MY162146A - Pharmaceutical composition - Google Patents

Pharmaceutical composition

Info

Publication number
MY162146A
MY162146A MYPI2013700146A MYPI2013700146A MY162146A MY 162146 A MY162146 A MY 162146A MY PI2013700146 A MYPI2013700146 A MY PI2013700146A MY PI2013700146 A MYPI2013700146 A MY PI2013700146A MY 162146 A MY162146 A MY 162146A
Authority
MY
Malaysia
Prior art keywords
pharmaceutical composition
subjects
formula
treatment
methods
Prior art date
Application number
MYPI2013700146A
Other languages
English (en)
Inventor
Mark Spyvee
Takashi Satoh
Jonathan Eric Carlson
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MY162146A publication Critical patent/MY162146A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • C07D231/20One oxygen atom attached in position 3 or 5
    • C07D231/22One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41521,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • C07D231/20One oxygen atom attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
MYPI2013700146A 2010-09-21 2011-09-12 Pharmaceutical composition MY162146A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38478110P 2010-09-21 2010-09-21

Publications (1)

Publication Number Publication Date
MY162146A true MY162146A (en) 2017-05-31

Family

ID=44674894

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2013700146A MY162146A (en) 2010-09-21 2011-09-12 Pharmaceutical composition

Country Status (31)

Country Link
US (2) US8686018B2 (OSRAM)
EP (2) EP2619182B1 (OSRAM)
JP (1) JP5956448B2 (OSRAM)
KR (1) KR101911105B1 (OSRAM)
CN (1) CN103097358B (OSRAM)
AU (1) AU2011305872B2 (OSRAM)
BR (1) BR112013002484B1 (OSRAM)
CA (1) CA2806121C (OSRAM)
CL (1) CL2013000675A1 (OSRAM)
CY (1) CY1118680T1 (OSRAM)
DK (1) DK2619182T3 (OSRAM)
ES (1) ES2610185T3 (OSRAM)
HR (1) HRP20170042T1 (OSRAM)
HU (1) HUE031408T2 (OSRAM)
IL (1) IL224288A (OSRAM)
LT (1) LT2619182T (OSRAM)
ME (1) ME02575B (OSRAM)
MX (1) MX2013003162A (OSRAM)
MY (1) MY162146A (OSRAM)
NZ (1) NZ606629A (OSRAM)
PE (1) PE20131343A1 (OSRAM)
PH (1) PH12013500467A1 (OSRAM)
PL (1) PL2619182T3 (OSRAM)
PT (1) PT2619182T (OSRAM)
RS (1) RS55566B1 (OSRAM)
RU (1) RU2606510C2 (OSRAM)
SG (1) SG188188A1 (OSRAM)
SI (1) SI2619182T1 (OSRAM)
SM (2) SMT201700008T1 (OSRAM)
UA (1) UA113499C2 (OSRAM)
WO (1) WO2012039972A1 (OSRAM)

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CN108368127B (zh) 2015-07-23 2020-12-11 武田药品工业株式会社 化合物及其作为ep4受体拮抗剂的用途
CN108473497B (zh) 2015-10-16 2021-09-10 卫材R&D 管理有限公司 Ep4拮抗剂
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
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KR102626982B1 (ko) 2017-05-18 2024-01-18 이도르시아 파마슈티컬스 리미티드 Pge2 수용체 조절제로서의 피리미딘 유도체
ES2896476T3 (es) 2017-05-18 2022-02-24 Idorsia Pharmaceuticals Ltd Derivados de pirimidina
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CN108929281B (zh) * 2017-05-27 2021-12-24 华东师范大学 三氮唑类化合物及其合成方法和应用
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WO2022037601A1 (zh) * 2020-08-18 2022-02-24 武汉人福创新药物研发中心有限公司 作为ep4受体拮抗剂的吡唑酰胺衍生物及其在制备治疗癌症和炎症药物中的用途
EP4245301A4 (en) 2020-11-13 2024-08-21 ONO Pharmaceutical Co., Ltd. TREATMENT OF CANCER BY COMBINED USE OF AN EP4 ANTAGONIST AND AN IMMUNE CHECKPOINT INHIBITOR
TWI877433B (zh) 2020-11-30 2025-03-21 大陸商杭州阿諾生物醫藥科技有限公司 用於治療pik3ca突變癌症的組合療法
WO2022161418A1 (zh) * 2021-01-28 2022-08-04 深圳晶泰科技有限公司 吡唑酰胺衍生物及其制备方法和应用
US20240368088A1 (en) * 2021-09-03 2024-11-07 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Ep4 antagonist compound as well as salt, polymorph and use thereof
CN115364222A (zh) * 2021-09-09 2022-11-22 首都医科大学附属北京地坛医院 Ep4受体抑制剂治疗肝纤维化的应用
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US20250381143A1 (en) * 2021-12-30 2025-12-18 Adlai Nortye Biopharma Co., Ltd. A solid pharmaceutical composition
WO2024027599A1 (zh) * 2022-08-04 2024-02-08 杭州阿诺生物医药科技有限公司 预测直肠癌对an0025联合放疗/放化疗(rt/crt)治疗敏感性的生物标志物

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Also Published As

Publication number Publication date
US20130237578A1 (en) 2013-09-12
IL224288A (en) 2015-02-26
BR112013002484B1 (pt) 2021-10-13
CL2013000675A1 (es) 2013-07-05
KR101911105B1 (ko) 2018-10-23
CA2806121C (en) 2018-10-09
WO2012039972A1 (en) 2012-03-29
EP3061751A1 (en) 2016-08-31
SI2619182T1 (sl) 2017-03-31
EP2619182B1 (en) 2016-11-09
SMT201700008B (it) 2017-03-08
UA113499C2 (xx) 2017-02-10
PH12013500467A1 (en) 2013-04-29
HRP20170042T1 (hr) 2017-03-10
AU2011305872B2 (en) 2015-03-26
PE20131343A1 (es) 2013-11-18
HUE031408T2 (en) 2017-07-28
SMT201700008T1 (it) 2017-03-08
EP2619182A1 (en) 2013-07-31
LT2619182T (lt) 2017-01-25
US8686018B2 (en) 2014-04-01
US20140155452A1 (en) 2014-06-05
RU2606510C2 (ru) 2017-01-10
US9000024B2 (en) 2015-04-07
PL2619182T3 (pl) 2017-03-31
PT2619182T (pt) 2017-01-17
CA2806121A1 (en) 2012-03-29
SG188188A1 (en) 2013-04-30
CN103097358B (zh) 2015-04-08
JP5956448B2 (ja) 2016-07-27
KR20130099008A (ko) 2013-09-05
JP2013538825A (ja) 2013-10-17
ME02575B (me) 2017-06-20
DK2619182T3 (en) 2017-01-30
ES2610185T3 (es) 2017-04-26
CN103097358A (zh) 2013-05-08
CY1118680T1 (el) 2017-07-12
RU2013118209A (ru) 2014-10-27
NZ606629A (en) 2015-03-27
AU2011305872A1 (en) 2013-01-31
RS55566B1 (sr) 2017-05-31
BR112013002484A2 (pt) 2016-05-31
MX2013003162A (es) 2013-05-06

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