AR021970A1 - Inhibidores de proteasas - Google Patents

Inhibidores de proteasas

Info

Publication number
AR021970A1
AR021970A1 ARP990106647A ARP990106647A AR021970A1 AR 021970 A1 AR021970 A1 AR 021970A1 AR P990106647 A ARP990106647 A AR P990106647A AR P990106647 A ARP990106647 A AR P990106647A AR 021970 A1 AR021970 A1 AR 021970A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
het
cycloalkyl
independently selected
Prior art date
Application number
ARP990106647A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR021970A1 publication Critical patent/AR021970A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

El presente proporciona compuestos de Formula (1) en la que: A se selecciona entre el grupo que consta de C(O) y CH(OH); R1 se selecciona entre el grupoque consta de las formulas (2), (3), (4) y (5); R2 se selecciona entre el grupo que consta de H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6,het-alquilo C0-6, R9C(O)-, R9C(S)-, R9SO2-, R9OC(O)-, R9R12NC(O)-, R9R12NC(S)-, R12HNCH(R12)C(O)-, R9OC(O)NR12CH(R12)C(O)-, adamantil-C(O)-, o un grupo deformula (6); R se selecciona entre el grupo que consta de H, alquilo C1-6, Ar-alquilo C0-6, y Het-alquilo C0-6; R se selecciona entre el grupo que constade H, alquilo 1-6, cicloalquil C3-6-alquilo C1-6, Ar-alquilo C0-6, y Het-alquilo C0-6; R3 y R8 se seleccionan independientemente entre el grupo que consta deH, alquenilo C2-6, alquinilo C2-6, Het, Ar o alquilo C1-6 opcionalmente sustituido con OR13, SR13, NR132, R13NC(O)OR5, CO2R13, CO2NR132, N(C=NH)NH2, Het y Ar;R4 se selecciona entre el grupo que consta de H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, Het-alquilo C0-6, R5C(O)-, R5C(S)-, R5SO2-,R5OC(O)-, R5R14NC(O)-, R5R14NC(S)-, R14HNCH(R14)C(O)- y R5OC(O)NR14CH(R14)C(O)-; R5, R9 y R10 se seleccionan independientemente entre el grupo que consta dealquiloC1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, y Het-alquilo C0-6; R6 se selecciona entre el grupo que consta de H, alquilo C1-6, Ar-alquiloC0-6 y Het-alquilo C0-6; R7 se selecciona entre el grupo que consta de H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, Het-alquilo C0-6,R10C(O)-, R10C(S)-, R10SO2-, R10OC(O)-, R10R15NC(O)-, R10R15NC(S)-, R15HNCH(R15)C(O)-, y R10OC(O)NR15CH(R15)C(O)-; o R6 y R7 se conectan para formar un anillode pirrolidina, piperidina o morfolina; cada R se selecciona independientemente entre el grupo que consta de H, alquilo C1-6, Ar-alquilo C0-6 y Het-alquiloC0-6; R11 es Ar; R12, R13, R14 y R15 se seleccionan independientemente entre el grupo que consta de H, alquilo C1-6, Ar-alquilo C0-6 y Het-alquilo C0-6; R* seselecciona entre el grupo que consta de H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6 y Het-alquilo C0-6; Z se selecciona entre el grupo que
ARP990106647A 1998-12-23 1999-12-21 Inhibidores de proteasas AR021970A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11414398P 1998-12-23 1998-12-23

Publications (1)

Publication Number Publication Date
AR021970A1 true AR021970A1 (es) 2002-09-04

Family

ID=22353596

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990106647A AR021970A1 (es) 1998-12-23 1999-12-21 Inhibidores de proteasas

Country Status (9)

Country Link
EP (1) EP1140897A4 (es)
JP (1) JP2002533452A (es)
AR (1) AR021970A1 (es)
AU (1) AU2713100A (es)
CO (1) CO5180541A1 (es)
DZ (1) DZ2976A1 (es)
HK (1) HK1041690A1 (es)
PE (1) PE20001355A1 (es)
WO (1) WO2000039115A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
WO2001034599A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
WO2001034600A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
US6534498B1 (en) 1999-11-10 2003-03-18 Smithkline Beecham Corporation Protease inhibitors
AU2001243441B2 (en) 2000-03-21 2004-11-25 Smithkline Beecham Corporation Protease inhibitors
US6982263B2 (en) 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
WO2003075853A2 (en) 2002-03-08 2003-09-18 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
JP2008512461A (ja) * 2004-09-07 2008-04-24 スミスクライン・ビーチャム・コーポレイション 新規化合物
WO2006076575A2 (en) * 2005-01-13 2006-07-20 Bristol-Myers Squibb Company Substituted biaryl compounds as factor xia inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ2285A1 (fr) * 1996-08-08 2002-12-25 Smithkline Beecham Corp Inhibiteurs de protéase de la cystéine.
BR9808502A (pt) * 1997-05-08 2000-05-23 Smithkline Beecham Corp Inibidores de protease

Also Published As

Publication number Publication date
WO2000039115A1 (en) 2000-07-06
JP2002533452A (ja) 2002-10-08
EP1140897A1 (en) 2001-10-10
DZ2976A1 (fr) 2004-03-15
PE20001355A1 (es) 2001-01-28
AU2713100A (en) 2000-07-31
CO5180541A1 (es) 2002-07-30
HK1041690A1 (zh) 2002-07-19
EP1140897A4 (en) 2002-04-03

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