MX9305930A - Derivados de piperidina, su preparacion y su aplicacion en terapeutica. - Google Patents
Derivados de piperidina, su preparacion y su aplicacion en terapeutica.Info
- Publication number
- MX9305930A MX9305930A MX9305930A MX9305930A MX9305930A MX 9305930 A MX9305930 A MX 9305930A MX 9305930 A MX9305930 A MX 9305930A MX 9305930 A MX9305930 A MX 9305930A MX 9305930 A MX9305930 A MX 9305930A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- hydrogen atom
- therapeutics
- straight
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compuestos de fórmula general (I)(ver fórmula I) en la cual representa, ya sea un átomo de hidrógeno, ya sea un grupo (C1-C6)-alquilo, recto o ramificado, R2 representa ya sea un átomo de hidrógeno, ya sea un grupo (C1-C8)-alquilo, recto o ramificado, Z y Z1 representan, cada uno independientemente uno del otro, ya sea un átomo de hidrógeno, ya sea un átomo de cloro, ya sea un grupo hidroxi, ya sea un grupo amino, ya sea un grupo nitro, ya sea un grupo hidroximetilo, ya sea un grupo (C1-C2)-alquilo, ya sea un grupo (C1-C8)-alcoxicalbonilo, recto o ramificado, ya sea un grupo aril-(C1-C2)-alcoxi, Z está en posición 4,6 ó 7 y Z y Z1 no pueden representar simultáneamente, un átomo de hidrógeno, así como sus sales de adición a los ácidos farmacéuticamente aceptables. Se aplica en terapéutica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9211550A FR2696176B1 (fr) | 1992-09-28 | 1992-09-28 | Dérivés de pipéridine, leur préparation et leur application en thérapeutique. |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9305930A true MX9305930A (es) | 1994-06-30 |
Family
ID=9433966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9305930A MX9305930A (es) | 1992-09-28 | 1993-09-27 | Derivados de piperidina, su preparacion y su aplicacion en terapeutica. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5418241A (es) |
EP (1) | EP0591026A1 (es) |
JP (1) | JPH06192254A (es) |
KR (1) | KR940007022A (es) |
CN (1) | CN1087340A (es) |
AU (1) | AU659033B2 (es) |
CA (1) | CA2107060A1 (es) |
CZ (1) | CZ201493A3 (es) |
FI (1) | FI934220A (es) |
FR (1) | FR2696176B1 (es) |
HU (2) | HUT65396A (es) |
IL (1) | IL107132A0 (es) |
MX (1) | MX9305930A (es) |
NO (1) | NO933434L (es) |
NZ (1) | NZ248775A (es) |
PL (1) | PL172852B1 (es) |
SK (1) | SK103293A3 (es) |
ZA (1) | ZA937155B (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2731707B1 (fr) * | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
FR2731708B1 (fr) * | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de piperidine, leur procede de preparation et leur application en therapeutique |
GB9815696D0 (en) * | 1998-07-20 | 1998-09-16 | Pfizer Ltd | Heterocyclics |
GB9818730D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
AU5259100A (en) * | 1999-04-28 | 2000-11-10 | Respiratorius Ab | Medicament |
JP2003501462A (ja) * | 1999-06-15 | 2003-01-14 | レスピラトリウス アクチボラゲット | 受容体アゴニストおよびアンタゴニスト |
GB9918425D0 (en) * | 1999-08-04 | 1999-10-06 | Novartis Ag | Organic compounds |
DE60025261T2 (de) * | 1999-11-23 | 2006-08-24 | Janssen Pharmaceutica N.V. | Verwendung von 5ht3 antagonisten zur fundusentspannung |
GB0321295D0 (en) * | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
ES2398975T3 (es) * | 2004-03-01 | 2013-03-25 | Spirogen Sàrl | Derivados de 11-hidroxi-5H-pirrolo[2,1-c][1,4]benzodiazepin-5-ona como intermedios clave para la preparación de pirrolobenzodiazepinas sustituidas en C2 |
GB0404577D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
JP5166861B2 (ja) * | 2004-03-09 | 2013-03-21 | スピロゲン リミティッド | ピロロベンゾジアゼピン |
EP1879901B1 (en) * | 2005-04-21 | 2009-12-23 | Spirogen Limited | Pyrrolobenzodiazepines |
GB0813432D0 (en) * | 2008-07-22 | 2008-08-27 | Spirogen Ltd | Pyrrolobenzodiazepines |
GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
AU2011239525B2 (en) | 2010-04-15 | 2015-04-09 | Medimmune Limited | Pyrrolobenzodiazepines used to treat proliferative diseases |
GB201006340D0 (en) | 2010-04-15 | 2010-06-02 | Spirogen Ltd | Synthesis method and intermediates |
EA024118B1 (ru) | 2010-04-15 | 2016-08-31 | Сиэтл Дженетикс, Инк. | Конъюгаты пирролбензодиазепина направленного действия |
AU2012311505B2 (en) | 2011-09-20 | 2016-09-29 | Medimmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates |
AU2012322933B2 (en) | 2011-10-14 | 2017-02-02 | Medimmune Limited | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines |
EP3309162A1 (en) | 2011-10-14 | 2018-04-18 | Seattle Genetics, Inc. | Targeted conjugates of pyrrolobenzodiazepines |
EA027386B1 (ru) | 2011-10-14 | 2017-07-31 | Медимьюн Лимитед | Пирролобензодиазепины |
CA2850373C (en) | 2011-10-14 | 2019-07-16 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
