NL300099I2 - 2-Cyclo alkyl of arylalkylderivaten van niet-zuur cyclopentaanheptaanzuur als therapeutische middelen. - Google Patents
2-Cyclo alkyl of arylalkylderivaten van niet-zuur cyclopentaanheptaanzuur als therapeutische middelen.Info
- Publication number
- NL300099I2 NL300099I2 NL300099C NL300099C NL300099I2 NL 300099 I2 NL300099 I2 NL 300099I2 NL 300099 C NL300099 C NL 300099C NL 300099 C NL300099 C NL 300099C NL 300099 I2 NL300099 I2 NL 300099I2
- Authority
- NL
- Netherlands
- Prior art keywords
- cycloalkyl
- arylalkyl
- derivatives
- cyclopentane heptanoic
- acid
- Prior art date
Links
- 125000003710 aryl alkyl group Chemical group 0.000 title abstract 5
- PRLVHZDMICRVJF-UHFFFAOYSA-N cyclopentane;heptanoic acid Chemical compound C1CCCC1.CCCCCCC(O)=O PRLVHZDMICRVJF-UHFFFAOYSA-N 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 239000000050 smooth muscle relaxant Substances 0.000 abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 208000018685 gastrointestinal system disease Diseases 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 125000000101 thioether group Chemical group 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
- C07C247/10—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/948,056 US5352708A (en) | 1992-09-21 | 1992-09-21 | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
PCT/US1993/008472 WO1994006433A1 (en) | 1992-09-21 | 1993-09-09 | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
NL300099I1 NL300099I1 (nl) | 2002-11-01 |
NL300099I2 true NL300099I2 (nl) | 2003-03-01 |
Family
ID=25487188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL300099C NL300099I2 (nl) | 1992-09-21 | 2002-09-05 | 2-Cyclo alkyl of arylalkylderivaten van niet-zuur cyclopentaanheptaanzuur als therapeutische middelen. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5352708A (nl) |
EP (1) | EP0660716B1 (nl) |
JP (3) | JP3681068B2 (nl) |
AT (1) | ATE209494T1 (nl) |
AU (1) | AU676492B2 (nl) |
CA (1) | CA2144967C (nl) |
DE (2) | DE69331233C5 (nl) |
DK (1) | DK0660716T3 (nl) |
ES (1) | ES2166364T3 (nl) |
LU (1) | LU90957I2 (nl) |
NL (1) | NL300099I2 (nl) |
PT (1) | PT660716E (nl) |
WO (1) | WO1994006433A1 (nl) |
Families Citing this family (147)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5834498A (en) * | 1992-09-21 | 1998-11-10 | Allergan | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US5972991A (en) * | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US5688819A (en) * | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US6602900B2 (en) | 1992-09-21 | 2003-08-05 | Allergan, Inc. | Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
US6184250B1 (en) | 1993-08-03 | 2001-02-06 | Alcon Laboratories, Inc. | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension |
US5486540A (en) * | 1993-10-28 | 1996-01-23 | Allergan, Inc. | Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalkenyl and derivatives as therapeutic agents |
US5545665A (en) * | 1993-12-28 | 1996-08-13 | Allergan | Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents |
AU693698B2 (en) * | 1995-05-18 | 1998-07-02 | Allergan, Inc. | Cyclopentane heptan(ene)oic acid, 2-heteroarylakenyl derivatives as therapeutic agents for the treatment of ocular hypertension |
US6441047B2 (en) | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
US5700835A (en) * | 1995-12-22 | 1997-12-23 | Alcon Laboratories, Inc. | 3-Oxa-D-prostaglandins for lowering IOP |
US5741810A (en) * | 1996-02-29 | 1998-04-21 | Allergan | Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents |
UA59384C2 (uk) * | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
EP1021179B1 (en) | 1997-02-04 | 2004-05-12 | Murray A. Johnstone | Method of enhancing hair growth |
IT1292377B1 (it) * | 1997-06-19 | 1999-02-08 | Nicox Sa | Composizioni farmaceutiche a base di prostaglandine |
IT1292426B1 (it) | 1997-06-27 | 1999-02-08 | Nicox Sa | Sali nitrati di ace-inibitori |
WO2000051980A1 (en) | 1999-03-05 | 2000-09-08 | The Procter & Gamble Company | C16 unsaturated fp-selective prostaglandins analogs |
IL143477A (en) * | 2001-05-31 | 2009-07-20 | Finetech Pharmaceutical Ltd | Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives |
US6395787B1 (en) | 2000-02-08 | 2002-05-28 | Allergan Sales, Inc. | Ocular hypotensive lipids |
WO2001066518A1 (fr) * | 2000-03-09 | 2001-09-13 | Ono Pharmaceutical Co., Ltd. | E-ALCOOLS PHENYL-PROSTAGLANDINE φ-SUBSTITUES, PROCEDE DE PREPARATION ASSOCIE ET MEDICAMENTS RENFERMANT CES DERNIERS EN TANT QUE PRINCIPE ACTIF |
US6927233B1 (en) | 2000-03-17 | 2005-08-09 | Alcon, Inc. | 5ht2 agonists for controlling IOP and treating glaucoma |
US7005443B1 (en) | 2000-03-17 | 2006-02-28 | Alcon, Inc. | 5-Hydroxy indazole derivatives for treating glaucoma |
US6956036B1 (en) | 2000-03-17 | 2005-10-18 | Alcon, Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
US20030119846A1 (en) * | 2000-03-17 | 2003-06-26 | Collier Jr Robert J. | Compounds with 5-ht activity useful for controlling visual field loss |
US7012090B1 (en) | 2000-03-17 | 2006-03-14 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
WO2001070705A1 (en) | 2000-03-17 | 2001-09-27 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
US6806285B1 (en) | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
US20020146439A1 (en) * | 2000-03-31 | 2002-10-10 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins |
US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
US6291522B1 (en) * | 2000-09-27 | 2001-09-18 | Allergan Sales, Inc. | Cyclopentane heptan(ENE)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents |
WO2004098807A1 (en) * | 2000-11-21 | 2004-11-18 | Barsplice Products, Inc. | Method of making steel couplers for joining concrete reinforcing bars |
US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
US7842727B2 (en) * | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
KR100437873B1 (ko) | 2001-05-08 | 2004-06-26 | 연성정밀화학(주) | 프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질 |
US20030212107A1 (en) * | 2001-05-10 | 2003-11-13 | Kapin Michael A. | R-reliprodil for treating glaucoma |
US6531504B2 (en) * | 2001-05-17 | 2003-03-11 | Allergan, Inc. | Prostanoic acid derivatives as agents for lowering intraocular pressure |
TWI298257B (en) | 2001-05-31 | 2008-07-01 | Allergan Inc | Hypotensive lipid and timolol compositions and methods of using same |
DE60209486T2 (de) * | 2001-06-01 | 2006-08-03 | Alcon Inc. | Pyranoindazole und ihre verwendung in der glaukombehandlung |
CN1512879A (zh) * | 2001-06-01 | 2004-07-14 | �Ƹ��� | 新的芳氨基丙烷类似物及其用于治疗青光眼的用途 |
JP2004532887A (ja) * | 2001-06-01 | 2004-10-28 | アルコン,インコーポレイテッド | 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用 |
US6713268B2 (en) | 2001-06-26 | 2004-03-30 | Allergan, Inc. | Methods of identifying ocular hypotensive compounds having reduced hyperpigmentation |
US6884816B2 (en) * | 2001-08-31 | 2005-04-26 | Alcon, Inc. | Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma |
US20040254230A1 (en) * | 2001-12-03 | 2004-12-16 | Ogidigben Miller J. | Method for treating ocular hypertension |
US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
