NL178074C - Geneeskrachtige preparaten met een remmende werking op de aggregatie van bloedplaatjes en op de fosfodiesterase, alsmede in deze preparaten te gebruiken carbostyrilderivaten. - Google Patents

Geneeskrachtige preparaten met een remmende werking op de aggregatie van bloedplaatjes en op de fosfodiesterase, alsmede in deze preparaten te gebruiken carbostyrilderivaten.

Info

Publication number
NL178074C
NL178074C NLAANVRAGE7806245,A NL7806245A NL178074C NL 178074 C NL178074 C NL 178074C NL 7806245 A NL7806245 A NL 7806245A NL 178074 C NL178074 C NL 178074C
Authority
NL
Netherlands
Prior art keywords
preparations
phosphodis
sterase
inhibitory effect
blade plate
Prior art date
Application number
NLAANVRAGE7806245,A
Other languages
English (en)
Dutch (nl)
Other versions
NL7806245A (nl
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6931977A external-priority patent/JPS545981A/ja
Priority claimed from JP7586377A external-priority patent/JPS5412385A/ja
Priority claimed from JP53023012A external-priority patent/JPS6059912B2/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NL7806245A publication Critical patent/NL7806245A/xx
Application granted granted Critical
Publication of NL178074C publication Critical patent/NL178074C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
NLAANVRAGE7806245,A 1977-06-10 1978-06-08 Geneeskrachtige preparaten met een remmende werking op de aggregatie van bloedplaatjes en op de fosfodiesterase, alsmede in deze preparaten te gebruiken carbostyrilderivaten. NL178074C (nl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6931977A JPS545981A (en) 1977-06-10 1977-06-10 Carbostyryl derivatives
JP7586377A JPS5412385A (en) 1977-06-24 1977-06-24 Carbostyril derivative
JP53023012A JPS6059912B2 (ja) 1978-02-28 1978-02-28 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
NL7806245A NL7806245A (nl) 1978-12-12
NL178074C true NL178074C (nl) 1986-01-16

Family

ID=27284068

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7806245,A NL178074C (nl) 1977-06-10 1978-06-08 Geneeskrachtige preparaten met een remmende werking op de aggregatie van bloedplaatjes en op de fosfodiesterase, alsmede in deze preparaten te gebruiken carbostyrilderivaten.

Country Status (21)

Country Link
US (1) US4298739A (Direct)
AR (2) AR224345A1 (Direct)
AT (1) AT367038B (Direct)
AU (1) AU510138B2 (Direct)
CA (1) CA1098907A (Direct)
CH (1) CH636087A5 (Direct)
DE (1) DE2825048A1 (Direct)
DK (1) DK149449C (Direct)
ES (2) ES470690A1 (Direct)
FI (1) FI69300C (Direct)
FR (1) FR2393795B1 (Direct)
GB (1) GB2002745B (Direct)
IE (1) IE46852B1 (Direct)
IT (1) IT1108326B (Direct)
MX (1) MX5527E (Direct)
NL (1) NL178074C (Direct)
NO (1) NO148813C (Direct)
NZ (1) NZ187452A (Direct)
PH (1) PH14670A (Direct)
PT (1) PT68157A (Direct)
SE (1) SE444562B (Direct)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
AT383594B (de) * 1980-02-29 1987-07-27 Otsuka Pharma Co Ltd Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
ZA851131B (en) * 1984-02-15 1986-09-24 Syntex Inc (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)oxyalkylamides
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
TW201305B (Direct) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
KR930702307A (ko) * 1991-08-23 1993-09-08 오오쓰까 아끼히꼬 카르보스티릴 유도체 및 혈소판 응집 억제제
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1956906A4 (en) 2005-11-09 2009-12-30 Combinatorx Inc METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
EP3239170B1 (en) 2008-06-04 2019-03-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2196453A1 (en) * 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
EP2468733A4 (en) 2009-08-21 2013-02-06 Otsuka Pharma Co Ltd PROCESS FOR PRODUCING BENZO [B] [1,4] DIAZEPINE-2,4-DIONE COMPOUND
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (en) 2011-03-01 2024-03-05 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
EP3718557A3 (en) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
HK1220611A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 用於治疗胃肠道病症的组成物
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5239035B2 (Direct) * 1972-12-14 1977-10-03
JPS5234629B2 (Direct) * 1973-02-03 1977-09-05
SE431451B (sv) * 1973-10-24 1984-02-06 Otsuka Pharma Co Ltd Forfarande for framstellning av 2,3-dihydroxipropoxikinoliner eller -isokinoliner
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS54119478A (en) * 1978-03-06 1979-09-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
DK149449B (da) 1986-06-16
IT1108326B (it) 1985-12-09
FI69300C (fi) 1986-01-10
DK149449C (da) 1986-11-24
GB2002745A (en) 1979-02-28
CA1098907A (en) 1981-04-07
ES479138A1 (es) 1979-07-01
IE781104L (en) 1978-12-10
GB2002745B (en) 1982-02-17
NO148813B (no) 1983-09-12
AU3686678A (en) 1979-12-13
NO782022L (no) 1978-12-12
IE46852B1 (en) 1983-10-05
AR225755A1 (es) 1982-04-30
FR2393795A1 (fr) 1979-01-05
SE7806710L (sv) 1978-12-11
DE2825048C2 (Direct) 1991-05-08
AT367038B (de) 1982-05-25
PT68157A (en) 1978-07-01
PH14670A (en) 1981-10-30
CH636087A5 (de) 1983-05-13
FI69300B (fi) 1985-09-30
IT7868355A0 (it) 1978-06-09
DE2825048A1 (de) 1978-12-14
AR224345A1 (es) 1981-11-30
FR2393795B1 (fr) 1986-07-25
NZ187452A (en) 1980-05-27
ES470690A1 (es) 1979-10-16
MX5527E (es) 1983-09-23
US4298739A (en) 1981-11-03
ATA421378A (de) 1981-10-15
SE444562B (sv) 1986-04-21
NO148813C (no) 1983-12-21
FI781811A7 (fi) 1978-12-11
DK254878A (da) 1979-02-09
NL7806245A (nl) 1978-12-12
AU510138B2 (en) 1980-06-12

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Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
BK Erratum

Free format text: CORRECTION TO PAMPHLET

V1 Lapsed because of non-payment of the annual fee