MXPA03007722A - Compuestos de carbamato para usar en la prevencion o tratamiento de trastornos sicoticos. - Google Patents
Compuestos de carbamato para usar en la prevencion o tratamiento de trastornos sicoticos.Info
- Publication number
- MXPA03007722A MXPA03007722A MXPA03007722A MXPA03007722A MXPA03007722A MX PA03007722 A MXPA03007722 A MX PA03007722A MX PA03007722 A MXPA03007722 A MX PA03007722A MX PA03007722 A MXPA03007722 A MX PA03007722A MX PA03007722 A MXPA03007722 A MX PA03007722A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- group
- compounds
- phenyl
- enantiomer
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title claims abstract description 42
- 150000004657 carbamic acid derivatives Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 83
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 31
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 20
- 239000001257 hydrogen Substances 0.000 claims abstract description 20
- 125000001424 substituent group Chemical group 0.000 claims abstract description 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 13
- 239000000460 chlorine Substances 0.000 claims abstract description 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 9
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract description 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 8
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract description 8
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 8
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 8
- 239000011737 fluorine Substances 0.000 claims abstract description 8
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 8
- 125000005843 halogen group Chemical group 0.000 claims abstract description 8
- 150000002367 halogens Chemical group 0.000 claims abstract description 8
- 201000000980 schizophrenia Diseases 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 19
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 8
- -1 Ci-C 4 alkoxy Chemical group 0.000 claims description 7
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 7
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 6
- 208000002851 paranoid schizophrenia Diseases 0.000 claims description 6
- 208000021465 Brief psychotic disease Diseases 0.000 claims description 3
- 208000009810 Catatonic Schizophrenia Diseases 0.000 claims description 3
- 208000024254 Delusional disease Diseases 0.000 claims description 3
- 208000001495 Disorganized Schizophrenia Diseases 0.000 claims description 3
- 208000036755 Schizophrenia simple Diseases 0.000 claims description 3
- 208000036754 Schizophrenia, catatonic type Diseases 0.000 claims description 3
- 208000036753 Schizophrenia, disorganised type Diseases 0.000 claims description 3
- 208000036752 Schizophrenia, paranoid type Diseases 0.000 claims description 3
- 208000036750 Schizophrenia, residual type Diseases 0.000 claims description 3
- 208000020186 Schizophreniform disease Diseases 0.000 claims description 3
- 208000019568 Shared Paranoid disease Diseases 0.000 claims description 3
- 208000028810 Shared psychotic disease Diseases 0.000 claims description 3
- 208000022610 schizoaffective disease Diseases 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 206010061921 Psychotic disorder due to a general medical condition Diseases 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 28
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract description 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 description 15
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 11
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000003937 drug carrier Substances 0.000 description 7
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 7
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- BGMZUEKZENQUJY-UHFFFAOYSA-N 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine Chemical compound COC1=CC(CC(C)N)=C(OC)C=C1I BGMZUEKZENQUJY-UHFFFAOYSA-N 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
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- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 2
- 206010012218 Delirium Diseases 0.000 description 2
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- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
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- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 2
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- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 description 2
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- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 2
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- QVFDMWGKHUFODK-UHFFFAOYSA-N 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine;hydrochloride Chemical compound Cl.COC1=CC(CC(C)N)=C(OC)C=C1I QVFDMWGKHUFODK-UHFFFAOYSA-N 0.000 description 1
- 102000049773 5-HT2A Serotonin Receptor Human genes 0.000 description 1
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- 206010002942 Apathy Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
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- 241000282412 Homo Species 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
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- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 description 1
- 229960000652 sertindole Drugs 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27188901P | 2001-02-27 | 2001-02-27 | |