US7351404B2 (en) * | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
AU2012261499B2 (en) * | 2002-02-04 | 2016-05-12 | Allergan, Inc. | Method of enhancing hair growth |
US20040110776A1 (en) * | 2002-02-22 | 2004-06-10 | Iok-Hou Pang | Use of propentofylline to control intraocular pressure |
AU2003243272A1 (en) * | 2002-05-22 | 2003-12-12 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds |
EP1513523A1 (en) * | 2002-06-06 | 2005-03-16 | Merck Frosst Canada & Co. | 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases |
EP1513589B1 (en) | 2002-06-06 | 2010-11-10 | Merck Frosst Canada Ltd. | 1,5-disubstituted pyrrolid-2-one derivatives for use as ep4 receptor agonists in the treatment of eye diseases such as glaucoma |
US6864282B2 (en) * | 2002-08-05 | 2005-03-08 | Allergan, Inc. | 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma |
JP2006504679A (ja) * | 2002-08-28 | 2006-02-09 | メルク フロスト カナダ アンド カンパニー | 緑内障の治療においてep4受容体作動薬として使用するためのオキサゾリジン−2−オンおよびチアゾリジン−2−オン誘導体 |
KR101092048B1 (ko) * | 2002-08-29 | 2011-12-12 | 산텐 세이야꾸 가부시키가이샤 | Rho 키나아제 억제제 및 프로스타글란딘류를 포함하는녹내장 치료제 |
KR20050033654A (ko) * | 2002-08-30 | 2005-04-12 | 알콘, 인코퍼레이티드 | 치환된 5-크로만-5-일-에틸아민 화합물 및 녹내장의 치료용그의 용도 |
US7196082B2 (en) | 2002-11-08 | 2007-03-27 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
EP1581503A4 (en) * | 2002-11-08 | 2007-07-25 | Merck & Co Inc | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION |
US20040092431A1 (en) * | 2002-11-12 | 2004-05-13 | Hellberg Peggy E. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
JP4314433B2 (ja) | 2002-11-18 | 2009-08-19 | 参天製薬株式会社 | Rhoキナーゼ阻害剤とβ遮断薬からなる緑内障治療剤 |
AU2003291097A1 (en) * | 2002-11-20 | 2004-06-15 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
WO2004054572A2 (en) * | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
US20040216749A1 (en) * | 2003-01-23 | 2004-11-04 | Hosheng Tu | Vasomodulation during glaucoma surgery |
CA2530081A1 (en) * | 2003-07-01 | 2005-01-13 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
JP2007504228A (ja) * | 2003-09-02 | 2007-03-01 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼組成物 |
CA2537430A1 (en) * | 2003-09-04 | 2005-03-24 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
JP4546961B2 (ja) * | 2003-09-04 | 2010-09-22 | メルク・シャープ・エンド・ドーム・コーポレイション | 高眼圧の治療のための眼科用組成物 |
ES2331313T3 (es) * | 2003-11-07 | 2009-12-29 | Senju Pharmaceutical Co., Ltd. | Composicion farmaceutica que contiene prostaglandina. |
US20090148527A1 (en) * | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
US7476687B2 (en) * | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
WO2005058911A2 (en) * | 2003-12-15 | 2005-06-30 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
EP1740164B1 (en) * | 2004-04-26 | 2008-08-13 | Alcon Inc. | Statins for the treatment of ocular hypertension and glaucoma |
CA2574078A1 (en) | 2004-07-20 | 2006-02-23 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
WO2006041875A1 (en) * | 2004-10-06 | 2006-04-20 | Allergan, Inc. | Novel prostamides for the treatment of glaucoma and related diseases |
AU2005295997A1 (en) * | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
JP2008515982A (ja) * | 2004-10-13 | 2008-05-15 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼科組成物 |
CA2587013A1 (en) * | 2004-11-08 | 2006-05-18 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
WO2006062839A1 (en) * | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
US9241918B2 (en) | 2005-03-16 | 2016-01-26 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
