NL190757C - 4-(3-Chloorfenyl)-1-piperazinylpropyl gesubstitueerde-1,2,4-triazool-3-on verbindingen met antidepressieve werking en farmaceutische preparaten daarvan. - Google Patents

4-(3-Chloorfenyl)-1-piperazinylpropyl gesubstitueerde-1,2,4-triazool-3-on verbindingen met antidepressieve werking en farmaceutische preparaten daarvan.

Info

Publication number
NL190757C
NL190757C NL8201021A NL8201021A NL190757C NL 190757 C NL190757 C NL 190757C NL 8201021 A NL8201021 A NL 8201021A NL 8201021 A NL8201021 A NL 8201021A NL 190757 C NL190757 C NL 190757C
Authority
NL
Netherlands
Prior art keywords
piperazinylpropyl
triazol
chlorophenyl
substituted
compounds
Prior art date
Application number
NL8201021A
Other languages
English (en)
Dutch (nl)
Other versions
NL8201021A (nl
NL190757B (nl
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22922879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL190757(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NL8201021A publication Critical patent/NL8201021A/nl
Publication of NL190757B publication Critical patent/NL190757B/xx
Application granted granted Critical
Publication of NL190757C publication Critical patent/NL190757C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8201021A 1981-03-16 1982-03-11 4-(3-Chloorfenyl)-1-piperazinylpropyl gesubstitueerde-1,2,4-triazool-3-on verbindingen met antidepressieve werking en farmaceutische preparaten daarvan. NL190757C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/244,464 US4338317A (en) 1981-03-16 1981-03-16 Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
US24446481 1981-03-16

Publications (3)

Publication Number Publication Date
NL8201021A NL8201021A (nl) 1982-10-18
NL190757B NL190757B (nl) 1994-03-01
NL190757C true NL190757C (nl) 1994-08-01

Family

ID=22922879

Family Applications (2)

Application Number Title Priority Date Filing Date
NL8201021A NL190757C (nl) 1981-03-16 1982-03-11 4-(3-Chloorfenyl)-1-piperazinylpropyl gesubstitueerde-1,2,4-triazool-3-on verbindingen met antidepressieve werking en farmaceutische preparaten daarvan.
NL970014C NL970014I2 (nl) 1981-03-16 1997-03-17 4-(3-Chloorfenyl)-1-piperazinylpropyl gesubstitueerde-1,2,4-triazool-3-on verbindingen met antidepressieve werking en farmaceutische preparaten daarvan.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL970014C NL970014I2 (nl) 1981-03-16 1997-03-17 4-(3-Chloorfenyl)-1-piperazinylpropyl gesubstitueerde-1,2,4-triazool-3-on verbindingen met antidepressieve werking en farmaceutische preparaten daarvan.

Country Status (26)

Country Link
US (1) US4338317A (cg-RX-API-DMAC10.html)
JP (1) JPS57159774A (cg-RX-API-DMAC10.html)
KR (1) KR880001374B1 (cg-RX-API-DMAC10.html)
AT (1) AT384022B (cg-RX-API-DMAC10.html)
BE (1) BE892503A (cg-RX-API-DMAC10.html)
CA (1) CA1198436A (cg-RX-API-DMAC10.html)
CH (1) CH649539A5 (cg-RX-API-DMAC10.html)
CY (1) CY1373A (cg-RX-API-DMAC10.html)
DE (1) DE3209557A1 (cg-RX-API-DMAC10.html)
DK (1) DK158728C (cg-RX-API-DMAC10.html)
ES (1) ES8305756A1 (cg-RX-API-DMAC10.html)
FI (1) FI73670C (cg-RX-API-DMAC10.html)
FR (1) FR2501690B1 (cg-RX-API-DMAC10.html)
GB (1) GB2096137B (cg-RX-API-DMAC10.html)
GR (1) GR76076B (cg-RX-API-DMAC10.html)
HK (1) HK4788A (cg-RX-API-DMAC10.html)
IE (1) IE52788B1 (cg-RX-API-DMAC10.html)
IT (1) IT1148137B (cg-RX-API-DMAC10.html)
KE (1) KE3711A (cg-RX-API-DMAC10.html)
LU (1) LU84011A1 (cg-RX-API-DMAC10.html)
MX (1) MX9203176A (cg-RX-API-DMAC10.html)
NL (2) NL190757C (cg-RX-API-DMAC10.html)
SE (1) SE447256B (cg-RX-API-DMAC10.html)
SG (1) SG30287G (cg-RX-API-DMAC10.html)
YU (1) YU43256B (cg-RX-API-DMAC10.html)
ZA (1) ZA821359B (cg-RX-API-DMAC10.html)

