MXPA05010368A - Sulfonamidas heterociclicas que contienen fluor- y trifluoroalquilo como inhibidores de la produccion beta amiloide y derivados de las mismas. - Google Patents

Sulfonamidas heterociclicas que contienen fluor- y trifluoroalquilo como inhibidores de la produccion beta amiloide y derivados de las mismas.

Info

Publication number
MXPA05010368A
MXPA05010368A MXPA05010368A MXPA05010368A MXPA05010368A MX PA05010368 A MXPA05010368 A MX PA05010368A MX PA05010368 A MXPA05010368 A MX PA05010368A MX PA05010368 A MXPA05010368 A MX PA05010368A MX PA05010368 A MXPA05010368 A MX PA05010368A
Authority
MX
Mexico
Prior art keywords
optionally substituted
hydrogen
lower alkyl
beta amyloid
trifluoroalkyl
Prior art date
Application number
MXPA05010368A
Other languages
English (en)
Spanish (es)
Inventor
Frank Kreft Anthony
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA05010368A publication Critical patent/MXPA05010368A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MXPA05010368A 2003-03-31 2004-03-26 Sulfonamidas heterociclicas que contienen fluor- y trifluoroalquilo como inhibidores de la produccion beta amiloide y derivados de las mismas. MXPA05010368A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31
PCT/US2004/009268 WO2004092155A1 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Publications (1)

Publication Number Publication Date
MXPA05010368A true MXPA05010368A (es) 2005-11-17

Family

ID=33299665

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05010368A MXPA05010368A (es) 2003-03-31 2004-03-26 Sulfonamidas heterociclicas que contienen fluor- y trifluoroalquilo como inhibidores de la produccion beta amiloide y derivados de las mismas.

Country Status (22)

