NL178320C - Werkwijze voor het bereiden van een verbinding met histamino-hŸ2-blokkerende activiteit en voor het bereiden van farmaceutische preparaten, die deze verbinding bevatten. - Google Patents

Werkwijze voor het bereiden van een verbinding met histamino-hŸ2-blokkerende activiteit en voor het bereiden van farmaceutische preparaten, die deze verbinding bevatten.

Info

Publication number
NL178320C
NL178320C NLAANVRAGE7708601,A NL7708601A NL178320C NL 178320 C NL178320 C NL 178320C NL 7708601 A NL7708601 A NL 7708601A NL 178320 C NL178320 C NL 178320C
Authority
NL
Netherlands
Prior art keywords
compound
preparing
histamino
procedure
pharmaceutical preparations
Prior art date
Application number
NLAANVRAGE7708601,A
Other languages
English (en)
Other versions
NL7708601A (nl
Original Assignee
Allen & Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL178320(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allen & Hanburys Ltd filed Critical Allen & Hanburys Ltd
Priority claimed from KR7701808A external-priority patent/KR810000355B1/ko
Publication of NL7708601A publication Critical patent/NL7708601A/nl
Priority to NLAANVRAGE8202659,A priority Critical patent/NL184219C/nl
Application granted granted Critical
Publication of NL178320C publication Critical patent/NL178320C/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
NLAANVRAGE7708601,A 1976-08-04 1977-08-03 Werkwijze voor het bereiden van een verbinding met histamino-hŸ2-blokkerende activiteit en voor het bereiden van farmaceutische preparaten, die deze verbinding bevatten. NL178320C (nl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NLAANVRAGE8202659,A NL184219C (nl) 1976-08-04 1982-07-01 Werkwijze voor het bereiden van een geneesmiddel met remmende werking op via histamine hÿ2-receptoren gestimuleerde afscheiding van maagzuur; therapeutisch voorwerp en werkwijze voor het bereiden van geneeskrachtige verbindingen met genoemde werking.

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB32465/76A GB1565966A (en) 1976-08-04 1976-08-04 Aminoalkyl furan derivatives
GB5068576 1976-12-06
GB2018777 1977-05-13
GB28187/78A GB1565967A (en) 1976-08-04 1977-07-22 Aminoalkyl furan derivatives
KR7701808A KR810000355B1 (ko) 1977-05-13 1977-08-04 아미노 알킬푸란 유도체의 제조방법

Publications (2)

Publication Number Publication Date
NL7708601A NL7708601A (nl) 1978-02-07
NL178320C true NL178320C (nl) 1986-03-03

Family

ID=27516213

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7708601,A NL178320C (nl) 1976-08-04 1977-08-03 Werkwijze voor het bereiden van een verbinding met histamino-hŸ2-blokkerende activiteit en voor het bereiden van farmaceutische preparaten, die deze verbinding bevatten.

Country Status (10)

Country Link
US (3) US4128658A (nl)
JP (3) JPS5840956B2 (nl)
AU (1) AU515628B2 (nl)
BE (1) BE857388A (nl)
CA (1) CA1099268A (nl)
DE (1) DE2734070C2 (nl)
FR (3) FR2360587B1 (nl)
GB (2) GB1565966A (nl)
LU (1) LU77911A1 (nl)
NL (1) NL178320C (nl)

