NL300953I2 - darvadstrocel - Google Patents

darvadstrocel Download PDF

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Publication number
NL300953I2
NL300953I2 NL300953C NL300953C NL300953I2 NL 300953 I2 NL300953 I2 NL 300953I2 NL 300953 C NL300953 C NL 300953C NL 300953 C NL300953 C NL 300953C NL 300953 I2 NL300953 I2 NL 300953I2
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NL
Netherlands
Prior art keywords
darvadstrocel
Prior art date
Application number
NL300953C
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English (en)
Dutch (nl)
Other versions
NL300953I1 (enExample
Original Assignee
Tigenix S A U
Univ Madrid Autonoma
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37116048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300953(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tigenix S A U, Univ Madrid Autonoma filed Critical Tigenix S A U
Publication of NL300953I1 publication Critical patent/NL300953I1/nl
Publication of NL300953I2 publication Critical patent/NL300953I2/nl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
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    • A61B17/16—Instruments for performing osteoclasis; Drills or chisels for bones; Trepans
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Surgery (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
NL300953C 2005-06-24 2018-09-21 darvadstrocel NL300953I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/167,061 US20060045872A1 (en) 2004-08-25 2005-06-24 Use of adipose tissue-derived stromal stem cells in treating fistula
EP06742940A EP1899458A2 (en) 2005-06-24 2006-05-16 Use of adipose tissue-derived stromal stem cells in treating fistula

Publications (2)

Publication Number Publication Date
NL300953I1 NL300953I1 (enExample) 2018-10-03
NL300953I2 true NL300953I2 (nl) 2021-02-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NL300953C NL300953I2 (nl) 2005-06-24 2018-09-21 darvadstrocel

Country Status (23)

