NL194389C - Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. - Google Patents
Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. Download PDFInfo
- Publication number
- NL194389C NL194389C NL8501578A NL8501578A NL194389C NL 194389 C NL194389 C NL 194389C NL 8501578 A NL8501578 A NL 8501578A NL 8501578 A NL8501578 A NL 8501578A NL 194389 C NL194389 C NL 194389C
- Authority
- NL
- Netherlands
- Prior art keywords
- active agent
- isradipine
- carrier
- solid
- solid dispersion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3422083 | 1984-06-14 | ||
| DE3422083 | 1984-06-14 | ||
| DE3442566 | 1984-11-22 | ||
| DE3442566 | 1984-11-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8501578A NL8501578A (nl) | 1986-01-02 |
| NL194389B NL194389B (nl) | 2001-11-01 |
| NL194389C true NL194389C (nl) | 2002-03-04 |
Family
ID=25822108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8501578A NL194389C (nl) | 1984-06-14 | 1985-05-31 | Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. |
Country Status (21)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1187751B (it) * | 1985-10-15 | 1987-12-23 | Eurand Spa | Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute |
| US4816263A (en) * | 1987-10-02 | 1989-03-28 | Alza Corporation | Dosage form for treating cardiovascular diseases comprising isradipine |
| WO1989009066A1 (en) * | 1988-03-24 | 1989-10-05 | Bukh Meditec A/S | Controlled release composition |
| GR1000270B (el) * | 1988-09-30 | 1992-05-12 | Alza Corp | Μορφη δοσολογιας για θεραπεια καρδιαγγειακων ασθενειων. |
| DK469989D0 (da) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | Farmaceutisk praeparat |
| MX9300110A (es) * | 1992-01-13 | 1994-07-29 | Gerhard Gergely | Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion. |
| DE4201179A1 (de) * | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung |
| US6726930B1 (en) | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
| GB2281697A (en) * | 1993-09-14 | 1995-03-15 | Euro Celtique Sa | Laxative compositions in capsules |
| DE69739165D1 (de) | 1996-07-08 | 2009-01-29 | Penwest Pharmaceuticals Co | Matrix mit verzögerter freisetzung für hochdosierte unlösliche arzneistoffe |
| DE19710009A1 (de) * | 1997-03-12 | 1998-09-24 | Knoll Ag | Mehrphasige wirkstoffhaltige Zubereitungsformen |
| US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
| US6787157B1 (en) | 1998-03-10 | 2004-09-07 | Abbott Laboratories | Multiphase active ingredient-containing formulations |
| US7001892B1 (en) | 1999-06-11 | 2006-02-21 | Purdue Research Foundation | Pharmaceutical materials and methods for their preparation and use |
| AU5483600A (en) * | 1999-06-11 | 2001-01-02 | Jean A. Chmielewski | Pharmaceutical materials and methods for their preparation and use |
| CN1193792C (zh) * | 1999-08-04 | 2005-03-23 | 山之内制药株式会社 | 稳定的口服医药组合物 |
| WO2001022940A1 (en) | 1999-09-30 | 2001-04-05 | Edward Mendell Co., Inc. | Sustained release matrix systems for highly soluble drugs |
| AU2002228579B2 (en) * | 2001-02-13 | 2006-07-27 | Astrazeneca Ab | Novel modified released formulation |
| US7135436B2 (en) | 2003-05-05 | 2006-11-14 | J.F. Daley International, Ltd. | Solid algicide, preparation and usage in recirculating water |
| EP1690528A1 (de) | 2005-02-11 | 2006-08-16 | Abbott GmbH & Co. KG | Herstellung von Dosierungsformen mit einer festen Dispersion eines mikrokristallinen Wirkstoffs |
| US8399007B2 (en) | 2006-12-05 | 2013-03-19 | Landec Corporation | Method for formulating a controlled-release pharmaceutical formulation |
| CA2670749A1 (en) | 2006-12-05 | 2008-06-12 | Landec Corporation | Drug delivery |
| US8114883B2 (en) | 2007-12-04 | 2012-02-14 | Landec Corporation | Polymer formulations for delivery of bioactive materials |