Families Citing this family (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601459A (en) * 1977-05-17 1981-10-28 Allen & Hanburys Ltd Aminoalkyl thiophene derivatives
US5021429A (en) * 1977-05-17 1991-06-04 Allen & Hansburys Limited Pharmacologically active aminoalkylphenyl compounds and their use
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
FI783098A (fi) * 1977-10-11 1979-04-12 Glaxo Group Ltd Farmakologiskt aktiva kompositioner
US4233302A (en) * 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
IN151188B (nl) * 1978-02-13 1983-03-05 Smith Kline French Lab
US4539207A (en) * 1978-02-13 1985-09-03 Smith Kline & French Laboratories Limited Pyrimidine compounds
AR228941A1 (es) 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
US4584384A (en) * 1978-05-30 1986-04-22 Smith Kline & French Laboratories Limited Nitro pyrroles
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
US4405624A (en) * 1978-05-30 1983-09-20 Smith Kline & French Laboratories Limited Nitro-substituted dihydropyrroles and tetrahydropyridines, compositions, compounds, and medicinal use
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
ZA793443B (en) * 1978-07-26 1980-12-31 Glaxo Group Ltd Heterocyclic derivatives
US4200760A (en) * 1978-09-26 1980-04-29 Bristol-Myers Company Imidazolylalkylthioalkylamino-ethylene derivatives
US4203909A (en) * 1978-09-26 1980-05-20 Bristol-Myers Company Furan compounds
FR2446829A1 (fr) * 1978-11-16 1980-08-14 Glaxo Group Ltd Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
US4282363A (en) * 1978-11-24 1981-08-04 Bristol-Myers Company 1-Nitro-2-(2-alkynylamino)-2-[(2-pyridylmethylthio)-ethylamino]ethylene derivatives
ZA801151B (en) * 1979-03-02 1981-02-25 Glaxo Group Ltd Heterocyclic derivatives
JPS55120571A (en) * 1979-03-02 1980-09-17 Glaxo Group Ltd Heterocyclic derivative
DK89480A (da) * 1979-03-02 1980-09-03 Glaxo Group Ltd R fremgangsmaade til fremstilling af heterocycliske forbindelse
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4293557A (en) * 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
JPS5610175A (en) * 1979-07-06 1981-02-02 Fujisawa Pharmaceut Co Ltd Preparation of imidazole derivative
AU538818B2 (en) * 1979-10-22 1984-08-30 Glaxo Group Limited 1-h-1,2,4-triazole compounds
EP0029303B1 (en) * 1979-10-22 1985-01-30 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
US4238487A (en) * 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
JPS5681578A (en) * 1979-12-07 1981-07-03 Shionogi & Co Ltd Novel thioalkyl amide derivative
US4431802A (en) * 1979-12-10 1984-02-14 G. D. Searle & Co. N-Heterocyclyl-N-cyano-N-(heterocyclythioalkyl)-guanidines
US4239908A (en) * 1979-12-10 1980-12-16 G.D. Searle & Co. N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines
CA1181084A (en) * 1980-01-08 1985-01-15 Glaxo Group Limited Process for the preparation of a furan derivative
CA1171096A (en) * 1980-01-08 1984-07-17 Glaxo Group Limited Process for the preparation of a furan derivative
PT72320B (en) * 1980-01-08 1982-07-23 Glaxo Group Ltd Process for preparation of a furan derivative
YU53681A (en) * 1980-03-08 1983-12-31 Smith Kline French Lab Process for obtaining 5-dimethylamino-methyl-2-furane methanol
CA1155842A (en) * 1980-03-29 1983-10-25 Thomas H. Brown Compounds
