NL189092C - Hybride menselijke leukocytinterferons, dubbelstrengs dna dat hiervoor codeert, expressievector, transformant micro-organisme, werkwijzen ter bereiding daarvan en farmaceutisch preparaat. - Google Patents
Hybride menselijke leukocytinterferons, dubbelstrengs dna dat hiervoor codeert, expressievector, transformant micro-organisme, werkwijzen ter bereiding daarvan en farmaceutisch preparaat.Info
- Publication number
- NL189092C NL189092C NLAANVRAGE8105078,A NL8105078A NL189092C NL 189092 C NL189092 C NL 189092C NL 8105078 A NL8105078 A NL 8105078A NL 189092 C NL189092 C NL 189092C
- Authority
- NL
- Netherlands
- Prior art keywords
- interferons
- preparation
- leukocytin
- transformant
- organism
- Prior art date
Links
- 102000014150 Interferons Human genes 0.000 title abstract 4
- 108010050904 Interferons Proteins 0.000 title abstract 4
- 229940047124 interferons Drugs 0.000 title abstract 4
- 241000282414 Homo sapiens Species 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 239000013598 vector Substances 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20557980A | 1980-11-10 | 1980-11-10 | |
| US20557980 | 1980-11-10 | ||
| US23738881 | 1981-02-23 | ||
| US06/237,388 US4414150A (en) | 1980-11-10 | 1981-02-23 | Hybrid human leukocyte interferons |
| US30565781 | 1981-09-25 | ||
| US06/305,657 US4456748A (en) | 1981-02-23 | 1981-09-25 | Hybrid human leukocyte interferons |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8105078A NL8105078A (nl) | 1982-06-01 |
| NL189092B NL189092B (nl) | 1992-08-03 |
| NL189092C true NL189092C (nl) | 1993-01-04 |
Family
ID=27394813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NLAANVRAGE8105078,A NL189092C (nl) | 1980-11-10 | 1981-11-10 | Hybride menselijke leukocytinterferons, dubbelstrengs dna dat hiervoor codeert, expressievector, transformant micro-organisme, werkwijzen ter bereiding daarvan en farmaceutisch preparaat. |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP0051873B1 (fr) |
| JP (1) | JP2642291B2 (fr) |
| KR (1) | KR920007439B1 (fr) |
| AT (1) | ATE46718T1 (fr) |
| AU (1) | AU555293B2 (fr) |
| BR (1) | BR8107293A (fr) |
| CA (2) | CA1212915A (fr) |
| CH (2) | CH663032A5 (fr) |
| DE (2) | DE3144469A1 (fr) |
| DK (1) | DK173590B1 (fr) |
| DO (1) | DOP1981004064A (fr) |
| DZ (1) | DZ350A1 (fr) |
| ES (2) | ES506955A0 (fr) |
| FI (1) | FI79550C (fr) |
| FR (1) | FR2493867B1 (fr) |
| GB (1) | GB2090258B (fr) |
| GR (1) | GR81947B (fr) |
| HK (1) | HK51685A (fr) |
| IE (1) | IE51850B1 (fr) |
| IL (1) | IL64243A (fr) |
| IT (1) | IT1169276B (fr) |
| KE (1) | KE3536A (fr) |
| LU (1) | LU83745A1 (fr) |
| MC (1) | MC1424A1 (fr) |
| MY (2) | MY8700710A (fr) |
| NL (1) | NL189092C (fr) |
| NO (1) | NO165201C (fr) |
| NZ (1) | NZ198906A (fr) |
| PH (1) | PH18565A (fr) |
| PL (1) | PL233748A1 (fr) |
| PT (1) | PT73955B (fr) |
| SE (1) | SE460539B (fr) |
| YU (1) | YU46597B (fr) |
| ZW (1) | ZW26981A1 (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH657141A5 (de) * | 1980-07-01 | 1986-08-15 | Hoffmann La Roche | Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen. |
| WO1983000693A1 (fr) * | 1981-08-14 | 1983-03-03 | Berg, Kurt, Frimann | SUJETS CONCERNANT DES PROTEINES DU SOUS-TYPE DE L'INTERFERON 'alpha' HUMAIN ET ANTICORPS CORRESPONDANTS |
| EP0072541A3 (fr) * | 1981-08-14 | 1984-04-18 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Interferons de leucocytes humains, procédé pour leur production microbiologique, intermédiaires et compositions les contenant |
| GB2108510B (en) * | 1981-10-03 | 1984-12-12 | Ciba Geigy Ag | Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof |
| EP0098876A1 (fr) * | 1982-01-19 | 1984-01-25 | Cetus Corporation | Interferons hybrides de classes multiples |
| DE3220116A1 (de) * | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung |
| CA1252046A (fr) * | 1982-11-04 | 1989-04-04 | Martin J. Cline | Methodes de depistage du cancer |
