NL191308C - Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside. - Google Patents

Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.

Info

Publication number
NL191308C
NL191308C NL8502869A NL8502869A NL191308C NL 191308 C NL191308 C NL 191308C NL 8502869 A NL8502869 A NL 8502869A NL 8502869 A NL8502869 A NL 8502869A NL 191308 C NL191308 C NL 191308C
Authority
NL
Netherlands
Prior art keywords
solution
injectable
anthracycline glycoside
preparation
preparation containing
Prior art date
Application number
NL8502869A
Other languages
English (en)
Dutch (nl)
Other versions
NL191308B (nl
NL8502869A (nl
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of NL8502869A publication Critical patent/NL8502869A/nl
Publication of NL191308B publication Critical patent/NL191308B/xx
Application granted granted Critical
Publication of NL191308C publication Critical patent/NL191308C/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL8502869A 1984-10-22 1985-10-21 Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside. NL191308C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions
GB8426672 1984-10-22

Publications (3)

Publication Number Publication Date
NL8502869A NL8502869A (nl) 1986-05-16
NL191308B NL191308B (nl) 1994-12-16
NL191308C true NL191308C (nl) 1995-05-16

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8502869A NL191308C (nl) 1984-10-22 1985-10-21 Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.

Country Status (35)

Country Link
US (4) US4675311A (pm)
JP (1) JPH0611700B2 (pm)
KR (1) KR920005813B1 (pm)
CN (1) CN85107562B (pm)
AT (1) AT401345B (pm)
AU (1) AU572003B2 (pm)
BE (1) BE903484A (pm)
BG (1) BG60934B2 (pm)
CA (1) CA1248453A (pm)
CH (1) CH667594A5 (pm)
CS (1) CS270421B2 (pm)
DE (1) DE3536896C2 (pm)
DK (1) DK165620C (pm)
ES (1) ES8605374A1 (pm)
FI (2) FI853913A7 (pm)
FR (1) FR2571966B1 (pm)
GB (2) GB8426672D0 (pm)
GR (1) GR852549B (pm)
HK (1) HK94390A (pm)
HU (1) HU197988B (pm)
IE (1) IE56992B1 (pm)
IL (1) IL76732A (pm)
IT (1) IT1186779B (pm)
MY (1) MY103956A (pm)
NL (1) NL191308C (pm)
NO (1) NO170616C (pm)
NZ (1) NZ213885A (pm)
PH (1) PH23982A (pm)
PT (1) PT81347B (pm)
RU (2) RU1836088C (pm)
SE (1) SE467520B (pm)
SG (1) SG80290G (pm)
UA (2) UA34419C2 (pm)
YU (1) YU46160B (pm)
ZA (1) ZA858033B (pm)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GR871846B (en) * 1986-12-05 1988-04-01 Erba Carlo Spa Injectable ready to use solutions containing an antitumor anthracycline glycoside
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300362B1 (en) 1990-07-25 2001-10-09 Novartis Ag (Formerly Sandoz Ltd.) Stabilized pharmaceutical compositions comprising acid donors
CA2275889C (en) 1996-12-30 2008-03-18 Battelle Memorial Institute Formulation and method for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
NZ534378A (en) 2002-02-22 2006-10-27 Schering Corp Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
US7485707B2 (en) * 2003-07-02 2009-02-03 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US7314862B2 (en) * 2003-09-25 2008-01-01 Astellas Pharma Inc. Antitumor agent
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
BRPI0605832A2 (pt) * 2005-05-11 2009-05-26 Sicor Inc glicosìdeos de antraciclina liofilizados estáveis
PL1921919T3 (pl) 2005-07-14 2012-09-28 Lithera Inc Ulepszona lipolityczna formulacja o podtrzymywanym uwalnianiu do traktowania lokalnej tkanki tłuszczowej
CN101331147B (zh) * 2005-12-13 2011-11-30 苏洛克股份有限公司 用于制备4-脱甲基柔红霉素的方法
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
CN101743020A (zh) * 2007-05-16 2010-06-16 Ktb肿瘤研究有限责任公司 低粘度蒽环制剂
CN101795694B (zh) 2007-09-04 2012-10-10 明治制果药业株式会社 注射剂、注射液和注射用试剂盒制剂
KR20100058662A (ko) * 2007-10-26 2010-06-03 화이자 프로덕츠 인코포레이티드 개에게서 림프종을 치료하기 위한 이다루비신
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
WO2011088413A2 (en) * 2010-01-15 2011-07-21 Lithera, Inc. Lyophilized cake formulations
EP2646012A4 (en) 2010-11-24 2014-12-10 Neothetics Inc MONOTHERAPEUTIC FORMULATIONS OF SELECTIVE, LIPOPHILIC AND PROLONGED BETA AGONISTS AND METHODS OF COSMETIC TREATMENT OF SILHOUETTE ADPOSITY AND REINFORCEMENT
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
CA2894548C (en) 2012-12-13 2021-01-12 Cytrx Corporation Anthracycline formulations
CN113842392A (zh) 2013-06-05 2021-12-28 西特克斯公司 用于治疗癌症的细胞毒素剂

