NL189199C - Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. - Google Patents

Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Info

Publication number
NL189199C
NL189199C NLAANVRAGE7504075,A NL7504075A NL189199C NL 189199 C NL189199 C NL 189199C NL 7504075 A NL7504075 A NL 7504075A NL 189199 C NL189199 C NL 189199C
Authority
NL
Netherlands
Prior art keywords
pharmaceutical preparations
benz
aryl
preparing
preparation
Prior art date
Application number
NLAANVRAGE7504075,A
Other languages
English (en)
Dutch (nl)
Other versions
NL7504075A (nl
NL189199B (nl
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19823518&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL189199(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nv filed Critical Akzo Nv
Priority to NLAANVRAGE7504075,A priority Critical patent/NL189199C/xx
Priority to US05/669,544 priority patent/US4062848A/en
Priority to IE614/76A priority patent/IE42969B1/en
Priority to ZA761756A priority patent/ZA761756B/xx
Priority to AU12361/76A priority patent/AU493450B2/en
Priority to GB12270/76A priority patent/GB1543171A/en
Priority to CH388676A priority patent/CH622261A5/de
Priority to DK142676AA priority patent/DK142498B/da
Priority to FI760884A priority patent/FI62087C/fi
Priority to LU74680A priority patent/LU74680A1/xx
Priority to FR7609686A priority patent/FR2305986A1/fr
Priority to SE7603931A priority patent/SE422941B/xx
Priority to JP51037678A priority patent/JPS5942678B2/ja
Priority to DE19762614406 priority patent/DE2614406A1/de
Priority to BE165832A priority patent/BE840362A/xx
Priority to ES446634A priority patent/ES446634A1/es
Priority to CA249,439A priority patent/CA1076571A/en
Priority to HU76AO437A priority patent/HU179401B/hu
Publication of NL7504075A publication Critical patent/NL7504075A/xx
Priority to ES459348A priority patent/ES459348A1/es
Publication of NL189199B publication Critical patent/NL189199B/xx
Publication of NL189199C publication Critical patent/NL189199C/xx
Application granted granted Critical
Priority to NL940007C priority patent/NL940007I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NLAANVRAGE7504075,A 1975-04-05 1975-04-05 Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. NL189199C (nl)

Priority Applications (20)

Application Number Priority Date Filing Date Title
NLAANVRAGE7504075,A NL189199C (nl) 1975-04-05 1975-04-05 Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
US05/669,544 US4062848A (en) 1975-04-05 1976-03-23 Tetracyclic compounds
IE614/76A IE42969B1 (en) 1975-04-05 1976-03-23 Tetracyclic compounds
ZA761756A ZA761756B (en) 1975-04-05 1976-03-23 Tetracyclic compounds
AU12361/76A AU493450B2 (en) 1976-03-25 Diazolo, diazino and diazepino [1,2-a] otrudi azeoube derivatives
GB12270/76A GB1543171A (en) 1975-04-05 1976-03-26 Tetracyclic compounds
CH388676A CH622261A5 (da) 1975-04-05 1976-03-29
DK142676AA DK142498B (da) 1975-04-05 1976-03-30 Analogifremgangsmåde til fremstilling af benzopyridoazepinderivater.
FI760884A FI62087C (fi) 1975-04-05 1976-04-01 Foerfarande foer framstaellning av 1,2,3,4,10,14b-hexahydrobenso(c)pyrazino(1,2-a)pyridoazepinderivat med antihistamin- oc centralnervstimulerande aktivitet
CA249,439A CA1076571A (en) 1975-04-05 1976-04-02 Tetracyclic derivatives of benzo-pyrido azepines
LU74680A LU74680A1 (da) 1975-04-05 1976-04-02
SE7603931A SE422941B (sv) 1975-04-05 1976-04-02 Analogiforfarande for framstellning av tetracykliska pyrido-bensazepinforeningar
JP51037678A JPS5942678B2 (ja) 1975-04-05 1976-04-02 四環式化合物及びその製法
DE19762614406 DE2614406A1 (de) 1975-04-05 1976-04-02 Tetracyclische verbindungen, verfahren zu deren herstellung und arzneimittel, enthaltend diese verbindungen
BE165832A BE840362A (fr) 1975-04-05 1976-04-02 Composes tetracycliques contenant un noyau azepine
ES446634A ES446634A1 (es) 1975-04-05 1976-04-02 Procedimiento para preparar compuestos tetraacidicos.
FR7609686A FR2305986A1 (fr) 1975-04-05 1976-04-02 Composes tetracycliques contenant un noyau azepine
HU76AO437A HU179401B (en) 1975-04-05 1976-04-05 Process for preparing tetracuclic benzo-pyrazino/imidazo,diazepino/-pyrido-azepine derivatives further pharmaceutical compositions containing thereof
ES459348A ES459348A1 (es) 1975-04-05 1977-05-31 Procedimiento para preparar compuestos tetraciclicos.
NL940007C NL940007I2 (nl) 1975-04-05 1994-04-21 Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwi jze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NLAANVRAGE7504075,A NL189199C (nl) 1975-04-05 1975-04-05 Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Publications (3)

