MX364556B - Derivados de aminociclobutano, su metodo de preparacion y su uso como medicamentos. - Google Patents
Derivados de aminociclobutano, su metodo de preparacion y su uso como medicamentos.Info
- Publication number
- MX364556B MX364556B MX2015006686A MX2015006686A MX364556B MX 364556 B MX364556 B MX 364556B MX 2015006686 A MX2015006686 A MX 2015006686A MX 2015006686 A MX2015006686 A MX 2015006686A MX 364556 B MX364556 B MX 364556B
- Authority
- MX
- Mexico
- Prior art keywords
- atom
- preparing same
- drugs
- group
- hydrogen atom
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a derivados de aminociclobutano, particularmente como antagonistas de los receptores de NMDA, su aplicación en terapia para seres humanos y su método de preparación. Estos compuestos corresponden a la fórmula general (I): (ver Fórmula) donde: - X1 representa un átomo de hidrógeno o átomo de flúor; - X2 es un átomo de hidrógeno o átomo de flúor o átomo de cloro; - R1 representa un átomo de hidrógeno o átomo de flúor o átomo de cloro o un grupo metilo o grupo metoxi o grupo ciano; - R2 representa independientemente o en forma conjunta un grupo metilo o un grupo etilo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1261621A FR2998892B1 (fr) | 2012-12-04 | 2012-12-04 | Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments |
| PCT/EP2013/075481 WO2014086825A1 (fr) | 2012-12-04 | 2013-12-04 | Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015006686A MX2015006686A (es) | 2015-08-10 |
| MX364556B true MX364556B (es) | 2019-04-30 |
Family
ID=48128432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015006686A MX364556B (es) | 2012-12-04 | 2013-12-04 | Derivados de aminociclobutano, su metodo de preparacion y su uso como medicamentos. |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US9469601B2 (es) |
| EP (1) | EP2928861B1 (es) |
| JP (1) | JP6391586B2 (es) |
| KR (1) | KR102221928B1 (es) |
| CN (2) | CN106957285B (es) |
| AR (1) | AR093787A1 (es) |
| AU (1) | AU2013354133B2 (es) |
| BR (1) | BR112015012752B1 (es) |
| CA (1) | CA2893216C (es) |
| CY (1) | CY1118841T1 (es) |
| DK (1) | DK2928861T3 (es) |
| ES (1) | ES2621896T3 (es) |
| FR (1) | FR2998892B1 (es) |
| HK (1) | HK1212968A1 (es) |
| HR (1) | HRP20170564T1 (es) |
| IL (1) | IL239146A (es) |
| LT (1) | LT2928861T (es) |
| MA (1) | MA38229B1 (es) |
| MX (1) | MX364556B (es) |
| MY (1) | MY179886A (es) |
| NZ (1) | NZ709572A (es) |
| PL (1) | PL2928861T3 (es) |
| PT (1) | PT2928861T (es) |
| RS (1) | RS55916B1 (es) |
| RU (1) | RU2655919C2 (es) |
| SA (1) | SA515360518B1 (es) |
| SI (1) | SI2928861T1 (es) |
| TN (1) | TN2015000240A1 (es) |
| TW (1) | TWI603947B (es) |
| UA (1) | UA114017C2 (es) |
| WO (1) | WO2014086825A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3774800A1 (en) | 2018-03-28 | 2021-02-17 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| CN114269747B (zh) * | 2019-11-18 | 2023-04-18 | 苏州恩华生物医药科技有限公司 | 一种1’,2’-二氢-3’h-螺[环丁烷1,4’-异喹啉]-3’-酮衍生物及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133924A (en) * | 1960-05-31 | 1964-05-19 | Bristol Myers Co | Amino-substituted cyclobutane carboxamides |
| FR2581059B1 (fr) * | 1985-04-25 | 1988-04-22 | Pf Medicament | Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z) |
| EP0747348A4 (en) * | 1994-02-22 | 1999-07-07 | Asahi Chemical Ind | AMINOALKYLCYCLOPROPAN DERIVATIVES |
| US6197830B1 (en) | 1995-09-22 | 2001-03-06 | Bruce M. Frome | Method for achieving relief from sympathetically mediated pain |
| CA2264182A1 (en) | 1996-08-23 | 1998-02-26 | Algos Pharmaceutical Corporation | Anticonvulsant containing composition for treating neuropathic pain |
| US6593368B2 (en) | 1997-09-08 | 2003-07-15 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
| US6118017A (en) | 1998-04-14 | 2000-09-12 | Smithkline Beecham Corporation | Substituted-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylcyanocyclobutan-1-one |
| DE69933874T2 (de) | 1998-07-16 | 2007-10-04 | Memorial Sloan-Kettering Institute For Cancer Research | Topische zusammensetzung enthaltend ein opioid-analgetika und einen nmda-antagonist |
| US6362201B1 (en) | 1999-03-02 | 2002-03-26 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
| US7820688B2 (en) | 2001-04-27 | 2010-10-26 | Memorial Sloan-Kettering Cancer Center | Topical anesthetic/opioid formulations and uses thereof |