US4491586A (en) * 1980-06-05 1985-01-01 Glaxo Group Limited Amine derivatives
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
AT407956B (de) * 1980-10-01 2001-07-25 Glaxo Group Ltd Verfahren zur herstellung eines arzneimittels
US4607107A (en) * 1980-10-01 1986-08-19 Smith Kline & French Laboratories Ltd. (4-aminoalkyl-2-pyridyl alkyl)guanidines
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4490533A (en) * 1980-12-22 1984-12-25 Merck & Co., Inc. Aminoalkyl pyridine derivatives
DK153841C (da) * 1980-12-30 1989-02-20 Glaxo Group Ltd Fremgangsmaade til fremstilling af ranitidin
FI84060C (fi) * 1980-12-30 1991-10-10 Glaxo Group Ltd Foerfarande foer framstaellning av n-/2-//5-/(dimetylamino)metyl/-2-furanylmetyl/tio/etyl/-n'-metyl-2- nitro-1,1-etendiamin.
DK558181A (da) * 1981-01-30 1982-07-31 Smithkline Corp Fremgangsmaade til fremstilling af 3,5-diamino-1,2,4-triazoler
EP0057981A3 (en) 1981-02-09 1982-08-25 Beecham Group Plc Aromatic compounds, processes for their preparation and their use
ES8307236A1 (es) * 1981-02-20 1983-02-01 Glaxo Group Ltd Un procedimiento para la preparacion de ranitidina.
DE3108753A1 (de) * 1981-03-07 1982-09-16 Degussa Ag, 6000 Frankfurt Neue substituierte alkyl-phenylsulfonylguanidine miteinem heterocyclischen rest
FR2501691A1 (fr) * 1981-03-11 1982-09-17 Sanofi Sa Thioalkylamides, procede de preparation et compositions pharmaceutiques en contenant
US4381395A (en) * 1981-04-03 1983-04-26 Sk & F Lab Co. Process for preparing an imidazole derivative
AR229878A1 (es) * 1981-05-07 1983-12-30 Glaxo Group Ltd Procedimiento para preparar ranitidina
US4390701A (en) * 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
US5171860A (en) * 1981-06-15 1992-12-15 Merck & Co., Inc. Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors
BE894285A (fr) * 1981-09-04 1983-03-02 Glaxo Group Ltd Composition pharmaceutique contenant un medicament anti-inflammatoire et de la ranitidine ou un sel de ce compose
ES507180A0 (es) * 1981-11-16 1982-08-16 Pharmedical Sa Lab Procedimiento de preparacion de amino alcosi furanos o tio- fenos.
US4525477A (en) * 1981-12-02 1985-06-25 Smith Kline & French Laboratories Limited 2-Thiazolyl, isothiazolyl, oxazolyl and isoxazolyl alkylamino-3-nitro-heterocyclic compounds
GR77847B (nl) * 1981-12-14 1984-09-25 American Home Prod
WO1983002113A1 (en) * 1981-12-17 1983-06-23 Yuki, Hiroshi Propenylamine derivatives and drug containing same
US4411899A (en) * 1981-12-21 1983-10-25 Merck & Co., Inc. Substituted derivatives of amino alkane diols as gastric secretion inhibitors
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
PT76557B (en) * 1982-04-16 1986-01-21 Inke Sa Process for preparing furan derivatives and addition salts thereof and of pharmaceutical compositions containing the same
DE3365869D1 (en) * 1982-07-30 1986-10-09 Smith Kline French Lab Amino pyrimidinones and their preparation
US4590192A (en) * 1982-10-01 1986-05-20 Beecham Group P.L.C. Benzisothiazoles, their pharmaceutical compositions, and method of use
EP0105732A3 (en) * 1982-10-01 1985-09-04 Beecham Group Plc Histamine h2 receptor antagonists of the benzisothiazole amino and benzthiadiazine amino series
JPS5988458A (ja) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd アミン誘導体およびその塩
US4458077A (en) * 1982-11-22 1984-07-03 American Home Products Corporation Heterocyclic anti-ulcer agents