| US4751287A (en) * | 1983-02-24 | 1988-06-14 | Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr | Human leukocyte interferon N and a method of producing same in bacterial cells |
| GB8315980D0 (en) * | 1983-06-10 | 1983-07-13 | Biogen Nv | Producing hybrid dna sequences |
| GB8317880D0 (en) * | 1983-07-01 | 1983-08-03 | Searle & Co | Structure and synthesis of interferons |
| US4892743A (en) * | 1983-12-21 | 1990-01-09 | Schering Corporation | Novel hybrid interferon species |
| EP0146903A3 (fr) * | 1983-12-19 | 1987-07-22 | Schering Corporation | Production d'un vecteur qui encode un interféron hybride |
| DE3409966A1 (de) * | 1984-03-19 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von human-gammainterferon und mittel zur durchfuehrung dieses verfahrens |
| JPS6156199A (ja) * | 1984-08-27 | 1986-03-20 | Shionogi & Co Ltd | 新規ヒトインタ−フエロンα類 |
| EP0173935A1 (fr) * | 1984-08-31 | 1986-03-12 | University Patents, Inc. | Interférons humains d'hybrides de lymphoblastoides-leucocytes |
| DE3434345A1 (de) * | 1984-09-19 | 1986-03-27 | Hoechst Ag, 6230 Frankfurt | Verwendung von (alpha)-interferonen zur bekaempfung von durchfaellen |
| EP0194006B1 (fr) * | 1985-02-01 | 1992-04-29 | Imperial Chemical Industries Plc | Polypeptides analogues d'interféron, procédé pour les préparer et compositions pharmaceutiques les contenant |
| ATE78262T1 (de) * | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
| EP0240550A4 (fr) * | 1985-09-26 | 1989-09-19 | Genetics Inst | Proteines tensio-actives pulmonaires. |
| US4806347A (en) * | 1985-12-11 | 1989-02-21 | Schering Corporation | Interferon combinations |
| DE3607835A1 (de) * | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
| EP0490233A1 (fr) * | 1986-03-10 | 1992-06-17 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Anticorps monoclonaux contre les interférons hybrides Bgl III, leur application et leur procédé de préparation |
| US4851220A (en) * | 1986-11-26 | 1989-07-25 | Schering Corporation | Stable oleaginous gel |
| US4853218A (en) * | 1987-02-24 | 1989-08-01 | Schering Corporation | Zinc-protamine-alpha interferon complex |
| EP0331635A3 (fr) * | 1988-02-29 | 1990-02-28 | The Board of Regents of the University of Texas System | Préparation pour le traitement du cancer de la vessie |
| US5372808A (en) † | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| GB2273931A (en) * | 1992-09-28 | 1994-07-06 | Unilever Plc | Mutant polypeptides |
| CA2223088A1 (fr) | 1995-06-07 | 1996-12-19 | Bob Dale Brown | Nouveaux lipides cationiques a base de carbamate |
| TW442492B (en) * | 1995-07-26 | 2001-06-23 | Novartis Ag | Process for the enrichment of interferon |
| FR2823220B1 (fr) | 2001-04-04 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo) |
| DE60332358D1 (de) | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| US7318918B2 (en) | 2004-05-19 | 2008-01-15 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| BRPI0609809A2 (pt) | 2005-05-18 | 2011-10-11 | Maxygen Inc | polipeptìdeo isolado ou recombinante, conjugado, composição, polinucleotìdeo isolado ou recombinante, célula hospedeira, vetor, métodos para preparar o polipeptìdeo, para preparar um conjugado, para inibir replicação de um vìrus em células infectadas com o vìrus para reduzir o numero de cópias de um vìrus em células infectadas com o vìrus, para reduzir o nìvel de rna de hcv no soro de um paciente infectado com hcv, para reduzir o nìvel de dna de hbv em soro de um paciente infectado com hbv e para reduzir o nìvel de rna de hiv em soro de um paciente infectado com hiv, e, uso do polipeptìdeo ou do conjugado |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0032134B2 (fr) * | 1980-01-08 | 1993-10-13 | Biogen, Inc. | Séquences d'ADN, molécules d'ADN recombinant et procédé pour la production de polypeptides semblables à l'interféron-alpha humain |
-
1981