Country Link
US (10) US20060045872A1 (enExample)
EP (7) EP2944688B1 (enExample)
JP (5) JP2008546397A (enExample)
KR (1) KR20080036588A (enExample)
CN (2) CN103143055A (enExample)
AU (1) AU2006261383B2 (enExample)
BR (1) BRPI0613811B8 (enExample)
CA (1) CA2613457C (enExample)
CY (3) CY1116764T1 (enExample)
DK (4) DK2292737T4 (enExample)
ES (6) ES2538657T5 (enExample)
HU (3) HUE025338T2 (enExample)
IL (1) IL188378A (enExample)
LT (3) LT2944688T (enExample)
LU (1) LUC00085I2 (enExample)
NL (1) NL300953I2 (enExample)
NZ (2) NZ565246A (enExample)
PL (3) PL3176255T3 (enExample)
PT (3) PT2944688T (enExample)
RU (3) RU2435846C2 (enExample)
SG (1) SG166770A1 (enExample)
SI (3) SI2944688T1 (enExample)
WO (1) WO2006136244A2 (enExample)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US7803787B2 (en) * 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
JP2008541238A (ja) 2005-05-05 2008-11-20 アーキペラゴ ホールディングス インコーポレイテッド 値段が付けられていない注文のオークション及び転送
US20070027543A1 (en) * 2005-08-01 2007-02-01 Gimble Jeffrey M Use of adipose tissue-derived stromal cells in spinal fusion
MX342474B (es) 2005-09-23 2016-09-30 Cellerix Sl Poblaciones celulares con actividad inmunoreguladora, método de aislamiento y usos.
JP5131833B2 (ja) * 2005-10-05 2013-01-30 晃文 松山 脂肪組織由来細胞から膵内分泌細胞を得る方法
CA2630452C (en) * 2005-12-02 2011-02-22 Cook Incorporated Devices, systems, and methods for occluding a defect
US20090209031A1 (en) * 2006-01-26 2009-08-20 Tyco Healthcare Group Lp Medical device package
US8592209B2 (en) * 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US20070224173A1 (en) * 2006-03-21 2007-09-27 Koullick Edouard A Nonexpansion Protocol for Autologous Cell-Based Therapies
US8021882B2 (en) * 2006-08-24 2011-09-20 Johnstone Brian H Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith
WO2008060374A2 (en) * 2006-10-06 2008-05-22 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
KR20080103637A (ko) 2007-05-25 2008-11-28 주식회사 알앤엘바이오 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물
US9186375B2 (en) 2007-06-21 2015-11-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan compositions in combination with stem cells
AU2014227541B2 (en) * 2007-09-19 2015-10-01 Pluristem Ltd. Methods of Treating Inflammatory Colon Diseases
US9393273B2 (en) * 2008-05-27 2016-07-19 Pluristem Ltd. Methods of treating inflammatory colon diseases
WO2009152084A2 (en) * 2008-06-11 2009-12-17 Cell4Vet Llc Adipose tissue-derived stem cells for veterinary use
EP2303183A4 (en) 2008-06-24 2015-11-04 Bioactive Surgical Inc SURGICAL SUTURES INCORPORATED IN STEM CELLS OR OTHER BIOACTIVE MATERIALS
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
US20100112696A1 (en) * 2008-11-03 2010-05-06 Baxter International Inc. Apparatus And Methods For Processing Tissue To Release Cells
US8309343B2 (en) * 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
ES2479621T3 (es) * 2009-04-28 2014-07-24 Anterogen Co., Ltd. Composición de células madre estromales derivadas de tejido adiposo autólogo y alogénico destinada al tratamiento de fístulas
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9669200B2 (en) 2010-08-06 2017-06-06 Boston Scientific Scimed, Inc. Systems and methods for the treatment of pelvic disorders including magnetic particulates
US20120087868A1 (en) 2010-10-08 2012-04-12 Gabriele Todd Nanoparticle-loaded cells
US9180172B2 (en) 2010-12-15 2015-11-10 Ams Research Corporation Treatment of Peyronies disease
US8979797B2 (en) 2010-12-16 2015-03-17 Ams Research Corporation High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics
ES2479544T1 (es) 2011-01-12 2014-08-20 Tigenix, S.A.U. Células madre mesenquimales derivadas de tejido adiposo para administración intralinfática en enfermedades autoimmunes e inflamatorias
KR20140016933A (ko) * 2011-03-11 2014-02-10 타이제닉스, 에스.에이.유. 면역조절 활성을 갖는 세포군, 분리방법 및 용도들
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
CL2011001904A1 (es) * 2011-08-08 2012-03-09 Univ Pontificia Catolica Chile Formulacion farmaceutica que comprende celulas madres mesenquimales vivas suspendidas en un vehiculo farmaceuticamente aceptable, sistema de aplicacion topica en aerosol que las comprende; y su uso para tratar heridas.
US20130072903A1 (en) * 2011-09-20 2013-03-21 John Chapman Adipose Tissue Graft for Wound Healing
GB201202319D0 (en) * 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
US20140024011A1 (en) * 2012-07-23 2014-01-23 AdiCyte, Inc. Method for Preparing Adipose Tissue
EP2908871B1 (en) * 2012-10-18 2018-08-08 Mayo Foundation For Medical Education And Research Techniques for treatment of abscesses
WO2014186854A1 (pt) * 2013-05-24 2014-11-27 Universidade Estadual De Campinas - Unicamp Processo de obtenção de fio de sutura enriquecido com celulas-tronco, fios obtidos, kit de sutura e seus usos
EP3027235A1 (en) 2013-07-30 2016-06-08 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US20170327584A1 (en) * 2014-11-26 2017-11-16 Millennium Pharmaceuticals, Inc. Vedolizumab for the Treatment of Fistulizing Crohn's Disease
RU2588835C1 (ru) * 2014-11-27 2016-07-10 Олег Германович Макеев Способ терапии повреждений кожи и биотрансплантат для его осуществления
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
PT3365432T (pt) 2015-10-23 2020-07-27 Rigshospitalet Terapêutica com células estaminais baseada em células estaminais derivadas de tecido adiposo
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
EP3484485A1 (en) * 2016-07-12 2019-05-22 Centre National De La Recherche Scientifique Compositions useful for mucosal healing
IT201700043316A1 (it) * 2017-04-20 2018-10-20 Lipogems Int S P A Drug delivery system
JP6999918B2 (ja) 2017-08-21 2022-02-04 学校法人慶應義塾 血小板表面抗原と間葉系細胞表面抗原を共発現する血小板様細胞を含む創傷治癒促進剤
AU2018372631B2 (en) 2017-11-22 2025-06-05 Mesoblast International Sarl Cellular compositions and methods of treatment I
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN111840645B (zh) * 2020-07-29 2022-04-01 沈阳细胞治疗工程技术研发中心有限公司 一种瘘洞修补制剂及其制备方法
CN115103696B (zh) * 2020-12-24 2024-07-09 罗基医疗保健公司 用于构建组织再生贴片的方法
CN114949361A (zh) * 2021-12-31 2022-08-30 浙江金时代生物技术有限公司 一种用于子宫内膜修复的聚乳酸-羟基乙酸共聚物支架与人脐带间充质干细胞复合物的制备方法
WO2024227193A2 (en) * 2023-04-28 2024-10-31 Angiocrine Bioscience, Inc. Endothelial cells for treatment of gastrointestinal fistula