YU42819B (en) * 1982-11-22 1988-12-31 Lek Tovarna Farmacevtskih Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate
US4565815A (en) * 1982-12-30 1986-01-21 Biomeasure, Inc. Pyrazolo[1,5-a]-1,3,5-triazines
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4495193A (en) * 1982-12-30 1985-01-22 Biomeasure, Inc. Imidazole compounds which reduce gastric acid secretion
US4665172A (en) * 1983-01-28 1987-05-12 Ube Industries, Ltd. Process for producing heterocyclic compound having nitromethylene group as the side chain group
US4558044A (en) * 1983-02-19 1985-12-10 Beecham Group P.L.C. 1,2,4-Benzothiadiazines
DE3306102C1 (de) * 1983-02-22 1984-08-02 Ludwig Heumann & Co GmbH, 8500 Nürnberg Pyridin-Pyrimidinon-Derivate,Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DK169255B1 (da) * 1983-02-22 1994-09-26 American Home Prod Analogifremgangsmåde til fremstilling af thieno-isothiazol-1,1-dioxid-derivater og farmaceutisk acceptable salte heraf
US4772622A (en) * 1983-03-25 1988-09-20 Merck & Co., Inc. 3,5-diamino-1,2,4-oxidiazoles as gastric secretion inhibitors
ES521588A0 (es) * 1983-03-30 1984-08-16 Ferrer Int Procedimiento de obtencion de nuevas n-ciano-formamidinas.
GB8313217D0 (en) * 1983-05-13 1983-06-22 Glaxo Group Ltd Pharmaceutical compositions
US4567191A (en) * 1983-06-07 1986-01-28 Merck & Co., Inc. Amino-phenyl-thiadiazoledioxides as gastric secretion inhibitors
US4539416A (en) * 1983-06-10 1985-09-03 The Dow Chemical Company Processes for making thioalkyl carboxamides and amines
FI88157C (fi) * 1983-07-15 1993-04-13 Richter Gedeon Vegyeszet Foerfarande foer framstaellning av vaetekloriden av 1- 2-/5-dimetylaminometyl-2-(furylmetyltio)-etyl/ -amino-1-metylamino-2-nitroetylen
JPS6067474A (ja) * 1983-09-24 1985-04-17 Wakamoto Pharmaceut Co Ltd 新規な1,3,4−チアジアゾ−ル誘導体及びそれを有効成分とする抗潰瘍剤
BG39661A1 (en) * 1984-04-13 1986-08-29 Ivanova Antiulcer means
HU198196B (en) * 1984-05-02 1989-08-28 Gyogyszerkutato Intezet Process for production of basic tioether and its salts
IT1196133B (it) * 1984-06-06 1988-11-10 Ausonia Farma Srl Derivati furanici con attivita' antiulcera
DE3546858C2 (de) * 1984-06-15 1995-04-20 Glaxo Group Ltd Verfahren zur Herstellung von Ranitidin
GB8415254D0 (en) 1984-06-15 1984-07-18 Glaxo Group Ltd Amine derivatives
JPS6172418A (ja) * 1984-09-17 1986-04-14 Alps Electric Co Ltd 衛星放送用受信機
GB8423804D0 (en) * 1984-09-20 1984-10-24 Glaxo Group Ltd Chemical process
IT1178026B (it) * 1984-10-05 1987-09-03 Medosan Ind Biochimi Derivati del 2-amino-tiazolo
FR2571723B1 (fr) * 1984-10-12 1988-08-26 Lipha Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant
AU7235287A (en) * 1986-03-28 1987-10-20 Janus Farmaceutici S.R.L Synthesis of antiulcer compounds
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
JPH0725745B2 (ja) * 1986-11-11 1995-03-22 株式会社日本触媒 アミン化合物の製造方法
GB8629781D0 (en) * 1986-12-12 1987-01-21 Glaxo Group Ltd Pharmaceutical compositions
EP0285681B1 (de) * 1987-04-06 1993-03-10 HEUMANN PHARMA GMBH & CO Verfahren zur Herstellung von Nitroethenderivaten
GB2209163B (en) * 1987-08-28 1991-04-24 Toyama Chemical Co Ltd Amine derivative and its salt, process for producing the same, and anti-ulcer agent containing the same
JPH01131172A (ja) * 1987-08-28 1989-05-24 Toyama Chem Co Ltd アミン誘導体およびその塩、それらの製造法、並びにそれらを含有する抗潰瘍剤
