IL107132A0 - Piperidine derivatives,their preparation and their application in therapeutics - Google Patents

Piperidine derivatives,their preparation and their application in therapeutics

Info

Publication number
IL107132A0
IL107132A0 IL107132A IL10713293A IL107132A0 IL 107132 A0 IL107132 A0 IL 107132A0 IL 107132 A IL107132 A IL 107132A IL 10713293 A IL10713293 A IL 10713293A IL 107132 A0 IL107132 A0 IL 107132A0
Authority
IL
Israel
Prior art keywords
therapeutics
preparation
application
piperidine derivatives
piperidine
Prior art date
Application number
IL107132A
Other languages
English (en)
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of IL107132A0 publication Critical patent/IL107132A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
IL107132A 1992-09-28 1993-09-27 Piperidine derivatives,their preparation and their application in therapeutics IL107132A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211550A FR2696176B1 (fr) 1992-09-28 1992-09-28 Dérivés de pipéridine, leur préparation et leur application en thérapeutique.

Publications (1)

Publication Number Publication Date
IL107132A0 true IL107132A0 (en) 1993-12-28

Family

ID=9433966

Family Applications (1)

Application Number Title Priority Date Filing Date
IL107132A IL107132A0 (en) 1992-09-28 1993-09-27 Piperidine derivatives,their preparation and their application in therapeutics

Country Status (18)

Country Link
US (1) US5418241A (xx)
EP (1) EP0591026A1 (xx)
JP (1) JPH06192254A (xx)
KR (1) KR940007022A (xx)
CN (1) CN1087340A (xx)
AU (1) AU659033B2 (xx)
CA (1) CA2107060A1 (xx)
CZ (1) CZ201493A3 (xx)
FI (1) FI934220A (xx)
FR (1) FR2696176B1 (xx)
HU (2) HUT65396A (xx)
IL (1) IL107132A0 (xx)
MX (1) MX9305930A (xx)
NO (1) NO933434L (xx)
NZ (1) NZ248775A (xx)
PL (1) PL172852B1 (xx)
SK (1) SK103293A3 (xx)
ZA (1) ZA937155B (xx)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2731708B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
FR2731707B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics
GB9818730D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
AU5259100A (en) * 1999-04-28 2000-11-10 Respiratorius Ab Medicament
JP2003501462A (ja) * 1999-06-15 2003-01-14 レスピラトリウス アクチボラゲット 受容体アゴニストおよびアンタゴニスト
GB9918425D0 (en) * 1999-08-04 1999-10-06 Novartis Ag Organic compounds
DE60025261T2 (de) * 1999-11-23 2006-08-24 Janssen Pharmaceutica N.V. Verwendung von 5ht3 antagonisten zur fundusentspannung
GB0321295D0 (en) * 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
EP2270010B1 (en) * 2004-03-01 2012-01-25 Spirogen Limited 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepins
EP1723152B1 (en) * 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazepines
DE602006011300D1 (de) * 2005-04-21 2010-02-04 Spirogen Ltd Pyrrolobenzodiazepine
GB0813432D0 (en) * 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
AU2011239525B2 (en) 2010-04-15 2015-04-09 Medimmune Limited Pyrrolobenzodiazepines used to treat proliferative diseases
AU2011239522B2 (en) 2010-04-15 2014-10-23 Medimmune Limited Targeted pyrrolobenzodiazapine conjugates
AU2012311505B2 (en) 2011-09-20 2016-09-29 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
EA036202B1 (ru) 2011-10-14 2020-10-14 Сиэтл Дженетикс, Инк. Пирролбензодиазепины и конъюгаты направленного действия
JP6117801B2 (ja) 2011-10-14 2017-04-19 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン
US9526798B2 (en) 2011-10-14 2016-12-27 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
KR101891859B1 (ko) 2011-10-14 2018-08-24 메디뮨 리미티드 피롤로벤조디아제핀
AU2012322933B2 (en) 2011-10-14 2017-02-02 Medimmune Limited Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
AU2013328625B2 (en) 2012-10-12 2016-12-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
EP2906248B1 (en) 2012-10-12 2018-12-05 MedImmune Limited Pyrrolobenzodiazepines and conjugates thereof
BR112015008238A2 (pt) 2012-10-12 2017-11-28 Adc Therapeutics Sarl conjugados de pirrolbenzodiazepina-anticorpo anti-cd22
ES2680153T3 (es) 2012-10-12 2018-09-04 Adc Therapeutics Sa Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
HUE042731T2 (hu) 2012-10-12 2019-07-29 Adc Therapeutics Sa Pirrolobenzodiazepin-antitest konjugátumok
HUE045435T2 (hu) 2012-10-12 2019-12-30 Medimmune Ltd Pirrolobenzodiazepinek és konjugátumaik
AU2013328673B2 (en) 2012-10-12 2017-07-13 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
SI2906253T1 (sl) 2012-10-12 2018-11-30 Adc Therapeutics Sa Konjugati pirolobenzodiazepin-protitelo proti PSMA
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054983B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107148285B (zh) 2014-11-25 2022-01-04 Adc治疗股份有限公司 吡咯并苯并二氮杂䓬-抗体缀合物
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
JP6671555B2 (ja) 2017-02-08 2020-03-25 アーデーセー セラピューティクス ソシエテ アノニム ピロロベンゾジアゼピン抗体複合体
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
AU2018255876B2 (en) 2017-04-18 2020-04-30 Medimmune Limited Pyrrolobenzodiazepine conjugates
AU2018253948A1 (en) 2017-04-20 2019-09-19 Adc Therapeutics Sa Combination therapy with an anti-AXL Antibody-Drug Conjugate
MX2019015042A (es) 2017-06-14 2020-08-06 Adc Therapeutics Sa Regimen de dosificacion.
KR102270107B1 (ko) 2017-08-18 2021-06-30 메디뮨 리미티드 피롤로벤조디아제핀 컨쥬게이트
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
US5008390A (en) * 1985-05-23 1991-04-16 Smithkline Beckman Corporation Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
IT1230703B (it) * 1989-01-26 1991-10-29 Luso Farmaco Inst Derivati imidazolonici ad attivita' antiipertensiva, loro metodi di preparazione e composizioni farmaceutiche che li contengono.
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
FR2671083B1 (fr) * 1990-12-31 1994-12-23 Inst Nat Sante Rech Med Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques.
FR2674855B1 (fr) * 1991-04-03 1994-01-14 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
JPH06192254A (ja) 1994-07-12
EP0591026A1 (fr) 1994-04-06
PL172852B1 (pl) 1997-12-31
AU659033B2 (en) 1995-05-04
ZA937155B (en) 1994-05-23
CZ201493A3 (en) 1994-04-13
FI934220A (fi) 1994-03-29
HU211490A9 (en) 1995-11-28
CN1087340A (zh) 1994-06-01
SK103293A3 (en) 1994-08-10
PL300514A1 (en) 1994-04-05
NO933434D0 (no) 1993-09-27
NO933434L (no) 1994-03-29
FR2696176A1 (fr) 1994-04-01
CA2107060A1 (en) 1994-03-29
HU9302726D0 (en) 1993-12-28
FI934220A0 (fi) 1993-09-27
AU4860593A (en) 1994-04-14
KR940007022A (ko) 1994-04-26
HUT65396A (en) 1994-06-28
NZ248775A (en) 1995-02-24
FR2696176B1 (fr) 1994-11-10
US5418241A (en) 1995-05-23
MX9305930A (es) 1994-06-30