US7851504B2 (en) | 2005-03-16 | 2010-12-14 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
CN101151034B (zh) | 2005-03-31 | 2012-06-06 | 旭硝子株式会社 | 含有前列腺素F2α衍生物作为有效成分的视网膜神经细胞保护剂 |
RU2392938C2 (ru) | 2005-04-13 | 2010-06-27 | Убе Индастриз, Лтд | Защитное средство для нейронных клеток сетчатки, содержащее в качестве активного ингредиента производные индазола |
WO2007002670A2 (en) * | 2005-06-28 | 2007-01-04 | Bausch & Lomb Incorporated | Method of lowering intraocular pressure |
US20070015838A1 (en) * | 2005-07-14 | 2007-01-18 | Allergan, Inc. | Cyclopentane n-lower alkyl heptenamide-5-cis-2-(3alpha-hydroxy-5-phenylpentyl)-3, 5-dihydroxy, [1alpha, 2beta, 3alpha, 5alpha] compounds as agents for lowering intraocular pressure |
CA2616608A1 (en) * | 2005-08-03 | 2007-02-08 | Merck Frosst Canada Ltd. | Ep4 receptor agonist, compositions and methods thereof |
TW200744567A (en) * | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
AU2006304553A1 (en) * | 2005-10-14 | 2007-04-26 | Alcon, Inc. | Method for treating primary and secondary forms of glaucoma |
US20080125406A1 (en) * | 2005-10-14 | 2008-05-29 | Robin Alan L | Method for Treating Primary and Secondary Forms of Glaucoma |
CA2628413C (en) * | 2005-11-03 | 2014-09-23 | Allergan, Inc. | Prostaglandins and analogues as agents for lowering intraocular pressure |
WO2007097205A1 (ja) * | 2006-02-02 | 2007-08-30 | Kenji Yoshida | 点眼剤 |
JP2009533326A (ja) * | 2006-03-13 | 2009-09-17 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症の治療用眼科用組成物 |
EP2032130A4 (en) * | 2006-06-12 | 2011-03-02 | Merck Sharp & Dohme | OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF EYE HIGH PRESSURE |
JP2009541340A (ja) * | 2006-06-20 | 2009-11-26 | アラーガン インコーポレイテッド | 治療用化合物 |
US20080015219A1 (en) * | 2006-07-11 | 2008-01-17 | Allergan, Inc. | Therapeutic compounds |
BRPI0714885B8 (pt) * | 2006-07-11 | 2021-05-25 | Allergan Inc | compostos terapêuticos e seu uso |
IL177762A0 (en) * | 2006-08-29 | 2006-12-31 | Arieh Gutman | Bimatoprost crystalline form i |
TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
JP5394927B2 (ja) * | 2006-09-28 | 2014-01-22 | アルコン リサーチ, リミテッド | 自己保存性水性医薬品組成物 |
US20090048146A1 (en) * | 2006-12-21 | 2009-02-19 | Alcon, Inc. | Use of agents that upregulate crystallin expression in the retina and optic nerve head |
UY30883A1 (es) | 2007-01-31 | 2008-05-31 | Alcon Res | Tapones punctales y metodos de liberacion de agentes terapeuticos |
WO2008094958A1 (en) * | 2007-02-01 | 2008-08-07 | Allergan, Inc. | Thiophene derivatives useful as medicaments for treating ocular hypertension |
EP2170345B1 (en) * | 2007-07-03 | 2013-03-06 | Allergan, Inc. | Therapeutic substituted cyclopentanes for reducing intraocular pressure |
US20090018204A1 (en) * | 2007-07-13 | 2009-01-15 | Brinkenhoff Michael C | Composition and method for enhancing hair growth |
KR101541303B1 (ko) * | 2008-03-17 | 2015-08-03 | 알콘 리서치, 리미티드 | 보레이트-폴리올 복합체를 함유하는 수성 약학적 조성물 |
AR076731A1 (es) * | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
EP2135860A1 (en) | 2008-06-20 | 2009-12-23 | Sandoz AG | Improved process for the production of bimatoprost |
US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US8722739B2 (en) * | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US20100204335A1 (en) * | 2008-12-01 | 2010-08-12 | Allergan, Inc. | Kit and composition for eyelash growth |
US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
WO2010112615A1 (en) | 2009-04-03 | 2010-10-07 | Dsm Ip Assets B.V. | Lysine derivatives functionalised with lipids |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