EP2751111B1 (en) | 2011-10-14 | 2017-04-26 | MedImmune Limited | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases |
HUE035694T2 (en) | 2012-10-12 | 2018-05-28 | Adc Therapeutics Sa | Pirrolobenzodiazepine anti-CD22 antibody conjugates |
SI2906296T1 (en) | 2012-10-12 | 2018-06-29 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
CA2885305C (en) | 2012-10-12 | 2019-11-12 | Spirogen Sarl | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
ES2703151T3 (es) | 2012-10-12 | 2019-03-07 | Adc Therapeutics Sa | Conjugados de anticuerpos de pirrolobenzodiazepinas |
PT2839860T (pt) | 2012-10-12 | 2019-07-29 | Medimmune Ltd | Pirrolobenzodiazepinas e conjugados das mesmas |
EP2906250B1 (en) | 2012-10-12 | 2018-05-30 | ADC Therapeutics SA | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
NZ707486A (en) | 2012-10-12 | 2018-09-28 | Adc Therapeutics Sa | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
ES2660029T3 (es) | 2012-10-12 | 2018-03-20 | Medimmune Limited | Conjugados de anticuerpo-pirrolobenzodiazepinas |
TR201902494T4 (tr) | 2012-10-12 | 2019-03-21 | Medimmune Ltd | Pirrolobenzodiazepinler ve onların konjugatları. |
WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
EP3054983B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
AU2015352545B2 (en) | 2014-11-25 | 2020-10-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
RS61795B1 (sr) | 2017-02-08 | 2021-06-30 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin antitela |
WO2018192944A1 (en) | 2017-04-18 | 2018-10-25 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
EP3612234B1 (en) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Combination therapy with an anti-axl antibody-drug conjugate |
MX2019015042A (es) | 2017-06-14 | 2020-08-06 | Adc Therapeutics Sa | Regimen de dosificacion. |
AU2018316532B2 (en) | 2017-08-18 | 2022-11-24 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
US5008390A (en) * | 1985-05-23 | 1991-04-16 | Smithkline Beckman Corporation | Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines |
FR2618435B1 (fr) * | 1987-07-23 | 1989-10-27 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
IT1230703B (it) * | 1989-01-26 | 1991-10-29 | Luso Farmaco Inst | Derivati imidazolonici ad attivita' antiipertensiva, loro metodi di preparazione e composizioni farmaceutiche che li contengono. |
FR2658823B1 (fr) * | 1990-02-27 | 1992-04-30 | Adir | Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent . |
FR2671083B1 (fr) * | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
FR2674855B1 (fr) * | 1991-04-03 | 1994-01-14 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique. |
-
1992
- 1992-09-28 FR FR9211550A patent/FR2696176B1/fr not_active Expired - Fee Related
-
1993
- 1993-09-20 EP EP93402280A patent/EP0591026A1/fr not_active Withdrawn
- 1993-09-27 JP JP5239568A patent/JPH06192254A/ja active Pending
- 1993-09-27 PL PL93300514A patent/PL172852B1/pl unknown
- 1993-09-27 NZ NZ248775A patent/NZ248775A/en unknown
- 1993-09-27 US US08/127,058 patent/US5418241A/en not_active Expired - Fee Related
- 1993-09-27 CZ CZ932014A patent/CZ201493A3/cs unknown
- 1993-09-27 CN CN93118081A patent/CN1087340A/zh active Pending
- 1993-09-27 AU AU48605/93A patent/AU659033B2/en not_active Ceased
- 1993-09-27 KR KR1019930019849A patent/KR940007022A/ko not_active Application Discontinuation
- 1993-09-27 IL IL107132A patent/IL107132A0/xx unknown
- 1993-09-27 HU HU9302726A patent/HUT65396A/hu unknown
- 1993-09-27 MX MX9305930A patent/MX9305930A/es unknown
- 1993-09-27 CA CA002107060A patent/CA2107060A1/en not_active Abandoned
- 1993-09-27 SK SK1032-93A patent/SK103293A3/sk unknown
- 1993-09-27 NO NO933434A patent/NO933434L/no unknown
- 1993-09-27 FI FI934220A patent/FI934220A/fi unknown
- 1993-09-27 ZA ZA937155A patent/ZA937155B/xx unknown
-
1995
- 1995-06-26 HU HU95P/P00434P patent/HU211490A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
CZ201493A3 (en) | 1994-04-13 |
HUT65396A (en) | 1994-06-28 |
HU211490A9 (en) | 1995-11-28 |
US5418241A (en) | 1995-05-23 |
NO933434L (no) | 1994-03-29 |
HU9302726D0 (en) | 1993-12-28 |
FR2696176A1 (fr) | 1994-04-01 |
CN1087340A (zh) | 1994-06-01 |
KR940007022A (ko) | 1994-04-26 |
IL107132A0 (en) | 1993-12-28 |
PL300514A1 (en) | 1994-04-05 |
JPH06192254A (ja) | 1994-07-12 |
AU659033B2 (en) | 1995-05-04 |
NZ248775A (en) | 1995-02-24 |
AU4860593A (en) | 1994-04-14 |
FR2696176B1 (fr) | 1994-11-10 |
ZA937155B (en) | 1994-05-23 |
CA2107060A1 (en) | 1994-03-29 |
EP0591026A1 (fr) | 1994-04-06 |
FI934220A0 (fi) | 1993-09-27 |
FI934220A (fi) | 1994-03-29 |
SK103293A3 (en) | 1994-08-10 |
NO933434D0 (no) | 1993-09-27 |
PL172852B1 (pl) | 1997-12-31 |
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