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298002A (en) 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5143842A (en) 1988-11-01 1992-09-01 The University Of Colorado Foundation, Inc. Media for normal human muscle satellite cells
US5145770A (en) 1990-06-04 1992-09-08 Biosurface Technology, Inc. Cryopreservation of cultured epithelial sheets
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US6010696A (en) * 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
US5733542A (en) 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
WO1994008808A1 (de) 1992-10-10 1994-04-28 Hemscheidt Fahrwerktechnik Gmbh & Co. Kg Hydropneumatisches federungssystem
US5627175A (en) 1992-12-02 1997-05-06 Shellinternationale Research Maatschappij B.V. Azoxycyanobenzene compounds
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5578475A (en) 1993-07-12 1996-11-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US6174333B1 (en) 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
ATE247933T1 (de) 1994-06-06 2003-09-15 Univ Case Western Reserve Biomatrix für geweberegenaration
ES2231819T3 (es) 1995-06-07 2005-05-16 Inex Pharmaceuticals Corp Particulas de lipido-acido nucleico preparadas a traves de un intermedio complejo de lipido-acido nucleico hidrofobo y uso para transferir genes.
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
AU723003C (en) 1995-08-04 2004-01-29 General Hospital Corporation, The Transgenic swine and swine cells having human HLA genes
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US5705308A (en) 1996-09-30 1998-01-06 Eastman Kodak Company Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element
WO1998031316A1 (en) * 1997-01-17 1998-07-23 Celadon Science, Llc Methods for promoting healing of corneal resurfacing wounds
JP4222726B2 (ja) 1997-12-02 2009-02-12 ゼン‐バイオ，インコーポレイテッド 骨芽細胞の発生および使用
AU748443B2 (en) 1998-02-04 2002-06-06 General Hospital Corporation, The Costimulatory blockade and mixed chimerism in transplantation
US6368636B1 (en) 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US9585916B2 (en) 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
JP2002510655A (ja) 1998-04-03 2002-04-09 オシリス セラピューティクス，インコーポレイテッド 免疫抑制剤としての間葉幹細胞によるｔ細胞応答を阻害する方法とその利用
US6546105B1 (en) 1998-10-30 2003-04-08 Matsushita Electric Industrial Co., Ltd. Sound image localization device and sound image localization method
KR100968164B1 (ko) 1999-03-10 2010-07-06 더 리전츠 오브 더 유니버시티 오브 캘리포니아 지방 유래 간세포 및 격자
US20050153442A1 (en) 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US7846465B1 (en) * 1999-05-28 2010-12-07 Fibrocell Science, Inc. Method of using autologous fibroblasts to promote healing of wounds and fistulas
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US7078232B2 (en) * 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
US6866843B2 (en) 1999-12-06 2005-03-15 Viacell, Inc. Method of transplanting in a mammal and treating diabetes mellitus by administering a pseudo-islet like aggregate differentiated from a nestin-positive pancreatic stem cell
US20020155096A1 (en) 2001-02-23 2002-10-24 Chancellor Michael B. Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
AU2002356935A1 (en) 2001-11-09 2003-05-19 Artecel Sciences, Inc. Methods and compositions for the use of stromal cells to support embryonic and adult stem cells
IL162369A0 (en) * 2001-12-04 2005-11-20 Woolverton Christopher J Storage-stable fibrin sealant
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
ES2287447T3 (es) * 2002-02-19 2007-12-16 Medipost, Co., Ltd. Metodos de aislamiento y expansion del cultivo de celulas troncales/madre mesenquimatosas a partir de sangre del cordon umbilical, y metodo de diferenciacion de celulas troncales/madre mesenquimatosas derivadas de sangre del cordon umbilical en diversos tejidos mesenquimatosos.