TWI489997B (zh) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸-多元醇錯合物之水性藥學組成物 |
CN102050772B (zh) | 2009-11-02 | 2013-08-21 | 上海天伟生物制药有限公司 | 一种比马前列素晶体及其制备方法和用途 |
AU2010314863A1 (en) * | 2009-11-09 | 2012-06-14 | Allergan, Inc. | Compositions for enhancing hair growth |
US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
KR101769637B1 (ko) | 2009-11-09 | 2017-08-18 | 알러간, 인코포레이티드 | 모발 성장을 촉진하기 위한 조성물 및 방법 |
US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
US8783923B2 (en) * | 2010-03-18 | 2014-07-22 | Chung Yuan Christian University | Auto lamp structure |
JP2013523821A (ja) | 2010-04-06 | 2013-06-17 | アラーガン、インコーポレイテッド | 前房内薬剤送達のための徐放性リザーバーインプラント |
US9061034B2 (en) | 2010-07-29 | 2015-06-23 | Allergan, Inc. | Preservative free bimatoprost and timolol solutions |
AU2011282681B2 (en) | 2010-07-29 | 2015-07-30 | Allergan, Inc. | Preservative free bimatoprost and timolol solutions |
EP2600825B1 (en) | 2010-08-02 | 2018-12-12 | Ac Patent Holding Inc. | Method for curling hair |
US8859616B2 (en) | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
CN103747775A (zh) | 2011-01-31 | 2014-04-23 | 阿勒根公司 | 促进毛发生长的方法 |
WO2012105674A1 (ja) | 2011-02-04 | 2012-08-09 | 興和株式会社 | 緑内障予防又は治療のための薬物療法 |
EP2675786B1 (en) | 2011-02-14 | 2018-12-26 | Allergan, Inc. | Ester derivatives of bimatoprost compositions and methods |
PT2723714T (pt) | 2011-06-02 | 2017-08-18 | Chinoin Zrt | Novos processos para a preparação de amidas de prostaglandina |
US9987213B2 (en) | 2012-06-13 | 2018-06-05 | Edward Dunne Corboy, JR. | Topical dihydrotestosterone (DHT) for promoting hair growth—containing formulations |
CN104884006B (zh) | 2012-10-26 | 2017-12-15 | 弗赛特影像5股份有限公司 | 用于持续释放药物到眼睛的眼科系统 |
EP2968093A1 (en) | 2013-03-14 | 2016-01-20 | Allergan, Inc. | Topical compositions comprising bimatoprost and methods for stimulating hair growth therewith |
TWI722298B (zh) * | 2013-03-15 | 2021-03-21 | 美商歐樂根公司 | 含有前列醯胺之眼內植入物 |
US9913849B2 (en) | 2014-01-10 | 2018-03-13 | Manistee Partners Llc | Treatment of migraines |
ES2954412T3 (es) | 2014-10-20 | 2023-11-22 | Sentiss Pharma Private Ltd | Solución oftálmica |
EP3223793B1 (en) | 2014-11-25 | 2023-06-28 | Eximore Ltd. | Compositions and methods for delivering a bio-active agent or bio-active agents |
EP3789027A1 (en) | 2015-01-13 | 2021-03-10 | Kyoto University | Bosutinib, sunitinib, tivozanib, imatinib, nilotinib, rebastinib or bafetinib for preventing and/or treating amyotrophic lateral sclerosis |
WO2016168141A1 (en) | 2015-04-13 | 2016-10-20 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
EP3235810A1 (en) | 2016-04-19 | 2017-10-25 | Gentec, S.A. | Process for the preparation of bimatoprost |
RU2718744C2 (ru) | 2018-05-17 | 2020-04-14 | Общество с ограниченной ответственностью "Гурус БиоФарм" | Производные простагландина F2альфа для снижения внутриглазного давления |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE37602B1 (en) * | 1971-05-11 | 1977-08-31 | Ici Ltd | Cyclopentane derivatives |
GB1402035A (en) * | 1972-12-07 | 1975-08-06 | Ici Ltd | Cyclopentane derivatives |
GB1451798A (en) * | 1973-08-02 | 1976-10-06 | Ici Ltd | Prostanoic acid derivatives |
US4183870A (en) * | 1974-01-26 | 1980-01-15 | May & Baker Limited | Cyclopentane derivatives |
GB1486832A (en) * | 1974-08-05 | 1977-09-28 | Ici Ltd | Prostanoic acid derivatives |
NL7605381A (nl) * | 1975-05-26 | 1976-11-30 | Schering Ag | Werkwijze voor het bereiden van prostaanderi- vaten en werkwijze voor het bereiden van een geneesmiddel met prostaglandinewerking. |