SE8704436D0 (sv) * 1987-11-13 1987-11-13 Pm Konsult Handelsbolag Anvendning av antisekretoriska substanser for nya indikationer
JPH01138013U (nl) * 1988-03-16 1989-09-21
IL90245A (en) * 1988-05-11 1994-04-12 Glaxo Group Ltd Resin adsorption containing ranitidine together with synthetic resin replaces cations, its preparation and pharmaceutical preparations containing it
US4880636A (en) * 1988-05-13 1989-11-14 Franz Robert M Film coated tablet of ranitidine HCl
CH679582A5 (nl) * 1988-07-18 1992-03-13 Glaxo Group Ltd
FR2636532B1 (fr) * 1988-09-20 1993-11-19 Glaxo Group Ltd Compositions pharmaceutiques
GB8904182D0 (en) * 1989-02-23 1989-04-05 Glaxo Canada Pharmaceutical compositions
ES2012285A6 (es) * 1989-03-09 1990-03-01 Vinas Lab Procedimiento para la obtencion de derivados furanicos.
JPH0730064B2 (ja) * 1989-08-17 1995-04-05 協和醗酵工業株式会社 フラン誘導体
GB9004328D0 (en) * 1990-02-27 1990-04-25 Glaxo Group Ltd Chemical compounds
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
HU210849B (en) * 1990-11-09 1995-08-28 Richter Gedeon Vegyeszet Process for preparing furil derivatives
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
KR950701312A (ko) * 1992-05-12 1995-03-23 이베 사치아키 신규 4급 암모늄염 및 약제로서 그의 사용
JPH0649615U (ja) * 1992-12-14 1994-07-08 日本建鐵株式会社 ドライシールカーテンウォールの排水構造
WO1995010274A1 (en) * 1993-10-14 1995-04-20 F.H. Faulding & Co. Limited Aqueous pharmaceutical composition
DE4341310A1 (de) * 1993-12-03 1995-06-08 Hexal Pharma Gmbh Tablette oder Kapsel mit einem Gehalt an stabilem Ranitidinhydrochlorid Form 1
US5407687A (en) * 1994-02-22 1995-04-18 Glaxo Inc. Ranitidine solid dosage form
EP0754182A1 (en) 1994-04-08 1997-01-22 Brantford Chemicals Inc. Form 1 ranitidine hydrochloride with increased density
CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
NZ272054A (en) * 1994-05-13 1996-05-28 Ranbaxy Lab Ltd Process for producing form 1 ranitidine hydrochloride
IN181698B (nl) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
IN181699B (nl) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
EP0694540B1 (en) 1994-06-24 1998-08-19 Ranbaxy Laboratories Limited Process for the manufacture of form 1 ranitidine hydrochloride
ES2119268T3 (es) * 1994-06-24 1998-10-01 Ranbaxy Lab Ltd Procedimiento para fabricar ranitidina base de calidad farmaceutica.
US5538737A (en) * 1994-11-30 1996-07-23 Applied Analytical Industries, Inc. Oral compositions of H2 -antagonists
ES2215182T3 (es) * 1994-12-08 2004-10-01 Aventis Pharmaceuticals Inc. Procedimiento para preparar ranitidina.
US5672724A (en) * 1994-12-08 1997-09-30 Hoechst Marion Roussel, Inc. Processes for preparing ranitidine
US5663381A (en) * 1995-04-21 1997-09-02 Hexal Pharmaceuticals, Inc. Process for preparing form 1 ranitidine hydrochloride
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
CA2237384A1 (en) * 1995-11-13 1997-05-22 The Albany Medical College Analgesic compounds and uses thereof
WO1997035853A1 (en) * 1996-03-25 1997-10-02 Hoechst Marion Roussel, Inc. Process for the preparation of form 1 ranitidine hydrochloride
WO1999036415A1 (en) * 1998-01-16 1999-07-22 Centaur Pharmaceuticals, Inc. Thioether furan nitrone compounds
IE990387A1 (en) * 1998-06-17 2000-12-13 Russinsky Ltd A ranitidine base water adduct