Country Link
US (3) US7300951B2 (US07858658-20101228-C00033.png)
EP (1) EP1608638A1 (US07858658-20101228-C00033.png)
JP (1) JP2006522126A (US07858658-20101228-C00033.png)
KR (1) KR20060002908A (US07858658-20101228-C00033.png)
CN (2) CN1780829B (US07858658-20101228-C00033.png)
AR (1) AR043940A1 (US07858658-20101228-C00033.png)
AU (1) AU2004230844B2 (US07858658-20101228-C00033.png)
BR (1) BRPI0408962A (US07858658-20101228-C00033.png)
CA (1) CA2517155A1 (US07858658-20101228-C00033.png)
CL (1) CL2004000647A1 (US07858658-20101228-C00033.png)
CO (1) CO5640049A2 (US07858658-20101228-C00033.png)
CR (1) CR7951A (US07858658-20101228-C00033.png)
EC (1) ECSP056128A (US07858658-20101228-C00033.png)
MX (1) MXPA05010368A (US07858658-20101228-C00033.png)
NO (1) NO20054263L (US07858658-20101228-C00033.png)
NZ (1) NZ542468A (US07858658-20101228-C00033.png)
RU (1) RU2342374C2 (US07858658-20101228-C00033.png)
SG (1) SG167669A1 (US07858658-20101228-C00033.png)
TW (1) TWI336698B (US07858658-20101228-C00033.png)
UA (1) UA82093C2 (US07858658-20101228-C00033.png)
WO (1) WO2004092155A1 (US07858658-20101228-C00033.png)
ZA (1) ZA200507896B (US07858658-20101228-C00033.png)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005255A (es) * 2000-12-13 2004-10-14 Wyeth Corp Inhibidores de produccion de beta-amiloide de sulfonamida heterociclica.
SI1465861T1 (sl) * 2001-12-20 2009-12-31 Bristol Myers Squibb Co Alfa-(n-sulfonamido)acetamidni derivati kot beta-amiloid inhibitorji
BR0311767A (pt) * 2002-06-11 2005-03-08 Wyeth Corp Compostos inibidores de sulfonamida substituìda da produção de beta amilóide, suas composições e usos
NZ542468A (en) * 2003-03-31 2009-01-31 Wyeth Corp Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
WO2005073198A1 (en) * 2004-01-16 2005-08-11 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
EP1984347A1 (en) * 2006-02-17 2008-10-29 Wyeth a Corporation of the State of Delaware Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
AR059518A1 (es) * 2006-02-17 2008-04-09 Wyeth Corp Metodos para preparar alcoholes sustituidos con sulfonamidas y sus compuestos intermedios
JP2009534385A (ja) 2006-04-21 2009-09-24 ワイス キラル的に純粋なアミノアルコール中間体、それらの誘導体の製造、及びそれらの使用
US7550629B2 (en) * 2006-04-21 2009-06-23 Wyeth Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
US7476762B2 (en) 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
CA2667802A1 (en) * 2006-11-03 2008-05-29 Northwestern University Multiple sclerosis therapy
PA8789801A1 (es) * 2007-07-16 2009-02-09 Wyeth Corp Procesos e intermadiarios para la preparacion de compuestos de silfonamida heterocíclica
PE20090824A1 (es) * 2007-07-16 2009-07-24 Wyeth Corp Proceso para la preparacion de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterociclicas
PE20090445A1 (es) * 2007-07-16 2009-05-18 Wyeth Corp Inhibidores de produccion de beta amiloide
US8093276B2 (en) * 2007-10-31 2012-01-10 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US8084477B2 (en) * 2007-10-31 2011-12-27 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
US20090181932A1 (en) * 2008-01-11 2009-07-16 Wyeth COMPOSITIONS CONTAINING O-SULFATE AND O-PHOSPHATE CONTAINING ARYL SULFONAMIDE DERIVATIVES USEFUL AS beta-AMYLOID INHIBITORS
JP2011523633A (ja) * 2008-05-08 2011-08-18 ブリストル−マイヤーズ スクイブ カンパニー ２−アリールグリシンアミド誘導体
EP2334620B1 (en) * 2008-09-05 2018-09-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Process for enantioseparation of chiral systems with compound formation using two subsequent crystallization steps
US8044077B2 (en) * 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
US7977362B2 (en) * 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
US20110071199A1 (en) * 2009-03-20 2011-03-24 Bristol-Myers Squibb Company Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease
TW201043269A (en) * 2009-04-14 2010-12-16 Bristol Myers Squibb Co Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound
US8252821B2 (en) * 2009-04-14 2012-08-28 Bristol-Myers Squibb Company Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound
WO2010126002A1 (ja) * 2009-04-28 2010-11-04 塩野義製薬株式会社 ヘテロ環スルホンアミド化合物を含有する医薬
WO2011084503A1 (en) * 2009-12-16 2011-07-14 North Carolina Central University Phenoxy thiophene sulfonamides and their use in the treatment of neurodegenerative diseases
US9223217B2 (en) 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing topcoat and photoresist additive compositions and methods of use
US9223209B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing photoresist compositions and methods of use
CA2792613C (en) 2010-03-10 2016-06-28 North Carolina Central University Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase
EP3970725A1 (en) 2012-09-07 2022-03-23 Massachusetts Eye & Ear Infirmary A gamma secretase inhibitor for treating hearing loss
WO2014171434A1 (ja) 2013-04-19 2014-10-23 国立大学法人岡山大学 アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
CA3024424A1 (en) 2016-05-16 2017-11-23 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
WO2019148067A1 (en) 2018-01-26 2019-08-01 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
EP4299062A1 (en) 2022-06-30 2024-01-03 Vilnius University Inhibition of protein amyloid aggregation using fluorinated benzenesulfonamides