US4128577A (en) * | 1975-12-29 | 1978-12-05 | The Upjohn Company | 15-Methyl- and 16-phenoxy-PGF2 α, amides |
US4055602A (en) * | 1976-01-08 | 1977-10-25 | The Upjohn Company | 2-Decarboxy-2-hydroxy-methyl-5-oxa-17-phenyl-18,19,20-trinor-PGF-analogs |
US4091207A (en) * | 1976-04-22 | 1978-05-23 | Pfizer Inc. | Prostaglandin intermediate including oxathio heterocyclic ring |
IL51877A (en) * | 1976-06-01 | 1981-09-13 | Carlo Erba Sa | -nor-16-benzyl or phenoxy-13,14-dehydro-prostaglandins and process for their preparation |
JPS53121742A (en) * | 1977-03-31 | 1978-10-24 | Ono Pharmaceut Co Ltd | Prostaglandin analogous compounds and process for their preparation |
DE2715838A1 (de) * | 1977-04-05 | 1978-10-19 | Schering Ag | Neue prostanderivate und verfahren zu ihrer herstellung |
US4163758A (en) * | 1977-09-09 | 1979-08-07 | Sagami Chemical Research Center | 2-Nitroethylcyclopentane compounds and process for preparing the same |
US4171331A (en) * | 1978-06-05 | 1979-10-16 | Miles Laboratories, Inc. | 1 And 2-substituted analogues of certain prostaglandins |
JPS5583775A (en) * | 1978-12-20 | 1980-06-24 | Toray Ind Inc | 13,14-epoxyprostaglandin |
US4275074A (en) * | 1979-03-09 | 1981-06-23 | Graham J. Dobbie | Catecholamine treatment of ocular hypertension |
US4292445A (en) * | 1980-04-28 | 1981-09-29 | The Upjohn Company | Amide and sulfonamide derivatives of 2-decarboxy-2-aminomethyl-PG-type compounds |
US4599353A (en) * | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
DE3371199D1 (en) * | 1982-08-24 | 1987-06-04 | Teijin Ltd | Novel 6-nitroprostaglandin derivatives, process for production thereof, and use thereof |
JPS59190964A (ja) * | 1983-04-15 | 1984-10-29 | Ono Pharmaceut Co Ltd | 新規なプロスタグランジンd類似化合物 |
US4824857A (en) * | 1986-05-16 | 1989-04-25 | Yasumasa Goh | Use of prostaglandin D2 -active substances |
EP0569046B1 (en) * | 1988-09-06 | 2002-11-13 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
US4994274A (en) * | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
US5034413A (en) * | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
CA2039420C (en) * | 1990-04-04 | 1996-12-10 | Ryuji Ueno | Treatment of cataract with 15-keto-prostaglandin compounds |
US5270049A (en) * | 1990-11-09 | 1993-12-14 | Allergan, Inc. | 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives |
WO1992008464A1 (en) * | 1990-11-15 | 1992-05-29 | Tanabe Seiyaku Co. Ltd. | Substituted urea and related cell adhesion modulation compounds |
US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
-
1992
- 1992-09-21 US US07/948,056 patent/US5352708A/en not_active Expired - Lifetime
-
1993
- 1993-09-09 CA CA002144967A patent/CA2144967C/en not_active Expired - Lifetime
- 1993-09-09 DK DK93921435T patent/DK0660716T3/da active
- 1993-09-09 AU AU48526/93A patent/AU676492B2/en not_active Expired
- 1993-09-09 DE DE69331233.5T patent/DE69331233C5/de not_active Expired - Lifetime
- 1993-09-09 AT AT93921435T patent/ATE209494T1/de active
- 1993-09-09 ES ES93921435T patent/ES2166364T3/es not_active Expired - Lifetime
- 1993-09-09 WO PCT/US1993/008472 patent/WO1994006433A1/en active IP Right Grant
- 1993-09-09 DE DE2002199037 patent/DE10299037I2/de active Active
- 1993-09-09 EP EP93921435A patent/EP0660716B1/en not_active Expired - Lifetime
- 1993-09-09 PT PT93921435T patent/PT660716E/pt unknown
- 1993-09-09 JP JP50815594A patent/JP3681068B2/ja not_active Expired - Lifetime
-
1995
- 1995-01-11 US US08/371,339 patent/US5607978A/en not_active Expired - Lifetime
-
2002
- 2002-09-04 LU LU90957C patent/LU90957I2/fr unknown