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
JPS563851A (en) * 1979-06-22 1981-01-16 Matsushita Electric Works Ltd Fireplace in floor
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
DE3317702A1 (de) * 1982-05-24 1983-11-24 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglykoside, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
GR79729B (pm) * 1982-12-20 1984-10-31 Univ Ohio State Res Found
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same

Also Published As

Publication number Publication date
KR860003014A (ko) 1986-05-19
UA34419C2 (uk) 2001-03-15
RU2101018C1 (ru) 1998-01-10
DK165620C (da) 1993-06-01
NO170616C (no) 1992-11-11
NO854194L (no) 1986-04-23
JPH0611700B2 (ja) 1994-02-16
FR2571966B1 (fr) 1988-04-15
NL191308B (nl) 1994-12-16
DK481585A (da) 1986-04-23
BG60934B2 (bg) 1996-06-28
HUT40759A (en) 1987-02-27
SE8504945D0 (sv) 1985-10-21
FI854035A0 (fi) 1985-10-16
NL8502869A (nl) 1986-05-16
ES547578A0 (es) 1986-03-16
DK165620B (da) 1992-12-28
DE3536896C2 (de) 1996-11-14
NO170616B (no) 1992-08-03
AU4880585A (en) 1986-05-01
DK481585D0 (da) 1985-10-21
CS270421B2 (en) 1990-06-13
SE467520B (sv) 1992-08-03
GB2165751A (en) 1986-04-23
NZ213885A (en) 1988-05-30
AU572003B2 (en) 1988-04-28
MY103956A (en) 1993-10-30
GR852549B (pm) 1986-02-24
ES8605374A1 (es) 1986-03-16
HK94390A (en) 1990-11-23
IL76732A (en) 1989-07-31
CN85107562B (zh) 1988-06-01
JPS61246129A (ja) 1986-11-01
YU46160B (sh) 1993-05-28
PT81347B (pt) 1987-11-11
YU164485A (en) 1987-10-31
DE3536896A1 (de) 1986-04-24
ATA303285A (de) 1996-01-15
CH667594A5 (de) 1988-10-31
BE903484A (fr) 1986-04-21
CA1248453A (en) 1989-01-10
RU1836088C (ru) 1993-08-23
FR2571966A1 (fr) 1986-04-25
FI86252B (fi) 1992-04-30
GB8525709D0 (en) 1985-11-20
FI854035L (fi) 1986-04-23
US4675311A (en) 1987-06-23
SG80290G (en) 1990-11-23
FI86252C (fi) 1992-08-10
IE56992B1 (en) 1992-02-26
US5091372A (en) 1992-02-25
IL76732A0 (en) 1986-02-28
SE8504945L (sv) 1986-04-23
PH23982A (en) 1990-02-09
IT8522507A0 (it) 1985-10-16
FI853913A0 (fi) 1985-10-08
PT81347A (en) 1985-11-01
FI853913A7 (fi) 1986-04-23
HU197988B (en) 1989-07-28
GB8426672D0 (en) 1984-11-28
KR920005813B1 (ko) 1992-07-20
CS756585A2 (en) 1989-11-14
AT401345B (de) 1996-08-26
US4840938A (en) 1989-06-20
GB2165751B (en) 1988-08-17
IT1186779B (it) 1987-12-16
CN85107562A (zh) 1986-07-23
UA19169A (uk) 1997-12-25
IE852593L (en) 1986-04-22
ZA858033B (en) 1986-06-25
US5091373A (en) 1992-02-25

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SNR Assignments of patents or rights arising from examined patent applications

Owner name: PHARMACIA S.P.A.

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Owner name: PHARMACIA & UPJOHN S.P.A.

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Owner name: PHARMACIA ITALIA S.P.A.

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20051021