CA2479309A1 (en) 2002-03-15 2003-12-24 Catherine A. Phillips Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
JP4399533B2 (ja) 2002-06-14 2010-01-20 キシンテラ、アクチボラグ 幹細胞のマーカーおよびその使用
EP1532173A4 (en) * 2002-06-14 2006-03-08 Dyax Corp PROTEIN ANALYSIS
US20040101959A1 (en) * 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
JP2004190976A (ja) * 2002-12-12 2004-07-08 Sony Corp 熱輸送装置及び電子デバイス
NZ542127A (en) * 2003-02-13 2008-04-30 Anthrogenesis Corp Use of umbilical cord blood to treat individuals having a disease, disorder or condition
CA2809195C (en) 2003-04-01 2014-05-20 United States Of America Department Of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
CA2530422C (en) 2003-06-27 2016-01-05 Ian Ross Harris Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
US7645229B2 (en) * 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
JP4749331B2 (ja) 2003-10-07 2011-08-17 株式会社バイオマスター 脂肪由来前駆細胞の細胞分化
ATE493492T1 (de) 2003-11-04 2011-01-15 Biomaster Inc Verfahren und system zur herstellung von stammzellen aus fettgewebe
WO2005062857A2 (en) 2003-12-24 2005-07-14 The Trustees Of Columbia University In The City Of New York Creation of a biological atrioventricular bypass to compensate for atrioventricular block
WO2005093044A1 (en) 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
US20080095749A1 (en) 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
WO2006029347A2 (en) 2004-09-03 2006-03-16 University Of Maryland, Baltimore Integrin cd18 is a novel stromal stem cell marker and functions to promote osteogenesis
US20060286089A1 (en) 2005-04-08 2006-12-21 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
MX342474B (es) 2005-09-23 2016-09-30 Cellerix Sl Poblaciones celulares con actividad inmunoreguladora, método de aislamiento y usos.
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
US20120269774A1 (en) 2006-09-21 2012-10-25 Medistem Laboratories, Inc Allogeneic stem cell transplants in non-conditioned recipients
WO2009031606A1 (ja) 2007-09-07 2009-03-12 Jcr Pharmaceuticals Co., Ltd. 関節炎治療及び予防剤
RU2010109698A (ru) 2007-09-19 2011-09-27 Плуристем Лтд. (Il) Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях
KR20160003307A (ko) 2007-10-17 2016-01-08 티엑셀 Tr1 세포, 중간엽 줄기 세포 및 이들의 용도
GB0814249D0 (en) 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
ES2345867B1 (es) 2009-04-03 2011-07-28 Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) Celulas madre multipotentes derivadas de estroma de mesenterio.
ES2479621T3 (es) 2009-04-28 2014-07-24 Anterogen Co., Ltd. Composición de células madre estromales derivadas de tejido adiposo autólogo y alogénico destinada al tratamiento de fístulas
CA2767300C (en) 2009-07-09 2020-01-07 Cellerix Sa Methods and compositions for use in cellular therapies
ES2479544T1 (es) 2011-01-12 2014-08-20 Tigenix, S.A.U. Células madre mesenquimales derivadas de tejido adiposo para administración intralinfática en enfermedades autoimmunes e inflamatorias
KR20140016933A (ko) 2011-03-11 2014-02-10 타이제닉스, 에스.에이.유. 면역조절 활성을 갖는 세포군, 분리방법 및 용도들
US20140134140A1 (en) 2012-11-09 2014-05-15 Case Western Reserve University Mesenchymal stem cell compositions for the treatment of microbial infections
WO2014140362A2 (en) 2013-03-15 2014-09-18 Tigenix, S.A.U Lymphocyte biomarkers for determining the clinical response to cell therapy
US20160120910A1 (en) 2013-06-25 2016-05-05 Tigenix S.A.U. Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

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