Publication Number Publication Date
NL7504075A NL7504075A (nl) 1976-10-07
NL189199B NL189199B (nl) 1992-09-01
NL189199C true NL189199C (nl) 1993-02-01

Family

ID=19823518

Family Applications (2)

Application Number Title Priority Date Filing Date
NLAANVRAGE7504075,A NL189199C (nl) 1975-04-05 1975-04-05 Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
NL940007C NL940007I2 (nl) 1975-04-05 1994-04-21 Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwi jze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL940007C NL940007I2 (nl) 1975-04-05 1994-04-21 Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwi jze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Country Status (17)

Country Link
US (1) US4062848A (da)
JP (1) JPS5942678B2 (da)
BE (1) BE840362A (da)
CA (1) CA1076571A (da)
CH (1) CH622261A5 (da)
DE (1) DE2614406A1 (da)
DK (1) DK142498B (da)
ES (2) ES446634A1 (da)
FI (1) FI62087C (da)
FR (1) FR2305986A1 (da)
GB (1) GB1543171A (da)
HU (1) HU179401B (da)
IE (1) IE42969B1 (da)
LU (1) LU74680A1 (da)
NL (2) NL189199C (da)
SE (1) SE422941B (da)
ZA (1) ZA761756B (da)

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CN103509020A (zh) * 2013-10-21 2014-01-15 山东鲁药制药有限公司 一种米氮平的合成方法
CN104356133A (zh) * 2014-11-25 2015-02-18 南京工业大学 一种制备抗抑郁药物米氮平的方法
JP6433809B2 (ja) * 2015-02-20 2018-12-05 株式会社トクヤマ １−（３−ヒドロキシメチルピリジル−２−）−２−フェニル−４−メチルピペラジンの製造方法
KR102540021B1 (ko) 2020-12-02 2023-06-07 (주)유케이케미팜 대량 생산에 적합한 미르타자핀의 제조방법

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NL129434C (da) * 1966-03-12
NL7202963A (da) * 1972-03-07 1973-09-11
US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation

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FI62087C (fi) 1982-11-10
FR2305986B1 (da) 1980-06-13
ES459348A1 (es) 1978-03-16
FI760884A (da) 1976-10-06
JPS5942678B2 (ja) 1984-10-16
IE42969B1 (en) 1980-11-19
CH622261A5 (da) 1981-03-31
DK142498C (da) 1981-07-06
AU1236176A (en) 1977-09-29
LU74680A1 (da) 1976-11-11
NL940007I2 (nl) 1994-10-17
NL7504075A (nl) 1976-10-07
NL189199B (nl) 1992-09-01
IE42969L (en) 1976-10-05
SE7603931L (sv) 1976-10-06
CA1076571A (en) 1980-04-29
GB1543171A (en) 1979-03-28
HU179401B (en) 1982-10-28
DK142676A (da) 1976-10-06
ES446634A1 (es) 1977-11-01
DK142498B (da) 1980-11-10
NL940007I1 (nl) 1994-06-01
DE2614406C2 (da) 1992-02-20
JPS51122099A (en) 1976-10-25
FR2305986A1 (fr) 1976-10-29
ZA761756B (en) 1977-03-30
BE840362A (fr) 1976-10-04
US4062848A (en) 1977-12-13
DE2614406A1 (de) 1976-10-14
FI62087B (fi) 1982-07-30
SE422941B (sv) 1982-04-05

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