NL181434C - Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing. - Google Patents

Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.

Info

Publication number
NL181434C
NL181434C NLAANVRAGE8000032,A NL8000032A NL181434C NL 181434 C NL181434 C NL 181434C NL 8000032 A NL8000032 A NL 8000032A NL 181434 C NL181434 C NL 181434C
Authority
NL
Netherlands
Prior art keywords
platinum
preparation
application
diamine complexes
diamine
Prior art date
Application number
NLAANVRAGE8000032,A
Other languages
English (en)
Dutch (nl)
Other versions
NL8000032A (nl
NL181434B (nl
Original Assignee
Tno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tno filed Critical Tno
Priority to NLAANVRAGE8000032,A priority Critical patent/NL181434C/xx
Priority to IE2744/80A priority patent/IE50653B1/en
Priority to CH8972/80A priority patent/CH650003A5/de
Priority to IL61708A priority patent/IL61708A/xx
Priority to AR283721A priority patent/AR227903A1/es
Priority to NZ195926A priority patent/NZ195926A/xx
Priority to SU803217401A priority patent/SU1083911A3/ru
Priority to ES498240A priority patent/ES498240A0/es
Priority to JP18945180A priority patent/JPS56100796A/ja
Priority to HU803161A priority patent/HU184922B/hu
Priority to GR63769A priority patent/GR72849B/el
Priority to PT72298A priority patent/PT72298B/pt
Priority to CS809611A priority patent/CS239911B2/cs
Priority to IT27029/80A priority patent/IT1193395B/it
Priority to CA000367793A priority patent/CA1154030A/en
Priority to BE0/203372A priority patent/BE886929A/nl
Priority to YU3363/80A priority patent/YU41754B/xx
Priority to DE19813100017 priority patent/DE3100017A1/de
Priority to LU83046A priority patent/LU83046A1/de
Priority to NO810004A priority patent/NO810004L/no
Priority to GB8100027A priority patent/GB2066819B/en
Priority to AT0000381A priority patent/AT377242B/de
Priority to ZA00810014A priority patent/ZA8114B/xx
Priority to FI810002A priority patent/FI72321C/fi
Priority to DD81226806A priority patent/DD156909A5/de
Priority to PH25046A priority patent/PH21998A/en
Priority to AU65949/81A priority patent/AU542600B2/en
Priority to DK001681A priority patent/DK153468C/da
Priority to SE8100006A priority patent/SE439921B/sv
Priority to FR8100058A priority patent/FR2473046A1/fr
Priority to US06/232,298 priority patent/US4431666A/en
Publication of NL8000032A publication Critical patent/NL8000032A/nl
Priority to SU813315399A priority patent/SU1186617A1/ru
Priority to ES507474A priority patent/ES8207119A1/es
Priority to US06/458,979 priority patent/US4482569A/en
Publication of NL181434B publication Critical patent/NL181434B/xx
Application granted granted Critical
Publication of NL181434C publication Critical patent/NL181434C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NLAANVRAGE8000032,A 1980-01-03 1980-01-03 Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing. NL181434C (nl)

Priority Applications (34)

