MX382253B - Formulaciones de 2-(terc-butilamino)-4-((1r,3r,4r)-3-hdroxi-4-metilciclohexilamino)-pirimidina-5-carboxamida. - Google Patents

Formulaciones de 2-(terc-butilamino)-4-((1r,3r,4r)-3-hdroxi-4-metilciclohexilamino)-pirimidina-5-carboxamida.

Info

Publication number
MX382253B
MX382253B MX2017007883A MX2017007883A MX382253B MX 382253 B MX382253 B MX 382253B MX 2017007883 A MX2017007883 A MX 2017007883A MX 2017007883 A MX2017007883 A MX 2017007883A MX 382253 B MX382253 B MX 382253B
Authority
MX
Mexico
Prior art keywords
butylamino
carboxamide
pyrimidine
tert
hydroxy
Prior art date
Application number
MX2017007883A
Other languages
English (en)
Other versions
MX2017007883A (es
Inventor
Daozhong Zou
Indrajit Ghosh
Lianfeng Huang
Nathan Andrew Boersen
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of MX2017007883A publication Critical patent/MX2017007883A/es
Publication of MX382253B publication Critical patent/MX382253B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se brindan composiciones farmacéuticas y formas de dosificación de 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metilciclohexilamino)-pirimidina-5-carboxamida o un estereoisómero, tautómero, forma sólida, polimorfo, sal, hidrato, clatrato o solvato farmacéuticamente aceptable de esta. También se brindan métodos para tratar, gestionar o prevenir diversos trastornos, como enfermedades o trastornos que se puedan tratar o prevenir inhibiendo una vía de JNK en mamíferos con dichas composiciones farmacéuticas o formas de dosificación. También se brindan sales de 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metilciclohexilamino)-pirimidina-5-carboxamida y métodos de preparación de dichas sales.
MX2017007883A 2014-12-16 2015-12-15 Formulaciones de 2-(terc-butilamino)-4-((1r,3r,4r)-3-hdroxi-4-metilciclohexilamino)-pirimidina-5-carboxamida. MX382253B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462092537P 2014-12-16 2014-12-16
US201562196044P 2015-07-23 2015-07-23
PCT/US2015/065774 WO2016100310A1 (en) 2014-12-16 2015-12-15 Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide

Publications (2)

Publication Number Publication Date
MX2017007883A MX2017007883A (es) 2017-09-05
MX382253B true MX382253B (es) 2025-03-12

Family

ID=56110500

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017007883A MX382253B (es) 2014-12-16 2015-12-15 Formulaciones de 2-(terc-butilamino)-4-((1r,3r,4r)-3-hdroxi-4-metilciclohexilamino)-pirimidina-5-carboxamida.
MX2021005207A MX2021005207A (es) 2014-12-16 2017-06-15 Formulaciones de 2-(terc-butilamino)-4-((1r,3r,4r)-3-hidroxi-4-met ilciclohexilamino)-pirimidina-5-carboxamida.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021005207A MX2021005207A (es) 2014-12-16 2017-06-15 Formulaciones de 2-(terc-butilamino)-4-((1r,3r,4r)-3-hidroxi-4-met ilciclohexilamino)-pirimidina-5-carboxamida.

Country Status (19)

Country Link
US (3) US9796685B2 (es)
EP (2) EP3233809B1 (es)
JP (2) JP6762940B2 (es)
KR (1) KR102606253B1 (es)
CN (2) CN107108524A (es)
AU (2) AU2015362728B2 (es)
BR (1) BR112017012795A2 (es)
CA (2) CA3210612A1 (es)
CL (1) CL2017001545A1 (es)
CO (1) CO2017006087A2 (es)
EA (1) EA033530B1 (es)
EC (1) ECSP17038150A (es)
ES (2) ES2877642T3 (es)
IL (1) IL252900B (es)
MX (2) MX382253B (es)
NZ (1) NZ732793A (es)
SA (1) SA517381749B1 (es)
SG (2) SG11201704827UA (es)
WO (1) WO2016100310A1 (es)

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Also Published As

Publication number Publication date
EP3233809A4 (en) 2018-05-30
CL2017001545A1 (es) 2018-02-09
ES2877642T3 (es) 2021-11-17
AU2015362728A1 (en) 2017-07-13
AU2015362728B2 (en) 2020-06-25
US10590089B2 (en) 2020-03-17
ECSP17038150A (es) 2017-07-31
MX2021005207A (es) 2021-07-15
EP3712134B1 (en) 2023-11-29
US20180009765A1 (en) 2018-01-11
NZ732793A (en) 2023-07-28
KR102606253B1 (ko) 2023-11-27
CA2970926C (en) 2023-10-24
SG10202010389TA (en) 2020-11-27
EP3233809A1 (en) 2017-10-25
CO2017006087A2 (es) 2017-10-20
JP2020158510A (ja) 2020-10-01
EA201791327A1 (ru) 2018-03-30
KR20170097037A (ko) 2017-08-25
JP2017537954A (ja) 2017-12-21
AU2020203497A1 (en) 2020-06-18
WO2016100310A1 (en) 2016-06-23
CN112451502A (zh) 2021-03-09
NZ771013A (en) 2024-05-31
AU2020203497B2 (en) 2022-03-03
CN107108524A (zh) 2017-08-29
EP3712134A1 (en) 2020-09-23
JP7022172B2 (ja) 2022-02-17
IL252900B (en) 2021-10-31
CN112451502B (zh) 2023-10-27
CA3210612A1 (en) 2016-06-23
BR112017012795A2 (pt) 2018-01-02
US9796685B2 (en) 2017-10-24
JP6762940B2 (ja) 2020-09-30
IL252900A0 (en) 2017-08-31
SA517381749B1 (ar) 2021-12-04
US20190031619A1 (en) 2019-01-31
US10131639B2 (en) 2018-11-20
CA2970926A1 (en) 2016-06-23
SG11201704827UA (en) 2017-07-28
MX2017007883A (es) 2017-09-05
ES2972295T3 (es) 2024-06-12
EP3233809B1 (en) 2021-04-21
US20160168105A1 (en) 2016-06-16
EA033530B1 (ru) 2019-10-31

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