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US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US4386091A (en) * 1982-02-24 1983-05-31 Mead Johnson & Company 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants
AT388555B (de) * 1983-06-29 1989-07-25 Bristol Myers Co Verfahren zur herstellung von neuen 1,2,4-triazol-3-on-derivaten
US4575555A (en) * 1983-06-29 1986-03-11 Mead Johnson & Company 4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative
US4613600A (en) * 1983-09-30 1986-09-23 Mead Johnson & Company Antidepressant 1,2,4-triazolone compounds
YU44721B (en) * 1983-11-30 1990-12-31 Bristol Myers Co Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
US4784998A (en) * 1987-04-06 1988-11-15 Bristol-Myers Company 1,3,4-oxadiazole pyschotropic compounds
US5116852A (en) * 1990-12-03 1992-05-26 Bristol-Myers Squibb Co. Treatment of sleep disorders
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
US5256664A (en) * 1992-04-28 1993-10-26 Bristol-Myers Squibb Company Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
IT1256387B (it) * 1992-11-13 1995-12-04 Acraf Procedimento per preparare triazoloni
DE4425144A1 (de) * 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
CA2160423A1 (en) * 1994-11-02 1996-05-03 Hemant N. Joshi Salts of nefazodone having improved dissolution rates
AU7025396A (en) 1995-10-17 1997-05-01 Bristol-Myers Squibb Company Nefazodone: treatment of panic attack
CA2182241C (en) * 1996-07-29 2002-09-17 Bo Lei Methods for the manufacture of nefazodone
AU2452397A (en) * 1996-07-31 1998-02-20 Bristol-Myers Squibb Company Nefazodone: use in migraine prophylaxis
US5852020A (en) * 1996-11-22 1998-12-22 Bristol-Myers Squibb Company Nefazodone: use in treating post traumatic stress disorder
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US5917050A (en) * 1998-02-11 1999-06-29 Bayer Corporation Process for preparing alkoxytriazolinones
ES2152860B1 (es) * 1998-10-23 2001-08-16 Finaf 92 Sa Forma cristalina de la nefazodona y procedimiento para su preparacion.
US6706282B1 (en) 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
US6586437B2 (en) 1999-04-09 2003-07-01 Sepracor Inc. (S)-hydroxynefazodone antipsychotic therapy
WO2000061128A2 (en) * 1999-04-09 2000-10-19 Sepracor Inc. R-hydroxynefazodone
US6469008B2 (en) 1999-04-09 2002-10-22 Sepracor Inc. (R)-hydroxynefazodone antipsychotic therapy
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CA2356450C (en) 2001-09-10 2003-11-25 Brantford Chemicals Inc. An improved process for the preparation of nefazodone hydrochloride
AU2003232805A1 (en) * 2002-05-24 2003-12-12 Carl-Fr. Coester Pharmaceutical active substance combination and the use thereof
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
WO2004099145A2 (en) * 2003-04-30 2004-11-18 Fmc Corporation Phenyl substituted cyclic derivatives
DE602004028150D1 (de) * 2003-11-26 2010-08-26 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
WO2005102366A2 (en) * 2004-04-19 2005-11-03 Philip Maxwell Satow Lithium combinations, and uses related thereto
TW200612961A (en) * 2004-05-18 2006-05-01 Fmc Corp Substituted cyclic urea derivatives
SG163588A1 (en) 2005-07-08 2010-08-30 Braincells Inc Methods for identifying agents and conditions that modulate neurogenesis
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
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IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
IT1052119B (it) * 1972-10-16 1981-06-20 Sigma Tau Ind Farmaceuti Derivati del triazolinone e procedimento per la loro preparazione

Also Published As

Publication number Publication date
HK4788A (en) 1988-01-29
FI820856L (fi) 1982-09-17
GB2096137A (en) 1982-10-13
ES510449A0 (es) 1983-04-16
SE8201631L (sv) 1982-09-17
YU43256B (en) 1989-06-30
IT1148137B (it) 1986-11-26
GB2096137B (en) 1985-01-03
DE3209557C2 (cg-RX-API-DMAC10.html) 1993-07-15
DK158728B (da) 1990-07-09
GR76076B (cg-RX-API-DMAC10.html) 1984-08-03
IE820589L (en) 1982-09-16
MX9203176A (es) 1992-07-01
CA1198436A (en) 1985-12-24
JPH0237353B2 (cg-RX-API-DMAC10.html) 1990-08-23
US4338317A (en) 1982-07-06
NL970014I1 (nl) 1997-06-02
JPS57159774A (en) 1982-10-01
DK112582A (da) 1982-09-17
SE447256B (sv) 1986-11-03
FI73670B (fi) 1987-07-31
KR830009089A (ko) 1983-12-17
ATA104582A (de) 1987-02-15
FI73670C (fi) 1987-11-09
KR880001374B1 (ko) 1988-07-29
DK158728C (da) 1990-12-03
IE52788B1 (en) 1988-03-02
FR2501690A1 (fr) 1982-09-17
AT384022B (de) 1987-09-25
ZA821359B (en) 1983-01-26
ES8305756A1 (es) 1983-04-16
NL8201021A (nl) 1982-10-18
DE3209557A1 (de) 1982-12-09
BE892503A (fr) 1982-09-15
IT8247978A0 (it) 1982-03-12
CY1373A (en) 1987-08-07
KE3711A (en) 1987-04-30
FR2501690B1 (fr) 1985-07-05
NL190757B (nl) 1994-03-01
YU52582A (en) 1985-06-30
SG30287G (en) 1987-07-17
LU84011A1 (fr) 1983-02-22
CH649539A5 (de) 1985-05-31
NL970014I2 (nl) 1997-09-01
AU555888B2 (en) 1986-10-16
AU8117082A (en) 1982-09-23

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