Application Number Priority Date Filing Date Title
NLAANVRAGE8000032,A NL181434C (nl) 1980-01-03 1980-01-03 Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.
IE2744/80A IE50653B1 (en) 1980-01-03 1980-12-03 Platinum(iv)-diamine-complexes,a process for the preparation thereof,a process for the preparation of a medicine using such a platinum(iv)-diamine-complex for the treatment of cancer as well as the shaped medicine thus obtained
CH8972/80A CH650003A5 (de) 1980-01-03 1980-12-04 Platin(iv)-diaminkomplexe, verfahren zu deren herstellung und diese enthaltende krebsmittel.
IL61708A IL61708A (en) 1980-01-03 1980-12-15 Platinum(iv)-diamine complexes,process for the preparation of a medicine using such a platinum(iv)-diamine complex for the treatment of cancer as well as the shaped medicine thus obtained
AR283721A AR227903A1 (es) 1980-01-03 1980-12-19 Procedimiento para la preparacion de complejos de platino(iv)-diamina
NZ195926A NZ195926A (en) 1980-01-03 1980-12-23 Platinum (iv)-diamine complexes and pharmaceutical compositions
SU803217401A SU1083911A3 (ru) 1980-01-03 1980-12-23 Способ получени платино (1у)-диаминовых комплексов
JP18945180A JPS56100796A (en) 1980-01-03 1980-12-30 Platinum*iv**diamine complex* its manufacture and manufacture of drug containing it
HU803161A HU184922B (en) 1980-01-03 1980-12-30 Process for preparing platinum/iv./-diamine complexes and pharma ceutical compositions containing thereof
GR63769A GR72849B (fi) 1980-01-03 1980-12-30
ES498240A ES498240A0 (es) 1980-01-03 1980-12-30 Procedimiento para preparar complejos de platino (iv)-diami-na
CS809611A CS239911B2 (en) 1980-01-03 1980-12-31 Processing of complexed diamino platinum
IT27029/80A IT1193395B (it) 1980-01-03 1980-12-31 Complessi platino-diamminici e formulazioni farmaceutiche per il trattamento del cancro che li contengono
CA000367793A CA1154030A (en) 1980-01-03 1980-12-31 Platinum (iv)-diamine-complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum (iv)-diamine- complex for the treatment of cancer as well as the shaped medicine thus obtained
BE0/203372A BE886929A (nl) 1980-01-03 1980-12-31 Platina (iv)-diamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platina (iv)-diamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel
YU3363/80A YU41754B (en) 1980-01-03 1980-12-31 Process for obtaining platinum complexes
PT72298A PT72298B (en) 1980-01-03 1980-12-31 Process for preparing platinum(iv)-diamine-complexes
SE8100006A SE439921B (sv) 1980-01-03 1981-01-02 Nya platina(iv)diamin-komplex, sett att framstella dessa komplex och ett lekemedel till anvendning for behandling av cancer
NO810004A NO810004L (no) 1980-01-03 1981-01-02 Analogifremgangsmaate ved fremstilling av platina(iv)-diaminkomplekser med virkning mot kreft
GB8100027A GB2066819B (en) 1980-01-03 1981-01-02 Platinum (iv)-diamine-complexes for the treatment of cancer
AT0000381A AT377242B (de) 1980-01-03 1981-01-02 Verfahren zur herstellung neuer platin(iv)-diaminkomplexe
ZA00810014A ZA8114B (en) 1980-01-03 1981-01-02 Platnum (iv)-diamine-complexes,a process for the preparation thereof ,a process for the preparation of a medicine using such a platinum (iv) -diamine-complex for the treamentof cancer as well as the shaped medicine thus obtained
FI810002A FI72321C (fi) 1980-01-03 1981-01-02 Foerfarande foer framstaellning av nya, vid behandling av cancer anvaendbara platina(iv)-diaminkomplexer.
DE19813100017 DE3100017A1 (de) 1980-01-03 1981-01-02 Neue platin(iv)-diaminkomplexe, verfahren zur herstellung derselben und verwendung derselben
PH25046A PH21998A (en) 1980-01-03 1981-01-02 Platinum (iv) diamine complexes and their composition
AU65949/81A AU542600B2 (en) 1980-01-03 1981-01-02 Platinum-diamines
DK001681A DK153468C (da) 1980-01-03 1981-01-02 Analogifremgangsmaade til fremstilling af platin(iv)-diamin-komplekser
LU83046A LU83046A1 (de) 1980-01-03 1981-01-02 Neue platin(iv)-diaminkomplexe,verfahren zur herstellung derselben und verwendung derselben
DD81226806A DD156909A5 (de) 1980-01-03 1981-01-02 Verfahren zur herstellung von platin(iv)-diaminkomplexen
FR8100058A FR2473046A1 (fr) 1980-01-03 1981-01-05 Complexes de platine (iv)-diamine et leur application comme medicament pour le traitement du cancer
US06/232,298 US4431666A (en) 1980-01-03 1981-02-06 Platinum(IV)-diamine complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum(IV)-diamine complex for the treatment of malignant tumors in mice
SU813315399A SU1186617A1 (ru) 1980-01-03 1981-08-10 Платино ( @ )-диаминовые комплексы,про вл ющие противоопухолевую активность
ES507474A ES8207119A1 (es) 1980-01-03 1981-11-26 Procedimiento para preparar complejos de platino (iv)-diami-na.
US06/458,979 US4482569A (en) 1980-01-03 1983-01-18 Platinum (IV)-diamine complexes, a process for the preparation of pharmaceutical compositions and a method of treating malignant tumors in mice

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NLAANVRAGE8000032,A NL181434C (nl) 1980-01-03 1980-01-03 Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.
NL8000032 1980-01-03

Publications (3)

Publication Number Publication Date
NL8000032A NL8000032A (nl) 1981-08-03
NL181434B NL181434B (nl) 1987-03-16
NL181434C true NL181434C (nl) 1987-08-17

Family

ID=19834620

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE8000032,A NL181434C (nl) 1980-01-03 1980-01-03 Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.

