MX373425B - Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden. - Google Patents

Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden.

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Publication number
MX373425B
MX373425B MX2016016288A MX2016016288A MX373425B MX 373425 B MX373425 B MX 373425B MX 2016016288 A MX2016016288 A MX 2016016288A MX 2016016288 A MX2016016288 A MX 2016016288A MX 373425 B MX373425 B MX 373425B
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MX
Mexico
Prior art keywords
cell
molecules
shiga toxin
present
targeted
Prior art date
Application number
MX2016016288A
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English (en)
Other versions
MX2016016288A (es
Inventor
Eric Poma
Erin Willert
Jack Higgins
Jason Kim
Original Assignee
Molecular Templates Inc
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Publication date
Priority claimed from PCT/US2015/012970 external-priority patent/WO2015113007A1/en
Application filed by Molecular Templates Inc filed Critical Molecular Templates Inc
Publication of MX2016016288A publication Critical patent/MX2016016288A/es
Publication of MX373425B publication Critical patent/MX373425B/es

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Abstract

La presente invención se refiere a moléculas resistentes a la disociación por proteasa que comprenden los polipéptidos efectores de la toxina Shiga capaces de exhibir potentes funciones de la toxina Shiga (por ejemplo, el encaminamiento subcelular y la citotoxicidad). La presente invención también proporciona moléculas resistentes a la disociación por proteasa dirigidas a las células para dirigirse a tipos específicos de células, por ejemplo, las células infectadas o malignas. Ciertas moléculas de la presente invención son citotóxicas, y ciertas moléculas dirigidas a las células de la presente invención se puede utilizar para la aniquilación dirigida de tipos específicos de células, y para el tratamiento de una variedad de enfermedades, trastornos y afecciones, incluyendo cánceres, tumores, anormalidades del crecimiento, trastornos inmunológicos e infecciones microbianas.
MX2016016288A 2014-06-11 2015-06-10 Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden. MX373425B (es)

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US201462010918P 2014-06-11 2014-06-11
PCT/US2015/012970 WO2015113007A1 (en) 2014-01-27 2015-01-26 De-immunized shiga toxin a subunit effector polypeptides for applications in mammals
PCT/US2015/035179 WO2015191764A1 (en) 2014-06-11 2015-06-10 Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeted molecules comprising the same

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IL286804B (en) 2022-08-01
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AU2015274647B2 (en) 2019-08-22
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EP3137488B1 (en) 2019-01-02
JP2020180154A (ja) 2020-11-05
EP3950706A1 (en) 2022-02-09
AU2022201220A1 (en) 2022-03-17
JP2017524342A (ja) 2017-08-31
IL249006A0 (en) 2017-01-31
MX2016016288A (es) 2017-10-12
JP2022088518A (ja) 2022-06-14
KR20170010896A (ko) 2017-02-01
IL249006B (en) 2021-10-31
IL286804A (en) 2021-10-31
EP3137488A1 (en) 2017-03-08
ES2717751T3 (es) 2019-06-25
AU2015274647A1 (en) 2016-12-15
CA2947048A1 (en) 2015-12-17
EP3514168B1 (en) 2021-09-01
AU2019240612B2 (en) 2020-09-17
JP6735237B2 (ja) 2020-08-05
US20210017512A1 (en) 2021-01-21
US10815469B2 (en) 2020-10-27
AU2019240612A1 (en) 2019-10-17

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