Similar Documents

Publication Publication Date Title
IL107132A0 (en) Piperidine derivatives,their preparation and their application in therapeutics
IL111148A0 (en) Imidazol-4- ylpiperidine derivatives, their preparation and their application in therapeutics
ZA923516B (en) New thiopyranopyrrole derivatives and their preparation
EP0412798A3 (en) Substituted pyridines, their preparation, formulations and use in dementia
ZA961994B (en) Piperidine derivatives process for the preparation thereof and application thereof in therapeutics
IL99612A0 (en) 2-aminopyrimidine-4-carboxamide derivatives,their preparation and their use in therapy
CY2291B1 (en) 1H-pyridoa3,4-buindole-4-carboxamide derivatives preparation and application thereof in therapeutics
ZA988921B (en) 3,4-diarylthiazolin-2-one or -2-thione derivatives their methods of preparation and their uses in therapeutics
ZA978089B (en) 3,4-diaryloxazolone derivatives, their methods of preparation, and their use in therapeutics.
AU2557892A (en) New beta -carbolin derivatives, their preparation and their use in drugs
IL107133A0 (en) Piperidine derivatives,their preparation and their application in therapy
ZA943649B (en) Piperidine derivatives their preparation and use
ZA898480B (en) Phenyloxypropanolamine derivatives,their preparation and their application in therapeutics
IL101617A0 (en) 2-aminopyrimidine-4-carboxamide derivatives,their preparation and their application in therapy
AU1807492A (en) New hetaryloxy-beta-carbolines, their production and use in pharmaceutical agents
AU6923994A (en) Piperidine derivatives, their preparation and use
AU1858692A (en) 2-piperidinylpyrimidine-4-carboxamide derivatives, their preparation and their use in therapeutics
AU6003394A (en) Novel heterocyclic aminomethyl-4 piperidine derivatives, their preparation and application in therapy
ZA892841B (en) Benzothiazepin-4-one derivative,their preparation and their application in therapy
ZA941532B (en) Novel 2-}henoxyethylamine derivatives their preparation and their application in therapeutics
ZA985727B (en) (1H-imidazol-4-YL) piperidine derivatives their preparation and their application in therapeutics
ZA967558B (en) Alpha-phenylpiperidine-1-propanol derivatives their preparation and their application in therapeutics
GB9112545D0 (en) Improvements in and relating to hinges
ZA924783B (en) 2-piperidinylpyrimidine-4-carboxamide derivatives,their preparation and their use in therapeutics
IL109439A0 (en) 2-Amino-4-heteroaryl-1, 4-dihydropyridines, processes for their preparation and their use in pharmaceutical compositions