Country Status (31)

Country Link
US (2) US4431666A (fi)
JP (1) JPS56100796A (fi)
AR (1) AR227903A1 (fi)
AT (1) AT377242B (fi)
AU (1) AU542600B2 (fi)
BE (1) BE886929A (fi)
CA (1) CA1154030A (fi)
CH (1) CH650003A5 (fi)
CS (1) CS239911B2 (fi)
DD (1) DD156909A5 (fi)
DE (1) DE3100017A1 (fi)
DK (1) DK153468C (fi)
ES (2) ES498240A0 (fi)
FI (1) FI72321C (fi)
FR (1) FR2473046A1 (fi)
GB (1) GB2066819B (fi)
GR (1) GR72849B (fi)
HU (1) HU184922B (fi)
IE (1) IE50653B1 (fi)
IL (1) IL61708A (fi)
IT (1) IT1193395B (fi)
LU (1) LU83046A1 (fi)
NL (1) NL181434C (fi)
NO (1) NO810004L (fi)
NZ (1) NZ195926A (fi)
PH (1) PH21998A (fi)
PT (1) PT72298B (fi)
SE (1) SE439921B (fi)
SU (1) SU1083911A3 (fi)
YU (1) YU41754B (fi)
ZA (1) ZA8114B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8101026A (nl) * 1981-03-03 1982-10-01 Tno Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
US4786725A (en) * 1982-06-28 1988-11-22 Engelhard Corporation Solubilized platinum (II) complexes
US4598091A (en) * 1983-02-18 1986-07-01 Degussa Aktiengesellschaft (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体
IL74449A (en) * 1984-03-01 1988-07-31 Us Commerce Tetrahalo-1,2-cyclohexane-diamino platinum complexes and anti-neoplastic compositions comprising them
US4550187A (en) * 1984-04-12 1985-10-29 The Research Foundation Of State University Of New York Synthesis of platinum (IV) antineoplastic agents
HU193809B (en) * 1984-09-12 1987-12-28 Chugai Pharmaceutical Co Ltd Process for producing new platinum complexes
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
US4658047A (en) * 1985-09-27 1987-04-14 The United States Of America As Represented By The Department Of Health And Human Services Method of preparing 1,2-diaminocyclohexane tetrachloro platinum (IV) isomers
US5041581A (en) * 1985-10-18 1991-08-20 The University Of Texas System Board Of Regents Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US5117022A (en) * 1985-10-18 1992-05-26 The Board Of Regents, The University Of Texas System Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US4760157A (en) * 1986-01-31 1988-07-26 American Cyanamid Company (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
ES2054778T3 (es) * 1988-01-09 1994-08-16 Asta Medica Ag Complejos de 1,2-bis (aminometil) ciclobutano-platino.
NL8802150A (nl) * 1988-08-31 1990-03-16 Tno Platina-(ii)-diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat deze verbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
NL8802149A (nl) * 1988-08-31 1990-03-16 Tno Platina-(iv)diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat ten minste een platinaverbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
US5041578A (en) * 1988-11-22 1991-08-20 Board Of Regents, The University Of Texas System Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5434256A (en) * 1988-11-22 1995-07-18 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US4994591A (en) * 1989-06-02 1991-02-19 The Research Foundation Of State University Of Ny Platinum complexes derived from b-silyamines
FI905018A0 (fi) * 1989-10-17 1990-10-12 Bristol Myers Squibb Co I vatten och loesningsmedel loesliga axiala hydroxi-och mono- och dikarboxylsyraderivat med stor tumoeraktivitet.
US5196555A (en) * 1989-10-17 1993-03-23 Bristol-Myers Squibb Company Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity
US5130450A (en) * 1990-04-25 1992-07-14 Nippon Kayaku Kabushiki Kaisha Platinum complexes
GB9211291D0 (en) * 1992-05-28 1992-07-15 British Tech Group Antifungal compounds
DE4415263C1 (de) * 1994-04-15 1995-11-30 Asta Medica Ag Cis-[trans-1,2-Cyclobutanbis(methylamin)-N,N']-[(2S)-lactato-O·1·, O·2·]-platin(II)-trihydrat (Lobaplatin-Trihydrat), seine Herstellung und arzneiliche Verwendung
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
US6264891B1 (en) * 1998-12-22 2001-07-24 Eos Biotechnology, Inc. Apparatus and method for concurrent chemical synthesis
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN105198933B (zh) * 2014-06-20 2018-08-14 贵州益佰制药股份有限公司 一种洛铂晶体、制备方法及药物应用
CA2990369A1 (en) 2015-06-24 2016-12-29 Nippon Kayaku Kabushiki Kaisha Novel platinum (iv) complex
CA2998559A1 (en) 2015-09-14 2017-03-23 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of hexa-coordinated platinum complex
CN105713046B (zh) * 2016-02-01 2018-10-26 复旦大学 一种铂类抗肿瘤前体药物，其纳米水凝胶药物及其制备方法
CN106946946A (zh) * 2017-03-29 2017-07-14 昆明贵研药业有限公司 一种铂类抗肿瘤药物米铂氧化物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH588505A5 (fi) * 1972-06-08 1977-06-15 Research Corp
US4053587A (en) * 1973-04-13 1977-10-11 Research Corporation Method of treating viral infections
GB1578323A (en) * 1976-02-26 1980-11-05 Rustenburg Platinum Mines Ltd Compositions containing platinum
SE7810798L (sv) * 1977-10-19 1979-04-20 Johnson Matthey Co Ltd Kompositioner, innehallande platina
SE7903360L (sv) * 1978-04-20 1979-10-21 Johnson Matthey Co Ltd Kompositioner innehallande platina
SE7903359L (sv) * 1978-04-20 1979-10-21 Johnson Matthey Co Ltd Kompositioner innehallande platina
SE7903361L (sv) * 1978-04-20 1979-10-21 Johnson Matthey Co Ltd Kompositioner innehallande platina
JPS6034958B2 (ja) * 1978-09-02 1985-08-12 喜徳 喜谷 新規白金錯体

Also Published As

Publication number Publication date
NL8000032A (nl) 1981-08-03
GB2066819A (en) 1981-07-15
NZ195926A (en) 1983-04-12
AU542600B2 (en) 1985-02-28
ES507474A0 (es) 1982-09-01
FI72321C (fi) 1987-05-11
DK153468C (da) 1988-12-12
PH21998A (en) 1988-05-02
YU41754B (en) 1987-12-31
AT377242B (de) 1985-02-25
ES8205231A1 (es) 1982-06-01
BE886929A (nl) 1981-06-30
JPH0428716B2 (fi) 1992-05-15
GR72849B (fi) 1983-12-07
FI72321B (fi) 1987-01-30
SE8100006L (sv) 1981-07-04
PT72298A (en) 1981-01-01
NO810004L (no) 1981-07-06
YU336380A (en) 1983-10-31
DE3100017A1 (de) 1981-11-19
HU184922B (en) 1984-11-28
AU6594981A (en) 1981-07-09
CS239911B2 (en) 1986-01-16
ES8207119A1 (es) 1982-09-01
CH650003A5 (de) 1985-06-28
IL61708A (en) 1984-05-31
IE802744L (en) 1981-07-03
SU1083911A3 (ru) 1984-03-30
IT1193395B (it) 1988-06-15
IL61708A0 (en) 1981-01-30
JPS56100796A (en) 1981-08-12
AR227903A1 (es) 1982-12-30
GB2066819B (en) 1984-01-18
FR2473046A1 (fr) 1981-07-10
CA1154030A (en) 1983-09-20
DK1681A (da) 1981-07-04
LU83046A1 (de) 1981-03-27
US4482569A (en) 1984-11-13
NL181434B (nl) 1987-03-16
ZA8114B (en) 1982-01-27
DD156909A5 (de) 1982-09-29
US4431666A (en) 1984-02-14
DK153468B (da) 1988-07-18
IT8027029A0 (it) 1980-12-31
ES498240A0 (es) 1982-06-01
ATA381A (de) 1984-07-15
FR2473046B1 (fi) 1985-03-01
SE439921B (sv) 1985-07-08
IE50653B1 (en) 1986-06-11
FI810002L (fi) 1981-07-04
PT72298B (en) 1981-11-10

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Legal Events

Date Code Title Description
A1C A request for examination has been filed
A85 Still pending on 85-01-01
V1 Lapsed because of non-payment of the annual fee