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591761A (en) 1993-05-20 1997-01-07 Texas Biotechnology Corporation Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5464853A (en) 1993-05-20 1995-11-07 Immunopharmaceutics, Inc. N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US5514691A (en) 1993-05-20 1996-05-07 Immunopharmaceutics, Inc. N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
EP0510700A3 (en) 1991-04-26 1992-12-16 Takeda Chemical Industries, Ltd. Azole compounds, their production and use
GB9110722D0 (en) 1991-05-17 1991-07-10 Fujisawa Pharmaceutical Co Amine derivatives
US5766846A (en) 1992-07-10 1998-06-16 Athena Neurosciences Methods of screening for compounds which inhibit soluble β-amyloid peptide production
US5968942A (en) 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
CZ184194A3 (en) 1993-08-09 1995-03-15 Lilly Co Eli Aspartylprotease inhibitor and method of identifying thereof
US5519040A (en) 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5624937A (en) 1995-03-02 1997-04-29 Eli Lilly And Company Chemical compounds as inhibitors of amyloid beta protein production
ATE377006T1 (de) 1995-11-28 2007-11-15 Cephalon Inc Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
CZ16899A3 (cs) 1996-07-22 1999-08-11 Monsanto Company Thiolsulfonamidové inhibitory metaloproteázy
US5703129A (en) 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production
US5985930A (en) 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
HUP0001383A3 (en) 1996-11-22 2001-11-28 Lilly Co Eli N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use
DE19650196A1 (de) 1996-12-04 1998-06-10 Bayer Ag Thienylsulfonylamino(thio)carbonylverbindungen
JPH11343279A (ja) 1998-03-16 1999-12-14 Shionogi & Co Ltd スルホンアミド誘導体およびそれらを含有するＴＮＦ―α産生抑制剤
US5981168A (en) 1998-05-15 1999-11-09 The University Of British Columbia Method and composition for modulating amyloidosis
US7410995B1 (en) 1998-08-14 2008-08-12 Gpi Nil Holdings Inc. N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders
MXPA01008606A (es) 1999-02-26 2003-05-05 Merck & Co Inc Compuestos de sulfonamida novedosos y uso de los mismos.
US6495578B1 (en) 1999-04-19 2002-12-17 Shionogi & Co., Ltd. Sulfonamide derivatives having oxadiazole rings
EP1088815A1 (en) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonyl amino acid derivatives
EP1088821A1 (en) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
AU7997700A (en) 1999-10-08 2001-04-23 Du Pont Pharmaceuticals Company Amino lactam sulfonamides as inhibitors of abeta protein production
AU2001240861B2 (en) 2000-03-20 2006-03-30 Merck Frosst Canada Ltd Sulphonamido-substituted bridged bicycloalkyl derivatives
MXPA03005255A (es) * 2000-12-13 2004-10-14 Wyeth Corp Inhibidores de produccion de beta-amiloide de sulfonamida heterociclica.
US6657070B2 (en) 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
KR100921641B1 (ko) 2001-12-11 2009-10-14 와이어쓰 순수한 키랄성 β-아미노 알콜의 합성방법
EP1461332A4 (en) 2001-12-11 2009-10-21 Wyeth Corp PRODUCTION OF ALPHA-AMINO ACIDS AND CHIRALLY PURE ALPHA-AMINO N-SULFONYL ACIDS
BR0311767A (pt) * 2002-06-11 2005-03-08 Wyeth Corp Compostos inibidores de sulfonamida substituìda da produção de beta amilóide, suas composições e usos
NZ542468A (en) * 2003-03-31 2009-01-31 Wyeth Corp Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
WO2005073198A1 (en) 2004-01-16 2005-08-11 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
EP1984347A1 (en) 2006-02-17 2008-10-29 Wyeth a Corporation of the State of Delaware Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
AR059518A1 (es) 2006-02-17 2008-04-09 Wyeth Corp Metodos para preparar alcoholes sustituidos con sulfonamidas y sus compuestos intermedios
US7550629B2 (en) 2006-04-21 2009-06-23 Wyeth Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
US7476762B2 (en) 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
JP2009534385A (ja) 2006-04-21 2009-09-24 ワイス キラル的に純粋なアミノアルコール中間体、それらの誘導体の製造、及びそれらの使用
PE20090445A1 (es) 2007-07-16 2009-05-18 Wyeth Corp Inhibidores de produccion de beta amiloide
PE20090824A1 (es) 2007-07-16 2009-07-24 Wyeth Corp Proceso para la preparacion de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterociclicas
PA8789801A1 (es) 2007-07-16 2009-02-09 Wyeth Corp Procesos e intermadiarios para la preparacion de compuestos de silfonamida heterocíclica