- 2002-09-05 NL NL300099C patent/NL300099I2/nl unknown
-
2004
- 2004-07-08 JP JP2004201577A patent/JP2004346080A/ja not_active Withdrawn
-
2010
- 2010-12-02 JP JP2010269407A patent/JP2011052014A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE69331233C5 (de) | 2014-06-18 |
DE69331233T2 (de) | 2002-06-27 |
US5607978A (en) | 1997-03-04 |
LU90957I2 (fr) | 2003-04-30 |
JP2004346080A (ja) | 2004-12-09 |
AU4852693A (en) | 1994-04-12 |
DE10299037I2 (de) | 2004-09-23 |
PT660716E (pt) | 2002-05-31 |
DE69331233D1 (de) | 2002-01-10 |
AU676492B2 (en) | 1997-03-13 |
CA2144967C (en) | 2003-11-11 |
WO1994006433A1 (en) | 1994-03-31 |
DK0660716T3 (da) | 2002-04-02 |
CA2144967A1 (en) | 1994-03-31 |
JP2011052014A (ja) | 2011-03-17 |
NL300099I1 (nl) | 2002-11-01 |
ATE209494T1 (de) | 2001-12-15 |
EP0660716B1 (en) | 2001-11-28 |
DE10299037I1 (de) | 2003-02-20 |
ES2166364T3 (es) | 2002-04-16 |
US5352708A (en) | 1994-10-04 |
EP0660716A1 (en) | 1995-07-05 |
JP3681068B2 (ja) | 2005-08-10 |
JPH08501310A (ja) | 1996-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NL300099I1 (nl) | 2-Cyclo alkyl of arylalkylderivaten van niet-zuur cyclopentaanheptaanzuur als therapeutische middelen. | |
WO2002085248A3 (en) | Prostanoids augment ocular drug penetration | |
ATE177657T1 (de) | Intravaginales wirkstoffabgabesystem | |
TR200101859T2 (tr) | Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler | |
BR9811827A (pt) | Preparações de aerossol aquosas contendo macromoléculas biologicamente ativas e processo para a produção de aerossóis correspondentes | |
NO970042L (no) | 2-£(Dihydro)pyrazolyl-3'-oksymetylen|-anilider, fremgangsmåte til fremstilling og anvendelse derav | |
BR9707892A (pt) | Derivados de ácido 2-heteroalrialquenil ciclopentano hepta(EN)óico como agentes terapêuticos | |
BRPI0418245A (pt) | nitróxi-derivados de prostaglandina | |
ATE302606T1 (de) | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren | |
WO2001028987A8 (en) | Benzylcycloalkyl amines as modulators of chemokine receptor activity | |
BR0017157A (pt) | Derivados de 6-hidroxi-indazol para o tratamento de glaucoma | |
WO2000018316A3 (en) | Sustained release, and comfortable ophthalmic composition and method for ocular therapy | |
WO1994018972A3 (en) | Methods for treating neurodegenerative diseases and disorders using n-(2,6-disubstituted aromatic)-n'-pyridinyl ureas and other anticonvulsant compounds | |
BR0017163A (pt) | Derivados 5-hidróxi-indazol para tratamento do glaucoma | |
DK0665741T3 (da) | Topiske, oftalmiske, farmaceutiske bærere | |
BR9812085A (pt) | "método para a sìntese de derivados de quinolina" | |
PT1187611E (pt) | Composicoes oftalmicas de histamina e sua utilizacoes | |
BR0010699A (pt) | Benzimidazóis substituìdos, sua produção e utilização dos mesmos como agente contra protozoários parasitários | |
ATE344247T1 (de) | 2-sulfamoylbenzoesäure-derivate | |
DK0745072T3 (da) | 4-aminoderivater af 5-substitueret mycophenolsyre | |
ES2171742T3 (es) | Agente reductor de la presion ocular. | |
CY1106232T1 (el) | Συνδεσμικα μεσα νευροφιλινης δια νοσηλειαν οφθαλμικων καταστασεων | |
BR9809435A (pt) | Sais farmaceuticamente aceitáveis de 3-sulfato de 5alfa-pregnan-3beta, 16alfa-diol-20-ona úteis como progestinas e distúrbios do snc | |
DE69633093D1 (de) | Verfahren und Zwischenprodukte für die Herstellung von herbizid wirkenden 1-[2-(Cyclopropylcarbonyl)phenyl]sulfamoyl-3-(4,6-dialkoxy-2-pyrimidinyl)harnstoff-Verbindungen | |
BR9901566A (pt) | Análogos cis-delta4 de prostaglandinas como hipotensores oculares |