- 1981-11-07 ES ES506955A patent/ES506955A0/es active Granted
- 1981-11-09 SE SE8106641A patent/SE460539B/sv not_active Application Discontinuation
- 1981-11-09 FR FR8120943A patent/FR2493867B1/fr not_active Expired
- 1981-11-09 PH PH26462A patent/PH18565A/en unknown
- 1981-11-09 NZ NZ198906A patent/NZ198906A/en unknown
- 1981-11-09 IL IL64243A patent/IL64243A/xx not_active IP Right Cessation
- 1981-11-09 DE DE19813144469 patent/DE3144469A1/de not_active Ceased
- 1981-11-09 DE DE8181109579T patent/DE3177106D1/de not_active Expired
- 1981-11-09 AT AT81109579T patent/ATE46718T1/de not_active IP Right Cessation
- 1981-11-09 EP EP81109579A patent/EP0051873B1/fr not_active Expired
- 1981-11-09 IE IE2622/81A patent/IE51850B1/en not_active IP Right Cessation
- 1981-11-09 PL PL23374881A patent/PL233748A1/xx unknown
- 1981-11-09 CH CH5574/85A patent/CH663032A5/de not_active IP Right Cessation
- 1981-11-09 GR GR66464A patent/GR81947B/el unknown
- 1981-11-09 DZ DZ816369A patent/DZ350A1/fr active
- 1981-11-09 CH CH7174/81A patent/CH660743A5/de not_active IP Right Cessation
- 1981-11-09 MC MC811558A patent/MC1424A1/fr unknown
- 1981-11-09 NO NO813785A patent/NO165201C/no not_active IP Right Cessation
- 1981-11-09 PT PT73955A patent/PT73955B/pt unknown
- 1981-11-09 GB GB8133762A patent/GB2090258B/en not_active Expired
- 1981-11-09 AU AU77304/81A patent/AU555293B2/en not_active Expired
- 1981-11-09 CA CA000389688A patent/CA1212915A/fr not_active Expired
- 1981-11-09 DK DK198104946A patent/DK173590B1/da active
- 1981-11-10 IT IT24967/81A patent/IT1169276B/it active
- 1981-11-10 BR BR8107293A patent/BR8107293A/pt unknown
- 1981-11-10 DO DO1981004064A patent/DOP1981004064A/es unknown
- 1981-11-10 NL NLAANVRAGE8105078,A patent/NL189092C/xx not_active IP Right Cessation
- 1981-11-10 ZW ZW269/81A patent/ZW26981A1/xx unknown
- 1981-11-10 YU YU265681A patent/YU46597B/sh unknown
- 1981-11-10 FI FI813539A patent/FI79550C/fi not_active IP Right Cessation
- 1981-11-10 KR KR1019810004343A patent/KR920007439B1/ko not_active Expired
- 1981-11-10 LU LU83745A patent/LU83745A1/de unknown
-
1982
- 1982-05-19 ES ES512354A patent/ES512354A0/es active Granted
-
1984
- 1984-12-18 CA CA000470467A patent/CA1277616C/fr not_active Expired - Lifetime
-
1985
- 1985-05-21 KE KE3536A patent/KE3536A/xx unknown
- 1985-07-04 HK HK516/85A patent/HK51685A/xx not_active IP Right Cessation
-
1987
- 1987-12-30 MY MY710/87A patent/MY8700710A/xx unknown
-
1988
- 1988-12-30 MY MY66/88A patent/MY8800066A/xx unknown
-
1992
- 1992-12-28 JP JP4349148A patent/JP2642291B2/ja not_active Expired - Lifetime
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| NL189092C (nl) | Hybride menselijke leukocytinterferons, dubbelstrengs dna dat hiervoor codeert, expressievector, transformant micro-organisme, werkwijzen ter bereiding daarvan en farmaceutisch preparaat. | |
| SE8105657L (sv) | Mikrobiell framstellning av humanfibroblastinterferon | |
| HK49285A (en) | Interferons and process for their preparation | |
| BG44877A3 (bg) | Метод за експресия на ген,кодиращ човешки имунен интерферон | |
| ATE159297T1 (de) | Expression von menschlichen serumalbumin in methylotrophischen hefen | |
| DE3683267D1 (de) | Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung. | |
| HUT40695A (en) | Dna sequences, recombinant dna molecules and processes for preparing humane lipocortine like polypeptides | |
| EP0072541A3 (fr) | Interferons de leucocytes humains, procédé pour leur production microbiologique, intermédiaires et compositions les contenant | |
| ATE132900T1 (de) | Gene, die ein protein mit menschlicher macif- aktivität kodieren, expressionsvektoren mit diesen genen, transformantenzellen und proteine mit menschlicher macif-aktivität | |
| NO890174L (no) | Rekombinante interleukin-1alfa-polypeptider. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| V1 | Lapsed because of non-payment of the annual fee |
Effective date: 19970601 |