Also Published As

Publication number Publication date
SG167669A1 (en) 2011-01-28
NZ542468A (en) 2009-01-31
NO20054263D0 (no) 2005-09-15
RU2005133434A (ru) 2006-07-10
US7300951B2 (en) 2007-11-27
ECSP056128A (es) 2006-03-01
KR20060002908A (ko) 2006-01-09
US7858658B2 (en) 2010-12-28
NO20054263L (no) 2005-12-14
US20070254929A1 (en) 2007-11-01
BRPI0408962A (pt) 2006-04-04
CN101274926A (zh) 2008-10-01
JP2006522126A (ja) 2006-09-28
CN1780829A (zh) 2006-05-31
CO5640049A2 (es) 2006-05-31
TW200504047A (en) 2005-02-01
CL2004000647A1 (es) 2005-02-04
AR043940A1 (es) 2005-08-17
CN1780829B (zh) 2010-12-29
UA82093C2 (uk) 2008-03-11
ZA200507896B (en) 2007-03-28
US7547725B2 (en) 2009-06-16
TWI336698B (en) 2011-02-01
CA2517155A1 (en) 2004-10-28
AU2004230844A1 (en) 2004-10-28
AU2004230844B2 (en) 2010-12-09
EP1608638A1 (en) 2005-12-28
US20040198778A1 (en) 2004-10-07
CR7951A (es) 2008-10-29
WO2004092155A1 (en) 2004-10-28
RU2342374C2 (ru) 2008-12-27
US20090227667A1 (en) 2009-09-10

Similar Documents

Publication Publication Date Title
MXPA05010368A (es) Sulfonamidas heterociclicas que contienen fluor- y trifluoroalquilo como inhibidores de la produccion beta amiloide y derivados de las mismas.
SG128491A1 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
HUP0204245A2 (hu) Új N-aza-biciklo-amid-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
NZ505220A (en) Arylpiperazines having activity at the serotonin 1A receptor, processes for their preparation and intermediates
SE0104334D0 (sv) Therapeutic agents
HUP0103224A2 (hu) Kinolinszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények
HUP0102084A2 (hu) Kinolinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
NO20064366L (no) Tiazolderivat
NZ528851A (en) N-aroyl cyclic amines
TW200508180A (en) Therapeutic agents
GEP20084357B (en) Pyrimidine derivatives for the treatment of abnormal cell growth
MXPA04009784A (es) Tiazolidin-4-carbonitrilos y analogos y su uso como inhibidores de dipeptidil-peptidas.
NZ528997A (en) Sulfonamides
MXPA05005790A (es) Aminoalcoxiindoles como ligandos del receptor 5-ht6 para el tratamiento de enfermedades del sistema nervioso central.
AR017072A1 (es) Compuestos derivados de pirrolopirrolona como inhibidores de elastasa neutrofilica, uso de dichos compuestos, metodos de tratamiento, procesos depreparacion e intermediarios utiles para su produccion
DE502004002171D1 (de) Verwendung von 2-amino-2h-chinazolin-derivaten zur herstellung von therapeutischen mitteln
PT982305E (pt) Novos derivados do indano-1-ol proceso para a sua preparacao e as composicoes farmaceuticas que os contem
HUP0302820A2 (hu) CNS rendellenességek kezelésében hasznos indolszármazékok és ezeket tartalmazó gyógyszerkészítmények
MXPA06000892A (es) Compuestos azapoliciclicos arilo fusionados.
ATE412416T1 (de) Indolin-2-one-pyridin-derivate, herstellung und therapeutische verwendung dafür
HUP0400744A2 (hu) Piridoindolon származékok felhasználása rákellenes gyógyszerek előállítására
TR200100475T2 (tr) N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları.
ATE356805T1 (de) Oxophenylcyclohexylpropanolaminderivate, deren herstellung und verwendung in therapeutika
HUP0204169A2 (hu) Szubsztituált 1,2,3,4,5,6-hexahidro-2,6-metano-3-benzazocinok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0303253A2 (hu) Aril-karbamát-származékok, eljárás előállításukra és alkalmazásuk

Legal Events

Date Code Title Description
FG Grant or registration