| PCT/US2002/006119 WO2002067927A1 (en) | 2001-02-27 | 2002-02-21 | Carbamate compounds for use in preventing or treating psychotic disorders |
| US10/081,761 US6541513B2 (en) | 2001-02-27 | 2002-02-21 | Carbamate compounds for use in preventing or treating psychotic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03007722A true MXPA03007722A (es) | 2004-11-12 |
Family
ID=26765939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03007722A MXPA03007722A (es) | 2001-02-27 | 2002-02-21 | Compuestos de carbamato para usar en la prevencion o tratamiento de trastornos sicoticos. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6541513B2 (enExample) |
| EP (1) | EP1401424B1 (enExample) |
| JP (1) | JP4276841B2 (enExample) |
| KR (1) | KR100886578B1 (enExample) |
| CN (1) | CN1262271C (enExample) |
| AR (1) | AR032876A1 (enExample) |
| AT (1) | ATE346597T1 (enExample) |
| AU (1) | AU2002242296B2 (enExample) |
| BR (1) | BR0207829A (enExample) |
| CA (1) | CA2439480C (enExample) |
| CZ (1) | CZ302412B6 (enExample) |
| DE (1) | DE60216457T2 (enExample) |
| DK (1) | DK1401424T3 (enExample) |
| ES (1) | ES2275844T3 (enExample) |
| HU (1) | HUP0303342A3 (enExample) |
| IL (2) | IL157588A0 (enExample) |
| MX (1) | MXPA03007722A (enExample) |
| NO (1) | NO20033801L (enExample) |
| NZ (1) | NZ527991A (enExample) |
| PL (1) | PL365021A1 (enExample) |
| PT (1) | PT1401424E (enExample) |
| RS (1) | RS51056B (enExample) |
| RU (1) | RU2302240C2 (enExample) |
| TW (1) | TWI251486B (enExample) |
| WO (1) | WO2002067927A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ523851A (en) * | 2000-07-21 | 2004-09-24 | Ortho Mcneil Pharm Inc | A method for use of carbamate enantiomers in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
| WO2002067925A1 (en) * | 2001-02-27 | 2002-09-06 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating neurodegenerative disorders |
| CA2439286A1 (en) * | 2001-02-27 | 2002-09-06 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating anxiety disorders |
| DE60232796D1 (de) | 2001-07-16 | 2009-08-13 | Ortho Mcneil Pharm Inc | Carbamate verbindungen zur vorbeugung oder behandlung von neuropathischen schmerzen |
| WO2005107719A2 (en) * | 2004-05-06 | 2005-11-17 | Sandoz Ag | Pharmaceutical composition comprising hydrophobic drug having improved solubility |
| EP1928451B1 (en) * | 2005-07-26 | 2011-12-28 | SK Biopharmaceuticals Co., LTD | Methods for treating substance-related disorders |
| EP2081648A2 (en) * | 2006-10-30 | 2009-07-29 | Janssen Pharmaceutica, N.V. | Carbamate compounds for use in treating depression |
| WO2008054984A1 (en) * | 2006-10-31 | 2008-05-08 | Janssen Pharmaceutica, N.V. | Treatment of pervasive developmental disorders |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| US9907776B2 (en) | 2013-03-12 | 2018-03-06 | Bio-Pharm Solutions, Co., Ltd. | Phenyl carbamate compound and a composition for preventing or treating a psychiatric disorder comprising the same |
| EP2968210B1 (en) | 2013-03-12 | 2024-09-11 | Bio-Pharm Solutions Co., Ltd. | Phenyl carbamate compounds for use in preventing or treating pediatric epilesy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US278380A (en) * | 1883-05-29 | Thermometer | ||
| US3313692A (en) * | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
| US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
| JP2955358B2 (ja) * | 1989-06-09 | 1999-10-04 | ファルマシア・アンド・アップジョン・カンパニー | 中枢神経系活性を有する複素環系アミン |
| US5492930A (en) | 1994-04-25 | 1996-02-20 | Schering Corporation | Method and formulation for treating CNS disorders |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
-
2002
- 2002-02-21 DE DE60216457T patent/DE60216457T2/de not_active Expired - Lifetime
- 2002-02-21 WO PCT/US2002/006119 patent/WO2002067927A1/en not_active Ceased
- 2002-02-21 CA CA2439480A patent/CA2439480C/en not_active Expired - Fee Related
- 2002-02-21 IL IL15758802A patent/IL157588A0/xx unknown
- 2002-02-21 RU RU2003128983/14A patent/RU2302240C2/ru active
- 2002-02-21 EP EP02707927A patent/EP1401424B1/en not_active Expired - Lifetime
- 2002-02-21 CZ CZ20032297A patent/CZ302412B6/cs not_active IP Right Cessation
- 2002-02-21 PL PL02365021A patent/PL365021A1/xx unknown
- 2002-02-21 BR BR0207829-5A patent/BR0207829A/pt not_active Application Discontinuation
- 2002-02-21 NZ NZ527991A patent/NZ527991A/en unknown
- 2002-02-21 MX MXPA03007722A patent/MXPA03007722A/es active IP Right Grant
- 2002-02-21 JP JP2002567294A patent/JP4276841B2/ja not_active Expired - Lifetime
- 2002-02-21 HU HU0303342A patent/HUP0303342A3/hu unknown
- 2002-02-21 ES ES02707927T patent/ES2275844T3/es not_active Expired - Lifetime
- 2002-02-21 CN CNB028089235A patent/CN1262271C/zh not_active Expired - Fee Related
- 2002-02-21 AU AU2002242296A patent/AU2002242296B2/en not_active Ceased
- 2002-02-21 US US10/081,761 patent/US6541513B2/en not_active Expired - Lifetime
- 2002-02-21 KR KR1020037011292A patent/KR100886578B1/ko not_active Expired - Lifetime
- 2002-02-21 DK DK02707927T patent/DK1401424T3/da active
- 2002-02-21 PT PT02707927T patent/PT1401424E/pt unknown
- 2002-02-21 RS YUP-675/03A patent/RS51056B/sr unknown
- 2002-02-21 AT AT02707927T patent/ATE346597T1/de active
- 2002-02-27 AR ARP020100702A patent/AR032876A1/es unknown
- 2002-03-05 TW TW091103972A patent/TWI251486B/zh not_active IP Right Cessation
-
2003
- 2003-08-26 IL IL157588A patent/IL157588A/en not_active IP Right Cessation
- 2003-08-26 NO NO20033801A patent/NO20033801L/no not_active Application Discontinuation
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