| WO2010022193A2 (en) | 2008-08-20 | 2010-02-25 | Board Of Regents, The University Of Texas System | Hot-melt extrusion of modified release multi-particulates |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1617362A1 (de) * | 1967-11-17 | 1971-03-25 | Beiersdorf Ag | Verfahren zur Herstellung von Arzneimitteln mit verzoegerter Wirkstoffabgabe in Form von Kapseln |
| DE2400819C2 (de) * | 1974-01-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung |
| DE2546577B2 (de) * | 1975-10-17 | 1981-04-02 | Sandoz-Patent-GmbH, 7850 Lörrach | Feste Stoffe aus Polyvinylpyrrolidon und Ergotalkaloiden |
| GB1504553A (en) * | 1975-11-17 | 1978-03-22 | Sandoz Ltd | Tablet formulations |
| GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
| FI64938C (fi) * | 1977-06-20 | 1984-02-10 | Sandoz Ag | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara bensoxa- och bensotiadiazolyl-1,4-dihydropyridinderivat |
| CH639659A5 (de) * | 1978-12-18 | 1983-11-30 | Sandoz Ag | Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung. |
| EP0001247A1 (en) * | 1977-09-14 | 1979-04-04 | Kanebo, Ltd. | Pharmaceutical preparation containing nifedipine and a method for producing the same. |
| DK154607C (da) * | 1978-12-21 | 1989-06-05 | Sandoz Ag | Fremgangsmaade til fremstilling af en laegemiddelform til oral administration af ergotalkaloider |
| DE2904310A1 (de) * | 1979-02-05 | 1980-08-07 | Boehringer Mannheim Gmbh | Formlinge mit retardierter wirkstofffreisetzung und verfahren zu deren herstellung |
| JPS56115726A (en) * | 1980-02-20 | 1981-09-11 | Kaken Pharmaceut Co Ltd | Pharmaceutical containing nifedipine |
| DE3033919A1 (de) * | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung |
| US4442112A (en) * | 1981-09-02 | 1984-04-10 | Sandoz Ltd. | Dihydropyridine derivatives useful in treating vascular headaches |
| DE3270785D1 (en) * | 1981-10-29 | 1986-05-28 | Bayer Ag | Process for preparing solid fast-releasing drug formulations of dihydropyridines |
| CA1208558A (en) * | 1982-10-07 | 1986-07-29 | Kazuo Kigasawa | Soft buccal |
| DE3318649A1 (de) * | 1983-05-21 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | Zweiphasenformulierung |
-
1985
- 1985-05-31 NL NL8501578A patent/NL194389C/nl not_active IP Right Cessation
- 1985-05-31 HU HU852126A patent/HU198844B/hu unknown
- 1985-06-05 DE DE3520184A patent/DE3520184C2/de not_active Expired - Lifetime
- 1985-06-10 BE BE1/011271A patent/BE902626A/fr not_active IP Right Cessation
- 1985-06-10 FR FR858508850A patent/FR2565822B1/fr not_active Expired
- 1985-06-12 PT PT80635A patent/PT80635B/pt unknown
- 1985-06-12 NZ NZ212390A patent/NZ212390A/en unknown
- 1985-06-12 AU AU43486/85A patent/AU587190B2/en not_active Ceased
- 1985-06-12 CA CA000483768A patent/CA1264441A/en not_active Expired
- 1985-06-12 ES ES544075A patent/ES8702141A1/es not_active Expired
- 1985-06-12 IE IE146085A patent/IE58834B1/en not_active IP Right Cessation
- 1985-06-12 AT AT0174885A patent/AT391806B/de not_active IP Right Cessation
- 1985-06-12 GB GB8514855A patent/GB2160100B/en not_active Expired
- 1985-06-12 GR GR851430A patent/GR851430B/el unknown
- 1985-06-12 IL IL75490A patent/IL75490A0/xx not_active IP Right Cessation
- 1985-06-12 DK DK264785A patent/DK167649B1/da not_active IP Right Cessation
- 1985-06-13 SE SE8502950A patent/SE504583C2/sv not_active IP Right Cessation
- 1985-06-13 LU LU85946A patent/LU85946A1/fr unknown
- 1985-06-13 IT IT8548210A patent/IT1200080B/it active
-
1987
- 1987-11-19 GB GB8727055A patent/GB2196851B/en not_active Expired
- 1987-11-19 GB GB8727056A patent/GB2196852B/en not_active Expired
-
1989
- 1989-11-09 AU AU44543/89A patent/AU4454389A/en not_active Abandoned
-
1992
- 1992-04-02 HK HK251/92A patent/HK25192A/xx not_active IP Right Cessation
- 1992-11-06 CY CY1635A patent/CY1635A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| CNR | Transfer of rights (patent application after its laying open for public inspection) |
Free format text: NOVARTIS AG |
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| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Effective date: 20050531 |