YU52598A (sh) * 1998-11-19 2001-05-28 D.D. Zdravlje- sektor za istraživanje i razvoj POSTUPAK ZA sintezu N-[2[[[5=[(DIALKILAMINO)METIL]-2= FURANIL]METIL]TIO]ETIL]-N'-ALKIL-2-NITRO 1,1 ALKENDIAMINA I NJIHOVIH HIDROHLORIDA
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
DE10300325A1 (de) * 2003-01-09 2004-07-22 Hexal Ag Granulat mit öliger Substanz, Herstellungsverfahren und Tablette
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
US20060088586A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US8383159B2 (en) * 2004-10-27 2013-02-26 Mcneil-Ppc, Inc. Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088593A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20070190133A1 (en) * 2004-10-27 2007-08-16 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060088587A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20070281022A1 (en) * 2004-10-27 2007-12-06 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
US20060087051A1 (en) * 2004-10-27 2006-04-27 Bunick Frank J Dosage forms having a microreliefed surface and methods and apparatus for their production
WO2006071659A1 (en) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivery of h2 antagonists
CA2500676A1 (en) * 2005-03-11 2006-09-11 Apotex Pharmachem Inc. Preparation of acid addition salts of amine bases by solid phase-gas phase reactions
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
EP2572713B1 (en) 2011-09-22 2014-08-13 King Saud University Extracts and isolated flavonoids from Euphorbia cuneata useful as anti-ulcer agents
EP2825159B1 (en) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
ES2860526T3 (es) 2013-07-19 2021-10-05 Boehringer Ingelheim Vetmedica Gmbh Derivados de ciclodextrina eterificada conservados que contienen una composición farmacéutica acuosa líquida
PL2925305T3 (pl) 2013-12-04 2017-07-31 Boehringer Ingelheim Vetmedica Gmbh Ulepszone kompozycje farmaceutyczne pimobendanu
US9457011B2 (en) 2014-02-25 2016-10-04 Muslim D. Shahid Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor
EP2929884A1 (en) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
WO2015169957A1 (en) 2014-05-09 2015-11-12 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and h2-receptor antagonists
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN108864001A (zh) * 2018-06-30 2018-11-23 郑州明泽医药科技有限公司 一种合成雷尼替丁的新方法
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer
CN114605360B (zh) * 2022-03-09 2023-05-05 河北海力恒远新材料股份有限公司 一种2-[[[5-(二甲氨基)甲基-2-呋喃基]甲基]硫代]乙胺的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2989546A (en) * 1961-06-20 Synthesis of furans
US3097206A (en) * 1962-03-19 1963-07-09 Smith Kline French Lab Aminomethylthienyl and furyl alcohol derivatives
US3433807A (en) * 1963-09-26 1969-03-18 Merck & Co Inc Aminopropoxymethylfurans and intermediates therefor
US3393209A (en) * 1965-10-04 1968-07-16 Dow Chemical Co Furfuryl and tetrahydrofurfuryl phenyl ureas
GB1307539A (en) 1970-06-25 1973-02-21 Smith Kline French Lab Thiourea derivatives
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
US4000164A (en) * 1973-04-02 1976-12-28 Richardson-Merrell Inc. Hypolipidemic agents
US4110351A (en) * 1973-04-02 1978-08-29 Richardson-Merrell Inc. Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts
GB1421792A (en) 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
FI783098A (fi) * 1977-10-11 1979-04-12 Glaxo Group Ltd Farmakologiskt aktiva kompositioner