| JP2005518411A (ja) | 2002-01-16 | 2005-06-23 | エンド ファーマシューティカルズ インコーポレーテッド | 中枢神経系の障害を治療する製薬組成物及び方法 |
| TW200307539A (en) * | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| US7687080B2 (en) | 2002-11-25 | 2010-03-30 | Taraxos Inc. | Treatment of neuropathy |
| JP2008528587A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| AU2008209697B2 (en) | 2007-02-01 | 2014-02-20 | Janssen Sciences Ireland Uc | Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV |
| US7638651B2 (en) * | 2007-04-26 | 2009-12-29 | Auspex Pharmaceuticals | Substituted cyclohexanones |
| WO2009029618A1 (en) | 2007-08-27 | 2009-03-05 | Wyeth | Compositions and methods employing nmda antagonists for achieving an anesthetic-sparing effect |
| PT2221296E (pt) | 2007-11-28 | 2012-11-23 | Astellas Pharma Inc | Composto de indano fundido |
| US8722714B2 (en) | 2008-01-16 | 2014-05-13 | The Honk Kong University of Science and Technology | Oxazolidine derivatives as NMDA antagonists |
| CA2738468A1 (en) | 2008-09-27 | 2010-04-01 | Taraxos Inc. | Topical formulations for treatment of neuropathy |
| TW201026667A (en) | 2008-09-30 | 2010-07-16 | Merz Pharma Gmbh & Co Kgaa | Glycine b antagonists |
| FR2943666B1 (fr) | 2009-03-31 | 2011-04-15 | Commissariat Energie Atomique | Metallophore derive de nicotianamine et ses procedes de fabrication |
| FR2944011B1 (fr) * | 2009-04-03 | 2011-05-20 | Pf Medicament | Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments. |
| NZ595759A (en) * | 2009-05-07 | 2014-03-28 | Gruenenthal Chemie | Substituted phenylureas and phenylamides as vanilloid receptor ligands |
| FR2946535B1 (fr) | 2009-06-10 | 2011-09-09 | Neureva | Composition comprenant une molecule favorisant l'interaction neurone-glie, notamment pour prevenir la formation de la cicatrice gliale et induire la regeneration neurale. |
| TWI544923B (zh) | 2009-12-29 | 2016-08-11 | 何應瑞 | 用於治療神經退化性疾病之醫藥組合物 |
-
2012
- 2012-12-04 FR FR1261621A patent/FR2998892B1/fr not_active Expired - Fee Related
-
2013
- 2013-12-03 TW TW102144198A patent/TWI603947B/zh not_active IP Right Cessation
- 2013-12-04 MX MX2015006686A patent/MX364556B/es active IP Right Grant
- 2013-12-04 US US14/649,448 patent/US9469601B2/en active Active
- 2013-12-04 EP EP13811402.0A patent/EP2928861B1/fr active Active
- 2013-12-04 RS RS20170379A patent/RS55916B1/sr unknown
- 2013-12-04 PT PT138114020T patent/PT2928861T/pt unknown
- 2013-12-04 NZ NZ709572A patent/NZ709572A/en not_active IP Right Cessation
- 2013-12-04 AR ARP130104484A patent/AR093787A1/es not_active Application Discontinuation
- 2013-12-04 MY MYPI2015701784A patent/MY179886A/en unknown
- 2013-12-04 AU AU2013354133A patent/AU2013354133B2/en not_active Ceased
- 2013-12-04 ES ES13811402.0T patent/ES2621896T3/es active Active
- 2013-12-04 BR BR112015012752-5A patent/BR112015012752B1/pt not_active IP Right Cessation
- 2013-12-04 JP JP2015545991A patent/JP6391586B2/ja active Active
- 2013-12-04 CA CA2893216A patent/CA2893216C/fr active Active
- 2013-12-04 LT LTEP13811402.0T patent/LT2928861T/lt unknown
- 2013-12-04 DK DK13811402.0T patent/DK2928861T3/en active
- 2013-12-04 SI SI201330607A patent/SI2928861T1/sl unknown
- 2013-12-04 RU RU2015126104A patent/RU2655919C2/ru active
- 2013-12-04 CN CN201710102368.2A patent/CN106957285B/zh not_active Expired - Fee Related
- 2013-12-04 PL PL13811402T patent/PL2928861T3/pl unknown
- 2013-12-04 CN CN201380063117.8A patent/CN104854083B/zh not_active Expired - Fee Related
- 2013-12-04 KR KR1020157017845A patent/KR102221928B1/ko active IP Right Grant
- 2013-12-04 WO PCT/EP2013/075481 patent/WO2014086825A1/fr active Application Filing
- 2013-12-04 MA MA38229A patent/MA38229B1/fr unknown
- 2013-12-04 UA UAA201506431A patent/UA114017C2/uk unknown
-
2015
- 2015-06-02 TN TNP2015000240A patent/TN2015000240A1/fr unknown
- 2015-06-02 IL IL239146A patent/IL239146A/en active IP Right Grant
- 2015-06-03 SA SA515360518A patent/SA515360518B1/ar unknown
-
2016
- 2016-01-29 HK HK16101031.1A patent/HK1212968A1/zh not_active IP Right Cessation
- 2016-09-12 US US15/262,885 patent/US9687459B2/en active Active
-
2017
- 2017-04-06 CY CY20171100409T patent/CY1118841T1/el unknown
- 2017-04-10 HR HRP20170564TT patent/HRP20170564T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |