3-b']dipyrol-4(5H)-one
|
US4423228A
(en)
*
|
1980-11-18 |
1983-12-27 |
The Upjohn Company |
Process for preparing N-(methyl-sulfonyl)-1,2,8,8a-cyclopropa[c]benzo[1,2-b:4,3-b']dipyrrol-4(5H)-one
|
US4413132A
(en)
*
|
1980-11-18 |
1983-11-01 |
The Upjohn Company |
Antibiotic CC-1065 indoline intermediates
|
US4423229A
(en)
*
|
1980-11-18 |
1983-12-27 |
The Upjohn Company |
Composition of matter and process
|
US4496492A
(en)
*
|
1980-11-18 |
1985-01-29 |
The Upjohn Company |
Substituted phenylalkyl compounds
|
US4400518A
(en)
*
|
1980-11-18 |
1983-08-23 |
The Upjohn Company |
Composition of matter and process
|
IT1143242B
(it)
|
1980-11-18 |
1986-10-22 |
Upjohn Co |
1,2,8,ba-ciclopropa(c)-benzo(1,2-b-4,3-b)dipirrol-4(5h)-one antibatte ricamente attivo e relativo metodo di preparazione
|
US4431820A
(en)
*
|
1980-11-18 |
1984-02-14 |
The Upjohn Company |
6-Methoxy indoline acetate and its 5-nitro and 5-amino derivatives
|
US4978757A
(en)
*
|
1984-02-21 |
1990-12-18 |
The Upjohn Company |
1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
|
US4912227A
(en)
*
|
1984-02-21 |
1990-03-27 |
The Upjohn Company |
1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
|
US4590280A
(en)
*
|
1985-03-15 |
1986-05-20 |
The Upjohn Company |
Preparing indoline derivatives
|
DE3783588T2
(de)
*
|
1986-04-17 |
1993-06-09 |
Kyowa Hakko Kogyo Kk |
Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren.
|
JP2642165B2
(ja)
*
|
1988-07-22 |
1997-08-20 |
協和醗酵工業株式会社 |
新規dc−89化合物およびその製造法
|
US5084468A
(en)
*
|
1988-08-11 |
1992-01-28 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-88a derivatives
|
US5541339A
(en)
*
|
1988-09-12 |
1996-07-30 |
The Upjohn Company |
CC-1065 analogs having two CPI subunits
|
US5008271A
(en)
*
|
1988-10-21 |
1991-04-16 |
Kyowa Hakko Kogyo Co., Ltd. |
DC-88A derivatives
|
JP2598116B2
(ja)
*
|
1988-12-28 |
1997-04-09 |
協和醗酵工業株式会社 |
新規物質dc113
|
JP2510335B2
(ja)
*
|
1989-07-03 |
1996-06-26 |
協和醗酵工業株式会社 |
Dc―88a誘導体
|
US5187186A
(en)
*
|
1989-07-03 |
1993-02-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Pyrroloindole derivatives
|
JPH05508394A
(ja)
*
|
1990-04-25 |
1993-11-25 |
ファルマシア・アンド・アップジョン・カンパニー |
新規なcc―1065アナログ
|
US5248692A
(en)
*
|
1990-06-11 |
1993-09-28 |
Kyowa Hakko Kogyo Co., Ltd. |
DC-89 derivatives as anti-tumor agents
|
US5214065A
(en)
*
|
1990-06-11 |
1993-05-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-89 derivatives
|
EP0520435A3
(en)
*
|
1991-06-28 |
1993-05-05 |
Kyowa Hakko Kogyo Co., Ltd. |
Dc-89 derivatives
|
US5248691A
(en)
*
|
1992-09-03 |
1993-09-28 |
Eli Lilly And Company |
Furanoindolines
|
US5786138A
(en)
*
|
1993-01-29 |
1998-07-28 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Hyperstabilizing antisense nucleic acid binding agents
|
US5801155A
(en)
|
1995-04-03 |
1998-09-01 |
Epoch Pharmaceuticals, Inc. |
Covalently linked oligonucleotide minor grove binder conjugates
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
WO2002092771A2
(en)
|
2001-05-11 |
2002-11-21 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
AU2002303929B9
(en)
*
|
2001-05-31 |
2007-01-25 |
E. R. Squibb & Sons, L.L.C. |
Cytotoxins, prodrugs, linkers and stabilizers useful therefor
|
US20030180766A1
(en)
*
|
2002-01-24 |
2003-09-25 |
Ecopia Biosciences, Inc. |
Method, system and knowledge repository for identifying a secondary metabolite from a microorganism
|
US7691962B2
(en)
*
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
BRPI0510909A2
(pt)
*
|
2004-05-19 |
2008-12-16 |
Medarex Inc |
composto de ligaÇço fÁrmaco-ligante citotàxico, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula e mÉtodo para retardar ou interromper o crescimento de tumor
|
AU2004224925C1
(en)
*
|
2004-08-30 |
2011-07-21 |
Biotest Ag |
Immunoconjugates targeting syndecan-1 expressing cells and use thereof
|
US7714016B2
(en)
*
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
BRPI0617546A2
(pt)
*
|
2005-09-26 |
2011-07-26 |
Medarex Inc |
conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
|
EP1940789B1
(en)
|
2005-10-26 |
2011-11-23 |
Medarex, Inc. |
Methods and compounds for preparing cc-1065 analogs
|
CA2627190A1
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
Medarex Llc |
化學鏈接劑與可裂解基質以及其之綴合物
|
EP2126127B1
(en)
|
2007-01-25 |
2016-09-28 |
Dana-Farber Cancer Institute, Inc. |
Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
|
CL2008000510A1
(es)
*
|
2007-02-21 |
2008-08-22 |
Medarex Inc |
Compuestos conjugados farmaco-ligandos, que se unen a citotoxinas potentes; composicion farmaceutica; y uso para retardar o detener el crecimiento de un tumor en un mamifero.
|
CA2680854C
(en)
|
2007-03-15 |
2017-02-14 |
Ludwig Institute For Cancer Research |
Treatment method using egfr antibodies and src inhibitors and related formulations
|
CN108424454B
(zh)
|
2007-08-14 |
2022-05-31 |
路德维格癌症研究所有限公司 |
靶向egf受体的单克隆抗体175及其衍生物和用途
|
ES2475201T3
(es)
*
|
2007-12-26 |
2014-07-10 |
Biotest Ag |
Agentes dirigidos contra CD138 y usos de los mismos
|
WO2009080831A1
(en)
*
|
2007-12-26 |
2009-07-02 |
Biotest Ag |
Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
|
WO2009080832A1
(en)
*
|
2007-12-26 |
2009-07-02 |
Biotest Ag |
Methods and agents for improving targeting of cd138 expressing tumor cells
|
KR20100097753A
(ko)
*
|
2007-12-26 |
2010-09-03 |
바이오테스트 아게 |
Cd138 표적성 면역접합체 및 이의 용도
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
US9228023B2
(en)
|
2010-10-01 |
2016-01-05 |
Oxford Biotherapeutics Ltd. |
Anti-ROR1 antibodies and methods of use for treatment of cancer
|
JOP20210044A1
(ar)
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
WO2013022855A1
(en)
|
2011-08-05 |
2013-02-14 |
Xencor, Inc. |
Antibodies with modified isoelectric points and immunofiltering
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
SG11201402887SA
(en)
|
2011-12-08 |
2014-07-30 |
Biotest Ag |
Uses of immunoconjugates targeting cd138
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
AU2014205086B2
(en)
|
2013-01-14 |
2019-04-18 |
Xencor, Inc. |
Novel heterodimeric proteins
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
WO2014113510A1
(en)
|
2013-01-15 |
2014-07-24 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
CA2906927C
(en)
|
2013-03-15 |
2021-07-13 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
CN105377889B
(zh)
|
2013-03-15 |
2020-07-17 |
Xencor股份有限公司 |
异二聚体蛋白
|
CR20160156A
(es)
|
2013-10-11 |
2016-11-01 |
Oxford Biotherapeutics Ltd |
Anticuerpos conjugados contra ly75 para el tratamiento del cáncer
|
CN106414465B
(zh)
|
2014-02-28 |
2021-11-16 |
杭州多禧生物科技有限公司 |
带电荷链接体及其在共轭反应上的应用
|
US9822186B2
(en)
|
2014-03-28 |
2017-11-21 |
Xencor, Inc. |
Bispecific antibodies that bind to CD38 and CD3
|
WO2016014984A1
(en)
|
2014-07-24 |
2016-01-28 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
MA41019A
(fr)
|
2014-11-26 |
2021-05-05 |
Xencor Inc |
Anticorps hétérodimériques se liant aux antigènes cd3 et cd38
|
MA55043A
(fr)
|
2014-11-26 |
2021-12-29 |
Xencor Inc |
Anticorps hétérodimériques se liant à l'antigène cd3 et l'antigène cd20
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
EP3237449A2
(en)
|
2014-12-22 |
2017-11-01 |
Xencor, Inc. |
Trispecific antibodies
|
WO2016141387A1
(en)
|
2015-03-05 |
2016-09-09 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
CN113350518A
(zh)
|
2015-07-12 |
2021-09-07 |
杭州多禧生物科技有限公司 |
与细胞结合分子的共轭偶联的桥连接体
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
EP3387013B1
(en)
|
2015-12-07 |
2022-06-08 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and psma
|
KR102523402B1
(ko)
|
2016-06-14 |
2023-04-19 |
젠코어 인코포레이티드 |
이중특이적 체크포인트 억제제 항체
|
JP7021127B2
(ja)
|
2016-06-28 |
2022-02-16 |
ゼンコア インコーポレイテッド |
ソマトスタチン受容体2に結合するヘテロ二量体抗体
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
SG11201903302UA
(en)
|
2016-10-14 |
2019-05-30 |
Xencor Inc |
Bispecific heterodimeric fusion proteins containing il-15/il-15ralpha fc-fusion proteins and pd-1 antibody fragments
|
NZ752394A
(en)
|
2016-11-14 |
2021-07-30 |
Hangzhou Dac Biotech Co Ltd |
Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
|
WO2019006472A1
(en)
|
2017-06-30 |
2019-01-03 |
Xencor, Inc. |
TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
CA3082383A1
(en)
|
2017-11-08 |
2019-05-16 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-pd-1 sequences
|
JP2021506291A
(ja)
|
2017-12-19 |
2021-02-22 |
ゼンコア インコーポレイテッド |
改変されたil−2 fc融合タンパク質
|
BR112020017053A2
(pt)
|
2018-02-21 |
2020-12-15 |
Celgene Corporation |
Anticorpos que se ligam ao bcma e usos dos mesmos
|
CA3096052A1
(en)
|
2018-04-04 |
2019-10-10 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
CN112437777A
(zh)
|
2018-04-18 |
2021-03-02 |
Xencor股份有限公司 |
包含IL-15/IL-15RA Fc融合蛋白和TIM-3抗原结合结构域的靶向TIM-3的异源二聚体融合蛋白
|
US11524991B2
(en)
|
2018-04-18 |
2022-12-13 |
Xencor, Inc. |
PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof
|
CN112584859A
(zh)
|
2018-07-02 |
2021-03-30 |
美国安进公司 |
抗steap1抗原结合蛋白
|
CN113195523A
(zh)
|
2018-10-03 |
2021-07-30 |
Xencor股份有限公司 |
IL-12异源二聚体Fc融合蛋白
|
CN114173875A
(zh)
|
2019-03-01 |
2022-03-11 |
Xencor股份有限公司 |
结合enpp3和cd3的异二聚抗体
|
US11919956B2
(en)
|
2020-05-14 |
2024-03-05 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
|
EP4305067A1
(en)
|
2021-03-09 |
2024-01-17 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cldn6
|
WO2022192586A1
(en)
|
2021-03-10 |
2022-09-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and gpc3
|