Also Published As

Publication number Publication date
FR2384765B1 (fr) 1982-09-10
GB1565967A (en) 1980-04-23
FR2384753B1 (fr) 1981-06-12
NL7708601A (nl) 1978-02-07
CA1099268A (en) 1981-04-14
FR2360587A1 (fr) 1978-03-03
JPS6132315B2 (nl) 1986-07-25
LU77911A1 (fr) 1979-05-23
US4128658A (en) 1978-12-05
GB1565966A (en) 1980-04-23
FR2384753A1 (fr) 1978-10-20
JPS55153779A (en) 1980-11-29
FR2384765A1 (fr) 1978-10-20
AU2751977A (en) 1979-02-08
AU515628B2 (en) 1981-04-16
BE857388A (fr) 1978-02-02
US4279819A (en) 1981-07-21
US4255440A (en) 1981-03-10
FR2360587B1 (fr) 1981-07-17
JPS5318557A (en) 1978-02-20
JPS55153761A (en) 1980-11-29
DE2734070C2 (de) 1983-12-29
JPS5840956B2 (ja) 1983-09-08
DE2734070A1 (de) 1978-02-09

Similar Documents

Publication Publication Date Title
NL178320C (nl) Werkwijze voor het bereiden van een verbinding met histamino-hŸ2-blokkerende activiteit en voor het bereiden van farmaceutische preparaten, die deze verbinding bevatten.
NL7612728A (nl) Werkwijze voor het bereiden van preparaten, die een werkzaam bestanddeel met een ingestelde snelheid afgeven, alsmede gevormde preparaten.
NL191793B (nl) Werkwijze voor de bereiding van een polypeptide, en van een farmaceutisch of veterinair preparaat.
NL7708569A (nl) Werkwijze voor het bereiden van een katalysator en zo gevormde katalysator.
NL7703752A (nl) Werkwijze voor het bereiden van een geneesmid- del tegen kanker en werkwijze voor het bereiden van een actieve component evenals het gevormde geneesmiddel.
NL7710380A (nl) Werkwijze ter bereiding van een geneesmiddel, zo gevormd geneesmiddel en werkwijze voor het bereiden van daartoe geschikte actieve ver- bindingen.
NL172917C (nl) Werkwijze voor het bereiden van een geneesmiddel tegen kanker.
NL7809404A (nl) Thiazoolderivaten en thiazoolderivaten bevattende farmaceutische preparaten, alsmede werkwijzen voor het bereiden van een en ander.
NL7605922A (nl) Werkwijze voor het bereiden van een verbinding met farmacologische werking, alsmede gevormd farmaceutisch preparaat dat een zodanige ver- binding bevat.
NL7712616A (nl) Werkwijze voor het bereiden en toepassen van een katalysator.
NL7703898A (nl) Werkwijze voor het bereiden van 2-gesubstitueer- de trans-hexahydropyridoindolen, werkwijze voor het bereiden van farmaceutische preparaten met toepassing daarvan alsmede zo gevormde prepara- ten.
NL7702123A (nl) Werkwijzen voor het bereiden en toepassen van een chinazoline-derivaat.
NL7704542A (nl) Werkwijze voor het bereiden van isothiazolopyri- dinederivaten, alsmede farmaceutische preparaten die deze verbinding bevatten.
NL187478C (nl) Werkwijze voor het bereiden van amidoximderivaten, alsmede werkwijze ter bereiding van een geneesmiddel.
NL7514970A (nl) Werkwijze voor het bereiden van een geneesmid- del, zo gevormd geneesmiddel en werkwijze voor het bereiden van daartoe geschikte actieve componenten.
NL182283C (nl) Werkwijze voor het bereiden van een farmaceutisch preparaat.
NL7706614A (nl) Werkwijze voor het bereiden van een geneesmiddel, zo gevormd geneesmiddel en werkwijze voor het bereiden van geneeskrachtigm verbindingen.
NL7701833A (nl) Werkwijze voor het bereiden van pyrroloben- zoxazalkanen, van deze verbindingen bevattende farmaceutische preparaten, alsmede behandeling met deze farmaceutische preparaten.
NL7703624A (nl) Werkwijze ter bereiding van een geneesmiddel, zo gevormd geneesmiddel en werkwijze voor het bereiden van geneeskrachtige verbindingen.
NL7802380A (nl) Benzylpyrimidinen, een werkwijze voor de berei- ding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
NL152246B (nl) Werkwijze voor het bereiden van een preparaat met anti-aritmische activiteit, gevormd preparaat en werkwijze voor het bereiden van een daartoe geschikte verbinding.
NL184898C (nl) Werkwijze voor het bereiden van aminoandrostaan-derivaten, werkwijze voor het bereiden van een geneesmiddel met neuro-musculair-blokkerende werking en gevormd geneesmiddel met neuro-musculair-blokkerende werking.
NL7701885A (nl) Werkwijze voor het bereiden van iminoverbindingen, werkwijze voor het bereiden van een farmaceutisch preparaat alsmede zo verkregen gevormd preparaat.
NL186447C (nl) Verbinding met anti-ulcerogene activiteit, werkwijze voor het bereiden daarvan en farmaceutische preparaten die deze stof bevatten.
NL188015C (nl) Werkwijze voor het bereiden van anti-inflammatoir actieve farmaceutische preparaten.

Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
V4 Discontinued because of reaching the maximum lifetime of a patent

Free format text: 970803